Diastolic dysfunction and exercise capacity in patients with metabolic syndrome and overweight/obesity
Background: Left ventricle diastolic dysfunction (LVDD) is a common finding in high risk individuals, its presence being associated with reduced exercise capacity (EC). We assessed the prevalence of LVDD, applying the 2016 guidelines of the American Society of Echocardiography (ASE)/European Associa...
| Autores: | , , , , , , , , , |
|---|---|
| Formato: | artículo |
| Fecha de publicación: | 2019 |
| País: | España |
| Recursos: | Universidad de Navarra |
| Repositorio: | Dadun. Depósito Académico Digital de la Universidad de Navarra |
| Idioma: | inglés |
| OAI Identifier: | oai:dadun.unav.edu:10171/63146 |
| Acesso em linha: | https://hdl.handle.net/10171/63146 |
| Access Level: | acceso abierto |
| Palavra-chave: | Diastolic dysfunction Doppler echocardiography Exercise capacity Metabolic syndrome Obesity |
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Diastolic dysfunction and exercise capacity in patients with metabolic syndrome and overweight/obesityAlonso-Gomez, A. (Ángel)|||/items/cf8eec22-d379-43a4-b291-c2cb4a4e6f2dTojal-Sierra, L. (Lucas)|||/items/0f1af7e4-5102-4c6a-8c37-4d2abf724f47Fortuny-Frau, E. (Elena)|||/items/eb5fc148-b5e5-4045-85b0-254a70ce9ab1Goicolea-Güemez, L. (Leire)|||/items/75b3467a-f850-4b5c-bd43-b6fe11215531Aboitiz-Uribarri, A. (Ane)|||/items/9d0297dc-02e4-4c9d-aab6-6ee987e4c38cPortillo, M.P. (María P.)|||/items/a9b050ad-eb19-4d20-8574-d4b2da33c873Toledo-Atucha, E. (Estefanía)|||/items/a67de95c-b88e-4c23-8fb9-6482b0f9fba0Schröder, H. (Helmut)|||/items/f7bf259b-c332-4660-8917-3dd70175db4aSalas-Salvado, J. (Jordi)|||/items/e2fc08dd-d21f-475b-83fa-157f0b0067e6Aros, F. (Fernando)|||/items/399e060f-9616-4d06-a6fd-9a2b2badc2ceDiastolic dysfunctionDoppler echocardiographyExercise capacityMetabolic syndromeObesityBackground: Left ventricle diastolic dysfunction (LVDD) is a common finding in high risk individuals, its presence being associated with reduced exercise capacity (EC). We assessed the prevalence of LVDD, applying the 2016 guidelines of the American Society of Echocardiography (ASE)/European Association of Cardiovascular Imaging (EACVI), in a population with overweight/obesity and metabolic syndrome and its association with EC. Methods and results: This was a prospective, cross-sectional study of a cohort of 235 patients (mean age of 65 ± 5 years old and 33% female) without heart disease and an ejection fraction N50% who underwent a complete echocardiographic assessment and cardiopulmonary exercise testing. Individuals meeting three or more criteria of the 2016 ASE/EACVI guidelines are considered to have LVDD, while tests are considered indeterminate in those meeting only two. Overall, 178 (76%) of our patients met one echocardiographic cutoff value for LVDD, 91 (39%) met two and 7 (3%) three or more. Patients meeting three cutoffs values showed a significant reduction in maximal oxygen uptake (16 ± 3 vs. 19.6 ± 5 ml/kg/min, p b .05), unlike those with indeterminate tests. In multiple regression analysis, meeting three cutoffs was associated with number of METS (ß = −2.2, p = .018). In exploratory analysis, using two criteria based on cutoffs different from those proposed in the guidelines, we identified groups with different EC. Conclusions: The application of 2016 ASE/EACVI guidelines limited the prevalence of LVDD to 3%. This group showed a clear reduction of the EC. New echocardiographic cutoff values proposed in this study allow us to establish subgroups with different levels of EC.Elsevier BVDadun. Depósito Académico Digital Universidad de Navarra20222022-03-1120192019-01-0120192019-01-01journal articlehttp://purl.org/coar/resource_type/c_6501info:eu-repo/semantics/articleapplication/pdfhttps://hdl.handle.net/10171/63146reponame:Dadun. Depósito Académico Digital de la Universidad de Navarrainstname:Universidad de NavarraInglésengopen accesshttp://purl.org/coar/access_right/c_abf2info:eu-repo/semantics/openAccessoai:dadun.unav.edu:10171/631462026-06-21T12:47:57Z |
| dc.title.none.fl_str_mv |
Diastolic dysfunction and exercise capacity in patients with metabolic syndrome and overweight/obesity |
| title |
Diastolic dysfunction and exercise capacity in patients with metabolic syndrome and overweight/obesity |
| spellingShingle |
Diastolic dysfunction and exercise capacity in patients with metabolic syndrome and overweight/obesity Alonso-Gomez, A. (Ángel)|||/items/cf8eec22-d379-43a4-b291-c2cb4a4e6f2d Diastolic dysfunction Doppler echocardiography Exercise capacity Metabolic syndrome Obesity |
| title_short |
Diastolic dysfunction and exercise capacity in patients with metabolic syndrome and overweight/obesity |
| title_full |
Diastolic dysfunction and exercise capacity in patients with metabolic syndrome and overweight/obesity |
| title_fullStr |
Diastolic dysfunction and exercise capacity in patients with metabolic syndrome and overweight/obesity |
| title_full_unstemmed |
Diastolic dysfunction and exercise capacity in patients with metabolic syndrome and overweight/obesity |
| title_sort |
Diastolic dysfunction and exercise capacity in patients with metabolic syndrome and overweight/obesity |
| dc.creator.none.fl_str_mv |
Alonso-Gomez, A. (Ángel)|||/items/cf8eec22-d379-43a4-b291-c2cb4a4e6f2d Tojal-Sierra, L. (Lucas)|||/items/0f1af7e4-5102-4c6a-8c37-4d2abf724f47 Fortuny-Frau, E. (Elena)|||/items/eb5fc148-b5e5-4045-85b0-254a70ce9ab1 Goicolea-Güemez, L. (Leire)|||/items/75b3467a-f850-4b5c-bd43-b6fe11215531 Aboitiz-Uribarri, A. (Ane)|||/items/9d0297dc-02e4-4c9d-aab6-6ee987e4c38c Portillo, M.P. (María P.)|||/items/a9b050ad-eb19-4d20-8574-d4b2da33c873 Toledo-Atucha, E. (Estefanía)|||/items/a67de95c-b88e-4c23-8fb9-6482b0f9fba0 Schröder, H. (Helmut)|||/items/f7bf259b-c332-4660-8917-3dd70175db4a Salas-Salvado, J. (Jordi)|||/items/e2fc08dd-d21f-475b-83fa-157f0b0067e6 Aros, F. (Fernando)|||/items/399e060f-9616-4d06-a6fd-9a2b2badc2ce |
| author |
Alonso-Gomez, A. (Ángel)|||/items/cf8eec22-d379-43a4-b291-c2cb4a4e6f2d |
| author_facet |
Alonso-Gomez, A. (Ángel)|||/items/cf8eec22-d379-43a4-b291-c2cb4a4e6f2d Tojal-Sierra, L. (Lucas)|||/items/0f1af7e4-5102-4c6a-8c37-4d2abf724f47 Fortuny-Frau, E. (Elena)|||/items/eb5fc148-b5e5-4045-85b0-254a70ce9ab1 Goicolea-Güemez, L. (Leire)|||/items/75b3467a-f850-4b5c-bd43-b6fe11215531 Aboitiz-Uribarri, A. (Ane)|||/items/9d0297dc-02e4-4c9d-aab6-6ee987e4c38c Portillo, M.P. (María P.)|||/items/a9b050ad-eb19-4d20-8574-d4b2da33c873 Toledo-Atucha, E. (Estefanía)|||/items/a67de95c-b88e-4c23-8fb9-6482b0f9fba0 Schröder, H. (Helmut)|||/items/f7bf259b-c332-4660-8917-3dd70175db4a Salas-Salvado, J. (Jordi)|||/items/e2fc08dd-d21f-475b-83fa-157f0b0067e6 Aros, F. (Fernando)|||/items/399e060f-9616-4d06-a6fd-9a2b2badc2ce |
| author_role |
author |
| author2 |
Tojal-Sierra, L. (Lucas)|||/items/0f1af7e4-5102-4c6a-8c37-4d2abf724f47 Fortuny-Frau, E. (Elena)|||/items/eb5fc148-b5e5-4045-85b0-254a70ce9ab1 Goicolea-Güemez, L. (Leire)|||/items/75b3467a-f850-4b5c-bd43-b6fe11215531 Aboitiz-Uribarri, A. (Ane)|||/items/9d0297dc-02e4-4c9d-aab6-6ee987e4c38c Portillo, M.P. (María P.)|||/items/a9b050ad-eb19-4d20-8574-d4b2da33c873 Toledo-Atucha, E. (Estefanía)|||/items/a67de95c-b88e-4c23-8fb9-6482b0f9fba0 Schröder, H. (Helmut)|||/items/f7bf259b-c332-4660-8917-3dd70175db4a Salas-Salvado, J. (Jordi)|||/items/e2fc08dd-d21f-475b-83fa-157f0b0067e6 Aros, F. (Fernando)|||/items/399e060f-9616-4d06-a6fd-9a2b2badc2ce |
| author2_role |
author author author author author author author author author |
| dc.contributor.none.fl_str_mv |
Dadun. Depósito Académico Digital Universidad de Navarra |
| dc.subject.none.fl_str_mv |
Diastolic dysfunction Doppler echocardiography Exercise capacity Metabolic syndrome Obesity |
| topic |
Diastolic dysfunction Doppler echocardiography Exercise capacity Metabolic syndrome Obesity |
| description |
Background: Left ventricle diastolic dysfunction (LVDD) is a common finding in high risk individuals, its presence being associated with reduced exercise capacity (EC). We assessed the prevalence of LVDD, applying the 2016 guidelines of the American Society of Echocardiography (ASE)/European Association of Cardiovascular Imaging (EACVI), in a population with overweight/obesity and metabolic syndrome and its association with EC. Methods and results: This was a prospective, cross-sectional study of a cohort of 235 patients (mean age of 65 ± 5 years old and 33% female) without heart disease and an ejection fraction N50% who underwent a complete echocardiographic assessment and cardiopulmonary exercise testing. Individuals meeting three or more criteria of the 2016 ASE/EACVI guidelines are considered to have LVDD, while tests are considered indeterminate in those meeting only two. Overall, 178 (76%) of our patients met one echocardiographic cutoff value for LVDD, 91 (39%) met two and 7 (3%) three or more. Patients meeting three cutoffs values showed a significant reduction in maximal oxygen uptake (16 ± 3 vs. 19.6 ± 5 ml/kg/min, p b .05), unlike those with indeterminate tests. In multiple regression analysis, meeting three cutoffs was associated with number of METS (ß = −2.2, p = .018). In exploratory analysis, using two criteria based on cutoffs different from those proposed in the guidelines, we identified groups with different EC. Conclusions: The application of 2016 ASE/EACVI guidelines limited the prevalence of LVDD to 3%. This group showed a clear reduction of the EC. New echocardiographic cutoff values proposed in this study allow us to establish subgroups with different levels of EC. |
| publishDate |
2019 |
| dc.date.none.fl_str_mv |
2019 2019-01-01 2019 2019-01-01 2022 2022-03-11 |
| dc.type.none.fl_str_mv |
journal article http://purl.org/coar/resource_type/c_6501 |
| dc.type.openaire.fl_str_mv |
info:eu-repo/semantics/article |
| format |
article |
| dc.identifier.none.fl_str_mv |
https://hdl.handle.net/10171/63146 |
| url |
https://hdl.handle.net/10171/63146 |
| dc.language.none.fl_str_mv |
Inglés eng |
| language_invalid_str_mv |
Inglés |
| language |
eng |
| dc.rights.none.fl_str_mv |
open access http://purl.org/coar/access_right/c_abf2 |
| dc.rights.openaire.fl_str_mv |
info:eu-repo/semantics/openAccess |
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open access http://purl.org/coar/access_right/c_abf2 |
| eu_rights_str_mv |
openAccess |
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application/pdf |
| dc.publisher.none.fl_str_mv |
Elsevier BV |
| publisher.none.fl_str_mv |
Elsevier BV |
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reponame:Dadun. Depósito Académico Digital de la Universidad de Navarra instname:Universidad de Navarra |
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Universidad de Navarra |
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Dadun. Depósito Académico Digital de la Universidad de Navarra |
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Dadun. Depósito Académico Digital de la Universidad de Navarra |
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1869411981949140992 |
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15,300719 |