Long-lasting reflexive and nonreflexive pain responses in two mouse models of Fibromyalgia-like condition

Nociplastic pain arises from altered nociception despite no clear evidence of tissue or somatosensory system damage, and fibromyalgia syndrome can be highlighted as a prototype of this chronic pain subtype. Currently, there is a lack of effective treatments to alleviate both reflexive and nonreflexi...

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Autores: Álvarez-Pérez, Beltrán, Deulofeu, Meritxell, Homs, Judit, Merlos, Manue, Vela, José Miguel, Verdú Navarro, Enrique, Boadas i Vaello, Pere
Tipo de recurso: artículo
Estado:Versión publicada
Fecha de publicación:2022
País:España
Institución:Varias* (Consorci de Biblioteques Universitáries de Catalunya, Centre de Serveis Científics i Acadèmics de Catalunya)
Repositorio:Recercat. Dipósit de la Recerca de Catalunya
OAI Identifier:oai:recercat.cat:10256/21281
Acceso en línea:http://hdl.handle.net/10256/21281
Access Level:acceso abierto
Palabra clave:Fibromiàlgia
Dolor crònic
Fibromyalgia
Chronic pain
Dolor -- Tractament
Pain -- Treatment
Immunohistoquímica
Immunohistochemistry
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spelling Long-lasting reflexive and nonreflexive pain responses in two mouse models of Fibromyalgia-like conditionÁlvarez-Pérez, BeltránDeulofeu, MeritxellHoms, JuditMerlos, ManueVela, José MiguelVerdú Navarro, EnriqueBoadas i Vaello, PereFibromiàlgiaDolor crònicFibromyalgiaChronic painDolor -- TractamentPain -- TreatmentImmunohistoquímicaImmunohistochemistryNociplastic pain arises from altered nociception despite no clear evidence of tissue or somatosensory system damage, and fibromyalgia syndrome can be highlighted as a prototype of this chronic pain subtype. Currently, there is a lack of effective treatments to alleviate both reflexive and nonreflexive pain responses associated with fibromyalgia condition, and suitable preclinical models are needed to assess new pharmacological strategies. In this context, although in recent years some remarkable animal models have been developed to mimic the main characteristics of human fibromyalgia, most of them show pain responses in the short term. Considering the chronicity of this condition, the present work aimed to develop two mouse models showing long-lasting reflexive and nonreflexive pain responses after several reserpine (RIM) or intramuscular acid saline solution (ASI) injections. To our knowledge, this is the first study showing that RIM6 and ASI mouse models show reflexive and nonreflexive responses up to 5-6 weeks, accompanied by either astro- or microgliosis in the spinal cord as pivotal physiopathology processes related to such condition development. In addition, acute treatment with pregabalin resulted in reflexive pain response alleviation in both the RIM6 and ASI models. Consequently, both may be considered suitable experimental models of fibromyalgia-like condition, especially RIM6Nature Publishing Group2022info:eu-repo/semantics/articleinfo:eu-repo/semantics/publishedVersionpeer-reviewedapplication/pdfhttp://hdl.handle.net/10256/21281http://hdl.handle.net/10256/21281Scientific Reports, 2022, vol. 12, núm. 1, p. 9719Articles publicats (D-CM)Álvarez-Pérez, Beltrán Deulofeu, Meritxell Homs Avila, Judit Merlos, Manue Vela, José Miguel Verdú Navarro, Enrique Boadas i Vaello, Pere 2022 Long-lasting reflexive and nonreflexive pain responses in two mouse models of Fibromyalgia-like condition Scientific Reports 12 1 9719reponame:Recercat. Dipósit de la Recerca de Catalunyainstname:Varias* (Consorci de Biblioteques Universitáries de Catalunya, Centre de Serveis Científics i Acadèmics de Catalunya)Inglésinfo:eu-repo/semantics/altIdentifier/doi/10.1038/s41598-022-13968-7info:eu-repo/semantics/altIdentifier/eissn/2045-2322Attribution 4.0 International (CC BY 4.0)https://creativecommons.org/licenses/by/4.0/info:eu-repo/semantics/openAccessoai:recercat.cat:10256/212812026-05-29T05:05:01Z
dc.title.none.fl_str_mv Long-lasting reflexive and nonreflexive pain responses in two mouse models of Fibromyalgia-like condition
title Long-lasting reflexive and nonreflexive pain responses in two mouse models of Fibromyalgia-like condition
spellingShingle Long-lasting reflexive and nonreflexive pain responses in two mouse models of Fibromyalgia-like condition
Álvarez-Pérez, Beltrán
Fibromiàlgia
Dolor crònic
Fibromyalgia
Chronic pain
Dolor -- Tractament
Pain -- Treatment
Immunohistoquímica
Immunohistochemistry
title_short Long-lasting reflexive and nonreflexive pain responses in two mouse models of Fibromyalgia-like condition
title_full Long-lasting reflexive and nonreflexive pain responses in two mouse models of Fibromyalgia-like condition
title_fullStr Long-lasting reflexive and nonreflexive pain responses in two mouse models of Fibromyalgia-like condition
title_full_unstemmed Long-lasting reflexive and nonreflexive pain responses in two mouse models of Fibromyalgia-like condition
title_sort Long-lasting reflexive and nonreflexive pain responses in two mouse models of Fibromyalgia-like condition
dc.creator.none.fl_str_mv Álvarez-Pérez, Beltrán
Deulofeu, Meritxell
Homs, Judit
Merlos, Manue
Vela, José Miguel
Verdú Navarro, Enrique
Boadas i Vaello, Pere
author Álvarez-Pérez, Beltrán
author_facet Álvarez-Pérez, Beltrán
Deulofeu, Meritxell
Homs, Judit
Merlos, Manue
Vela, José Miguel
Verdú Navarro, Enrique
Boadas i Vaello, Pere
author_role author
author2 Deulofeu, Meritxell
Homs, Judit
Merlos, Manue
Vela, José Miguel
Verdú Navarro, Enrique
Boadas i Vaello, Pere
author2_role author
author
author
author
author
author
dc.subject.none.fl_str_mv Fibromiàlgia
Dolor crònic
Fibromyalgia
Chronic pain
Dolor -- Tractament
Pain -- Treatment
Immunohistoquímica
Immunohistochemistry
topic Fibromiàlgia
Dolor crònic
Fibromyalgia
Chronic pain
Dolor -- Tractament
Pain -- Treatment
Immunohistoquímica
Immunohistochemistry
description Nociplastic pain arises from altered nociception despite no clear evidence of tissue or somatosensory system damage, and fibromyalgia syndrome can be highlighted as a prototype of this chronic pain subtype. Currently, there is a lack of effective treatments to alleviate both reflexive and nonreflexive pain responses associated with fibromyalgia condition, and suitable preclinical models are needed to assess new pharmacological strategies. In this context, although in recent years some remarkable animal models have been developed to mimic the main characteristics of human fibromyalgia, most of them show pain responses in the short term. Considering the chronicity of this condition, the present work aimed to develop two mouse models showing long-lasting reflexive and nonreflexive pain responses after several reserpine (RIM) or intramuscular acid saline solution (ASI) injections. To our knowledge, this is the first study showing that RIM6 and ASI mouse models show reflexive and nonreflexive responses up to 5-6 weeks, accompanied by either astro- or microgliosis in the spinal cord as pivotal physiopathology processes related to such condition development. In addition, acute treatment with pregabalin resulted in reflexive pain response alleviation in both the RIM6 and ASI models. Consequently, both may be considered suitable experimental models of fibromyalgia-like condition, especially RIM6
publishDate 2022
dc.date.none.fl_str_mv 2022
dc.type.none.fl_str_mv info:eu-repo/semantics/article
info:eu-repo/semantics/publishedVersion
peer-reviewed
format article
status_str publishedVersion
dc.identifier.none.fl_str_mv http://hdl.handle.net/10256/21281
http://hdl.handle.net/10256/21281
url http://hdl.handle.net/10256/21281
dc.language.none.fl_str_mv Inglés
language_invalid_str_mv Inglés
dc.relation.none.fl_str_mv info:eu-repo/semantics/altIdentifier/doi/10.1038/s41598-022-13968-7
info:eu-repo/semantics/altIdentifier/eissn/2045-2322
dc.rights.none.fl_str_mv Attribution 4.0 International (CC BY 4.0)
https://creativecommons.org/licenses/by/4.0/
info:eu-repo/semantics/openAccess
rights_invalid_str_mv Attribution 4.0 International (CC BY 4.0)
https://creativecommons.org/licenses/by/4.0/
eu_rights_str_mv openAccess
dc.format.none.fl_str_mv application/pdf
dc.publisher.none.fl_str_mv Nature Publishing Group
publisher.none.fl_str_mv Nature Publishing Group
dc.source.none.fl_str_mv Scientific Reports, 2022, vol. 12, núm. 1, p. 9719
Articles publicats (D-CM)
Álvarez-Pérez, Beltrán Deulofeu, Meritxell Homs Avila, Judit Merlos, Manue Vela, José Miguel Verdú Navarro, Enrique Boadas i Vaello, Pere 2022 Long-lasting reflexive and nonreflexive pain responses in two mouse models of Fibromyalgia-like condition Scientific Reports 12 1 9719
reponame:Recercat. Dipósit de la Recerca de Catalunya
instname:Varias* (Consorci de Biblioteques Universitáries de Catalunya, Centre de Serveis Científics i Acadèmics de Catalunya)
instname_str Varias* (Consorci de Biblioteques Universitáries de Catalunya, Centre de Serveis Científics i Acadèmics de Catalunya)
reponame_str Recercat. Dipósit de la Recerca de Catalunya
collection Recercat. Dipósit de la Recerca de Catalunya
repository.name.fl_str_mv
repository.mail.fl_str_mv
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score 15.81155

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