Semantic and phonemic verbal fluency in Parkinson's disease: Influence of clinical and demographic variables

Changes of cognitive function in PD have been extensively documented and defined as a 'frontal' type executive dysfunction. One of the main components of this executive dysfunction is the impairment of verbal fluency. The aim of the present study was to assess semantic and phonemic fluency...

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Autores: Obeso, Ignacio, Casabona, Enrique, Bringas, María Luisa, Álvarez, Lázaro, Jahanshahi, Marjan
Tipo de recurso: artículo
Estado:Versión publicada
Fecha de publicación:2012
País:España
Institución:Consejo Superior de Investigaciones Científicas (CSIC)
Repositorio:DIGITAL.CSIC. Repositorio Institucional del CSIC
OAI Identifier:oai:digital.csic.es:10261/350875
Acceso en línea:http://hdl.handle.net/10261/350875
https://api.elsevier.com/content/abstract/scopus_id/84858693584
Access Level:acceso abierto
Palabra clave:Verbal fluency
Cognition
Executive function
Parkinson's disease
Phonemic
Semantic
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spelling Semantic and phonemic verbal fluency in Parkinson's disease: Influence of clinical and demographic variablesObeso, IgnacioCasabona, EnriqueBringas, María LuisaÁlvarez, LázaroJahanshahi, MarjanVerbal fluencyCognitionExecutive functionParkinson's diseasePhonemicSemanticChanges of cognitive function in PD have been extensively documented and defined as a 'frontal' type executive dysfunction. One of the main components of this executive dysfunction is the impairment of verbal fluency. The aim of the present study was to assess semantic and phonemic fluency in a large sample of PD patients and to investigate the effect of clinical and sociodemographic variables on verbal fluency in this patient group. Three hundred patients with idiopathic Parkinson's disease who were consecutive referrals to our clinic and 50 age and education matched healthy controls completed the phonemic and semantic verbal fluency tasks. Both phonemic and semantic verbal fluency were significantly impaired in PD patients relative to matched controls. Stage of illness, presence of depression, education and age influenced verbal fluency measures. Regression analyses established that global measures of cognitive ability (MMSE) and executive function (FAB) and side of onset of motor symptoms predicted 36-37% of variance of phonemic or semantic verbal fluency measures. Thus, future studies aimed at assessing cognitive functioning in PD patients treated by deep brain stimulation (DBS) should adequately take into account several factors (stage of illness, depression, executive functioning) which may potentially influence performance on verbal fluency tasks.This research was supported by a PhD studentship from Fundación Caja Madrid, Spain (IO), and a Royal Society Travelling Fellowship.Peer reviewedHindawi Publishing CorporationFundación Caja MadridRoyal Society (UK)202420242012info:eu-repo/semantics/articlehttp://purl.org/coar/resource_type/c_6501Publisher's versioninfo:eu-repo/semantics/publishedVersionapplication/pdfhttp://hdl.handle.net/10261/350875https://api.elsevier.com/content/abstract/scopus_id/84858693584reponame:DIGITAL.CSIC. Repositorio Institucional del CSICinstname:Consejo Superior de Investigaciones Científicas (CSIC)Ingléshttps://doi.org/10.3233/BEN-2011-0354Noinfo:eu-repo/semantics/openAccessoai:digital.csic.es:10261/3508752026-05-22T06:33:51Z
dc.title.none.fl_str_mv Semantic and phonemic verbal fluency in Parkinson's disease: Influence of clinical and demographic variables
title Semantic and phonemic verbal fluency in Parkinson's disease: Influence of clinical and demographic variables
spellingShingle Semantic and phonemic verbal fluency in Parkinson's disease: Influence of clinical and demographic variables
Obeso, Ignacio
Verbal fluency
Cognition
Executive function
Parkinson's disease
Phonemic
Semantic
title_short Semantic and phonemic verbal fluency in Parkinson's disease: Influence of clinical and demographic variables
title_full Semantic and phonemic verbal fluency in Parkinson's disease: Influence of clinical and demographic variables
title_fullStr Semantic and phonemic verbal fluency in Parkinson's disease: Influence of clinical and demographic variables
title_full_unstemmed Semantic and phonemic verbal fluency in Parkinson's disease: Influence of clinical and demographic variables
title_sort Semantic and phonemic verbal fluency in Parkinson's disease: Influence of clinical and demographic variables
dc.creator.none.fl_str_mv Obeso, Ignacio
Casabona, Enrique
Bringas, María Luisa
Álvarez, Lázaro
Jahanshahi, Marjan
author Obeso, Ignacio
author_facet Obeso, Ignacio
Casabona, Enrique
Bringas, María Luisa
Álvarez, Lázaro
Jahanshahi, Marjan
author_role author
author2 Casabona, Enrique
Bringas, María Luisa
Álvarez, Lázaro
Jahanshahi, Marjan
author2_role author
author
author
author
dc.contributor.none.fl_str_mv Fundación Caja Madrid
Royal Society (UK)
dc.subject.none.fl_str_mv Verbal fluency
Cognition
Executive function
Parkinson's disease
Phonemic
Semantic
topic Verbal fluency
Cognition
Executive function
Parkinson's disease
Phonemic
Semantic
description Changes of cognitive function in PD have been extensively documented and defined as a 'frontal' type executive dysfunction. One of the main components of this executive dysfunction is the impairment of verbal fluency. The aim of the present study was to assess semantic and phonemic fluency in a large sample of PD patients and to investigate the effect of clinical and sociodemographic variables on verbal fluency in this patient group. Three hundred patients with idiopathic Parkinson's disease who were consecutive referrals to our clinic and 50 age and education matched healthy controls completed the phonemic and semantic verbal fluency tasks. Both phonemic and semantic verbal fluency were significantly impaired in PD patients relative to matched controls. Stage of illness, presence of depression, education and age influenced verbal fluency measures. Regression analyses established that global measures of cognitive ability (MMSE) and executive function (FAB) and side of onset of motor symptoms predicted 36-37% of variance of phonemic or semantic verbal fluency measures. Thus, future studies aimed at assessing cognitive functioning in PD patients treated by deep brain stimulation (DBS) should adequately take into account several factors (stage of illness, depression, executive functioning) which may potentially influence performance on verbal fluency tasks.
publishDate 2012
dc.date.none.fl_str_mv 2012
2024
2024
dc.type.none.fl_str_mv info:eu-repo/semantics/article
http://purl.org/coar/resource_type/c_6501
Publisher's version
info:eu-repo/semantics/publishedVersion
format article
status_str publishedVersion
dc.identifier.none.fl_str_mv http://hdl.handle.net/10261/350875
https://api.elsevier.com/content/abstract/scopus_id/84858693584
url http://hdl.handle.net/10261/350875
https://api.elsevier.com/content/abstract/scopus_id/84858693584
dc.language.none.fl_str_mv Inglés
language_invalid_str_mv Inglés
dc.relation.none.fl_str_mv https://doi.org/10.3233/BEN-2011-0354
No
dc.rights.none.fl_str_mv info:eu-repo/semantics/openAccess
eu_rights_str_mv openAccess
dc.format.none.fl_str_mv application/pdf
dc.publisher.none.fl_str_mv Hindawi Publishing Corporation
publisher.none.fl_str_mv Hindawi Publishing Corporation
dc.source.none.fl_str_mv reponame:DIGITAL.CSIC. Repositorio Institucional del CSIC
instname:Consejo Superior de Investigaciones Científicas (CSIC)
instname_str Consejo Superior de Investigaciones Científicas (CSIC)
reponame_str DIGITAL.CSIC. Repositorio Institucional del CSIC
collection DIGITAL.CSIC. Repositorio Institucional del CSIC
repository.name.fl_str_mv
repository.mail.fl_str_mv
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