Antimicrobial and hemolytic studies of a series of polycations bearing quaternary ammonium moieties: Structural and topological effects
A series of polycations bearing quaternary ammonium moieties have shown antimicrobial activity against the Gram-negative bacterium Escherichia coli. Different polymer topologies governed by a disubstituted aromatic core as well as different diamine-based linkers were found to influence the antimicro...
| Autores: | , , , |
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| Tipo de recurso: | artículo |
| Estado: | Versión publicada |
| Fecha de publicación: | 2017 |
| País: | España |
| Institución: | Consejo Superior de Investigaciones Científicas (CSIC) |
| Repositorio: | DIGITAL.CSIC. Repositorio Institucional del CSIC |
| OAI Identifier: | oai:digital.csic.es:10261/177313 |
| Acceso en línea: | http://hdl.handle.net/10261/177313 |
| Access Level: | acceso abierto |
| Palabra clave: | Topomers Antimicrobial polymers Hemolysis Ionenes Polycations Quaternary ammonium |
| Sumario: | A series of polycations bearing quaternary ammonium moieties have shown antimicrobial activity against the Gram-negative bacterium Escherichia coli. Different polymer topologies governed by a disubstituted aromatic core as well as different diamine-based linkers were found to influence the antimicrobial properties. Moreover, the hemolytic activity against human red blood cells was measured and demonstrated good biocompatibility and selectivity of these polycations for bacteria over mammalian cells. © 2017 by the authors; licensee MDPI, Basel, Switzerland. |
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