Urine metabolites and antioxidant effect after oral intake of date (phoenix dactylifera L.) seeds-based products (powder, bread and extract) by human

A cross-over study was conducted in 16 healthy adult volunteers to describe the urinary excretion of polyphenols from date seeds and investigate the antioxidant effect after consumption of different doses of date seeds powder (DSP), bread (DSB) and extract (DSE). After 12 h of fasting, one of the si...

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Autores: Platat, Carine, Hillary, Serene, Tomás Barberán, Francisco, Martínez-Blázquez, J. Alberto, Al-Meqbali, Fatima, Souka, Usama, Al-Hammadi, Suleiman, Ibrahim, Wissam
Tipo de recurso: artículo
Estado:Versión publicada
Fecha de publicación:2019
País:España
Institución:Consejo Superior de Investigaciones Científicas (CSIC)
Repositorio:DIGITAL.CSIC. Repositorio Institucional del CSIC
OAI Identifier:oai:digital.csic.es:10261/193508
Acceso en línea:http://hdl.handle.net/10261/193508
Access Level:acceso abierto
Palabra clave:Date seeds
Oxidative damages
Antioxidants
Human
Urine metabolites
Polyphenols
Proanthocyanidins
UPLC-ESI-QTOF(MS/MS)
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spelling Urine metabolites and antioxidant effect after oral intake of date (phoenix dactylifera L.) seeds-based products (powder, bread and extract) by humanPlatat, CarineHillary, SereneTomás Barberán, FranciscoMartínez-Blázquez, J. AlbertoAl-Meqbali, FatimaSouka, UsamaAl-Hammadi, SuleimanIbrahim, WissamDate seedsOxidative damagesAntioxidantsHumanUrine metabolitesPolyphenolsProanthocyanidinsUPLC-ESI-QTOF(MS/MS)A cross-over study was conducted in 16 healthy adult volunteers to describe the urinary excretion of polyphenols from date seeds and investigate the antioxidant effect after consumption of different doses of date seeds powder (DSP), bread (DSB) and extract (DSE). After 12 h of fasting, one of the six treatments (0.25 g and 0.5 g/kg bodyweight DSP, 360 g of 10% and 15% DSB, 30 mg and 60 mg/kg bodyweight DSE) was provided along with breakfast, with a two weeks wash-out period between 2 consecutive treatments. Blood was drawn at baseline, 1, 2, 8 and 24 h post intake. Urine was collected at baseline, 3, 8, and 24 h post intake. An abundant release of polyphenols was detected in urine within the 0–3 h post intake, reached a peak at 8 h, then decreased with polyphenols still being detected up to 24 h post intake. The antioxidant defence system, as measured by reduced glutathione (GSH), was strengthened as soon as 1 h and up to 8 h post intake. Markers of protein and lipid oxidative damages were reduced from 1 h and up to 8 and 24 h post intake, respectively. This supports an antioxidant effect of date seeds products in humans, most probably due to their polyphenols.This project was funded by the Zayed Center-Based research grant 2013, United Arab Emirates University (Fund 31 R023-Research Center- ZCHS -9-2013).Peer reviewedMultidisciplinary Digital Publishing InstituteUnited Arab Emirates UniversityConsejo Superior de Investigaciones Científicas [https://ror.org/02gfc7t72]2019201920192019info:eu-repo/semantics/articlehttp://purl.org/coar/resource_type/c_6501Publisher's versioninfo:eu-repo/semantics/publishedVersionhttp://hdl.handle.net/10261/193508reponame:DIGITAL.CSIC. Repositorio Institucional del CSICinstname:Consejo Superior de Investigaciones Científicas (CSIC)Ingléshttps://doi.org/10.3390/nu11102489Síinfo:eu-repo/semantics/openAccessoai:digital.csic.es:10261/1935082026-05-22T06:33:51Z
dc.title.none.fl_str_mv Urine metabolites and antioxidant effect after oral intake of date (phoenix dactylifera L.) seeds-based products (powder, bread and extract) by human
title Urine metabolites and antioxidant effect after oral intake of date (phoenix dactylifera L.) seeds-based products (powder, bread and extract) by human
spellingShingle Urine metabolites and antioxidant effect after oral intake of date (phoenix dactylifera L.) seeds-based products (powder, bread and extract) by human
Platat, Carine
Date seeds
Oxidative damages
Antioxidants
Human
Urine metabolites
Polyphenols
Proanthocyanidins
UPLC-ESI-QTOF(MS/MS)
title_short Urine metabolites and antioxidant effect after oral intake of date (phoenix dactylifera L.) seeds-based products (powder, bread and extract) by human
title_full Urine metabolites and antioxidant effect after oral intake of date (phoenix dactylifera L.) seeds-based products (powder, bread and extract) by human
title_fullStr Urine metabolites and antioxidant effect after oral intake of date (phoenix dactylifera L.) seeds-based products (powder, bread and extract) by human
title_full_unstemmed Urine metabolites and antioxidant effect after oral intake of date (phoenix dactylifera L.) seeds-based products (powder, bread and extract) by human
title_sort Urine metabolites and antioxidant effect after oral intake of date (phoenix dactylifera L.) seeds-based products (powder, bread and extract) by human
dc.creator.none.fl_str_mv Platat, Carine
Hillary, Serene
Tomás Barberán, Francisco
Martínez-Blázquez, J. Alberto
Al-Meqbali, Fatima
Souka, Usama
Al-Hammadi, Suleiman
Ibrahim, Wissam
author Platat, Carine
author_facet Platat, Carine
Hillary, Serene
Tomás Barberán, Francisco
Martínez-Blázquez, J. Alberto
Al-Meqbali, Fatima
Souka, Usama
Al-Hammadi, Suleiman
Ibrahim, Wissam
author_role author
author2 Hillary, Serene
Tomás Barberán, Francisco
Martínez-Blázquez, J. Alberto
Al-Meqbali, Fatima
Souka, Usama
Al-Hammadi, Suleiman
Ibrahim, Wissam
author2_role author
author
author
author
author
author
author
dc.contributor.none.fl_str_mv United Arab Emirates University
Consejo Superior de Investigaciones Científicas [https://ror.org/02gfc7t72]
dc.subject.none.fl_str_mv Date seeds
Oxidative damages
Antioxidants
Human
Urine metabolites
Polyphenols
Proanthocyanidins
UPLC-ESI-QTOF(MS/MS)
topic Date seeds
Oxidative damages
Antioxidants
Human
Urine metabolites
Polyphenols
Proanthocyanidins
UPLC-ESI-QTOF(MS/MS)
description A cross-over study was conducted in 16 healthy adult volunteers to describe the urinary excretion of polyphenols from date seeds and investigate the antioxidant effect after consumption of different doses of date seeds powder (DSP), bread (DSB) and extract (DSE). After 12 h of fasting, one of the six treatments (0.25 g and 0.5 g/kg bodyweight DSP, 360 g of 10% and 15% DSB, 30 mg and 60 mg/kg bodyweight DSE) was provided along with breakfast, with a two weeks wash-out period between 2 consecutive treatments. Blood was drawn at baseline, 1, 2, 8 and 24 h post intake. Urine was collected at baseline, 3, 8, and 24 h post intake. An abundant release of polyphenols was detected in urine within the 0–3 h post intake, reached a peak at 8 h, then decreased with polyphenols still being detected up to 24 h post intake. The antioxidant defence system, as measured by reduced glutathione (GSH), was strengthened as soon as 1 h and up to 8 h post intake. Markers of protein and lipid oxidative damages were reduced from 1 h and up to 8 and 24 h post intake, respectively. This supports an antioxidant effect of date seeds products in humans, most probably due to their polyphenols.
publishDate 2019
dc.date.none.fl_str_mv 2019
2019
2019
2019
dc.type.none.fl_str_mv info:eu-repo/semantics/article
http://purl.org/coar/resource_type/c_6501
Publisher's version
info:eu-repo/semantics/publishedVersion
format article
status_str publishedVersion
dc.identifier.none.fl_str_mv http://hdl.handle.net/10261/193508
url http://hdl.handle.net/10261/193508
dc.language.none.fl_str_mv Inglés
language_invalid_str_mv Inglés
dc.relation.none.fl_str_mv https://doi.org/10.3390/nu11102489
Sí
dc.rights.none.fl_str_mv info:eu-repo/semantics/openAccess
eu_rights_str_mv openAccess
dc.publisher.none.fl_str_mv Multidisciplinary Digital Publishing Institute
publisher.none.fl_str_mv Multidisciplinary Digital Publishing Institute
dc.source.none.fl_str_mv reponame:DIGITAL.CSIC. Repositorio Institucional del CSIC
instname:Consejo Superior de Investigaciones Científicas (CSIC)
instname_str Consejo Superior de Investigaciones Científicas (CSIC)
reponame_str DIGITAL.CSIC. Repositorio Institucional del CSIC
collection DIGITAL.CSIC. Repositorio Institucional del CSIC
repository.name.fl_str_mv
repository.mail.fl_str_mv
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score 15,812429

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