Causal effects of physical activity and sedentary behaviour on health deficits accumulation in older adults.

Background: Increasing physical activity (PA) and reducing sedentary behaviour (SB) have been associated with healthy ageing, but their effects when adjusted for reverse causation and selection bias remain unclear. Methods: A deficits accumulation (DA) index based on the number and severity of 51 he...

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Autores: García-Esquinas, Esther, Ortolá, Rosario, Martínez-Gómez, David, Damian, Javier, Prina, Matthew, Rodríguez-Artalejo, Fernando, Pastor-Barriuso, Roberto
Tipo de recurso: artículo
Fecha de publicación:2021
País:España
Institución:Instituto de Salud Carlos III (ISCIII)
Repositorio:Repisalud
Idioma:inglés
OAI Identifier:oai:repisalud.isciii.es:20.500.12105/27166
Acceso en línea:https://hdl.handle.net/20.500.12105/27166
Access Level:acceso abierto
Palabra clave:Causality
Health deficits
Older adults
Physical activity
Sedentary behaviour
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spelling Causal effects of physical activity and sedentary behaviour on health deficits accumulation in older adults.García-Esquinas, EstherOrtolá, RosarioMartínez-Gómez, DavidDamian, JavierPrina, MatthewRodríguez-Artalejo, FernandoPastor-Barriuso, RobertoCausalityHealth deficitsOlder adultsPhysical activitySedentary behaviourBackground: Increasing physical activity (PA) and reducing sedentary behaviour (SB) have been associated with healthy ageing, but their effects when adjusted for reverse causation and selection bias remain unclear. Methods: A deficits accumulation (DA) index based on the number and severity of 51 health deficits (0-100%) was calculated at baseline and three biannual follow-up visits, in a representative cohort of 3 228 community-dwelling older adults in Spain. Average differences in DA index by previous recreational PA, household PA, mentally-active SB and passive SB were estimated using marginal structural models with inverse probability of exposure and censoring weights. Results: Compared with participants with previous recreational PA of 10-19.9 metabolic equivalent hours/week (MET-hours/week), average differences in DA index (95% confidence intervals) were 0.19 (-1.09, 1.48), 0.69 (-0.23, 1.61), -0.66 (-1.34, 0.02), -0.87 (-1.59, -0.13) and -0.55 (-1.37, 0.28) for 0, 0.1-9.9, 20-29.9, 30-39.9 and ≥40 MET-hours/week, respectively (P for trend = 0.006). Household PA showed no effect on subsequent DA after adjusting for reverse causation. Women, but not men, who spent 7-14.9, 15-20.9 and ≥21 h/week on mentally active SB had DA decreases of 0.09 (-1.00, 1.19), 1.08 (-0.28, 2.45) and 2.17 (0.58, 3.75), respectively, compared with 1-6.9 h/week (P for trend = 0.005); whereas women who spent 3-3.9, 4-4.9 and ≥5 h/day on passive SB showed DA increases of 0.41 (-0.52, 1.35), 1.35 (0.13, 2.57) and 2.13 (0.78, 3.47), respectively, compared with 2-2.9 h/day (P for trend = 0.001). Conclusions: The proposed methodology allows estimation of the causal effects of PA and SB on ageing, by simulating a random assignment in which all subjects have the same probability of exposure.Oxford University Press20262026-01-2120212021-07-0920212021-07-09research articlehttp://purl.org/coar/resource_type/c_2df8fbb1AMhttp://purl.org/coar/version/c_ab4af688f83e57aainfo:eu-repo/semantics/articleapplication/pdfapplication/vnd.openxmlformats-officedocument.wordprocessingml.documenthttps://hdl.handle.net/20.500.12105/27166reponame:Repisaludinstname:Instituto de Salud Carlos III (ISCIII)Inglésengopen accesshttp://purl.org/coar/access_right/c_abf2info:eu-repo/semantics/openAccessoai:repisalud.isciii.es:20.500.12105/271662026-06-12T12:43:37Z
dc.title.none.fl_str_mv Causal effects of physical activity and sedentary behaviour on health deficits accumulation in older adults.
title Causal effects of physical activity and sedentary behaviour on health deficits accumulation in older adults.
spellingShingle Causal effects of physical activity and sedentary behaviour on health deficits accumulation in older adults.
García-Esquinas, Esther
Causality
Health deficits
Older adults
Physical activity
Sedentary behaviour
title_short Causal effects of physical activity and sedentary behaviour on health deficits accumulation in older adults.
title_full Causal effects of physical activity and sedentary behaviour on health deficits accumulation in older adults.
title_fullStr Causal effects of physical activity and sedentary behaviour on health deficits accumulation in older adults.
title_full_unstemmed Causal effects of physical activity and sedentary behaviour on health deficits accumulation in older adults.
title_sort Causal effects of physical activity and sedentary behaviour on health deficits accumulation in older adults.
dc.creator.none.fl_str_mv García-Esquinas, Esther
Ortolá, Rosario
Martínez-Gómez, David
Damian, Javier
Prina, Matthew
Rodríguez-Artalejo, Fernando
Pastor-Barriuso, Roberto
author García-Esquinas, Esther
author_facet García-Esquinas, Esther
Ortolá, Rosario
Martínez-Gómez, David
Damian, Javier
Prina, Matthew
Rodríguez-Artalejo, Fernando
Pastor-Barriuso, Roberto
author_role author
author2 Ortolá, Rosario
Martínez-Gómez, David
Damian, Javier
Prina, Matthew
Rodríguez-Artalejo, Fernando
Pastor-Barriuso, Roberto
author2_role author
author
author
author
author
author
dc.contributor.none.fl_str_mv
dc.subject.none.fl_str_mv Causality
Health deficits
Older adults
Physical activity
Sedentary behaviour
topic Causality
Health deficits
Older adults
Physical activity
Sedentary behaviour
description Background: Increasing physical activity (PA) and reducing sedentary behaviour (SB) have been associated with healthy ageing, but their effects when adjusted for reverse causation and selection bias remain unclear. Methods: A deficits accumulation (DA) index based on the number and severity of 51 health deficits (0-100%) was calculated at baseline and three biannual follow-up visits, in a representative cohort of 3 228 community-dwelling older adults in Spain. Average differences in DA index by previous recreational PA, household PA, mentally-active SB and passive SB were estimated using marginal structural models with inverse probability of exposure and censoring weights. Results: Compared with participants with previous recreational PA of 10-19.9 metabolic equivalent hours/week (MET-hours/week), average differences in DA index (95% confidence intervals) were 0.19 (-1.09, 1.48), 0.69 (-0.23, 1.61), -0.66 (-1.34, 0.02), -0.87 (-1.59, -0.13) and -0.55 (-1.37, 0.28) for 0, 0.1-9.9, 20-29.9, 30-39.9 and ≥40 MET-hours/week, respectively (P for trend = 0.006). Household PA showed no effect on subsequent DA after adjusting for reverse causation. Women, but not men, who spent 7-14.9, 15-20.9 and ≥21 h/week on mentally active SB had DA decreases of 0.09 (-1.00, 1.19), 1.08 (-0.28, 2.45) and 2.17 (0.58, 3.75), respectively, compared with 1-6.9 h/week (P for trend = 0.005); whereas women who spent 3-3.9, 4-4.9 and ≥5 h/day on passive SB showed DA increases of 0.41 (-0.52, 1.35), 1.35 (0.13, 2.57) and 2.13 (0.78, 3.47), respectively, compared with 2-2.9 h/day (P for trend = 0.001). Conclusions: The proposed methodology allows estimation of the causal effects of PA and SB on ageing, by simulating a random assignment in which all subjects have the same probability of exposure.
publishDate 2021
dc.date.none.fl_str_mv 2021
2021-07-09
2021
2021-07-09
2026
2026-01-21
dc.type.none.fl_str_mv research article
http://purl.org/coar/resource_type/c_2df8fbb1
AM
http://purl.org/coar/version/c_ab4af688f83e57aa
dc.type.openaire.fl_str_mv info:eu-repo/semantics/article
format article
dc.identifier.none.fl_str_mv https://hdl.handle.net/20.500.12105/27166
url https://hdl.handle.net/20.500.12105/27166
dc.language.none.fl_str_mv Inglés
eng
language_invalid_str_mv Inglés
language eng
dc.rights.none.fl_str_mv open access
http://purl.org/coar/access_right/c_abf2
dc.rights.openaire.fl_str_mv info:eu-repo/semantics/openAccess
rights_invalid_str_mv open access
http://purl.org/coar/access_right/c_abf2
eu_rights_str_mv openAccess
dc.format.none.fl_str_mv application/pdf
application/vnd.openxmlformats-officedocument.wordprocessingml.document
dc.publisher.none.fl_str_mv Oxford University Press
publisher.none.fl_str_mv Oxford University Press
dc.source.none.fl_str_mv reponame:Repisalud
instname:Instituto de Salud Carlos III (ISCIII)
instname_str Instituto de Salud Carlos III (ISCIII)
reponame_str Repisalud
collection Repisalud
repository.name.fl_str_mv
repository.mail.fl_str_mv
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