Evaluation of the Geriatric Nutritional Risk Index in predicting mortality in older patients with COVID-19 in the AgeBru cohort

Objective: To determine whether the Geriatric Nutritional Risk Index (GNRI) on hospital admission was associated to an increased 14-day and 12-month mortality-risk in older inpatients with COVID-19. Methods: Cohort study of consecutive inpatients admitted with COVID-19 in a university hospital (20/0...

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Autores: De Meester, Dorien, Goossens, Mathijs, Marco Navarro, Ester, Claessens, Marie, Gautier, Jennifer, Annweiler, Cédric, Lieten, Siddhartha, Benoit, Florence, Surquin, Murielle, Sánchez-Rodríguez, Dolores
Tipo de recurso: artículo
Estado:Versión aceptada para publicación
Fecha de publicación:2023
País:España
Institución:Universitat Pompeu Fabra
Repositorio:Repositorio Digital de la UPF
OAI Identifier:oai:repositori.upf.edu:10230/60146
Acceso en línea:http://hdl.handle.net/10230/60146
http://dx.doi.org/10.1016/j.clnesp.2023.06.025
Access Level:acceso abierto
Palabra clave:COVID-19
GNRI
Inflammation
Malnutrition risk screening
Mortality
Older people
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spelling Evaluation of the Geriatric Nutritional Risk Index in predicting mortality in older patients with COVID-19 in the AgeBru cohortDe Meester, DorienGoossens, MathijsMarco Navarro, EsterClaessens, MarieGautier, JenniferAnnweiler, CédricLieten, SiddharthaBenoit, FlorenceSurquin, MurielleSánchez-Rodríguez, DoloresCOVID-19GNRIInflammationMalnutrition risk screeningMortalityOlder peopleObjective: To determine whether the Geriatric Nutritional Risk Index (GNRI) on hospital admission was associated to an increased 14-day and 12-month mortality-risk in older inpatients with COVID-19. Methods: Cohort study of consecutive inpatients admitted with COVID-19 in a university hospital (20/03/2020-11/05/2021). Inclusion criteria: age over 65 years and positive polymerase chain reaction test. Exclusion criteria: missing data for weight, height, and/or albumin, hospital-acquired COVID-19, or patients transferred to other health facilities. Outcome: all-cause mortality at 14-day and 12-month follow-up. GNRI [1.489 × albumin (g/L)] + [41.7 (weight/ideal body weight)] was assessed at admission; scores ≤98 indicated risk of malnutrition. Cox-proportional hazards models assessed the association between the admission GNRI and 14-day and 12-month mortality-risk, after adjusting by demographic and clinical variables, including inflammation (C-reactive protein). Results: Of the 570 eligible patients, 224 (mean age 78 years; 52.2% women) met inclusion criteria and 151 (67.4%) were classified at risk of malnutrition. Twenty patients died during the 14-day and 42 during the 12-month follow-up. The risk of 14-day mortality was nearly 10 times higher in patients with GNRI scores ≤98 (HR = 9.6 [95%CI 1.3-71.6], P = 0.028); this association was marginally significant in the adjusted model (HR = 6.73 [95%CI 0.89-51.11], P = 0.065)]. No association between GNRI and the 12-month mortality-risk was found. Conclusions: The GNRI may play a role in the short-term prognosis of older inpatients with COVID-19. Further studies are required to confirm the short-term predictive validity of the GNRI within this population (Clinicaltrials.gov_NCT05276752).Elsevier20242023info:eu-repo/semantics/articleinfo:eu-repo/semantics/acceptedVersionapplication/pdfapplication/pdfhttp://hdl.handle.net/10230/60146http://dx.doi.org/10.1016/j.clnesp.2023.06.025reponame:Repositorio Digital de la UPFinstname:Universitat Pompeu FabraInglésClin Nutr ESPEN. 2023 Oct;57:65-72© Elsevier http://dx.doi.org/10.1016/j.clnesp.2023.06.025info:eu-repo/semantics/openAccessoai:repositori.upf.edu:10230/601462026-06-12T07:21:37Z
dc.title.none.fl_str_mv Evaluation of the Geriatric Nutritional Risk Index in predicting mortality in older patients with COVID-19 in the AgeBru cohort
title Evaluation of the Geriatric Nutritional Risk Index in predicting mortality in older patients with COVID-19 in the AgeBru cohort
spellingShingle Evaluation of the Geriatric Nutritional Risk Index in predicting mortality in older patients with COVID-19 in the AgeBru cohort
De Meester, Dorien
COVID-19
GNRI
Inflammation
Malnutrition risk screening
Mortality
Older people
title_short Evaluation of the Geriatric Nutritional Risk Index in predicting mortality in older patients with COVID-19 in the AgeBru cohort
title_full Evaluation of the Geriatric Nutritional Risk Index in predicting mortality in older patients with COVID-19 in the AgeBru cohort
title_fullStr Evaluation of the Geriatric Nutritional Risk Index in predicting mortality in older patients with COVID-19 in the AgeBru cohort
title_full_unstemmed Evaluation of the Geriatric Nutritional Risk Index in predicting mortality in older patients with COVID-19 in the AgeBru cohort
title_sort Evaluation of the Geriatric Nutritional Risk Index in predicting mortality in older patients with COVID-19 in the AgeBru cohort
dc.creator.none.fl_str_mv De Meester, Dorien
Goossens, Mathijs
Marco Navarro, Ester
Claessens, Marie
Gautier, Jennifer
Annweiler, Cédric
Lieten, Siddhartha
Benoit, Florence
Surquin, Murielle
Sánchez-Rodríguez, Dolores
author De Meester, Dorien
author_facet De Meester, Dorien
Goossens, Mathijs
Marco Navarro, Ester
Claessens, Marie
Gautier, Jennifer
Annweiler, Cédric
Lieten, Siddhartha
Benoit, Florence
Surquin, Murielle
Sánchez-Rodríguez, Dolores
author_role author
author2 Goossens, Mathijs
Marco Navarro, Ester
Claessens, Marie
Gautier, Jennifer
Annweiler, Cédric
Lieten, Siddhartha
Benoit, Florence
Surquin, Murielle
Sánchez-Rodríguez, Dolores
author2_role author
author
author
author
author
author
author
author
author
dc.subject.none.fl_str_mv COVID-19
GNRI
Inflammation
Malnutrition risk screening
Mortality
Older people
topic COVID-19
GNRI
Inflammation
Malnutrition risk screening
Mortality
Older people
description Objective: To determine whether the Geriatric Nutritional Risk Index (GNRI) on hospital admission was associated to an increased 14-day and 12-month mortality-risk in older inpatients with COVID-19. Methods: Cohort study of consecutive inpatients admitted with COVID-19 in a university hospital (20/03/2020-11/05/2021). Inclusion criteria: age over 65 years and positive polymerase chain reaction test. Exclusion criteria: missing data for weight, height, and/or albumin, hospital-acquired COVID-19, or patients transferred to other health facilities. Outcome: all-cause mortality at 14-day and 12-month follow-up. GNRI [1.489 × albumin (g/L)] + [41.7 (weight/ideal body weight)] was assessed at admission; scores ≤98 indicated risk of malnutrition. Cox-proportional hazards models assessed the association between the admission GNRI and 14-day and 12-month mortality-risk, after adjusting by demographic and clinical variables, including inflammation (C-reactive protein). Results: Of the 570 eligible patients, 224 (mean age 78 years; 52.2% women) met inclusion criteria and 151 (67.4%) were classified at risk of malnutrition. Twenty patients died during the 14-day and 42 during the 12-month follow-up. The risk of 14-day mortality was nearly 10 times higher in patients with GNRI scores ≤98 (HR = 9.6 [95%CI 1.3-71.6], P = 0.028); this association was marginally significant in the adjusted model (HR = 6.73 [95%CI 0.89-51.11], P = 0.065)]. No association between GNRI and the 12-month mortality-risk was found. Conclusions: The GNRI may play a role in the short-term prognosis of older inpatients with COVID-19. Further studies are required to confirm the short-term predictive validity of the GNRI within this population (Clinicaltrials.gov_NCT05276752).
publishDate 2023
dc.date.none.fl_str_mv 2023
2024
dc.type.none.fl_str_mv info:eu-repo/semantics/article
info:eu-repo/semantics/acceptedVersion
format article
status_str acceptedVersion
dc.identifier.none.fl_str_mv http://hdl.handle.net/10230/60146
http://dx.doi.org/10.1016/j.clnesp.2023.06.025
url http://hdl.handle.net/10230/60146
http://dx.doi.org/10.1016/j.clnesp.2023.06.025
dc.language.none.fl_str_mv Inglés
language_invalid_str_mv Inglés
dc.relation.none.fl_str_mv Clin Nutr ESPEN. 2023 Oct;57:65-72
dc.rights.none.fl_str_mv © Elsevier http://dx.doi.org/10.1016/j.clnesp.2023.06.025
info:eu-repo/semantics/openAccess
rights_invalid_str_mv © Elsevier http://dx.doi.org/10.1016/j.clnesp.2023.06.025
eu_rights_str_mv openAccess
dc.format.none.fl_str_mv application/pdf
application/pdf
dc.publisher.none.fl_str_mv Elsevier
publisher.none.fl_str_mv Elsevier
dc.source.none.fl_str_mv reponame:Repositorio Digital de la UPF
instname:Universitat Pompeu Fabra
instname_str Universitat Pompeu Fabra
reponame_str Repositorio Digital de la UPF
collection Repositorio Digital de la UPF
repository.name.fl_str_mv
repository.mail.fl_str_mv
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score 15,81155

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