Impact of COVID-19 infection on cognition and its association with neurological symptoms

Objective: To characterize the cognitive profile following COVID-19 infection and its possible association to clinical symptoms, emotional disturbance, biomarkers, and disease severity. Methods: This was a single-center cross-sectional cohort study. Subjects between 20- and 60-year old with confirme...

Descripción completa

Detalles Bibliográficos
Autores: Almeria, M., Cejudo, Juan Carlos, Sanz-Santos, José, Deus, Joan, Krupinski, Jerzy
Tipo de recurso: artículo
Estado:Versión publicada
Fecha de publicación:2023
País:España
Institución:Universitat Pompeu Fabra
Repositorio:Repositorio Digital de la UPF
OAI Identifier:oai:repositori.upf.edu:10230/60200
Acceso en línea:http://hdl.handle.net/10230/60200
http://dx.doi.org/10.1002/brb3.2902
Access Level:acceso abierto
Palabra clave:COVID-19
Cognitive impairment
Neurologic symptoms
Neuropsychology
id ES_7fec8a7d1dbbfb09b6fecbee9cd6a724
oai_identifier_str oai:repositori.upf.edu:10230/60200
network_acronym_str ES
network_name_str España
repository_id_str
spelling Impact of COVID-19 infection on cognition and its association with neurological symptomsAlmeria, M.Cejudo, Juan CarlosSanz-Santos, JoséDeus, JoanKrupinski, JerzyCOVID-19Cognitive impairmentNeurologic symptomsNeuropsychologyObjective: To characterize the cognitive profile following COVID-19 infection and its possible association to clinical symptoms, emotional disturbance, biomarkers, and disease severity. Methods: This was a single-center cross-sectional cohort study. Subjects between 20- and 60-year old with confirmed COVID-19 infection were included. Evaluation was performed between April 2020 and July 2021. Patients with previous cognitive impairment and other neurological or severe psychiatric disorders were excluded. Demographic and laboratory data were extracted from the medical records. Results: Altogether 200 patients were included, 85 subjects were female (42.3%), and mean age was 49.12 years (SD: 7.84). Patients were classified into four groups: nonhospitalized (NH, n = 21), hospitalized without intensive care unit (ICU) nor oxygen therapy (HOSP, n = 42), hospitalized without ICU but with oxygen therapy (OXY, n = 107), and ICU (ICU, n = 31) patients. NH group was younger (p = .026). No significant differences were found in any test performed attending severity of illness (p > .05). A total of 55 patients reported subjective cognitive complaints (SCC). Subjects with neurological symptoms (NS) performed worse in trail making test B (p = .013), digits backwards (p = .006), letter&numbers (p = .002), symbol digit modalities test (p = .016), and Stroop color (p = .010) tests. Conclusions: OXY patients and females referred more SCC associated with symptoms of anxiety and depression. Objective cognitive performance was unrelated to SCC. No cognitive impairment was found regarding the severity of COVID-19 infection. Results suggest that NS such as headache, anosmia, and dysgeusia during infection were a risk factor for later cognitive deficits. Tests assessing attention, processing speed, and executive function were the most sensitive in detecting cognitive changes in these patients.Wiley202420242023info:eu-repo/semantics/articleinfo:eu-repo/semantics/publishedVersionapplication/pdfapplication/pdfhttp://hdl.handle.net/10230/60200http://dx.doi.org/10.1002/brb3.2902reponame:Repositorio Digital de la UPFinstname:Universitat Pompeu FabraInglésBrain Behav. 2023 Apr;13(4):e2902© 2023 The Authors. Brain and Behavior published by Wiley Periodicals LLC. This is an open access article under the terms of the Creative Commons Attribution License (http://creativecommons.org/licenses/by/4.0/), which permits use, distribution and reproduction in any medium, provided the original work is properly cited.http://creativecommons.org/licenses/by/4.0/info:eu-repo/semantics/openAccessoai:repositori.upf.edu:10230/602002026-06-12T07:21:37Z
dc.title.none.fl_str_mv Impact of COVID-19 infection on cognition and its association with neurological symptoms
title Impact of COVID-19 infection on cognition and its association with neurological symptoms
spellingShingle Impact of COVID-19 infection on cognition and its association with neurological symptoms
Almeria, M.
COVID-19
Cognitive impairment
Neurologic symptoms
Neuropsychology
title_short Impact of COVID-19 infection on cognition and its association with neurological symptoms
title_full Impact of COVID-19 infection on cognition and its association with neurological symptoms
title_fullStr Impact of COVID-19 infection on cognition and its association with neurological symptoms
title_full_unstemmed Impact of COVID-19 infection on cognition and its association with neurological symptoms
title_sort Impact of COVID-19 infection on cognition and its association with neurological symptoms
dc.creator.none.fl_str_mv Almeria, M.
Cejudo, Juan Carlos
Sanz-Santos, José
Deus, Joan
Krupinski, Jerzy
author Almeria, M.
author_facet Almeria, M.
Cejudo, Juan Carlos
Sanz-Santos, José
Deus, Joan
Krupinski, Jerzy
author_role author
author2 Cejudo, Juan Carlos
Sanz-Santos, José
Deus, Joan
Krupinski, Jerzy
author2_role author
author
author
author
dc.subject.none.fl_str_mv COVID-19
Cognitive impairment
Neurologic symptoms
Neuropsychology
topic COVID-19
Cognitive impairment
Neurologic symptoms
Neuropsychology
description Objective: To characterize the cognitive profile following COVID-19 infection and its possible association to clinical symptoms, emotional disturbance, biomarkers, and disease severity. Methods: This was a single-center cross-sectional cohort study. Subjects between 20- and 60-year old with confirmed COVID-19 infection were included. Evaluation was performed between April 2020 and July 2021. Patients with previous cognitive impairment and other neurological or severe psychiatric disorders were excluded. Demographic and laboratory data were extracted from the medical records. Results: Altogether 200 patients were included, 85 subjects were female (42.3%), and mean age was 49.12 years (SD: 7.84). Patients were classified into four groups: nonhospitalized (NH, n = 21), hospitalized without intensive care unit (ICU) nor oxygen therapy (HOSP, n = 42), hospitalized without ICU but with oxygen therapy (OXY, n = 107), and ICU (ICU, n = 31) patients. NH group was younger (p = .026). No significant differences were found in any test performed attending severity of illness (p > .05). A total of 55 patients reported subjective cognitive complaints (SCC). Subjects with neurological symptoms (NS) performed worse in trail making test B (p = .013), digits backwards (p = .006), letter&numbers (p = .002), symbol digit modalities test (p = .016), and Stroop color (p = .010) tests. Conclusions: OXY patients and females referred more SCC associated with symptoms of anxiety and depression. Objective cognitive performance was unrelated to SCC. No cognitive impairment was found regarding the severity of COVID-19 infection. Results suggest that NS such as headache, anosmia, and dysgeusia during infection were a risk factor for later cognitive deficits. Tests assessing attention, processing speed, and executive function were the most sensitive in detecting cognitive changes in these patients.
publishDate 2023
dc.date.none.fl_str_mv 2023
2024
2024
dc.type.none.fl_str_mv info:eu-repo/semantics/article
info:eu-repo/semantics/publishedVersion
format article
status_str publishedVersion
dc.identifier.none.fl_str_mv http://hdl.handle.net/10230/60200
http://dx.doi.org/10.1002/brb3.2902
url http://hdl.handle.net/10230/60200
http://dx.doi.org/10.1002/brb3.2902
dc.language.none.fl_str_mv Inglés
language_invalid_str_mv Inglés
dc.relation.none.fl_str_mv Brain Behav. 2023 Apr;13(4):e2902
dc.rights.none.fl_str_mv http://creativecommons.org/licenses/by/4.0/
info:eu-repo/semantics/openAccess
rights_invalid_str_mv http://creativecommons.org/licenses/by/4.0/
eu_rights_str_mv openAccess
dc.format.none.fl_str_mv application/pdf
application/pdf
dc.publisher.none.fl_str_mv Wiley
publisher.none.fl_str_mv Wiley
dc.source.none.fl_str_mv reponame:Repositorio Digital de la UPF
instname:Universitat Pompeu Fabra
instname_str Universitat Pompeu Fabra
reponame_str Repositorio Digital de la UPF
collection Repositorio Digital de la UPF
repository.name.fl_str_mv
repository.mail.fl_str_mv
_version_ 1869411860704395264
score 15,812429

Similares en LA Referencia