Fat: Quality, or Quantity? What Matters Most for the Progression of Metabolic Associated Fatty Liver Disease (MAFLD)
Objectives: Lately, many countries have restricted or even banned transfat, and palm oil has become a preferred replacement for food manufacturers. Whether palm oil is potentially an unhealthy food mainly due to its high content of saturated Palmitic Acid (PA) is a matter of debate. The aim of this...
| Autores: | , , , , , , , , , , , , , , , , , , , , , , , , , , |
|---|---|
| Tipo de recurso: | artículo |
| Fecha de publicación: | 2021 |
| País: | España |
| Institución: | Universidad Complutense de Madrid (UCM) |
| Repositorio: | Docta Complutense |
| Idioma: | inglés |
| OAI Identifier: | oai:docta.ucm.es:20.500.14352/4884 |
| Acceso en línea: | https://hdl.handle.net/20.500.14352/4884 |
| Access Level: | acceso abierto |
| Palabra clave: | 616.36 616-056.25 577.27 Obesity Metabolic associated fatty liver disease (MAFLD) Steatohepatitis Fibrosis Palmitic acid (PA) Gastroenterología y hepatología Inmunología 3205.03 Gastroenterología 2412 Inmunología |
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Fat: Quality, or Quantity? What Matters Most for the Progression of Metabolic Associated Fatty Liver Disease (MAFLD)Estévez Vázquez, OlgaBenedé Ubieto, RaquelGuo, FeifeiGómez Santos, BeatrizAspichueta, PatriciaReissing, JohannaBruns, TonySanz García, CarlosSydor, SvenjaBechmann, Lars PMaranillo Alcaide, EvaSañudo Tejero, José RamónVázquez Osorio, María TeresaLamas Paz, ArantzaMorán, LauraMazariegos, Marina SCiudin, AndreeaPericàs, Juan M.Peligros Gómez, María IsabelVaquero, JavierMartínez Naves, EduardoLiedtke, ChristianRegueiro González-Barros, José RamónTrautwein, ChristianBañares Cañizares, RafaelCubero Palero, Francisco JavierNevzorova, Yulia616.36616-056.25577.27ObesityMetabolic associated fatty liver disease (MAFLD)SteatohepatitisFibrosisPalmitic acid (PA)Gastroenterología y hepatologíaInmunología3205.03 Gastroenterología2412 InmunologíaObjectives: Lately, many countries have restricted or even banned transfat, and palm oil has become a preferred replacement for food manufacturers. Whether palm oil is potentially an unhealthy food mainly due to its high content of saturated Palmitic Acid (PA) is a matter of debate. The aim of this study was to test whether qualitative aspects of diet such as levels of PA and the fat source are risk factors for Metabolic Syndrome (MS) and Metabolic Associated Fatty Liver Disease (MAFLD). Methods: C57BL/6 male mice were fed for 14 weeks with three types of Western diet (WD): 1. LP-WD—low concentration of PA (main fat source—corn and soybean oils); 2. HP-WD—high concentration of PA (main fat source—palm oil); 3. HP-Trans-WD—high concentration of PA (mainly transfat). Results: All types of WD caused weight gain, adipocyte enlargement, hepatomegaly, lipid metabolism alterations, and steatohepatitis. Feeding with HP diets led to more prominent obesity, hypercholesterolemia, stronger hepatic injury, and fibrosis. Only the feeding with HP-Trans-WD resulted in glucose intolerance and elevation of serum transaminases. Brief withdrawal of WDs reversed MS and signs of MAFLD. However, mild hepatic inflammation was still detectable in HP groups. Conclusions: HP and HP-Trans-WD play a crucial role in the genesis of MS and MAFLD.MDPIUniversidad Complutense de Madrid20212021-09-2220212021-09-22journal articlehttp://purl.org/coar/resource_type/c_6501info:eu-repo/semantics/articleapplication/pdfhttps://hdl.handle.net/20.500.14352/4884reponame:Docta Complutenseinstname:Universidad Complutense de Madrid (UCM)Inglésengopen accesshttp://purl.org/coar/access_right/c_abf2Atribución 3.0 Españahttps://creativecommons.org/licenses/by/3.0/es/info:eu-repo/semantics/openAccessoai:docta.ucm.es:20.500.14352/48842026-06-02T12:44:21Z |
| dc.title.none.fl_str_mv |
Fat: Quality, or Quantity? What Matters Most for the Progression of Metabolic Associated Fatty Liver Disease (MAFLD) |
| title |
Fat: Quality, or Quantity? What Matters Most for the Progression of Metabolic Associated Fatty Liver Disease (MAFLD) |
| spellingShingle |
Fat: Quality, or Quantity? What Matters Most for the Progression of Metabolic Associated Fatty Liver Disease (MAFLD) Estévez Vázquez, Olga 616.36 616-056.25 577.27 Obesity Metabolic associated fatty liver disease (MAFLD) Steatohepatitis Fibrosis Palmitic acid (PA) Gastroenterología y hepatología Inmunología 3205.03 Gastroenterología 2412 Inmunología |
| title_short |
Fat: Quality, or Quantity? What Matters Most for the Progression of Metabolic Associated Fatty Liver Disease (MAFLD) |
| title_full |
Fat: Quality, or Quantity? What Matters Most for the Progression of Metabolic Associated Fatty Liver Disease (MAFLD) |
| title_fullStr |
Fat: Quality, or Quantity? What Matters Most for the Progression of Metabolic Associated Fatty Liver Disease (MAFLD) |
| title_full_unstemmed |
Fat: Quality, or Quantity? What Matters Most for the Progression of Metabolic Associated Fatty Liver Disease (MAFLD) |
| title_sort |
Fat: Quality, or Quantity? What Matters Most for the Progression of Metabolic Associated Fatty Liver Disease (MAFLD) |
| dc.creator.none.fl_str_mv |
Estévez Vázquez, Olga Benedé Ubieto, Raquel Guo, Feifei Gómez Santos, Beatriz Aspichueta, Patricia Reissing, Johanna Bruns, Tony Sanz García, Carlos Sydor, Svenja Bechmann, Lars P Maranillo Alcaide, Eva Sañudo Tejero, José Ramón Vázquez Osorio, María Teresa Lamas Paz, Arantza Morán, Laura Mazariegos, Marina S Ciudin, Andreea Pericàs, Juan M. Peligros Gómez, María Isabel Vaquero, Javier Martínez Naves, Eduardo Liedtke, Christian Regueiro González-Barros, José Ramón Trautwein, Christian Bañares Cañizares, Rafael Cubero Palero, Francisco Javier Nevzorova, Yulia |
| author |
Estévez Vázquez, Olga |
| author_facet |
Estévez Vázquez, Olga Benedé Ubieto, Raquel Guo, Feifei Gómez Santos, Beatriz Aspichueta, Patricia Reissing, Johanna Bruns, Tony Sanz García, Carlos Sydor, Svenja Bechmann, Lars P Maranillo Alcaide, Eva Sañudo Tejero, José Ramón Vázquez Osorio, María Teresa Lamas Paz, Arantza Morán, Laura Mazariegos, Marina S Ciudin, Andreea Pericàs, Juan M. Peligros Gómez, María Isabel Vaquero, Javier Martínez Naves, Eduardo Liedtke, Christian Regueiro González-Barros, José Ramón Trautwein, Christian Bañares Cañizares, Rafael Cubero Palero, Francisco Javier Nevzorova, Yulia |
| author_role |
author |
| author2 |
Benedé Ubieto, Raquel Guo, Feifei Gómez Santos, Beatriz Aspichueta, Patricia Reissing, Johanna Bruns, Tony Sanz García, Carlos Sydor, Svenja Bechmann, Lars P Maranillo Alcaide, Eva Sañudo Tejero, José Ramón Vázquez Osorio, María Teresa Lamas Paz, Arantza Morán, Laura Mazariegos, Marina S Ciudin, Andreea Pericàs, Juan M. Peligros Gómez, María Isabel Vaquero, Javier Martínez Naves, Eduardo Liedtke, Christian Regueiro González-Barros, José Ramón Trautwein, Christian Bañares Cañizares, Rafael Cubero Palero, Francisco Javier Nevzorova, Yulia |
| author2_role |
author author author author author author author author author author author author author author author author author author author author author author author author author author |
| dc.contributor.none.fl_str_mv |
Universidad Complutense de Madrid |
| dc.subject.none.fl_str_mv |
616.36 616-056.25 577.27 Obesity Metabolic associated fatty liver disease (MAFLD) Steatohepatitis Fibrosis Palmitic acid (PA) Gastroenterología y hepatología Inmunología 3205.03 Gastroenterología 2412 Inmunología |
| topic |
616.36 616-056.25 577.27 Obesity Metabolic associated fatty liver disease (MAFLD) Steatohepatitis Fibrosis Palmitic acid (PA) Gastroenterología y hepatología Inmunología 3205.03 Gastroenterología 2412 Inmunología |
| description |
Objectives: Lately, many countries have restricted or even banned transfat, and palm oil has become a preferred replacement for food manufacturers. Whether palm oil is potentially an unhealthy food mainly due to its high content of saturated Palmitic Acid (PA) is a matter of debate. The aim of this study was to test whether qualitative aspects of diet such as levels of PA and the fat source are risk factors for Metabolic Syndrome (MS) and Metabolic Associated Fatty Liver Disease (MAFLD). Methods: C57BL/6 male mice were fed for 14 weeks with three types of Western diet (WD): 1. LP-WD—low concentration of PA (main fat source—corn and soybean oils); 2. HP-WD—high concentration of PA (main fat source—palm oil); 3. HP-Trans-WD—high concentration of PA (mainly transfat). Results: All types of WD caused weight gain, adipocyte enlargement, hepatomegaly, lipid metabolism alterations, and steatohepatitis. Feeding with HP diets led to more prominent obesity, hypercholesterolemia, stronger hepatic injury, and fibrosis. Only the feeding with HP-Trans-WD resulted in glucose intolerance and elevation of serum transaminases. Brief withdrawal of WDs reversed MS and signs of MAFLD. However, mild hepatic inflammation was still detectable in HP groups. Conclusions: HP and HP-Trans-WD play a crucial role in the genesis of MS and MAFLD. |
| publishDate |
2021 |
| dc.date.none.fl_str_mv |
2021 2021-09-22 2021 2021-09-22 |
| dc.type.none.fl_str_mv |
journal article http://purl.org/coar/resource_type/c_6501 |
| dc.type.openaire.fl_str_mv |
info:eu-repo/semantics/article |
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article |
| dc.identifier.none.fl_str_mv |
https://hdl.handle.net/20.500.14352/4884 |
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https://hdl.handle.net/20.500.14352/4884 |
| dc.language.none.fl_str_mv |
Inglés eng |
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Inglés |
| language |
eng |
| dc.rights.none.fl_str_mv |
open access http://purl.org/coar/access_right/c_abf2 Atribución 3.0 España https://creativecommons.org/licenses/by/3.0/es/ |
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info:eu-repo/semantics/openAccess |
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open access http://purl.org/coar/access_right/c_abf2 Atribución 3.0 España https://creativecommons.org/licenses/by/3.0/es/ |
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openAccess |
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application/pdf |
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MDPI |
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MDPI |
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reponame:Docta Complutense instname:Universidad Complutense de Madrid (UCM) |
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Universidad Complutense de Madrid (UCM) |
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Docta Complutense |
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Docta Complutense |
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