Aeroplysinin-1, a Sponge-Derived Multi-Targeted Bioactive Marine Drug.

Organisms lacking external defense mechanisms have developed chemical defense strategies, particularly through the production of secondary metabolites with antibiotic or repellent effects. Secondary metabolites from marine organisms have proven to be an exceptionally rich source of small molecules w...

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Detalles Bibliográficos
Autores: García-Vilas, Javier A, Martínez-Poveda, Beatriz, Quesada, Ana R, Medina, Miguel Ángel
Tipo de recurso: artículo
Fecha de publicación:2015
País:España
Institución:Instituto de Salud Carlos III (ISCIII)
Repositorio:Repisalud
Idioma:inglés
OAI Identifier:oai:repisalud.isciii.es:20.500.12105/17111
Acceso en línea:http://hdl.handle.net/20.500.12105/17111
Access Level:acceso abierto
Palabra clave:(+)-aeroplysinin-1
angiogenesis
cancer
inflammation
marine drugs
sponges
Acetonitriles
Animals
Anti-Bacterial Agents
Cyclohexenes
Gram-Positive Bacteria
Humans
Porifera
Seawater
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oai_identifier_str oai:repisalud.isciii.es:20.500.12105/17111
network_acronym_str ES
network_name_str España
repository_id_str
spelling Aeroplysinin-1, a Sponge-Derived Multi-Targeted Bioactive Marine Drug.García-Vilas, Javier AMartínez-Poveda, BeatrizQuesada, Ana RMedina, Miguel Ángel(+)-aeroplysinin-1angiogenesiscancerinflammationmarine drugsspongesAcetonitrilesAnimalsAnti-Bacterial AgentsCyclohexenesGram-Positive BacteriaHumansPoriferaSeawaterOrganisms lacking external defense mechanisms have developed chemical defense strategies, particularly through the production of secondary metabolites with antibiotic or repellent effects. Secondary metabolites from marine organisms have proven to be an exceptionally rich source of small molecules with pharmacological activities potentially beneficial to human health. (+)-Aeroplysinin-1 is a secondary metabolite isolated from marine sponges with a wide spectrum of bio-activities. (+)-Aeroplysinin-1 has potent antibiotic effects on Gram-positive bacteria and several dinoflagellate microalgae causing toxic blooms. In preclinical studies, (+)-aeroplysinin-1 has been shown to have promising anti-inflammatory, anti-angiogenic and anti-tumor effects. Due to its versatility, (+)-aeroplysinin-1 might have a pharmaceutical interest for the treatment of different pathologies.20242024-01-1520152015-12-2220152015-12-22research articlehttp://purl.org/coar/resource_type/c_2df8fbb1VoRhttp://purl.org/coar/version/c_970fb48d4fbd8a85info:eu-repo/semantics/articlehttp://hdl.handle.net/20.500.12105/17111reponame:Repisaludinstname:Instituto de Salud Carlos III (ISCIII)Inglésengopen accesshttp://purl.org/coar/access_right/c_abf2Attribution 4.0 Internationalhttp://creativecommons.org/licenses/by/4.0/info:eu-repo/semantics/openAccessoai:repisalud.isciii.es:20.500.12105/171112026-06-12T12:43:37Z
dc.title.none.fl_str_mv Aeroplysinin-1, a Sponge-Derived Multi-Targeted Bioactive Marine Drug.
title Aeroplysinin-1, a Sponge-Derived Multi-Targeted Bioactive Marine Drug.
spellingShingle Aeroplysinin-1, a Sponge-Derived Multi-Targeted Bioactive Marine Drug.
García-Vilas, Javier A
(+)-aeroplysinin-1
angiogenesis
cancer
inflammation
marine drugs
sponges
Acetonitriles
Animals
Anti-Bacterial Agents
Cyclohexenes
Gram-Positive Bacteria
Humans
Porifera
Seawater
title_short Aeroplysinin-1, a Sponge-Derived Multi-Targeted Bioactive Marine Drug.
title_full Aeroplysinin-1, a Sponge-Derived Multi-Targeted Bioactive Marine Drug.
title_fullStr Aeroplysinin-1, a Sponge-Derived Multi-Targeted Bioactive Marine Drug.
title_full_unstemmed Aeroplysinin-1, a Sponge-Derived Multi-Targeted Bioactive Marine Drug.
title_sort Aeroplysinin-1, a Sponge-Derived Multi-Targeted Bioactive Marine Drug.
dc.creator.none.fl_str_mv García-Vilas, Javier A
Martínez-Poveda, Beatriz
Quesada, Ana R
Medina, Miguel Ángel
author García-Vilas, Javier A
author_facet García-Vilas, Javier A
Martínez-Poveda, Beatriz
Quesada, Ana R
Medina, Miguel Ángel
author_role author
author2 Martínez-Poveda, Beatriz
Quesada, Ana R
Medina, Miguel Ángel
author2_role author
author
author
dc.contributor.none.fl_str_mv
dc.subject.none.fl_str_mv (+)-aeroplysinin-1
angiogenesis
cancer
inflammation
marine drugs
sponges
Acetonitriles
Animals
Anti-Bacterial Agents
Cyclohexenes
Gram-Positive Bacteria
Humans
Porifera
Seawater
topic (+)-aeroplysinin-1
angiogenesis
cancer
inflammation
marine drugs
sponges
Acetonitriles
Animals
Anti-Bacterial Agents
Cyclohexenes
Gram-Positive Bacteria
Humans
Porifera
Seawater
description Organisms lacking external defense mechanisms have developed chemical defense strategies, particularly through the production of secondary metabolites with antibiotic or repellent effects. Secondary metabolites from marine organisms have proven to be an exceptionally rich source of small molecules with pharmacological activities potentially beneficial to human health. (+)-Aeroplysinin-1 is a secondary metabolite isolated from marine sponges with a wide spectrum of bio-activities. (+)-Aeroplysinin-1 has potent antibiotic effects on Gram-positive bacteria and several dinoflagellate microalgae causing toxic blooms. In preclinical studies, (+)-aeroplysinin-1 has been shown to have promising anti-inflammatory, anti-angiogenic and anti-tumor effects. Due to its versatility, (+)-aeroplysinin-1 might have a pharmaceutical interest for the treatment of different pathologies.
publishDate 2015
dc.date.none.fl_str_mv 2015
2015-12-22
2015
2015-12-22
2024
2024-01-15
dc.type.none.fl_str_mv research article
http://purl.org/coar/resource_type/c_2df8fbb1
VoR
http://purl.org/coar/version/c_970fb48d4fbd8a85
dc.type.openaire.fl_str_mv info:eu-repo/semantics/article
format article
dc.identifier.none.fl_str_mv http://hdl.handle.net/20.500.12105/17111
url http://hdl.handle.net/20.500.12105/17111
dc.language.none.fl_str_mv Inglés
eng
language_invalid_str_mv Inglés
language eng
dc.rights.none.fl_str_mv open access
http://purl.org/coar/access_right/c_abf2
Attribution 4.0 International
http://creativecommons.org/licenses/by/4.0/
dc.rights.openaire.fl_str_mv info:eu-repo/semantics/openAccess
rights_invalid_str_mv open access
http://purl.org/coar/access_right/c_abf2
Attribution 4.0 International
http://creativecommons.org/licenses/by/4.0/
eu_rights_str_mv openAccess
dc.source.none.fl_str_mv reponame:Repisalud
instname:Instituto de Salud Carlos III (ISCIII)
instname_str Instituto de Salud Carlos III (ISCIII)
reponame_str Repisalud
collection Repisalud
repository.name.fl_str_mv
repository.mail.fl_str_mv
_version_ 1869411864033624064
score 15,811543

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