C-myc regulates cell size and ploidy but is not essential for postnatal proliferation in liver.

The c-Myc protein is a transcription factor implicated in the regulation of multiple biological processes, including cell proliferation, cell growth, and apoptosis. In vivo overexpression of c-myc is linked to tumor development in a number of mouse models. Here, we show that perinatal inactivation o...

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Autores: Baena, Esther, Gandarillas, Alberto, Vallespinós, Mireia, Zanet, Jennifer, Bachs Valldeneu, Oriol, Redondo, Clara, Fabregat Romero, Isabel, Martinez-A., Carlos, Moreno de Alboran, Ignacio
Tipo de recurso: artículo
Estado:Versión publicada
Fecha de publicación:2005
País:España
Institución:Universidad de Barcelona
Repositorio:Dipòsit Digital de la UB
OAI Identifier:oai:diposit.ub.edu:2445/194142
Acceso en línea:https://hdl.handle.net/2445/194142
Access Level:acceso abierto
Palabra clave:Cèl·lules
Factors de transcripció
Cicle cel·lular
Fetge
Proliferació cel·lular
Cells
Transcription factors
Cell cycle
Liver
Cell proliferation
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spelling C-myc regulates cell size and ploidy but is not essential for postnatal proliferation in liver.Baena, EstherGandarillas, AlbertoVallespinós, MireiaZanet, JenniferBachs Valldeneu, OriolRedondo, ClaraFabregat Romero, IsabelMartinez-A., CarlosMoreno de Alboran, IgnacioCèl·lulesFactors de transcripcióCicle cel·lularFetgeProliferació cel·lularCellsTranscription factorsCell cycleLiverCell proliferationThe c-Myc protein is a transcription factor implicated in the regulation of multiple biological processes, including cell proliferation, cell growth, and apoptosis. In vivo overexpression of c-myc is linked to tumor development in a number of mouse models. Here, we show that perinatal inactivation of c-Myc in liver causes disorganized organ architecture, decreased hepatocyte size, and cell ploidy. Furthermore, c-Myc appears to have distinct roles in proliferation in liver. Thus, postnatal hepatocyte proliferation does not require c-Myc, whereas it is necessary for liver regeneration in adult mice. These results show novel physiological functions of c-myc in liver development and hepatocyte proliferation and growth.National Academy of Sciences2005info:eu-repo/semantics/articleinfo:eu-repo/semantics/publishedVersionapplication/pdfhttps://hdl.handle.net/2445/194142Articles publicats en revistes (Biomedicina)reponame:Dipòsit Digital de la UBinstname:Universidad de BarcelonaInglésReproducció del document publicat a: https://doi.org/10.1073/pnas.0409260102Proceedings of the National Academy of Sciences of the United States of America - PNAS, 2005, vol. 102, num. 20, p. 7286-7291https://doi.org/10.1073/pnas.0409260102cc-by-nc-nd (c) Baena, Esther et al., 2005http://creativecommons.org/licenses/by-nc-nd/3.0/es/info:eu-repo/semantics/openAccessoai:diposit.ub.edu:2445/1941422026-05-27T06:46:51Z
dc.title.none.fl_str_mv C-myc regulates cell size and ploidy but is not essential for postnatal proliferation in liver.
title C-myc regulates cell size and ploidy but is not essential for postnatal proliferation in liver.
spellingShingle C-myc regulates cell size and ploidy but is not essential for postnatal proliferation in liver.
Baena, Esther
Cèl·lules
Factors de transcripció
Cicle cel·lular
Fetge
Proliferació cel·lular
Cells
Transcription factors
Cell cycle
Liver
Cell proliferation
title_short C-myc regulates cell size and ploidy but is not essential for postnatal proliferation in liver.
title_full C-myc regulates cell size and ploidy but is not essential for postnatal proliferation in liver.
title_fullStr C-myc regulates cell size and ploidy but is not essential for postnatal proliferation in liver.
title_full_unstemmed C-myc regulates cell size and ploidy but is not essential for postnatal proliferation in liver.
title_sort C-myc regulates cell size and ploidy but is not essential for postnatal proliferation in liver.
dc.creator.none.fl_str_mv Baena, Esther
Gandarillas, Alberto
Vallespinós, Mireia
Zanet, Jennifer
Bachs Valldeneu, Oriol
Redondo, Clara
Fabregat Romero, Isabel
Martinez-A., Carlos
Moreno de Alboran, Ignacio
author Baena, Esther
author_facet Baena, Esther
Gandarillas, Alberto
Vallespinós, Mireia
Zanet, Jennifer
Bachs Valldeneu, Oriol
Redondo, Clara
Fabregat Romero, Isabel
Martinez-A., Carlos
Moreno de Alboran, Ignacio
author_role author
author2 Gandarillas, Alberto
Vallespinós, Mireia
Zanet, Jennifer
Bachs Valldeneu, Oriol
Redondo, Clara
Fabregat Romero, Isabel
Martinez-A., Carlos
Moreno de Alboran, Ignacio
author2_role author
author
author
author
author
author
author
author
dc.subject.none.fl_str_mv Cèl·lules
Factors de transcripció
Cicle cel·lular
Fetge
Proliferació cel·lular
Cells
Transcription factors
Cell cycle
Liver
Cell proliferation
topic Cèl·lules
Factors de transcripció
Cicle cel·lular
Fetge
Proliferació cel·lular
Cells
Transcription factors
Cell cycle
Liver
Cell proliferation
description The c-Myc protein is a transcription factor implicated in the regulation of multiple biological processes, including cell proliferation, cell growth, and apoptosis. In vivo overexpression of c-myc is linked to tumor development in a number of mouse models. Here, we show that perinatal inactivation of c-Myc in liver causes disorganized organ architecture, decreased hepatocyte size, and cell ploidy. Furthermore, c-Myc appears to have distinct roles in proliferation in liver. Thus, postnatal hepatocyte proliferation does not require c-Myc, whereas it is necessary for liver regeneration in adult mice. These results show novel physiological functions of c-myc in liver development and hepatocyte proliferation and growth.
publishDate 2005
dc.date.none.fl_str_mv 2005
dc.type.none.fl_str_mv info:eu-repo/semantics/article
info:eu-repo/semantics/publishedVersion
format article
status_str publishedVersion
dc.identifier.none.fl_str_mv https://hdl.handle.net/2445/194142
url https://hdl.handle.net/2445/194142
dc.language.none.fl_str_mv Inglés
language_invalid_str_mv Inglés
dc.relation.none.fl_str_mv Reproducció del document publicat a: https://doi.org/10.1073/pnas.0409260102
Proceedings of the National Academy of Sciences of the United States of America - PNAS, 2005, vol. 102, num. 20, p. 7286-7291
https://doi.org/10.1073/pnas.0409260102
dc.rights.none.fl_str_mv cc-by-nc-nd (c) Baena, Esther et al., 2005
http://creativecommons.org/licenses/by-nc-nd/3.0/es/
info:eu-repo/semantics/openAccess
rights_invalid_str_mv cc-by-nc-nd (c) Baena, Esther et al., 2005
http://creativecommons.org/licenses/by-nc-nd/3.0/es/
eu_rights_str_mv openAccess
dc.format.none.fl_str_mv application/pdf
dc.publisher.none.fl_str_mv National Academy of Sciences
publisher.none.fl_str_mv National Academy of Sciences
dc.source.none.fl_str_mv Articles publicats en revistes (Biomedicina)
reponame:Dipòsit Digital de la UB
instname:Universidad de Barcelona
instname_str Universidad de Barcelona
reponame_str Dipòsit Digital de la UB
collection Dipòsit Digital de la UB
repository.name.fl_str_mv
repository.mail.fl_str_mv
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score 15,301603

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