The interactions between nanoparticles and the innate immune system from a nanotechnologist perspective

The immune system contributes to maintaining the body's functional integrity through its two main functions: recognizing and destroying foreign external agents (invading microorganisms) and identifying and eliminating senescent cells and damaged or abnormal endogenous entities (such as cellular...

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Autores: Ernst, Lena M.|||0000-0002-5713-7513, Casals, Eudald|||0000-0002-2900-7295, Italiani, Paola|||0000-0001-9830-2733, Boraschi, Diana|||0000-0002-3953-4056, Puntes, Víctor|||0000-0001-8996-9499
Tipo de recurso: artículo
Fecha de publicación:2021
País:España
Institución:Universitat Autònoma de Barcelona
Repositorio:Dipòsit Digital de Documents de la UAB
Idioma:inglés
OAI Identifier:oai:ddd.uab.cat:268419
Acceso en línea:https://ddd.uab.cat/record/268419
https://dx.doi.org/urn:doi:10.3390/nano11112991
Access Level:acceso abierto
Palabra clave:Nanoparticles
Immune system
Innate immunity
Inflammation
Tolerance
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spelling The interactions between nanoparticles and the innate immune system from a nanotechnologist perspectiveErnst, Lena M.|||0000-0002-5713-7513Casals, Eudald|||0000-0002-2900-7295Italiani, Paola|||0000-0001-9830-2733Boraschi, Diana|||0000-0002-3953-4056Puntes, Víctor|||0000-0001-8996-9499NanoparticlesImmune systemInnate immunityInflammationToleranceThe immune system contributes to maintaining the body's functional integrity through its two main functions: recognizing and destroying foreign external agents (invading microorganisms) and identifying and eliminating senescent cells and damaged or abnormal endogenous entities (such as cellular debris or misfolded/degraded proteins). Accordingly, the immune system can detect molecular and cellular structures with a spatial resolution of a few nm, which allows for detecting molecular patterns expressed in a great variety of pathogens, including viral and bacterial proteins and bacterial nucleic acid sequences. Such patterns are also expressed in abnormal cells. In this context, it is expected that nanostructured materials in the size range of proteins, protein aggregates, and viruses with different molecular coatings can engage in a sophisticated interaction with the immune system. Nanoparticles can be recognized or passed undetected by the immune system. Once detected, they can be tolerated or induce defensive (inflammatory) or anti-inflammatory responses. This paper describes the different modes of interaction between nanoparticles, especially inorganic nanoparticles, and the immune system, especially the innate immune system. This perspective should help to propose a set of selection rules for nanosafety-by-design and medical nanoparticle design. 22021-01-0120212021-01-01Articlehttp://purl.org/coar/resource_type/c_6501VoRhttp://purl.org/coar/version/c_970fb48d4fbd8a85info:eu-repo/semantics/articleapplication/pdfhttps://ddd.uab.cat/record/268419https://dx.doi.org/urn:doi:10.3390/nano11112991reponame:Dipòsit Digital de Documents de la UABinstname:Universitat Autònoma de BarcelonaInglésengEuropean Commission https://doi.org/10.13039/501100000780 812661European Commission https://doi.org/10.13039/501100000780 671881Agencia Estatal de Investigación https://doi.org/10.13039/501100011033 RTI2018-099965-B-I00Agència de Gestió d'Ajuts Universitaris i de Recerca https://doi.org/10.13039/501100003030 2017/SGR-1431open accesshttp://purl.org/coar/access_right/c_abf2Aquest document està subjecte a una llicència d'ús Creative Commons. Es permet la reproducció total o parcial, la distribució, la comunicació pública de l'obra i la creació d'obres derivades, fins i tot amb finalitats comercials, sempre i quan es reconegui l'autoria de l'obra original.https://creativecommons.org/licenses/by/4.0/info:eu-repo/semantics/openAccessoai:ddd.uab.cat:2684192026-06-06T12:50:31Z
dc.title.none.fl_str_mv The interactions between nanoparticles and the innate immune system from a nanotechnologist perspective
title The interactions between nanoparticles and the innate immune system from a nanotechnologist perspective
spellingShingle The interactions between nanoparticles and the innate immune system from a nanotechnologist perspective
Ernst, Lena M.|||0000-0002-5713-7513
Nanoparticles
Immune system
Innate immunity
Inflammation
Tolerance
title_short The interactions between nanoparticles and the innate immune system from a nanotechnologist perspective
title_full The interactions between nanoparticles and the innate immune system from a nanotechnologist perspective
title_fullStr The interactions between nanoparticles and the innate immune system from a nanotechnologist perspective
title_full_unstemmed The interactions between nanoparticles and the innate immune system from a nanotechnologist perspective
title_sort The interactions between nanoparticles and the innate immune system from a nanotechnologist perspective
dc.creator.none.fl_str_mv Ernst, Lena M.|||0000-0002-5713-7513
Casals, Eudald|||0000-0002-2900-7295
Italiani, Paola|||0000-0001-9830-2733
Boraschi, Diana|||0000-0002-3953-4056
Puntes, Víctor|||0000-0001-8996-9499
author Ernst, Lena M.|||0000-0002-5713-7513
author_facet Ernst, Lena M.|||0000-0002-5713-7513
Casals, Eudald|||0000-0002-2900-7295
Italiani, Paola|||0000-0001-9830-2733
Boraschi, Diana|||0000-0002-3953-4056
Puntes, Víctor|||0000-0001-8996-9499
author_role author
author2 Casals, Eudald|||0000-0002-2900-7295
Italiani, Paola|||0000-0001-9830-2733
Boraschi, Diana|||0000-0002-3953-4056
Puntes, Víctor|||0000-0001-8996-9499
author2_role author
author
author
author
dc.subject.none.fl_str_mv Nanoparticles
Immune system
Innate immunity
Inflammation
Tolerance
topic Nanoparticles
Immune system
Innate immunity
Inflammation
Tolerance
description The immune system contributes to maintaining the body's functional integrity through its two main functions: recognizing and destroying foreign external agents (invading microorganisms) and identifying and eliminating senescent cells and damaged or abnormal endogenous entities (such as cellular debris or misfolded/degraded proteins). Accordingly, the immune system can detect molecular and cellular structures with a spatial resolution of a few nm, which allows for detecting molecular patterns expressed in a great variety of pathogens, including viral and bacterial proteins and bacterial nucleic acid sequences. Such patterns are also expressed in abnormal cells. In this context, it is expected that nanostructured materials in the size range of proteins, protein aggregates, and viruses with different molecular coatings can engage in a sophisticated interaction with the immune system. Nanoparticles can be recognized or passed undetected by the immune system. Once detected, they can be tolerated or induce defensive (inflammatory) or anti-inflammatory responses. This paper describes the different modes of interaction between nanoparticles, especially inorganic nanoparticles, and the immune system, especially the innate immune system. This perspective should help to propose a set of selection rules for nanosafety-by-design and medical nanoparticle design.
publishDate 2021
dc.date.none.fl_str_mv 2
2021-01-01
2021
2021-01-01
dc.type.none.fl_str_mv Article
http://purl.org/coar/resource_type/c_6501
VoR
http://purl.org/coar/version/c_970fb48d4fbd8a85
dc.type.openaire.fl_str_mv info:eu-repo/semantics/article
format article
dc.identifier.none.fl_str_mv https://ddd.uab.cat/record/268419
https://dx.doi.org/urn:doi:10.3390/nano11112991
url https://ddd.uab.cat/record/268419
https://dx.doi.org/urn:doi:10.3390/nano11112991
dc.language.none.fl_str_mv Inglés
eng
language_invalid_str_mv Inglés
language eng
dc.relation.none.fl_str_mv European Commission https://doi.org/10.13039/501100000780 812661
European Commission https://doi.org/10.13039/501100000780 671881
Agencia Estatal de Investigación https://doi.org/10.13039/501100011033 RTI2018-099965-B-I00
Agència de Gestió d'Ajuts Universitaris i de Recerca https://doi.org/10.13039/501100003030 2017/SGR-1431
dc.rights.none.fl_str_mv open access
http://purl.org/coar/access_right/c_abf2
https://creativecommons.org/licenses/by/4.0/
dc.rights.openaire.fl_str_mv info:eu-repo/semantics/openAccess
rights_invalid_str_mv open access
http://purl.org/coar/access_right/c_abf2
https://creativecommons.org/licenses/by/4.0/
eu_rights_str_mv openAccess
dc.format.none.fl_str_mv application/pdf
dc.source.none.fl_str_mv reponame:Dipòsit Digital de Documents de la UAB
instname:Universitat Autònoma de Barcelona
instname_str Universitat Autònoma de Barcelona
reponame_str Dipòsit Digital de Documents de la UAB
collection Dipòsit Digital de Documents de la UAB
repository.name.fl_str_mv
repository.mail.fl_str_mv
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score 15,300719

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