ApoD, a Glia-Derived Apolipoprotein, Is Required for Peripheral Nerve Functional Integrity and a Timely Response to Injury

Producción Científica

Detalles Bibliográficos
Autores: Ganfornina Álvarez, María Dolores, Carmo, Sonia do, Martínez, Eva, Tolivia Fernández, Jorge Luis, Navarro, Ana, Rassart, Eric, Sánchez Romero, Diego
Tipo de recurso: artículo
Fecha de publicación:2010
País:España
Institución:Universidad de Valladolid
Repositorio:UVaDOC. Repositorio Documental de la Universidad de Valladolid
OAI Identifier:oai:uvadoc.uva.es:10324/6084
Acceso en línea:https://doi.org/10.1002/glia.21010
http://uvadoc.uva.es/handle/10324/6084
Access Level:acceso abierto
Palabra clave:Células reproductoras
Lipocainas
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spelling ApoD, a Glia-Derived Apolipoprotein, Is Required for Peripheral Nerve Functional Integrity and a Timely Response to InjuryGanfornina Álvarez, María DoloresCarmo, Sonia doMartínez, EvaTolivia Fernández, Jorge LuisNavarro, AnaRassart, EricSánchez Romero, DiegoCélulas reproductorasLipocainasProducción CientíficaGlial cells are a key element to the process of axonal regeneration, either promoting or inhibiting axonal growth. The study of glial derived factors induced by injury is important to understand the processes that allow or preclude regeneration, and can explain why the PNS has a remarkable ability to regenerate, while the CNS does not. In this work we focus on Apolipoprotein D (ApoD), a Lipocalin expressed by glial cells in the PNS and CNS. ApoD expression is strongly induced upon PNS injury, but its role has not been elucidated. Here we show that ApoD is required for: (1) the maintenance of peripheral nerve function and tissue homeostasis with age, and (2) an adequate and timely response to injury. We study crushed sciatic nerves at two ages using ApoD knock-out and transgenic mice over-expressing human ApoD. The lack of ApoD decreases motor nerve conduction velocity and the thickness of myelin sheath in intact nerves. Following injury, we analyze the functional recovery, the cellular processes, and the protein and mRNA expression profiles of a group of injury-induced genes. ApoD helps to recover locomotor function after injury, promoting myelin clearance, and regulating the extent of angiogenesis and the number of macrophages recruited to the injury site. Axon regeneration and remyelination are delayed without ApoD and stimulated by excess ApoD. The mRNA and protein expression profiles reveal that ApoD is functionally connected in an age-dependent manner to specific molecular programs triggered by injury.2015-09-19Wiley-Liss2010info:eu-repo/semantics/articleapplication/pdfhttps://doi.org/10.1002/glia.21010http://uvadoc.uva.es/handle/10324/6084reponame:UVaDOC. Repositorio Documental de la Universidad de Valladolidinstname:Universidad de ValladolidInglésinfo:eu-repo/semantics/openAccesshttp://creativecommons.org/licenses/by-nc-nd/4.0/oai:uvadoc.uva.es:10324/60842026-06-13T12:44:47Z
dc.title.none.fl_str_mv ApoD, a Glia-Derived Apolipoprotein, Is Required for Peripheral Nerve Functional Integrity and a Timely Response to Injury
title ApoD, a Glia-Derived Apolipoprotein, Is Required for Peripheral Nerve Functional Integrity and a Timely Response to Injury
spellingShingle ApoD, a Glia-Derived Apolipoprotein, Is Required for Peripheral Nerve Functional Integrity and a Timely Response to Injury
Ganfornina Álvarez, María Dolores
Células reproductoras
Lipocainas
title_short ApoD, a Glia-Derived Apolipoprotein, Is Required for Peripheral Nerve Functional Integrity and a Timely Response to Injury
title_full ApoD, a Glia-Derived Apolipoprotein, Is Required for Peripheral Nerve Functional Integrity and a Timely Response to Injury
title_fullStr ApoD, a Glia-Derived Apolipoprotein, Is Required for Peripheral Nerve Functional Integrity and a Timely Response to Injury
title_full_unstemmed ApoD, a Glia-Derived Apolipoprotein, Is Required for Peripheral Nerve Functional Integrity and a Timely Response to Injury
title_sort ApoD, a Glia-Derived Apolipoprotein, Is Required for Peripheral Nerve Functional Integrity and a Timely Response to Injury
dc.creator.none.fl_str_mv Ganfornina Álvarez, María Dolores
Carmo, Sonia do
Martínez, Eva
Tolivia Fernández, Jorge Luis
Navarro, Ana
Rassart, Eric
Sánchez Romero, Diego
author Ganfornina Álvarez, María Dolores
author_facet Ganfornina Álvarez, María Dolores
Carmo, Sonia do
Martínez, Eva
Tolivia Fernández, Jorge Luis
Navarro, Ana
Rassart, Eric
Sánchez Romero, Diego
author_role author
author2 Carmo, Sonia do
Martínez, Eva
Tolivia Fernández, Jorge Luis
Navarro, Ana
Rassart, Eric
Sánchez Romero, Diego
author2_role author
author
author
author
author
author
dc.subject.none.fl_str_mv Células reproductoras
Lipocainas
topic Células reproductoras
Lipocainas
description Producción Científica
publishDate 2010
dc.date.none.fl_str_mv 2010
dc.type.none.fl_str_mv info:eu-repo/semantics/article
format article
dc.identifier.none.fl_str_mv https://doi.org/10.1002/glia.21010
http://uvadoc.uva.es/handle/10324/6084
url https://doi.org/10.1002/glia.21010
http://uvadoc.uva.es/handle/10324/6084
dc.language.none.fl_str_mv Inglés
language_invalid_str_mv Inglés
dc.rights.none.fl_str_mv info:eu-repo/semantics/openAccess
http://creativecommons.org/licenses/by-nc-nd/4.0/
eu_rights_str_mv openAccess
rights_invalid_str_mv http://creativecommons.org/licenses/by-nc-nd/4.0/
dc.format.none.fl_str_mv application/pdf
dc.publisher.none.fl_str_mv Wiley-Liss
publisher.none.fl_str_mv Wiley-Liss
dc.source.none.fl_str_mv reponame:UVaDOC. Repositorio Documental de la Universidad de Valladolid
instname:Universidad de Valladolid
instname_str Universidad de Valladolid
reponame_str UVaDOC. Repositorio Documental de la Universidad de Valladolid
collection UVaDOC. Repositorio Documental de la Universidad de Valladolid
repository.name.fl_str_mv
repository.mail.fl_str_mv
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score 15,301603

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