Fungal antigenic variation using mosaicism and reassortment of subtelomeric genes’ repertoires

© The Author(s) 2023, corrected publication 2023. Open Access This article is licensed under a Creative Commons Attribution 4.0 International License, which permits use, sharing, adaptation, distribution and reproduction in any medium or format, as long as you give appropriate credit to the original...

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Autores: Meier, Caroline S., Pagni, Marco, Richard, Sophie, Mühlethaler, Konrad, Almeida, João M. G. C. F., Nevez, Gilles, Cushion, Melanie T., Calderón, Enrique J., Hauser, Philippe M.
Tipo de recurso: artículo
Estado:Versión publicada
Fecha de publicación:2023
País:España
Institución:Consejo Superior de Investigaciones Científicas (CSIC)
Repositorio:DIGITAL.CSIC. Repositorio Institucional del CSIC
OAI Identifier:oai:digital.csic.es:10261/350455
Acceso en línea:http://hdl.handle.net/10261/350455
Access Level:acceso abierto
Palabra clave:Fungal genetics
Fungal immune evasion
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spelling Fungal antigenic variation using mosaicism and reassortment of subtelomeric genes’ repertoiresMeier, Caroline S.Pagni, MarcoRichard, SophieMühlethaler, KonradAlmeida, João M. G. C. F.Nevez, GillesCushion, Melanie T.Calderón, Enrique J.Hauser, Philippe M.Fungal geneticsFungal immune evasion© The Author(s) 2023, corrected publication 2023. Open Access This article is licensed under a Creative Commons Attribution 4.0 International License, which permits use, sharing, adaptation, distribution and reproduction in any medium or format, as long as you give appropriate credit to the original author(s) and the source, provide a link to the Creative Commons license, and indicate if changes were made. The images or other third party material in this article are included in the article’s Creative Commons license, unless indicated otherwise in a credit line to the material. If material is not included in the article’s Creative Commons license and your intended use is not permitted by statutory regulation or exceeds the permitted use, you will need to obtain permission directly from the copyright holder. To view a copy of this license, visit http://creativecommons.org/licenses/by/4.0/.Surface antigenic variation is crucial for major pathogens that infect humans. To escape the immune system, they exploit various mechanisms. Understanding these mechanisms is important to better prevent and fight the deadly diseases caused. Those used by the fungus Pneumocystis jirovecii that causes life-threatening pneumonia in immunocompromised individuals remain poorly understood. Here, though this fungus is currently not cultivable, our detailed analysis of the subtelomeric sequence motifs and genes encoding surface proteins suggests that the system involves the reassortment of the repertoire of ca. 80 non-expressed genes present in each strain, from which single genes are retrieved for mutually exclusive expression. Dispersion of the new repertoires, supposedly by healthy carrier individuals, appears very efficient because identical alleles are observed in patients from different countries. Our observations reveal a unique strategy of antigenic variation. They also highlight the possible role in genome rearrangements of small imperfect mirror sequences forming DNA triplexes.This work was supported by Swiss National Science Foundation grant 310030_192802 to P.M.H.; M.T.C. is a Senior Research Career Scientist supported by IK6BX005232 Department of Veterans Affairs.Peer reviewedNature Publishing GroupSwiss National Science FoundationUS Department of Veterans AffairsConsejo Superior de Investigaciones Científicas [https://ror.org/02gfc7t72]202420242023info:eu-repo/semantics/articlehttp://purl.org/coar/resource_type/c_6501Publisher's versioninfo:eu-repo/semantics/publishedVersionapplication/pdfhttp://hdl.handle.net/10261/350455reponame:DIGITAL.CSIC. Repositorio Institucional del CSICinstname:Consejo Superior de Investigaciones Científicas (CSIC)Ingléshttps://doi.org/10.1038/s41467-023-42685-6Síinfo:eu-repo/semantics/openAccessoai:digital.csic.es:10261/3504552026-05-22T06:33:51Z
dc.title.none.fl_str_mv Fungal antigenic variation using mosaicism and reassortment of subtelomeric genes’ repertoires
title Fungal antigenic variation using mosaicism and reassortment of subtelomeric genes’ repertoires
spellingShingle Fungal antigenic variation using mosaicism and reassortment of subtelomeric genes’ repertoires
Meier, Caroline S.
Fungal genetics
Fungal immune evasion
title_short Fungal antigenic variation using mosaicism and reassortment of subtelomeric genes’ repertoires
title_full Fungal antigenic variation using mosaicism and reassortment of subtelomeric genes’ repertoires
title_fullStr Fungal antigenic variation using mosaicism and reassortment of subtelomeric genes’ repertoires
title_full_unstemmed Fungal antigenic variation using mosaicism and reassortment of subtelomeric genes’ repertoires
title_sort Fungal antigenic variation using mosaicism and reassortment of subtelomeric genes’ repertoires
dc.creator.none.fl_str_mv Meier, Caroline S.
Pagni, Marco
Richard, Sophie
Mühlethaler, Konrad
Almeida, João M. G. C. F.
Nevez, Gilles
Cushion, Melanie T.
Calderón, Enrique J.
Hauser, Philippe M.
author Meier, Caroline S.
author_facet Meier, Caroline S.
Pagni, Marco
Richard, Sophie
Mühlethaler, Konrad
Almeida, João M. G. C. F.
Nevez, Gilles
Cushion, Melanie T.
Calderón, Enrique J.
Hauser, Philippe M.
author_role author
author2 Pagni, Marco
Richard, Sophie
Mühlethaler, Konrad
Almeida, João M. G. C. F.
Nevez, Gilles
Cushion, Melanie T.
Calderón, Enrique J.
Hauser, Philippe M.
author2_role author
author
author
author
author
author
author
author
dc.contributor.none.fl_str_mv Swiss National Science Foundation
US Department of Veterans Affairs
Consejo Superior de Investigaciones Científicas [https://ror.org/02gfc7t72]
dc.subject.none.fl_str_mv Fungal genetics
Fungal immune evasion
topic Fungal genetics
Fungal immune evasion
description © The Author(s) 2023, corrected publication 2023. Open Access This article is licensed under a Creative Commons Attribution 4.0 International License, which permits use, sharing, adaptation, distribution and reproduction in any medium or format, as long as you give appropriate credit to the original author(s) and the source, provide a link to the Creative Commons license, and indicate if changes were made. The images or other third party material in this article are included in the article’s Creative Commons license, unless indicated otherwise in a credit line to the material. If material is not included in the article’s Creative Commons license and your intended use is not permitted by statutory regulation or exceeds the permitted use, you will need to obtain permission directly from the copyright holder. To view a copy of this license, visit http://creativecommons.org/licenses/by/4.0/.
publishDate 2023
dc.date.none.fl_str_mv 2023
2024
2024
dc.type.none.fl_str_mv info:eu-repo/semantics/article
http://purl.org/coar/resource_type/c_6501
Publisher's version
info:eu-repo/semantics/publishedVersion
format article
status_str publishedVersion
dc.identifier.none.fl_str_mv http://hdl.handle.net/10261/350455
url http://hdl.handle.net/10261/350455
dc.language.none.fl_str_mv Inglés
language_invalid_str_mv Inglés
dc.relation.none.fl_str_mv https://doi.org/10.1038/s41467-023-42685-6
Sí
dc.rights.none.fl_str_mv info:eu-repo/semantics/openAccess
eu_rights_str_mv openAccess
dc.format.none.fl_str_mv application/pdf
dc.publisher.none.fl_str_mv Nature Publishing Group
publisher.none.fl_str_mv Nature Publishing Group
dc.source.none.fl_str_mv reponame:DIGITAL.CSIC. Repositorio Institucional del CSIC
instname:Consejo Superior de Investigaciones Científicas (CSIC)
instname_str Consejo Superior de Investigaciones Científicas (CSIC)
reponame_str DIGITAL.CSIC. Repositorio Institucional del CSIC
collection DIGITAL.CSIC. Repositorio Institucional del CSIC
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