Deep versus periventricular white matter lesions and cognitive function in a community sample of middle-aged participants

The association of cerebral white matter lesions (WMLs) with cognitive status is not well understood in middle-aged individuals. Our aim was to determine the specific contribution of periventricular hyperintensities (PVHs) and deep white matter hyperintensities (DWMHs) to cognitive function in a com...

ver descrição completa

Detalhes bibliográficos
Autores: Soriano Raya, Juan José, Miralbell Blanch, Júlia, López Cancio, Elena, Bargalló Alabart, Núria, Arenillas, Juan Francisco, Barrios Cerrejón, M. Teresa, Cáceres, Cynthia, Toran, Pere, Alzamora, María Teresa, Dávalos, Antoni, Mataró Serrat, Maria
Tipo de documento: artigo
Estado:Versão publicada
Data de publicação:2012
País:España
Recursos:Varias* (Consorci de Biblioteques Universitáries de Catalunya, Centre de Serveis Científics i Acadèmics de Catalunya)
Repositório:Recercat. Dipósit de la Recerca de Catalunya
OAI Identifier:oai:recercat.cat:2445/226257
Acesso em linha:https://hdl.handle.net/2445/226257
Access Level:Acceso aberto
Palavra-chave:Funcions executives (Neuropsicologia)
Trastorns de la cognició
Malalties cerebrals
Executive functions (Neuropsychology)
Cognition disorders
Brain diseases
id ES_80b83d4e314f84c40c16e70ff2a7c623
oai_identifier_str oai:recercat.cat:2445/226257
network_acronym_str ES
network_name_str España
repository_id_str
spelling Deep versus periventricular white matter lesions and cognitive function in a community sample of middle-aged participantsSoriano Raya, Juan JoséMiralbell Blanch, JúliaLópez Cancio, ElenaBargalló Alabart, NúriaArenillas, Juan FranciscoBarrios Cerrejón, M. TeresaCáceres, CynthiaToran, PereAlzamora, María TeresaDávalos, AntoniMataró Serrat, MariaFuncions executives (Neuropsicologia)Trastorns de la cognicióMalalties cerebralsExecutive functions (Neuropsychology)Cognition disordersBrain diseasesThe association of cerebral white matter lesions (WMLs) with cognitive status is not well understood in middle-aged individuals. Our aim was to determine the specific contribution of periventricular hyperintensities (PVHs) and deep white matter hyperintensities (DWMHs) to cognitive function in a community sample of asymptomatic participants aged 50 to 65 years. One hundred stroke- and dementia-free adults completed a comprehensive neuropsychological battery and brain MRI protocol. Participants were classified according to PVH and DWMH scores (Fazekas scale). We dichotomized our sample into low grade WMLs (participants without or with mild lesions) and high grade WMLs (participants with moderate or severe lesions). Analyses were performed separately in PVH and DWMH groups. High grade DWMHs were associated with significantly lower scores in executive functioning (−0.45 standard deviations [SD]), attention (−0.42 SD), verbal fluency (−0.68 SD), visual memory (−0.52 SD), visuospatial skills (−0.79 SD), and psychomotor speed (−0.46 SD). Further analyses revealed that high grade DWMHs were also associated with a three- to fourfold increased risk of impaired scores (i.e.,<1.5 SD) in executive functioning, verbal fluency, visuospatial skills, and psychomotor speed. Our findings suggest that only DWMHs, not PVHs, are related to diminished cognitive function in middle-aged individuals. (JINS, 2012, 18, 1–12)Cambridge University Press (CUP)2026202620122026info:eu-repo/semantics/articleinfo:eu-repo/semantics/publishedVersion12 p.application/pdfhttps://hdl.handle.net/2445/226257Articles publicats en revistes (Cognició, Desenvolupament i Psicologia de l'Educació)reponame:Recercat. Dipósit de la Recerca de Catalunyainstname:Varias* (Consorci de Biblioteques Universitáries de Catalunya, Centre de Serveis Científics i Acadèmics de Catalunya)InglésReproducció del document publicat a: https://doi.org/10.1017/S1355617712000677Journal of the International Neuropsychological Society, 2012, vol. 18, num.5, p. 874-885https://doi.org/10.1017/S1355617712000677(c) The International Neuropsychological Society, 2012info:eu-repo/semantics/openAccessoai:recercat.cat:2445/2262572026-05-29T05:05:01Z
dc.title.none.fl_str_mv Deep versus periventricular white matter lesions and cognitive function in a community sample of middle-aged participants
title Deep versus periventricular white matter lesions and cognitive function in a community sample of middle-aged participants
spellingShingle Deep versus periventricular white matter lesions and cognitive function in a community sample of middle-aged participants
Soriano Raya, Juan José
Funcions executives (Neuropsicologia)
Trastorns de la cognició
Malalties cerebrals
Executive functions (Neuropsychology)
Cognition disorders
Brain diseases
title_short Deep versus periventricular white matter lesions and cognitive function in a community sample of middle-aged participants
title_full Deep versus periventricular white matter lesions and cognitive function in a community sample of middle-aged participants
title_fullStr Deep versus periventricular white matter lesions and cognitive function in a community sample of middle-aged participants
title_full_unstemmed Deep versus periventricular white matter lesions and cognitive function in a community sample of middle-aged participants
title_sort Deep versus periventricular white matter lesions and cognitive function in a community sample of middle-aged participants
dc.creator.none.fl_str_mv Soriano Raya, Juan José
Miralbell Blanch, Júlia
López Cancio, Elena
Bargalló Alabart, Núria
Arenillas, Juan Francisco
Barrios Cerrejón, M. Teresa
Cáceres, Cynthia
Toran, Pere
Alzamora, María Teresa
Dávalos, Antoni
Mataró Serrat, Maria
author Soriano Raya, Juan José
author_facet Soriano Raya, Juan José
Miralbell Blanch, Júlia
López Cancio, Elena
Bargalló Alabart, Núria
Arenillas, Juan Francisco
Barrios Cerrejón, M. Teresa
Cáceres, Cynthia
Toran, Pere
Alzamora, María Teresa
Dávalos, Antoni
Mataró Serrat, Maria
author_role author
author2 Miralbell Blanch, Júlia
López Cancio, Elena
Bargalló Alabart, Núria
Arenillas, Juan Francisco
Barrios Cerrejón, M. Teresa
Cáceres, Cynthia
Toran, Pere
Alzamora, María Teresa
Dávalos, Antoni
Mataró Serrat, Maria
author2_role author
author
author
author
author
author
author
author
author
author
dc.subject.none.fl_str_mv Funcions executives (Neuropsicologia)
Trastorns de la cognició
Malalties cerebrals
Executive functions (Neuropsychology)
Cognition disorders
Brain diseases
topic Funcions executives (Neuropsicologia)
Trastorns de la cognició
Malalties cerebrals
Executive functions (Neuropsychology)
Cognition disorders
Brain diseases
description The association of cerebral white matter lesions (WMLs) with cognitive status is not well understood in middle-aged individuals. Our aim was to determine the specific contribution of periventricular hyperintensities (PVHs) and deep white matter hyperintensities (DWMHs) to cognitive function in a community sample of asymptomatic participants aged 50 to 65 years. One hundred stroke- and dementia-free adults completed a comprehensive neuropsychological battery and brain MRI protocol. Participants were classified according to PVH and DWMH scores (Fazekas scale). We dichotomized our sample into low grade WMLs (participants without or with mild lesions) and high grade WMLs (participants with moderate or severe lesions). Analyses were performed separately in PVH and DWMH groups. High grade DWMHs were associated with significantly lower scores in executive functioning (−0.45 standard deviations [SD]), attention (−0.42 SD), verbal fluency (−0.68 SD), visual memory (−0.52 SD), visuospatial skills (−0.79 SD), and psychomotor speed (−0.46 SD). Further analyses revealed that high grade DWMHs were also associated with a three- to fourfold increased risk of impaired scores (i.e.,<1.5 SD) in executive functioning, verbal fluency, visuospatial skills, and psychomotor speed. Our findings suggest that only DWMHs, not PVHs, are related to diminished cognitive function in middle-aged individuals. (JINS, 2012, 18, 1–12)
publishDate 2012
dc.date.none.fl_str_mv 2012
2026
2026
2026
dc.type.none.fl_str_mv info:eu-repo/semantics/article
info:eu-repo/semantics/publishedVersion
format article
status_str publishedVersion
dc.identifier.none.fl_str_mv https://hdl.handle.net/2445/226257
url https://hdl.handle.net/2445/226257
dc.language.none.fl_str_mv Inglés
language_invalid_str_mv Inglés
dc.relation.none.fl_str_mv Reproducció del document publicat a: https://doi.org/10.1017/S1355617712000677
Journal of the International Neuropsychological Society, 2012, vol. 18, num.5, p. 874-885
https://doi.org/10.1017/S1355617712000677
dc.rights.none.fl_str_mv (c) The International Neuropsychological Society, 2012
info:eu-repo/semantics/openAccess
rights_invalid_str_mv (c) The International Neuropsychological Society, 2012
eu_rights_str_mv openAccess
dc.format.none.fl_str_mv 12 p.
application/pdf
dc.publisher.none.fl_str_mv Cambridge University Press (CUP)
publisher.none.fl_str_mv Cambridge University Press (CUP)
dc.source.none.fl_str_mv Articles publicats en revistes (Cognició, Desenvolupament i Psicologia de l'Educació)
reponame:Recercat. Dipósit de la Recerca de Catalunya
instname:Varias* (Consorci de Biblioteques Universitáries de Catalunya, Centre de Serveis Científics i Acadèmics de Catalunya)
instname_str Varias* (Consorci de Biblioteques Universitáries de Catalunya, Centre de Serveis Científics i Acadèmics de Catalunya)
reponame_str Recercat. Dipósit de la Recerca de Catalunya
collection Recercat. Dipósit de la Recerca de Catalunya
repository.name.fl_str_mv
repository.mail.fl_str_mv
_version_ 1869411920386195456
score 15,812429

Registros relacionados