Regional, circuit and network heterogeneity of brain abnormalities in psychiatric disorders

The substantial individual heterogeneity that characterizes people with mental illness is often ignored by classical case-control research, which relies on group mean comparisons. Here we present a comprehensive, multiscale characterization of the heterogeneity of gray matter volume (GMV) difference...

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Bibliographic Details
Authors: Segal, Ashlea, Parkes, Linden, Aquino, Kevin, Kia, Seyed Mostafa, Wolfers, Thomas, Franke, Barbara, Hoogman, Martine, Beckmann, Christian F., Westlye, Lars T., Andreassen, Ole A., Zalesky, Andrew, Harrison, Ben J., Davey, Christopher G., Soriano Mas, Carles, Cardoner, N. (Narcís), Tiego, Jeggan, Yücel, Murat, Braganza, Leah, Suo, Chao, Berk, Michael, Cotton, Sue, Bellgrove, Mark A., Marquand, Andre, Fornito, Alex
Format: article
Status:Published version
Publication Date:2023
Country:España
Institution:Varias* (Consorci de Biblioteques Universitáries de Catalunya, Centre de Serveis Científics i Acadèmics de Catalunya)
Repository:Recercat. Dipósit de la Recerca de Catalunya
OAI Identifier:oai:recercat.cat:2445/202602
Online Access:https://hdl.handle.net/2445/202602
Access Level:Open access
Keyword:Psicopatologia
Encèfal
Pathological psychology
Encephalon
Description
Summary:The substantial individual heterogeneity that characterizes people with mental illness is often ignored by classical case-control research, which relies on group mean comparisons. Here we present a comprehensive, multiscale characterization of the heterogeneity of gray matter volume (GMV) differences in 1,294 cases diagnosed with one of six conditions (attention-deficit/hyperactivity disorder, autism spectrum disorder, bipolar disorder, depression, obsessive-compulsive disorder and schizophrenia) and 1,465 matched controls. Normative models indicated that person-specific deviations from population expectations for regional GMV were highly heterogeneous, affecting the same area in <7% of people with the same diagnosis. However, these deviations were embedded within common functional circuits and networks in up to 56% of cases. The salience-ventral attention system was implicated transdiagnostically, with other systems selectively involved in depression, bipolar disorder, schizophrenia and attention-deficit/hyperactivity disorder. Phenotypic differences between cases assigned the same diagnosis may thus arise from the heterogeneous localization of specific regional deviations, whereas phenotypic similarities may be attributable to the dysfunction of common functional circuits and networks.

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