Chromosomal inversions promote genomic islands of concerted evolution of Hsp70 genes in the Drosophila subobscura species subgroup

Heat-shock (HS) assays to understand the connection between standing inversion variation and evolutionary response to climate change in Drosophila subobscura found that "warm-climate" inversion O 3+4 exhibits non-HS levels of Hsp70 protein like those of "cold-climate" O ST after...

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Autores: Puig Giribets, Marta, García Guerreiro, María Pilar|||0000-0001-9951-1879, Santos Maroño, Mauro|||0000-0002-6478-6570, Ayala, Francisco J.|||https://es.wikipedia.org/wiki/Francisco_Jos%C3%A9_Ayala, Tarrío, Rosa|||0000-0003-2814-261X, Rodríguez-Trelles, Francisco|||0000-0001-6279-3630
Tipo de recurso: artículo
Fecha de publicación:2019
País:España
Institución:Universitat Autònoma de Barcelona
Repositorio:Dipòsit Digital de Documents de la UAB
Idioma:inglés
OAI Identifier:oai:ddd.uab.cat:305723
Acceso en línea:https://ddd.uab.cat/record/305723
https://dx.doi.org/urn:doi:10.1111/mec.14511
Access Level:acceso abierto
Palabra clave:Chromosomal inversion polymorphism
Climate change
Concerted evolution
Drosophila subobscura subgroup
Evolution on islands
Hsp70
SDG 13 - Climate Action
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spelling Chromosomal inversions promote genomic islands of concerted evolution of Hsp70 genes in the Drosophila subobscura species subgroupPuig Giribets, MartaGarcía Guerreiro, María Pilar|||0000-0001-9951-1879Santos Maroño, Mauro|||0000-0002-6478-6570Ayala, Francisco J.|||https://es.wikipedia.org/wiki/Francisco_Jos%C3%A9_AyalaTarrío, Rosa|||0000-0003-2814-261XRodríguez-Trelles, Francisco|||0000-0001-6279-3630Chromosomal inversion polymorphismClimate changeConcerted evolutionDrosophila subobscura subgroupEvolution on islandsHsp70SDG 13 - Climate ActionHeat-shock (HS) assays to understand the connection between standing inversion variation and evolutionary response to climate change in Drosophila subobscura found that "warm-climate" inversion O 3+4 exhibits non-HS levels of Hsp70 protein like those of "cold-climate" O ST after HS induction. This was unexpected, as overexpression of Hsp70 can incur multiple fitness costs. To understand the genetic basis of this finding, we have determined the genomic sequence organization of the Hsp70 family in four different inversions, including O ST , O 3+4 , O 3+4+8 and O 3+4+16 , using as outgroups the remainder of the subobscura species subgroup, namely Drosophila madeirensis and Drosophila guanche. We found (i) in all the assayed lines, the Hsp70 family resides in cytological locus 94A and consists of only two genes, each with four HS elements (HSEs) and three GAGA sites on its promoter. Yet, in O ST, the family is comparatively more compact; (ii) the two Hsp70 copies evolve in concert through gene conversion, except in D. guanche; (iii) within D. subobscura, the rate of concerted evolution is strongly structured by inversion, being higher in O ST than in O 3+4 ; and (iv) in D. guanche, the two copies accumulated multiple differences, including a newly evolved "gap-type" HSE2. The absence of concerted evolution in this species may be related to a long-gone-unnoticed observation that it lacks Hsp70 HS response, perhaps because it has evolved within a narrow thermal range in an oceanic island. Our results point to a previously unrealized link between inversions and concerted evolution, with potentially major implications for understanding genome evolution. 22019-01-0120192019-01-01Articlehttp://purl.org/coar/resource_type/c_6501AMhttp://purl.org/coar/version/c_ab4af688f83e57aainfo:eu-repo/semantics/articleapplication/pdfhttps://ddd.uab.cat/record/305723https://dx.doi.org/urn:doi:10.1111/mec.14511reponame:Dipòsit Digital de Documents de la UABinstname:Universitat Autònoma de BarcelonaInglésengMinisterio de Economía y Competitividad https://doi.org/10.13039/501100003329 CGL2013-42432PAgencia Estatal de Investigación https://doi.org/10.13039/501100011033 CGL2017-89160PAgència de Gestió d'Ajuts Universitaris i de Recerca https://doi.org/10.13039/501100003030 2009/SGR-636Agència de Gestió d'Ajuts Universitaris i de Recerca https://doi.org/10.13039/501100003030 2017/SGR-1379open accesshttp://purl.org/coar/access_right/c_abf2Aquest material està protegit per drets d'autor i/o drets afins. Podeu utilitzar aquest material en funció del que permet la legislació de drets d'autor i drets afins d'aplicació al vostre cas. Per a d'altres usos heu d'obtenir permís del(s) titular(s) de drets.https://rightsstatements.org/vocab/InC/1.0/info:eu-repo/semantics/openAccessoai:ddd.uab.cat:3057232026-06-06T12:50:31Z
dc.title.none.fl_str_mv Chromosomal inversions promote genomic islands of concerted evolution of Hsp70 genes in the Drosophila subobscura species subgroup
title Chromosomal inversions promote genomic islands of concerted evolution of Hsp70 genes in the Drosophila subobscura species subgroup
spellingShingle Chromosomal inversions promote genomic islands of concerted evolution of Hsp70 genes in the Drosophila subobscura species subgroup
Puig Giribets, Marta
Chromosomal inversion polymorphism
Climate change
Concerted evolution
Drosophila subobscura subgroup
Evolution on islands
Hsp70
SDG 13 - Climate Action
title_short Chromosomal inversions promote genomic islands of concerted evolution of Hsp70 genes in the Drosophila subobscura species subgroup
title_full Chromosomal inversions promote genomic islands of concerted evolution of Hsp70 genes in the Drosophila subobscura species subgroup
title_fullStr Chromosomal inversions promote genomic islands of concerted evolution of Hsp70 genes in the Drosophila subobscura species subgroup
title_full_unstemmed Chromosomal inversions promote genomic islands of concerted evolution of Hsp70 genes in the Drosophila subobscura species subgroup
title_sort Chromosomal inversions promote genomic islands of concerted evolution of Hsp70 genes in the Drosophila subobscura species subgroup
dc.creator.none.fl_str_mv Puig Giribets, Marta
García Guerreiro, María Pilar|||0000-0001-9951-1879
Santos Maroño, Mauro|||0000-0002-6478-6570
Ayala, Francisco J.|||https://es.wikipedia.org/wiki/Francisco_Jos%C3%A9_Ayala
Tarrío, Rosa|||0000-0003-2814-261X
Rodríguez-Trelles, Francisco|||0000-0001-6279-3630
author Puig Giribets, Marta
author_facet Puig Giribets, Marta
García Guerreiro, María Pilar|||0000-0001-9951-1879
Santos Maroño, Mauro|||0000-0002-6478-6570
Ayala, Francisco J.|||https://es.wikipedia.org/wiki/Francisco_Jos%C3%A9_Ayala
Tarrío, Rosa|||0000-0003-2814-261X
Rodríguez-Trelles, Francisco|||0000-0001-6279-3630
author_role author
author2 García Guerreiro, María Pilar|||0000-0001-9951-1879
Santos Maroño, Mauro|||0000-0002-6478-6570
Ayala, Francisco J.|||https://es.wikipedia.org/wiki/Francisco_Jos%C3%A9_Ayala
Tarrío, Rosa|||0000-0003-2814-261X
Rodríguez-Trelles, Francisco|||0000-0001-6279-3630
author2_role author
author
author
author
author
dc.subject.none.fl_str_mv Chromosomal inversion polymorphism
Climate change
Concerted evolution
Drosophila subobscura subgroup
Evolution on islands
Hsp70
SDG 13 - Climate Action
topic Chromosomal inversion polymorphism
Climate change
Concerted evolution
Drosophila subobscura subgroup
Evolution on islands
Hsp70
SDG 13 - Climate Action
description Heat-shock (HS) assays to understand the connection between standing inversion variation and evolutionary response to climate change in Drosophila subobscura found that "warm-climate" inversion O 3+4 exhibits non-HS levels of Hsp70 protein like those of "cold-climate" O ST after HS induction. This was unexpected, as overexpression of Hsp70 can incur multiple fitness costs. To understand the genetic basis of this finding, we have determined the genomic sequence organization of the Hsp70 family in four different inversions, including O ST , O 3+4 , O 3+4+8 and O 3+4+16 , using as outgroups the remainder of the subobscura species subgroup, namely Drosophila madeirensis and Drosophila guanche. We found (i) in all the assayed lines, the Hsp70 family resides in cytological locus 94A and consists of only two genes, each with four HS elements (HSEs) and three GAGA sites on its promoter. Yet, in O ST, the family is comparatively more compact; (ii) the two Hsp70 copies evolve in concert through gene conversion, except in D. guanche; (iii) within D. subobscura, the rate of concerted evolution is strongly structured by inversion, being higher in O ST than in O 3+4 ; and (iv) in D. guanche, the two copies accumulated multiple differences, including a newly evolved "gap-type" HSE2. The absence of concerted evolution in this species may be related to a long-gone-unnoticed observation that it lacks Hsp70 HS response, perhaps because it has evolved within a narrow thermal range in an oceanic island. Our results point to a previously unrealized link between inversions and concerted evolution, with potentially major implications for understanding genome evolution.
publishDate 2019
dc.date.none.fl_str_mv 2
2019-01-01
2019
2019-01-01
dc.type.none.fl_str_mv Article
http://purl.org/coar/resource_type/c_6501
AM
http://purl.org/coar/version/c_ab4af688f83e57aa
dc.type.openaire.fl_str_mv info:eu-repo/semantics/article
format article
dc.identifier.none.fl_str_mv https://ddd.uab.cat/record/305723
https://dx.doi.org/urn:doi:10.1111/mec.14511
url https://ddd.uab.cat/record/305723
https://dx.doi.org/urn:doi:10.1111/mec.14511
dc.language.none.fl_str_mv Inglés
eng
language_invalid_str_mv Inglés
language eng
dc.relation.none.fl_str_mv Ministerio de Economía y Competitividad https://doi.org/10.13039/501100003329 CGL2013-42432P
Agencia Estatal de Investigación https://doi.org/10.13039/501100011033 CGL2017-89160P
Agència de Gestió d'Ajuts Universitaris i de Recerca https://doi.org/10.13039/501100003030 2009/SGR-636
Agència de Gestió d'Ajuts Universitaris i de Recerca https://doi.org/10.13039/501100003030 2017/SGR-1379
dc.rights.none.fl_str_mv open access
http://purl.org/coar/access_right/c_abf2
https://rightsstatements.org/vocab/InC/1.0/
dc.rights.openaire.fl_str_mv info:eu-repo/semantics/openAccess
rights_invalid_str_mv open access
http://purl.org/coar/access_right/c_abf2
https://rightsstatements.org/vocab/InC/1.0/
eu_rights_str_mv openAccess
dc.format.none.fl_str_mv application/pdf
dc.source.none.fl_str_mv reponame:Dipòsit Digital de Documents de la UAB
instname:Universitat Autònoma de Barcelona
instname_str Universitat Autònoma de Barcelona
reponame_str Dipòsit Digital de Documents de la UAB
collection Dipòsit Digital de Documents de la UAB
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