Long Non-coding RNA PVT1 as a Prognostic and Therapeutic Target in Pediatric Cancer

In recent decades, biomedical research has focused on understanding the functionality of the human translated genome, which represents a minor part of all genetic information transcribed from the human genome. However, researchers have become aware of the importance of non-coding RNA species that co...

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Autores: Boloix, Ariadna|||0000-0002-1648-5589, Masanas, Marc|||0000-0002-2249-8554, Jiménez Jiménez, Carlos|||0000-0001-9219-3492, Antonelli, Roberta|||0000-0001-6884-7847, Soriano, Aroa|||0000-0001-9659-1471, Roma, Josep|||0000-0001-7692-6123, Sánchez de Toledo Codina, José|||0000-0002-1034-1920, Gallego, Soledad|||0000-0002-4712-9624, Segura, Miguel F.|||0000-0003-0916-3618
Tipo de recurso: artículo
Fecha de publicación:2019
País:España
Institución:Universitat Autònoma de Barcelona
Repositorio:Dipòsit Digital de Documents de la UAB
Idioma:inglés
OAI Identifier:oai:ddd.uab.cat:227870
Acceso en línea:https://ddd.uab.cat/record/227870
https://dx.doi.org/urn:doi:10.3389/fonc.2019.01173
Access Level:acceso abierto
Palabra clave:PVT1
Lncrna
Epigenetic
8q32
Pediatric cancer
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spelling Long Non-coding RNA PVT1 as a Prognostic and Therapeutic Target in Pediatric CancerBoloix, Ariadna|||0000-0002-1648-5589Masanas, Marc|||0000-0002-2249-8554Jiménez Jiménez, Carlos|||0000-0001-9219-3492Antonelli, Roberta|||0000-0001-6884-7847Soriano, Aroa|||0000-0001-9659-1471Roma, Josep|||0000-0001-7692-6123Sánchez de Toledo Codina, José|||0000-0002-1034-1920Gallego, Soledad|||0000-0002-4712-9624Segura, Miguel F.|||0000-0003-0916-3618PVT1LncrnaEpigenetic8q32Pediatric cancerIn recent decades, biomedical research has focused on understanding the functionality of the human translated genome, which represents a minor part of all genetic information transcribed from the human genome. However, researchers have become aware of the importance of non-coding RNA species that constitute the vast majority of the transcriptome. In addition to their crucial role in tissue development and homeostasis, mounting evidence shows non-coding RNA to be deregulated and functionally contributing to the development and progression of different types of human disease including cancer both in adults and children. Small non-coding RNAs (i.e., microRNA) are in the vanguard of clinical research which revealed that RNA could be used as disease biomarkers or new therapeutic targets. Furthermore, many more expectations have been raised for long non-coding RNAs, by far the largest fraction of non-coding transcripts, and still fewer findings have been translated into clinical applications. In this review, we center on PVT1, a large and complex long non-coding RNA that usually confers oncogenic properties on different tumor types. We focus on the compilation of early advances in the field of pediatric tumors which often lags behind clinical improvements in adult tumors, and provide a rationale to continue studying PVT1 as a possible functional contributor to pediatric malignancies and as a potential prognostic marker or therapeutic target.Universitat Autònoma de Barcelona 22019-01-0120192019-01-01Articlehttp://purl.org/coar/resource_type/c_6501VoRhttp://purl.org/coar/version/c_970fb48d4fbd8a85info:eu-repo/semantics/articleapplication/pdfhttps://ddd.uab.cat/record/227870https://dx.doi.org/urn:doi:10.3389/fonc.2019.01173reponame:Dipòsit Digital de Documents de la UABinstname:Universitat Autònoma de BarcelonaInglésengInstituto de Salud Carlos III https://doi.org/10.13039/501100004587 CP16/00006Instituto de Salud Carlos III https://doi.org/10.13039/501100004587 PI17/00564Ministerio de Educación, Cultura y Deporte https://doi.org/10.13039/501100003176 FPU16/01099open accesshttp://purl.org/coar/access_right/c_abf2Aquest document està subjecte a una llicència d'ús Creative Commons. Es permet la reproducció total o parcial, la distribució, la comunicació pública de l'obra i la creació d'obres derivades, fins i tot amb finalitats comercials, sempre i quan es reconegui l'autoria de l'obra original.https://creativecommons.org/licenses/by/4.0/info:eu-repo/semantics/openAccessoai:ddd.uab.cat:2278702026-06-06T12:50:31Z
dc.title.none.fl_str_mv Long Non-coding RNA PVT1 as a Prognostic and Therapeutic Target in Pediatric Cancer
title Long Non-coding RNA PVT1 as a Prognostic and Therapeutic Target in Pediatric Cancer
spellingShingle Long Non-coding RNA PVT1 as a Prognostic and Therapeutic Target in Pediatric Cancer
Boloix, Ariadna|||0000-0002-1648-5589
PVT1
Lncrna
Epigenetic
8q32
Pediatric cancer
title_short Long Non-coding RNA PVT1 as a Prognostic and Therapeutic Target in Pediatric Cancer
title_full Long Non-coding RNA PVT1 as a Prognostic and Therapeutic Target in Pediatric Cancer
title_fullStr Long Non-coding RNA PVT1 as a Prognostic and Therapeutic Target in Pediatric Cancer
title_full_unstemmed Long Non-coding RNA PVT1 as a Prognostic and Therapeutic Target in Pediatric Cancer
title_sort Long Non-coding RNA PVT1 as a Prognostic and Therapeutic Target in Pediatric Cancer
dc.creator.none.fl_str_mv Boloix, Ariadna|||0000-0002-1648-5589
Masanas, Marc|||0000-0002-2249-8554
Jiménez Jiménez, Carlos|||0000-0001-9219-3492
Antonelli, Roberta|||0000-0001-6884-7847
Soriano, Aroa|||0000-0001-9659-1471
Roma, Josep|||0000-0001-7692-6123
Sánchez de Toledo Codina, José|||0000-0002-1034-1920
Gallego, Soledad|||0000-0002-4712-9624
Segura, Miguel F.|||0000-0003-0916-3618
author Boloix, Ariadna|||0000-0002-1648-5589
author_facet Boloix, Ariadna|||0000-0002-1648-5589
Masanas, Marc|||0000-0002-2249-8554
Jiménez Jiménez, Carlos|||0000-0001-9219-3492
Antonelli, Roberta|||0000-0001-6884-7847
Soriano, Aroa|||0000-0001-9659-1471
Roma, Josep|||0000-0001-7692-6123
Sánchez de Toledo Codina, José|||0000-0002-1034-1920
Gallego, Soledad|||0000-0002-4712-9624
Segura, Miguel F.|||0000-0003-0916-3618
author_role author
author2 Masanas, Marc|||0000-0002-2249-8554
Jiménez Jiménez, Carlos|||0000-0001-9219-3492
Antonelli, Roberta|||0000-0001-6884-7847
Soriano, Aroa|||0000-0001-9659-1471
Roma, Josep|||0000-0001-7692-6123
Sánchez de Toledo Codina, José|||0000-0002-1034-1920
Gallego, Soledad|||0000-0002-4712-9624
Segura, Miguel F.|||0000-0003-0916-3618
author2_role author
author
author
author
author
author
author
author
dc.contributor.none.fl_str_mv Universitat Autònoma de Barcelona
dc.subject.none.fl_str_mv PVT1
Lncrna
Epigenetic
8q32
Pediatric cancer
topic PVT1
Lncrna
Epigenetic
8q32
Pediatric cancer
description In recent decades, biomedical research has focused on understanding the functionality of the human translated genome, which represents a minor part of all genetic information transcribed from the human genome. However, researchers have become aware of the importance of non-coding RNA species that constitute the vast majority of the transcriptome. In addition to their crucial role in tissue development and homeostasis, mounting evidence shows non-coding RNA to be deregulated and functionally contributing to the development and progression of different types of human disease including cancer both in adults and children. Small non-coding RNAs (i.e., microRNA) are in the vanguard of clinical research which revealed that RNA could be used as disease biomarkers or new therapeutic targets. Furthermore, many more expectations have been raised for long non-coding RNAs, by far the largest fraction of non-coding transcripts, and still fewer findings have been translated into clinical applications. In this review, we center on PVT1, a large and complex long non-coding RNA that usually confers oncogenic properties on different tumor types. We focus on the compilation of early advances in the field of pediatric tumors which often lags behind clinical improvements in adult tumors, and provide a rationale to continue studying PVT1 as a possible functional contributor to pediatric malignancies and as a potential prognostic marker or therapeutic target.
publishDate 2019
dc.date.none.fl_str_mv 2
2019-01-01
2019
2019-01-01
dc.type.none.fl_str_mv Article
http://purl.org/coar/resource_type/c_6501
VoR
http://purl.org/coar/version/c_970fb48d4fbd8a85
dc.type.openaire.fl_str_mv info:eu-repo/semantics/article
format article
dc.identifier.none.fl_str_mv https://ddd.uab.cat/record/227870
https://dx.doi.org/urn:doi:10.3389/fonc.2019.01173
url https://ddd.uab.cat/record/227870
https://dx.doi.org/urn:doi:10.3389/fonc.2019.01173
dc.language.none.fl_str_mv Inglés
eng
language_invalid_str_mv Inglés
language eng
dc.relation.none.fl_str_mv Instituto de Salud Carlos III https://doi.org/10.13039/501100004587 CP16/00006
Instituto de Salud Carlos III https://doi.org/10.13039/501100004587 PI17/00564
Ministerio de Educación, Cultura y Deporte https://doi.org/10.13039/501100003176 FPU16/01099
dc.rights.none.fl_str_mv open access
http://purl.org/coar/access_right/c_abf2
https://creativecommons.org/licenses/by/4.0/
dc.rights.openaire.fl_str_mv info:eu-repo/semantics/openAccess
rights_invalid_str_mv open access
http://purl.org/coar/access_right/c_abf2
https://creativecommons.org/licenses/by/4.0/
eu_rights_str_mv openAccess
dc.format.none.fl_str_mv application/pdf
dc.source.none.fl_str_mv reponame:Dipòsit Digital de Documents de la UAB
instname:Universitat Autònoma de Barcelona
instname_str Universitat Autònoma de Barcelona
reponame_str Dipòsit Digital de Documents de la UAB
collection Dipòsit Digital de Documents de la UAB
repository.name.fl_str_mv
repository.mail.fl_str_mv
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