Cognitive patterns in relation to biomarkers of cerebrovascular disease and vascular risk factors

Background: Risk factors for vascular cognitive impairment (VCI) are the same as traditional risk factors for cerebrovascular disease (CVD). Early identification of subjects at higher risk of VCI is important for the development of effective preventive strategies. In addition to traditional vascular...

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Autores: Miralbell Blanch, Júlia, López Cancio, Elena, López-Olóriz, Jorge, Arenillas, Juan Francisco, Barrios Cerrejón, M. Teresa, Soriano Raya, Juan José, Galán, Amparo, Cáceres, Cynthia, Alzamora, María Teresa, Pera, Guillem, Toran, Pere, Dávalos, Antoni, Mataró Serrat, Maria
Tipo de recurso: artículo
Estado:Versión aceptada para publicación
Fecha de publicación:2013
País:España
Institución:Universidad de Barcelona
Repositorio:Dipòsit Digital de la UB
OAI Identifier:oai:diposit.ub.edu:2445/226412
Acceso en línea:https://hdl.handle.net/2445/226412
Access Level:acceso abierto
Palabra clave:Malalties cerebrovasculars
Cognició
Cerebrovascular disease
Cognition
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spelling Cognitive patterns in relation to biomarkers of cerebrovascular disease and vascular risk factorsMiralbell Blanch, JúliaLópez Cancio, ElenaLópez-Olóriz, JorgeArenillas, Juan FranciscoBarrios Cerrejón, M. TeresaSoriano Raya, Juan JoséGalán, AmparoCáceres, CynthiaAlzamora, María TeresaPera, GuillemToran, PereDávalos, AntoniMataró Serrat, MariaMalalties cerebrovascularsCognicióCerebrovascular diseaseCognitionBackground: Risk factors for vascular cognitive impairment (VCI) are the same as traditional risk factors for cerebrovascular disease (CVD). Early identification of subjects at higher risk of VCI is important for the development of effective preventive strategies. In addition to traditional vascular risk factors (VRF), circulating biomarkers have emerged as potential tools for early diagnoses, as they could provide in vivo measures of the underlying pathophysiology. While VRF have been consistently linked to a VCI profile (i.e., deficits in executive functions and processing speed), the cognitive correlates of CVD biomarkers remain unclear. In this population-based study, the aim was to study and compare cognitive patterns in relation to VRF and circulating biomarkers of CVD. Methods: The Barcelona-AsIA Neuropsychology Study included 747 subjects older than 50, without a prior history of stroke or coronary disease and with a moderate to high vascular risk (mean age, 66 years; 34.1% women). Three cognitive domains were derived from factoral analysis: visuospatial skills/speed, verbal memory and verbal fluency. Multiple linear regression was used to assess relationships between cognitive performance (multiple domains) and a panel of circulating biomarkers, including indicators of inflammation, C-reactive protein (CRP) and resistin, endothelial dysfunction, asymmetric dimethylarginine (ADMA), thrombosis, plasminogen activator inhibitor 1 (PAI-1), as well as traditional VRF, metabolic syndrome and insulin resistance (homeostatic model assessment for insulin resistance index). Analyses were adjusted for age, gender, years of education and depressive symptoms. Results: Traditional VRF were related to lower performance in verbal fluency, insulin resistance accounted for lower performance in visuospatial skills/speed and the metabolic syndrome predicted lower performance in both cognitive domains. From the biomarkers of CVD, CRP was negatively related to verbal fluency performance and increasing ADMA levels were associated with lower performance in verbal memory. Resistin and PAI-1 did not relate to cognitive function performance. Conclusion: Vascular risk factors, and markers of inflammation and endothelial dysfunction predicted lower performance in several cognitive domains. Specifically, cognitive functions associated with CRP are typically affected in VCI and overlap those related to VRF. ADMA indicated a dissociation in the cognitive profile involving verbal memory. These findings suggest that inflammation and endothelial dysfunction might play a role in the predementia cognitive impairment stages.Karger2013info:eu-repo/semantics/articleinfo:eu-repo/semantics/acceptedVersionapplication/pdfhttps://hdl.handle.net/2445/226412Articles publicats en revistes (Cognició, Desenvolupament i Psicologia de l'Educació)reponame:Dipòsit Digital de la UBinstname:Universidad de BarcelonaInglésVersió postprint del document publicat a: https://doi.org/10.1159/000352059Cerebrovascular Diseases, 2013, vol. 36, num.2, p. 98-105https://doi.org/10.1159/000352059(c) Karger, 2013info:eu-repo/semantics/openAccessoai:diposit.ub.edu:2445/2264122026-05-27T06:46:51Z
dc.title.none.fl_str_mv Cognitive patterns in relation to biomarkers of cerebrovascular disease and vascular risk factors
title Cognitive patterns in relation to biomarkers of cerebrovascular disease and vascular risk factors
spellingShingle Cognitive patterns in relation to biomarkers of cerebrovascular disease and vascular risk factors
Miralbell Blanch, Júlia
Malalties cerebrovasculars
Cognició
Cerebrovascular disease
Cognition
title_short Cognitive patterns in relation to biomarkers of cerebrovascular disease and vascular risk factors
title_full Cognitive patterns in relation to biomarkers of cerebrovascular disease and vascular risk factors
title_fullStr Cognitive patterns in relation to biomarkers of cerebrovascular disease and vascular risk factors
title_full_unstemmed Cognitive patterns in relation to biomarkers of cerebrovascular disease and vascular risk factors
title_sort Cognitive patterns in relation to biomarkers of cerebrovascular disease and vascular risk factors
dc.creator.none.fl_str_mv Miralbell Blanch, Júlia
López Cancio, Elena
López-Olóriz, Jorge
Arenillas, Juan Francisco
Barrios Cerrejón, M. Teresa
Soriano Raya, Juan José
Galán, Amparo
Cáceres, Cynthia
Alzamora, María Teresa
Pera, Guillem
Toran, Pere
Dávalos, Antoni
Mataró Serrat, Maria
author Miralbell Blanch, Júlia
author_facet Miralbell Blanch, Júlia
López Cancio, Elena
López-Olóriz, Jorge
Arenillas, Juan Francisco
Barrios Cerrejón, M. Teresa
Soriano Raya, Juan José
Galán, Amparo
Cáceres, Cynthia
Alzamora, María Teresa
Pera, Guillem
Toran, Pere
Dávalos, Antoni
Mataró Serrat, Maria
author_role author
author2 López Cancio, Elena
López-Olóriz, Jorge
Arenillas, Juan Francisco
Barrios Cerrejón, M. Teresa
Soriano Raya, Juan José
Galán, Amparo
Cáceres, Cynthia
Alzamora, María Teresa
Pera, Guillem
Toran, Pere
Dávalos, Antoni
Mataró Serrat, Maria
author2_role author
author
author
author
author
author
author
author
author
author
author
author
dc.subject.none.fl_str_mv Malalties cerebrovasculars
Cognició
Cerebrovascular disease
Cognition
topic Malalties cerebrovasculars
Cognició
Cerebrovascular disease
Cognition
description Background: Risk factors for vascular cognitive impairment (VCI) are the same as traditional risk factors for cerebrovascular disease (CVD). Early identification of subjects at higher risk of VCI is important for the development of effective preventive strategies. In addition to traditional vascular risk factors (VRF), circulating biomarkers have emerged as potential tools for early diagnoses, as they could provide in vivo measures of the underlying pathophysiology. While VRF have been consistently linked to a VCI profile (i.e., deficits in executive functions and processing speed), the cognitive correlates of CVD biomarkers remain unclear. In this population-based study, the aim was to study and compare cognitive patterns in relation to VRF and circulating biomarkers of CVD. Methods: The Barcelona-AsIA Neuropsychology Study included 747 subjects older than 50, without a prior history of stroke or coronary disease and with a moderate to high vascular risk (mean age, 66 years; 34.1% women). Three cognitive domains were derived from factoral analysis: visuospatial skills/speed, verbal memory and verbal fluency. Multiple linear regression was used to assess relationships between cognitive performance (multiple domains) and a panel of circulating biomarkers, including indicators of inflammation, C-reactive protein (CRP) and resistin, endothelial dysfunction, asymmetric dimethylarginine (ADMA), thrombosis, plasminogen activator inhibitor 1 (PAI-1), as well as traditional VRF, metabolic syndrome and insulin resistance (homeostatic model assessment for insulin resistance index). Analyses were adjusted for age, gender, years of education and depressive symptoms. Results: Traditional VRF were related to lower performance in verbal fluency, insulin resistance accounted for lower performance in visuospatial skills/speed and the metabolic syndrome predicted lower performance in both cognitive domains. From the biomarkers of CVD, CRP was negatively related to verbal fluency performance and increasing ADMA levels were associated with lower performance in verbal memory. Resistin and PAI-1 did not relate to cognitive function performance. Conclusion: Vascular risk factors, and markers of inflammation and endothelial dysfunction predicted lower performance in several cognitive domains. Specifically, cognitive functions associated with CRP are typically affected in VCI and overlap those related to VRF. ADMA indicated a dissociation in the cognitive profile involving verbal memory. These findings suggest that inflammation and endothelial dysfunction might play a role in the predementia cognitive impairment stages.
publishDate 2013
dc.date.none.fl_str_mv 2013
dc.type.none.fl_str_mv info:eu-repo/semantics/article
info:eu-repo/semantics/acceptedVersion
format article
status_str acceptedVersion
dc.identifier.none.fl_str_mv https://hdl.handle.net/2445/226412
url https://hdl.handle.net/2445/226412
dc.language.none.fl_str_mv Inglés
language_invalid_str_mv Inglés
dc.relation.none.fl_str_mv Versió postprint del document publicat a: https://doi.org/10.1159/000352059
Cerebrovascular Diseases, 2013, vol. 36, num.2, p. 98-105
https://doi.org/10.1159/000352059
dc.rights.none.fl_str_mv (c) Karger, 2013
info:eu-repo/semantics/openAccess
rights_invalid_str_mv (c) Karger, 2013
eu_rights_str_mv openAccess
dc.format.none.fl_str_mv application/pdf
dc.publisher.none.fl_str_mv Karger
publisher.none.fl_str_mv Karger
dc.source.none.fl_str_mv Articles publicats en revistes (Cognició, Desenvolupament i Psicologia de l'Educació)
reponame:Dipòsit Digital de la UB
instname:Universidad de Barcelona
instname_str Universidad de Barcelona
reponame_str Dipòsit Digital de la UB
collection Dipòsit Digital de la UB
repository.name.fl_str_mv
repository.mail.fl_str_mv
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score 15.811543

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