Possible Reduction of Cardiac Risk after Supplementation with Epigallocatechin Gallate and Increase of Ketone Bodies in the Blood in Patients with Multiple Sclerosis

Multiple sclerosis (MS) is a neurodegenerative disease that causes anthropometric changes characterised by functional disability, increase in fat mass, and decrease in lean mass. All these variables are related to a greater cardiac risk. The polyphenol epigallocatechin gallate (EGCG) and an increase...

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Autores: Benlloch García, María, Moreno Sancho, María de la Luz, Drehmer Rieger, Eraci, Cuerda Ballester, María, Sandra Carrera, Julia, Platero Armero, José Luis, Cerón, José Joaquín, Tvarijonaviciute, Asta, Navarro Moreno, María Ángeles, de la Rubia Ortí, José Enrique
Tipo de recurso: artículo
Fecha de publicación:2020
País:España
Institución:Universidad Católica de Valencia San Vicente Mártir
Repositorio:RIUCV. Repositorio de la Universidad Católica de Valencia San Vicente Mártir
Idioma:inglés
OAI Identifier:oai:riucv.ucv.es:20.500.12466/3204
Acceso en línea:http://hdl.handle.net/20.500.12466/3204
Access Level:acceso abierto
Palabra clave:Multiple sclerosis
Cardiac risk
Epigallocatechin gallate
Ketone bodies
3206 Ciencias de la Nutrición
3205.07 Neurología
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spelling Possible Reduction of Cardiac Risk after Supplementation with Epigallocatechin Gallate and Increase of Ketone Bodies in the Blood in Patients with Multiple SclerosisBenlloch García, MaríaMoreno Sancho, María de la LuzDrehmer Rieger, EraciCuerda Ballester, MaríaSandra Carrera, JuliaPlatero Armero, José LuisCerón, José JoaquínTvarijonaviciute, AstaNavarro Moreno, María Ángelesde la Rubia Ortí, José EnriqueMultiple sclerosisCardiac riskEpigallocatechin gallateKetone bodies3206 Ciencias de la Nutrición3205.07 NeurologíaMultiple sclerosis (MS) is a neurodegenerative disease that causes anthropometric changes characterised by functional disability, increase in fat mass, and decrease in lean mass. All these variables are related to a greater cardiac risk. The polyphenol epigallocatechin gallate (EGCG) and an increase in ketone bodies in the blood have been shown to have beneficial effects on anthropometric and biochemical variables related to cardiovascular activity. The aim of this study was to analyse the impact of the intervention with EGCG and ketone bodies on cardiac risk in MS patients. A population of 51 MS patients were randomly assigned to a control group and an intervention group (daily dose of 800 mg of EGCG and 60 mL of coconut oil). Both groups followed an isocaloric diet for 4 months. Levels of beta-hydroxybutyrate (BHB), albumin, paraoxonase 1 (PON1) and C-reactive protein (CRP) were measured in serum before and after the intervention, as well as determining functional ability, waist circumference, waist-to-hip ratio (WHR), waist-to-height ratio (WHtR), fat percentage and muscle percentage. After 4 months, in the intervention group there was a significant increase in BHB, PON1 and albumin, while CRP did not vary; a significant decrease in cardiac risk associated with a significant decline in WHR; as well as a significant increase in muscle percentage. By contrast, these changes were not observed in the control group. Finally, results from analysis of variance (ANOVA) revealed a significant time-condition interaction effect, observing that WHtR and fat mass decreased in the intervention group, while they increased in the control group.20232023-11-2820202020-12-1020202020-12-1020232023-11-28journal articlehttp://purl.org/coar/resource_type/c_6501info:eu-repo/semantics/articleapplication/pdfhttp://hdl.handle.net/20.500.12466/3204reponame:RIUCV. Repositorio de la Universidad Católica de Valencia San Vicente Mártirinstname:Universidad Católica de Valencia San Vicente MártirInglésengopen accesshttp://purl.org/coar/access_right/c_abf2Attribution 4.0 Internacionalhttp://creativecommons.org/licenses/by/4.0/info:eu-repo/semantics/openAccessoai:riucv.ucv.es:20.500.12466/32042026-06-19T08:32:07Z
dc.title.none.fl_str_mv Possible Reduction of Cardiac Risk after Supplementation with Epigallocatechin Gallate and Increase of Ketone Bodies in the Blood in Patients with Multiple Sclerosis
title Possible Reduction of Cardiac Risk after Supplementation with Epigallocatechin Gallate and Increase of Ketone Bodies in the Blood in Patients with Multiple Sclerosis
spellingShingle Possible Reduction of Cardiac Risk after Supplementation with Epigallocatechin Gallate and Increase of Ketone Bodies in the Blood in Patients with Multiple Sclerosis
Benlloch García, María
Multiple sclerosis
Cardiac risk
Epigallocatechin gallate
Ketone bodies
3206 Ciencias de la Nutrición
3205.07 Neurología
title_short Possible Reduction of Cardiac Risk after Supplementation with Epigallocatechin Gallate and Increase of Ketone Bodies in the Blood in Patients with Multiple Sclerosis
title_full Possible Reduction of Cardiac Risk after Supplementation with Epigallocatechin Gallate and Increase of Ketone Bodies in the Blood in Patients with Multiple Sclerosis
title_fullStr Possible Reduction of Cardiac Risk after Supplementation with Epigallocatechin Gallate and Increase of Ketone Bodies in the Blood in Patients with Multiple Sclerosis
title_full_unstemmed Possible Reduction of Cardiac Risk after Supplementation with Epigallocatechin Gallate and Increase of Ketone Bodies in the Blood in Patients with Multiple Sclerosis
title_sort Possible Reduction of Cardiac Risk after Supplementation with Epigallocatechin Gallate and Increase of Ketone Bodies in the Blood in Patients with Multiple Sclerosis
dc.creator.none.fl_str_mv Benlloch García, María
Moreno Sancho, María de la Luz
Drehmer Rieger, Eraci
Cuerda Ballester, María
Sandra Carrera, Julia
Platero Armero, José Luis
Cerón, José Joaquín
Tvarijonaviciute, Asta
Navarro Moreno, María Ángeles
de la Rubia Ortí, José Enrique
author Benlloch García, María
author_facet Benlloch García, María
Moreno Sancho, María de la Luz
Drehmer Rieger, Eraci
Cuerda Ballester, María
Sandra Carrera, Julia
Platero Armero, José Luis
Cerón, José Joaquín
Tvarijonaviciute, Asta
Navarro Moreno, María Ángeles
de la Rubia Ortí, José Enrique
author_role author
author2 Moreno Sancho, María de la Luz
Drehmer Rieger, Eraci
Cuerda Ballester, María
Sandra Carrera, Julia
Platero Armero, José Luis
Cerón, José Joaquín
Tvarijonaviciute, Asta
Navarro Moreno, María Ángeles
de la Rubia Ortí, José Enrique
author2_role author
author
author
author
author
author
author
author
author
dc.contributor.none.fl_str_mv
dc.subject.none.fl_str_mv Multiple sclerosis
Cardiac risk
Epigallocatechin gallate
Ketone bodies
3206 Ciencias de la Nutrición
3205.07 Neurología
topic Multiple sclerosis
Cardiac risk
Epigallocatechin gallate
Ketone bodies
3206 Ciencias de la Nutrición
3205.07 Neurología
description Multiple sclerosis (MS) is a neurodegenerative disease that causes anthropometric changes characterised by functional disability, increase in fat mass, and decrease in lean mass. All these variables are related to a greater cardiac risk. The polyphenol epigallocatechin gallate (EGCG) and an increase in ketone bodies in the blood have been shown to have beneficial effects on anthropometric and biochemical variables related to cardiovascular activity. The aim of this study was to analyse the impact of the intervention with EGCG and ketone bodies on cardiac risk in MS patients. A population of 51 MS patients were randomly assigned to a control group and an intervention group (daily dose of 800 mg of EGCG and 60 mL of coconut oil). Both groups followed an isocaloric diet for 4 months. Levels of beta-hydroxybutyrate (BHB), albumin, paraoxonase 1 (PON1) and C-reactive protein (CRP) were measured in serum before and after the intervention, as well as determining functional ability, waist circumference, waist-to-hip ratio (WHR), waist-to-height ratio (WHtR), fat percentage and muscle percentage. After 4 months, in the intervention group there was a significant increase in BHB, PON1 and albumin, while CRP did not vary; a significant decrease in cardiac risk associated with a significant decline in WHR; as well as a significant increase in muscle percentage. By contrast, these changes were not observed in the control group. Finally, results from analysis of variance (ANOVA) revealed a significant time-condition interaction effect, observing that WHtR and fat mass decreased in the intervention group, while they increased in the control group.
publishDate 2020
dc.date.none.fl_str_mv 2020
2020-12-10
2020
2020-12-10
2023
2023-11-28
2023
2023-11-28
dc.type.none.fl_str_mv journal article
http://purl.org/coar/resource_type/c_6501
dc.type.openaire.fl_str_mv info:eu-repo/semantics/article
format article
dc.identifier.none.fl_str_mv http://hdl.handle.net/20.500.12466/3204
url http://hdl.handle.net/20.500.12466/3204
dc.language.none.fl_str_mv Inglés
eng
language_invalid_str_mv Inglés
language eng
dc.rights.none.fl_str_mv open access
http://purl.org/coar/access_right/c_abf2
Attribution 4.0 Internacional
http://creativecommons.org/licenses/by/4.0/
dc.rights.openaire.fl_str_mv info:eu-repo/semantics/openAccess
rights_invalid_str_mv open access
http://purl.org/coar/access_right/c_abf2
Attribution 4.0 Internacional
http://creativecommons.org/licenses/by/4.0/
eu_rights_str_mv openAccess
dc.format.none.fl_str_mv application/pdf
dc.source.none.fl_str_mv reponame:RIUCV. Repositorio de la Universidad Católica de Valencia San Vicente Mártir
instname:Universidad Católica de Valencia San Vicente Mártir
instname_str Universidad Católica de Valencia San Vicente Mártir
reponame_str RIUCV. Repositorio de la Universidad Católica de Valencia San Vicente Mártir
collection RIUCV. Repositorio de la Universidad Católica de Valencia San Vicente Mártir
repository.name.fl_str_mv
repository.mail.fl_str_mv
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score 15.301629

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