BioMOF@cellulose Glycerogel Scaffold with Multifold Bioactivity

The development of new biomaterials for musculoskeletal tissue repair is currently an important branch in biomedicine research. The approach presented here is centered around the development of a prototypic synthetic glycerogel scaffold for bone regeneration, which simultaneously features therapeuti...

Descripción completa

Detalles Bibliográficos
Autores: Rosado, Albert|||0000-0003-3222-9566, Borrás Caballero, Alejandro|||0000-0002-0725-421X, Sánchez-Soto, Miguel|||0000-0002-0023-5059, Labíková, Magdaléna, Hettegger, Hubert|||0000-0002-9343-5673, Ramírez-Jiménez, Rosa Ana|||0000-0001-7563-2553, Rojo, Luís|||0000-0001-6334-6736, García-Fernández, Luis|||0000-0002-4179-2556, Aguilar, María Rosa|||0000-0001-7395-5754, Liebner, Falk|||0000-0002-8244-8153, Lopez-Periago, Ana M.|||0000-0002-3777-3205, Ayllón, José A.|||0000-0001-7965-7424, Domingo, Concepción|||0000-0001-7857-2760
Tipo de recurso: artículo
Fecha de publicación:2024
País:España
Institución:Universitat Autònoma de Barcelona
Repositorio:Dipòsit Digital de Documents de la UAB
Idioma:inglés
OAI Identifier:oai:ddd.uab.cat:308219
Acceso en línea:https://ddd.uab.cat/record/308219
https://dx.doi.org/urn:doi:10.3390/gels10100631
Access Level:acceso abierto
Palabra clave:Glycerogel
Cellulose
Biomof
Composite
Scaffold
Tissue repair
id ES_80ef8e30760fdede6944704dc8d643ef
oai_identifier_str oai:ddd.uab.cat:308219
network_acronym_str ES
network_name_str España
repository_id_str
spelling BioMOF@cellulose Glycerogel Scaffold with Multifold BioactivityPerspective in Bone Tissue RepairRosado, Albert|||0000-0003-3222-9566Borrás Caballero, Alejandro|||0000-0002-0725-421XSánchez-Soto, Miguel|||0000-0002-0023-5059Labíková, MagdalénaHettegger, Hubert|||0000-0002-9343-5673Ramírez-Jiménez, Rosa Ana|||0000-0001-7563-2553Rojo, Luís|||0000-0001-6334-6736García-Fernández, Luis|||0000-0002-4179-2556Aguilar, María Rosa|||0000-0001-7395-5754Liebner, Falk|||0000-0002-8244-8153Lopez-Periago, Ana M.|||0000-0002-3777-3205Ayllón, José A.|||0000-0001-7965-7424Domingo, Concepción|||0000-0001-7857-2760GlycerogelCelluloseBiomofCompositeScaffoldTissue repairThe development of new biomaterials for musculoskeletal tissue repair is currently an important branch in biomedicine research. The approach presented here is centered around the development of a prototypic synthetic glycerogel scaffold for bone regeneration, which simultaneously features therapeutic activity. The main novelty of this work lies in the combination of an open meso and macroporous nanocrystalline cellulose (NCC)-based glycerogel with a fully biocompatible microporous bioMOF system (CaSyr-1) composed of calcium ions and syringic acid. The bioMOF framework is further impregnated with a third bioactive component, i.e., ibuprofen (ibu), to generate a multifold bioactive system. The integrated CaSyr-1(ibu) serves as a reservoir for bioactive compounds delivery, while the NCC scaffold is the proposed matrix for cell ingrowth, proliferation and differentiation. The measured drug delivery profiles, studied in a phosphate-buffered saline solution at 310 K, indicate that the bioactive components are released concurrently with bioMOF dissolution after ca. 30 min following a pseudo-first-order kinetic model. Furthermore, according to the semi-empirical Korsmeyer-Peppas kinetic model, this release is governed by a case-II mechanism, suggesting that the molecular transport is influenced by the relaxation of the NCC matrix. Preliminary in vitro results denote that the initial high concentration of glycerol in the NCC scaffold can be toxic in direct contact with human osteoblasts (HObs). However, when the excess of glycerol is diluted in the system (after the second day of the experiment), the direct and indirect assays confirm full biocompatibility and suitability for HOb proliferation. 22024-01-0120242024-01-01Articlehttp://purl.org/coar/resource_type/c_6501VoRhttp://purl.org/coar/version/c_970fb48d4fbd8a85info:eu-repo/semantics/articleapplication/pdfhttps://ddd.uab.cat/record/308219https://dx.doi.org/urn:doi:10.3390/gels10100631reponame:Dipòsit Digital de Documents de la UABinstname:Universitat Autònoma de BarcelonaInglésengMinisterio de Ciencia e Innovación https://doi.org/10.13039/501100004837 CEX2019-000917-SAgencia Estatal de Investigación https://doi.org/10.13039/501100011033 PID2020-115631GB-I00Agencia Estatal de Investigación https://doi.org/10.13039/501100011033 PID2020-114086RB-I00Agencia Estatal de Investigación https://doi.org/10.13039/501100011033 PID2019-106518RB-I00Ministerio de Sanidad y Consumo CB06/01/0013Agència de Gestió d'Ajuts Universitaris i de Recerca https://doi.org/10.13039/501100003030 2021/SGR-01042open accesshttp://purl.org/coar/access_right/c_abf2Aquest document està subjecte a una llicència d'ús Creative Commons. Es permet la reproducció total o parcial, la distribució, la comunicació pública de l'obra i la creació d'obres derivades, fins i tot amb finalitats comercials, sempre i quan es reconegui l'autoria de l'obra original.https://creativecommons.org/licenses/by/4.0/info:eu-repo/semantics/openAccessoai:ddd.uab.cat:3082192026-06-06T12:50:31Z
dc.title.none.fl_str_mv BioMOF@cellulose Glycerogel Scaffold with Multifold Bioactivity
Perspective in Bone Tissue Repair
title BioMOF@cellulose Glycerogel Scaffold with Multifold Bioactivity
spellingShingle BioMOF@cellulose Glycerogel Scaffold with Multifold Bioactivity
Rosado, Albert|||0000-0003-3222-9566
Glycerogel
Cellulose
Biomof
Composite
Scaffold
Tissue repair
title_short BioMOF@cellulose Glycerogel Scaffold with Multifold Bioactivity
title_full BioMOF@cellulose Glycerogel Scaffold with Multifold Bioactivity
title_fullStr BioMOF@cellulose Glycerogel Scaffold with Multifold Bioactivity
title_full_unstemmed BioMOF@cellulose Glycerogel Scaffold with Multifold Bioactivity
title_sort BioMOF@cellulose Glycerogel Scaffold with Multifold Bioactivity
dc.creator.none.fl_str_mv Rosado, Albert|||0000-0003-3222-9566
Borrás Caballero, Alejandro|||0000-0002-0725-421X
Sánchez-Soto, Miguel|||0000-0002-0023-5059
Labíková, Magdaléna
Hettegger, Hubert|||0000-0002-9343-5673
Ramírez-Jiménez, Rosa Ana|||0000-0001-7563-2553
Rojo, Luís|||0000-0001-6334-6736
García-Fernández, Luis|||0000-0002-4179-2556
Aguilar, María Rosa|||0000-0001-7395-5754
Liebner, Falk|||0000-0002-8244-8153
Lopez-Periago, Ana M.|||0000-0002-3777-3205
Ayllón, José A.|||0000-0001-7965-7424
Domingo, Concepción|||0000-0001-7857-2760
author Rosado, Albert|||0000-0003-3222-9566
author_facet Rosado, Albert|||0000-0003-3222-9566
Borrás Caballero, Alejandro|||0000-0002-0725-421X
Sánchez-Soto, Miguel|||0000-0002-0023-5059
Labíková, Magdaléna
Hettegger, Hubert|||0000-0002-9343-5673
Ramírez-Jiménez, Rosa Ana|||0000-0001-7563-2553
Rojo, Luís|||0000-0001-6334-6736
García-Fernández, Luis|||0000-0002-4179-2556
Aguilar, María Rosa|||0000-0001-7395-5754
Liebner, Falk|||0000-0002-8244-8153
Lopez-Periago, Ana M.|||0000-0002-3777-3205
Ayllón, José A.|||0000-0001-7965-7424
Domingo, Concepción|||0000-0001-7857-2760
author_role author
author2 Borrás Caballero, Alejandro|||0000-0002-0725-421X
Sánchez-Soto, Miguel|||0000-0002-0023-5059
Labíková, Magdaléna
Hettegger, Hubert|||0000-0002-9343-5673
Ramírez-Jiménez, Rosa Ana|||0000-0001-7563-2553
Rojo, Luís|||0000-0001-6334-6736
García-Fernández, Luis|||0000-0002-4179-2556
Aguilar, María Rosa|||0000-0001-7395-5754
Liebner, Falk|||0000-0002-8244-8153
Lopez-Periago, Ana M.|||0000-0002-3777-3205
Ayllón, José A.|||0000-0001-7965-7424
Domingo, Concepción|||0000-0001-7857-2760
author2_role author
author
author
author
author
author
author
author
author
author
author
author
dc.subject.none.fl_str_mv Glycerogel
Cellulose
Biomof
Composite
Scaffold
Tissue repair
topic Glycerogel
Cellulose
Biomof
Composite
Scaffold
Tissue repair
description The development of new biomaterials for musculoskeletal tissue repair is currently an important branch in biomedicine research. The approach presented here is centered around the development of a prototypic synthetic glycerogel scaffold for bone regeneration, which simultaneously features therapeutic activity. The main novelty of this work lies in the combination of an open meso and macroporous nanocrystalline cellulose (NCC)-based glycerogel with a fully biocompatible microporous bioMOF system (CaSyr-1) composed of calcium ions and syringic acid. The bioMOF framework is further impregnated with a third bioactive component, i.e., ibuprofen (ibu), to generate a multifold bioactive system. The integrated CaSyr-1(ibu) serves as a reservoir for bioactive compounds delivery, while the NCC scaffold is the proposed matrix for cell ingrowth, proliferation and differentiation. The measured drug delivery profiles, studied in a phosphate-buffered saline solution at 310 K, indicate that the bioactive components are released concurrently with bioMOF dissolution after ca. 30 min following a pseudo-first-order kinetic model. Furthermore, according to the semi-empirical Korsmeyer-Peppas kinetic model, this release is governed by a case-II mechanism, suggesting that the molecular transport is influenced by the relaxation of the NCC matrix. Preliminary in vitro results denote that the initial high concentration of glycerol in the NCC scaffold can be toxic in direct contact with human osteoblasts (HObs). However, when the excess of glycerol is diluted in the system (after the second day of the experiment), the direct and indirect assays confirm full biocompatibility and suitability for HOb proliferation.
publishDate 2024
dc.date.none.fl_str_mv 2
2024-01-01
2024
2024-01-01
dc.type.none.fl_str_mv Article
http://purl.org/coar/resource_type/c_6501
VoR
http://purl.org/coar/version/c_970fb48d4fbd8a85
dc.type.openaire.fl_str_mv info:eu-repo/semantics/article
format article
dc.identifier.none.fl_str_mv https://ddd.uab.cat/record/308219
https://dx.doi.org/urn:doi:10.3390/gels10100631
url https://ddd.uab.cat/record/308219
https://dx.doi.org/urn:doi:10.3390/gels10100631
dc.language.none.fl_str_mv Inglés
eng
language_invalid_str_mv Inglés
language eng
dc.relation.none.fl_str_mv Ministerio de Ciencia e Innovación https://doi.org/10.13039/501100004837 CEX2019-000917-S
Agencia Estatal de Investigación https://doi.org/10.13039/501100011033 PID2020-115631GB-I00
Agencia Estatal de Investigación https://doi.org/10.13039/501100011033 PID2020-114086RB-I00
Agencia Estatal de Investigación https://doi.org/10.13039/501100011033 PID2019-106518RB-I00
Ministerio de Sanidad y Consumo CB06/01/0013
Agència de Gestió d'Ajuts Universitaris i de Recerca https://doi.org/10.13039/501100003030 2021/SGR-01042
dc.rights.none.fl_str_mv open access
http://purl.org/coar/access_right/c_abf2
https://creativecommons.org/licenses/by/4.0/
dc.rights.openaire.fl_str_mv info:eu-repo/semantics/openAccess
rights_invalid_str_mv open access
http://purl.org/coar/access_right/c_abf2
https://creativecommons.org/licenses/by/4.0/
eu_rights_str_mv openAccess
dc.format.none.fl_str_mv application/pdf
dc.source.none.fl_str_mv reponame:Dipòsit Digital de Documents de la UAB
instname:Universitat Autònoma de Barcelona
instname_str Universitat Autònoma de Barcelona
reponame_str Dipòsit Digital de Documents de la UAB
collection Dipòsit Digital de Documents de la UAB
repository.name.fl_str_mv
repository.mail.fl_str_mv
_version_ 1869411936750272512
score 15,811543

Similares en LA Referencia