Relationship between trabecular bone score, bone mineral density and vertebral fractures in patients with axial spondyloarthritis

BackgroundIn patients with axial spondyloarthritis, vertebral fracture risk is elevated and not always correlated with bone mineral density (BMD). Trabecular bone score (TBS) may offer some advantages in the assessment of vertebral fracture risk in these patients. The primary objective of this study...

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Autores: Valls-Pascual E, Orenes-Vera AV, Sendra-García A, Martínez-Ferrer À, Montolío-Chiva L, Vázquez-Gómez I, Flores-Fernández E, Ybáñez-García D, Vega-Martínez M, García-Ferrer L, Graells-Ferrer M, Alegre-Sancho JJ
Formato: artículo
Estado:Versión publicada
Fecha de publicación:2023
País:España
Recursos:Fundación para el Fomento de la Investigación Sanitaria y Biomédica de la Comunitat Valenciana (FISABIO)
Repositorio:r-FISABIO. Repositorio Institucional de Producción Científica
OAI Identifier:oai:fisabio.fundanetsuite.com:p15178
Acesso em linha:https://fisabio.portalinvestigacion.com/publicaciones/15178
Access Level:acceso abierto
Palavra-chave:Trabecular bone score
Bone mineral density
Axial spondyloarthritis
Syndesmophytes
Vertebral fracture
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spelling Relationship between trabecular bone score, bone mineral density and vertebral fractures in patients with axial spondyloarthritisValls-Pascual EOrenes-Vera AVSendra-García AMartínez-Ferrer ÀMontolío-Chiva LVázquez-Gómez IFlores-Fernández EYbáñez-García DVega-Martínez MGarcía-Ferrer LGraells-Ferrer MAlegre-Sancho JJTrabecular bone scoreBone mineral densityAxial spondyloarthritisSyndesmophytesVertebral fractureBackgroundIn patients with axial spondyloarthritis, vertebral fracture risk is elevated and not always correlated with bone mineral density (BMD). Trabecular bone score (TBS) may offer some advantages in the assessment of vertebral fracture risk in these patients. The primary objective of this study was to compare TBS and BMD between axial spondyloarthritis patients depending on their vertebral fracture status. Secondary objectives were to estimate the prevalence of morphometric vertebral fractures, and to explore factors associated with fracture, as well as the interference of syndesmophytes on BMD and TBS.MethodsA cross-sectional study was conducted. Data were collected on demographic and clinical characteristics, lab results, imaging findings and treatment. Statistical analysis was performed using SPSS v.13 statistical software.ResultsEighty-four patients (60 men and 24 women; mean age of 59 years) were included. Nearly half (47.6%) of them had lumbar syndesmophytes. The rate of morphometric fracture was 11.9%. TBS showed a higher area under the curve (0.89) than total hip, femoral neck and lumbar BMD (0.80, 0.78, and 0.70 respectively) for classifying patients regarding their fracture status. Nonetheless, the differences did not reach statistical significance.Syndesmophytes affected lumbar spine BMD (p < 0.001), but not hip BMD or TBS. Fractures were associated with TBS, total hip BMD, erythrocyte sedimentation rate and C-reactive protein levels.ConclusionsWe identified decreased TBS and total hip BMD, as well as increased erythrocyte sedimentation rate and C-reactive protein levels as factors associated with morphometric vertebral fractures. Unlike lumbar spine BMD, TBS is not affected by the presence of syndesmophytes.BMC2023info:eu-repo/semantics/articleinfo:eu-repo/semantics/publishedVersionhttps://fisabio.portalinvestigacion.com/publicaciones/15178BMC MUSCULOSKELETAL DISORDERSISSN: 14712474reponame:r-FISABIO. Repositorio Institucional de Producción Científicainstname:Fundación para el Fomento de la Investigación Sanitaria y Biomédica de la Comunitat Valenciana (FISABIO)Inglésinfo:eu-repo/semantics/openAccessoai:fisabio.fundanetsuite.com:p151782026-06-11T12:45:17Z
dc.title.none.fl_str_mv Relationship between trabecular bone score, bone mineral density and vertebral fractures in patients with axial spondyloarthritis
title Relationship between trabecular bone score, bone mineral density and vertebral fractures in patients with axial spondyloarthritis
spellingShingle Relationship between trabecular bone score, bone mineral density and vertebral fractures in patients with axial spondyloarthritis
Valls-Pascual E
Trabecular bone score
Bone mineral density
Axial spondyloarthritis
Syndesmophytes
Vertebral fracture
title_short Relationship between trabecular bone score, bone mineral density and vertebral fractures in patients with axial spondyloarthritis
title_full Relationship between trabecular bone score, bone mineral density and vertebral fractures in patients with axial spondyloarthritis
title_fullStr Relationship between trabecular bone score, bone mineral density and vertebral fractures in patients with axial spondyloarthritis
title_full_unstemmed Relationship between trabecular bone score, bone mineral density and vertebral fractures in patients with axial spondyloarthritis
title_sort Relationship between trabecular bone score, bone mineral density and vertebral fractures in patients with axial spondyloarthritis
dc.creator.none.fl_str_mv Valls-Pascual E
Orenes-Vera AV
Sendra-García A
Martínez-Ferrer À
Montolío-Chiva L
Vázquez-Gómez I
Flores-Fernández E
Ybáñez-García D
Vega-Martínez M
García-Ferrer L
Graells-Ferrer M
Alegre-Sancho JJ
author Valls-Pascual E
author_facet Valls-Pascual E
Orenes-Vera AV
Sendra-García A
Martínez-Ferrer À
Montolío-Chiva L
Vázquez-Gómez I
Flores-Fernández E
Ybáñez-García D
Vega-Martínez M
García-Ferrer L
Graells-Ferrer M
Alegre-Sancho JJ
author_role author
author2 Orenes-Vera AV
Sendra-García A
Martínez-Ferrer À
Montolío-Chiva L
Vázquez-Gómez I
Flores-Fernández E
Ybáñez-García D
Vega-Martínez M
García-Ferrer L
Graells-Ferrer M
Alegre-Sancho JJ
author2_role author
author
author
author
author
author
author
author
author
author
author
dc.subject.none.fl_str_mv Trabecular bone score
Bone mineral density
Axial spondyloarthritis
Syndesmophytes
Vertebral fracture
topic Trabecular bone score
Bone mineral density
Axial spondyloarthritis
Syndesmophytes
Vertebral fracture
description BackgroundIn patients with axial spondyloarthritis, vertebral fracture risk is elevated and not always correlated with bone mineral density (BMD). Trabecular bone score (TBS) may offer some advantages in the assessment of vertebral fracture risk in these patients. The primary objective of this study was to compare TBS and BMD between axial spondyloarthritis patients depending on their vertebral fracture status. Secondary objectives were to estimate the prevalence of morphometric vertebral fractures, and to explore factors associated with fracture, as well as the interference of syndesmophytes on BMD and TBS.MethodsA cross-sectional study was conducted. Data were collected on demographic and clinical characteristics, lab results, imaging findings and treatment. Statistical analysis was performed using SPSS v.13 statistical software.ResultsEighty-four patients (60 men and 24 women; mean age of 59 years) were included. Nearly half (47.6%) of them had lumbar syndesmophytes. The rate of morphometric fracture was 11.9%. TBS showed a higher area under the curve (0.89) than total hip, femoral neck and lumbar BMD (0.80, 0.78, and 0.70 respectively) for classifying patients regarding their fracture status. Nonetheless, the differences did not reach statistical significance.Syndesmophytes affected lumbar spine BMD (p < 0.001), but not hip BMD or TBS. Fractures were associated with TBS, total hip BMD, erythrocyte sedimentation rate and C-reactive protein levels.ConclusionsWe identified decreased TBS and total hip BMD, as well as increased erythrocyte sedimentation rate and C-reactive protein levels as factors associated with morphometric vertebral fractures. Unlike lumbar spine BMD, TBS is not affected by the presence of syndesmophytes.
publishDate 2023
dc.date.none.fl_str_mv 2023
dc.type.none.fl_str_mv info:eu-repo/semantics/article
info:eu-repo/semantics/publishedVersion
format article
status_str publishedVersion
dc.identifier.none.fl_str_mv https://fisabio.portalinvestigacion.com/publicaciones/15178
url https://fisabio.portalinvestigacion.com/publicaciones/15178
dc.language.none.fl_str_mv Inglés
language_invalid_str_mv Inglés
dc.rights.none.fl_str_mv info:eu-repo/semantics/openAccess
eu_rights_str_mv openAccess
dc.publisher.none.fl_str_mv BMC
publisher.none.fl_str_mv BMC
dc.source.none.fl_str_mv BMC MUSCULOSKELETAL DISORDERS
ISSN: 14712474
reponame:r-FISABIO. Repositorio Institucional de Producción Científica
instname:Fundación para el Fomento de la Investigación Sanitaria y Biomédica de la Comunitat Valenciana (FISABIO)
instname_str Fundación para el Fomento de la Investigación Sanitaria y Biomédica de la Comunitat Valenciana (FISABIO)
reponame_str r-FISABIO. Repositorio Institucional de Producción Científica
collection r-FISABIO. Repositorio Institucional de Producción Científica
repository.name.fl_str_mv
repository.mail.fl_str_mv
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score 15.811543

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