L1CAM expression in endometrial carcinomas

Identification of aggressive endometrioid endometrial carcinomas (EECs) and non-endometrioid carcinomas (NEECs) is essential to improve outcome. L1 cell adhesion molecule (L1CAM) expression is a strong prognostic marker in stage I EECs, but less is known about L1CAM expression in advanced-stage EECs...

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Authors: van der Putten, Louis J. M., Visser, Nicole C. M.|||0000-0003-3919-3922, van de Vijver, Koen|||0000-0002-2026-9790, Santacana, Maria|||0000-0003-1975-2598, Bronsert, Peter|||0000-0001-8558-0347, Bulten, Johan, Hirschfeld, Marc|||0000-0002-4796-024X, Colás Ortega, Eva|||0000-0003-0302-4828, Gil-Moreno, Antonio|||0000-0003-1106-5590, Garcia, Angel, Mancebo, Gemma|||0000-0001-5859-7936, Alameda, Francesc|||0000-0002-7302-6901, Trovik, Jone|||0000-0002-3808-6407, Kopperud, Reidun K., Huvila, Jutta|||0000-0002-2685-0877, Schrauwen, Stefanie, Koskas, Martin, Walker, Francine, Weinberger, Vit|||0000-0003-4858-1951, Minar, Lubos, Jandakova, Eva, Snijders, Marc P. L. M., van den Berg-van Erp, Saskia, Matías-Guiu, Xavier|||0000-0002-7201-6605, Salvesen, Helga B., Amant, Frederic|||0000-0002-5452-4905, Massuger, Leon FAG., Pijnenborg, Johanna M. A.|||0000-0002-6138-1236
Format: article
Publication Date:2016
Country:España
Institution:Universitat Autònoma de Barcelona
Repository:Dipòsit Digital de Documents de la UAB
Language:English
OAI Identifier:oai:ddd.uab.cat:185951
Online Access:https://ddd.uab.cat/record/185951
https://dx.doi.org/urn:doi:10.1038/bjc.2016.235
Access Level:Open access
Keyword:Endometrial cancer
Endometrioid
Non-endometrioid
L1CAM
Immunohistochemistry
Description
Summary:Identification of aggressive endometrioid endometrial carcinomas (EECs) and non-endometrioid carcinomas (NEECs) is essential to improve outcome. L1 cell adhesion molecule (L1CAM) expression is a strong prognostic marker in stage I EECs, but less is known about L1CAM expression in advanced-stage EECs and NEECs. This study analyses L1CAM expression in a clinically representative cohort of endometrial carcinomas. The expression of L1CAM was immunohistochemically determined in 1199 endometrial carcinomas, treated at one of the European Network for Individualized Treatment of Endometrial Cancer (ENITEC) centres. Staining was considered positive when.

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