The Contribution of QF-PCR and pathology studies in the diagnosis of diandric triploidy/partial mole

Objective: the aim of our study was to assess the contribution of quantitative fluorescent polymerase chain reaction (QF-PCR) and pathology studies in the diagnosis of diandric triploidies/partial hydatidiform moles. Methods: this study included all fet al triploidies diagnosed by QF-PCR in chorioni...

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Autores: Benitez, Leticia, Pauta, Montse, Badenas Orquin, Celia, Madrigal Bajo, Irene, Nadal Serra, Alfons, Marimon, Edda, Borrell, Antoni
Tipo de recurso: artículo
Estado:Versión publicada
Fecha de publicación:2021
País:España
Institución:Varias* (Consorci de Biblioteques Universitáries de Catalunya, Centre de Serveis Científics i Acadèmics de Catalunya)
Repositorio:Recercat. Dipósit de la Recerca de Catalunya
OAI Identifier:oai:recercat.cat:2445/181200
Acceso en línea:https://hdl.handle.net/2445/181200
Access Level:acceso abierto
Palabra clave:Reacció en cadena de la polimerasa
Polymerase chain reaction
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spelling The Contribution of QF-PCR and pathology studies in the diagnosis of diandric triploidy/partial moleBenitez, LeticiaPauta, MontseBadenas Orquin, CeliaMadrigal Bajo, IreneNadal Serra, AlfonsMarimon, EddaBorrell, AntoniReacció en cadena de la polimerasaPolymerase chain reactionObjective: the aim of our study was to assess the contribution of quantitative fluorescent polymerase chain reaction (QF-PCR) and pathology studies in the diagnosis of diandric triploidies/partial hydatidiform moles. Methods: this study included all fet al triploidies diagnosed by QF-PCR in chorionic villi or amniotic fluid in the 2 centers of BCNatal in which a maternal saliva sample was used to establish its parental origin. Pathology studies were performed in products of conception and concordance between a partial hydatidiform mole diagnosis and the finding of a diandric triploidy was assessed. Results: among 46 fetal triploidies, found in 13 ongoing pregnancies and in 33 miscarriages, there were 26 (56%) diandric triploidies. Concordant molecular (diandric triploidy) and pathology results (partial mole) were achieved in 14 cases (54%), while in 6 cases (23%) pathology studies were normal, and in the remaining 6 cases (23%) pathology studies could not be performed because miscarriage was managed medically. Conclusions: diandric triploidy is associated with partial hydatidiform mole and its diagnosis is crucial to prevent the development of persistent trophoblastic disease. QF-PCR analysis in chorionic villi or amniotic fluid provides a more accurate diagnosis of the parental origin of triploidy than the classical pathology studiesMDPI2021202120212021info:eu-repo/semantics/articleinfo:eu-repo/semantics/publishedVersion8 p.application/pdfhttps://hdl.handle.net/2445/181200Articles publicats en revistes (Fonaments Clínics)reponame:Recercat. Dipósit de la Recerca de Catalunyainstname:Varias* (Consorci de Biblioteques Universitáries de Catalunya, Centre de Serveis Científics i Acadèmics de Catalunya)InglésReproducció del document publicat a: https://doi.org/10.3390/diagnostics11101811Diagnostics, 2021, vol. 11, num. 10, p. 1811https://doi.org/10.3390/diagnostics11101811cc-by (c) Benítez, Leticia et al., 2021https://creativecommons.org/licenses/by/4.0/info:eu-repo/semantics/openAccessoai:recercat.cat:2445/1812002026-05-29T05:05:01Z
dc.title.none.fl_str_mv The Contribution of QF-PCR and pathology studies in the diagnosis of diandric triploidy/partial mole
title The Contribution of QF-PCR and pathology studies in the diagnosis of diandric triploidy/partial mole
spellingShingle The Contribution of QF-PCR and pathology studies in the diagnosis of diandric triploidy/partial mole
Benitez, Leticia
Reacció en cadena de la polimerasa
Polymerase chain reaction
title_short The Contribution of QF-PCR and pathology studies in the diagnosis of diandric triploidy/partial mole
title_full The Contribution of QF-PCR and pathology studies in the diagnosis of diandric triploidy/partial mole
title_fullStr The Contribution of QF-PCR and pathology studies in the diagnosis of diandric triploidy/partial mole
title_full_unstemmed The Contribution of QF-PCR and pathology studies in the diagnosis of diandric triploidy/partial mole
title_sort The Contribution of QF-PCR and pathology studies in the diagnosis of diandric triploidy/partial mole
dc.creator.none.fl_str_mv Benitez, Leticia
Pauta, Montse
Badenas Orquin, Celia
Madrigal Bajo, Irene
Nadal Serra, Alfons
Marimon, Edda
Borrell, Antoni
author Benitez, Leticia
author_facet Benitez, Leticia
Pauta, Montse
Badenas Orquin, Celia
Madrigal Bajo, Irene
Nadal Serra, Alfons
Marimon, Edda
Borrell, Antoni
author_role author
author2 Pauta, Montse
Badenas Orquin, Celia
Madrigal Bajo, Irene
Nadal Serra, Alfons
Marimon, Edda
Borrell, Antoni
author2_role author
author
author
author
author
author
dc.subject.none.fl_str_mv Reacció en cadena de la polimerasa
Polymerase chain reaction
topic Reacció en cadena de la polimerasa
Polymerase chain reaction
description Objective: the aim of our study was to assess the contribution of quantitative fluorescent polymerase chain reaction (QF-PCR) and pathology studies in the diagnosis of diandric triploidies/partial hydatidiform moles. Methods: this study included all fet al triploidies diagnosed by QF-PCR in chorionic villi or amniotic fluid in the 2 centers of BCNatal in which a maternal saliva sample was used to establish its parental origin. Pathology studies were performed in products of conception and concordance between a partial hydatidiform mole diagnosis and the finding of a diandric triploidy was assessed. Results: among 46 fetal triploidies, found in 13 ongoing pregnancies and in 33 miscarriages, there were 26 (56%) diandric triploidies. Concordant molecular (diandric triploidy) and pathology results (partial mole) were achieved in 14 cases (54%), while in 6 cases (23%) pathology studies were normal, and in the remaining 6 cases (23%) pathology studies could not be performed because miscarriage was managed medically. Conclusions: diandric triploidy is associated with partial hydatidiform mole and its diagnosis is crucial to prevent the development of persistent trophoblastic disease. QF-PCR analysis in chorionic villi or amniotic fluid provides a more accurate diagnosis of the parental origin of triploidy than the classical pathology studies
publishDate 2021
dc.date.none.fl_str_mv 2021
2021
2021
2021
dc.type.none.fl_str_mv info:eu-repo/semantics/article
info:eu-repo/semantics/publishedVersion
format article
status_str publishedVersion
dc.identifier.none.fl_str_mv https://hdl.handle.net/2445/181200
url https://hdl.handle.net/2445/181200
dc.language.none.fl_str_mv Inglés
language_invalid_str_mv Inglés
dc.relation.none.fl_str_mv Reproducció del document publicat a: https://doi.org/10.3390/diagnostics11101811
Diagnostics, 2021, vol. 11, num. 10, p. 1811
https://doi.org/10.3390/diagnostics11101811
dc.rights.none.fl_str_mv cc-by (c) Benítez, Leticia et al., 2021
https://creativecommons.org/licenses/by/4.0/
info:eu-repo/semantics/openAccess
rights_invalid_str_mv cc-by (c) Benítez, Leticia et al., 2021
https://creativecommons.org/licenses/by/4.0/
eu_rights_str_mv openAccess
dc.format.none.fl_str_mv 8 p.
application/pdf
dc.publisher.none.fl_str_mv MDPI
publisher.none.fl_str_mv MDPI
dc.source.none.fl_str_mv Articles publicats en revistes (Fonaments Clínics)
reponame:Recercat. Dipósit de la Recerca de Catalunya
instname:Varias* (Consorci de Biblioteques Universitáries de Catalunya, Centre de Serveis Científics i Acadèmics de Catalunya)
instname_str Varias* (Consorci de Biblioteques Universitáries de Catalunya, Centre de Serveis Científics i Acadèmics de Catalunya)
reponame_str Recercat. Dipósit de la Recerca de Catalunya
collection Recercat. Dipósit de la Recerca de Catalunya
repository.name.fl_str_mv
repository.mail.fl_str_mv
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