Nanocolumnar coatings with selective behavior towards osteoblast and Staphylococcus aureus proliferation

Bacterial colonization and biofilm formation on orthopedic implants is one of the worst scenarios in orthopedic surgery, in terms of both patient prognosis and healthcare costs. Tailoring the surfaces of implants at the nanoscale to actively promote bone bonding while avoiding bacterial colonization...

Descripción completa

Detalles Bibliográficos
Autores: Izquierdo Barba, Isabel, García Martín, José Miguel, Álvarez, Rafael, Palmero, Alberto, Esteban, Jaime, Pérez-Jorge Peremarch, María de la Concepción, Arcos Navarrete, Daniel, Vallet Regí, María Dulce Nombre
Tipo de recurso: artículo
Fecha de publicación:2015
País:España
Institución:Universidad Complutense de Madrid (UCM)
Repositorio:Docta Complutense
Idioma:inglés
OAI Identifier:oai:docta.ucm.es:20.500.14352/24049
Acceso en línea:https://hdl.handle.net/20.500.14352/24049
Access Level:acceso abierto
Palabra clave:546
Titanium nanocolumns
Magnetron sputtering
Biocompatibility
Antibacterial effects
Biofilm
Staphylococcus aureus
Química inorgánica (Química)
2303 Química Inorgánica
id ES_7fd35d03b30e90cf4cc498ec224de5bb
oai_identifier_str oai:docta.ucm.es:20.500.14352/24049
network_acronym_str ES
network_name_str España
repository_id_str
spelling Nanocolumnar coatings with selective behavior towards osteoblast and Staphylococcus aureus proliferationIzquierdo Barba, IsabelGarcía Martín, José MiguelÁlvarez, RafaelPalmero, AlbertoEsteban, JaimePérez-Jorge Peremarch, María de la ConcepciónArcos Navarrete, DanielVallet Regí, María Dulce Nombre546Titanium nanocolumnsMagnetron sputteringBiocompatibilityAntibacterial effectsBiofilmStaphylococcus aureusQuímica inorgánica (Química)2303 Química InorgánicaBacterial colonization and biofilm formation on orthopedic implants is one of the worst scenarios in orthopedic surgery, in terms of both patient prognosis and healthcare costs. Tailoring the surfaces of implants at the nanoscale to actively promote bone bonding while avoiding bacterial colonization represents an interesting challenge to achieving better clinical outcomes. Herein, a Ti6Al4V alloy of medical grade has been coated with Ti nanostructures employing the glancing angle deposition technique by magnetron sputtering. The resulting surfaces have a high density of nanocolumnar structures, which exhibit strongly impaired bacterial adhesion that inhibits biofilm formation, while osteoblasts exhibit good cell response with similar behavior to the initial substrates. These results are discussed on the basis of a ‘‘lotus leaf effect’’ induced by the surface nanostructures and the different sizes and biological characteristics of osteoblasts and Staphylococcus aureus.ElsevierUniversidad Complutense de Madrid20152015-03-1520152015-03-15journal articlehttp://purl.org/coar/resource_type/c_6501info:eu-repo/semantics/articleapplication/pdfhttps://hdl.handle.net/20.500.14352/24049reponame:Docta Complutenseinstname:Universidad Complutense de Madrid (UCM)Inglésengopen accesshttp://purl.org/coar/access_right/c_abf2info:eu-repo/semantics/openAccessoai:docta.ucm.es:20.500.14352/240492026-06-02T12:44:21Z
dc.title.none.fl_str_mv Nanocolumnar coatings with selective behavior towards osteoblast and Staphylococcus aureus proliferation
title Nanocolumnar coatings with selective behavior towards osteoblast and Staphylococcus aureus proliferation
spellingShingle Nanocolumnar coatings with selective behavior towards osteoblast and Staphylococcus aureus proliferation
Izquierdo Barba, Isabel
546
Titanium nanocolumns
Magnetron sputtering
Biocompatibility
Antibacterial effects
Biofilm
Staphylococcus aureus
Química inorgánica (Química)
2303 Química Inorgánica
title_short Nanocolumnar coatings with selective behavior towards osteoblast and Staphylococcus aureus proliferation
title_full Nanocolumnar coatings with selective behavior towards osteoblast and Staphylococcus aureus proliferation
title_fullStr Nanocolumnar coatings with selective behavior towards osteoblast and Staphylococcus aureus proliferation
title_full_unstemmed Nanocolumnar coatings with selective behavior towards osteoblast and Staphylococcus aureus proliferation
title_sort Nanocolumnar coatings with selective behavior towards osteoblast and Staphylococcus aureus proliferation
dc.creator.none.fl_str_mv Izquierdo Barba, Isabel
García Martín, José Miguel
Álvarez, Rafael
Palmero, Alberto
Esteban, Jaime
Pérez-Jorge Peremarch, María de la Concepción
Arcos Navarrete, Daniel
Vallet Regí, María Dulce Nombre
author Izquierdo Barba, Isabel
author_facet Izquierdo Barba, Isabel
García Martín, José Miguel
Álvarez, Rafael
Palmero, Alberto
Esteban, Jaime
Pérez-Jorge Peremarch, María de la Concepción
Arcos Navarrete, Daniel
Vallet Regí, María Dulce Nombre
author_role author
author2 García Martín, José Miguel
Álvarez, Rafael
Palmero, Alberto
Esteban, Jaime
Pérez-Jorge Peremarch, María de la Concepción
Arcos Navarrete, Daniel
Vallet Regí, María Dulce Nombre
author2_role author
author
author
author
author
author
author
dc.contributor.none.fl_str_mv Universidad Complutense de Madrid
dc.subject.none.fl_str_mv 546
Titanium nanocolumns
Magnetron sputtering
Biocompatibility
Antibacterial effects
Biofilm
Staphylococcus aureus
Química inorgánica (Química)
2303 Química Inorgánica
topic 546
Titanium nanocolumns
Magnetron sputtering
Biocompatibility
Antibacterial effects
Biofilm
Staphylococcus aureus
Química inorgánica (Química)
2303 Química Inorgánica
description Bacterial colonization and biofilm formation on orthopedic implants is one of the worst scenarios in orthopedic surgery, in terms of both patient prognosis and healthcare costs. Tailoring the surfaces of implants at the nanoscale to actively promote bone bonding while avoiding bacterial colonization represents an interesting challenge to achieving better clinical outcomes. Herein, a Ti6Al4V alloy of medical grade has been coated with Ti nanostructures employing the glancing angle deposition technique by magnetron sputtering. The resulting surfaces have a high density of nanocolumnar structures, which exhibit strongly impaired bacterial adhesion that inhibits biofilm formation, while osteoblasts exhibit good cell response with similar behavior to the initial substrates. These results are discussed on the basis of a ‘‘lotus leaf effect’’ induced by the surface nanostructures and the different sizes and biological characteristics of osteoblasts and Staphylococcus aureus.
publishDate 2015
dc.date.none.fl_str_mv 2015
2015-03-15
2015
2015-03-15
dc.type.none.fl_str_mv journal article
http://purl.org/coar/resource_type/c_6501
dc.type.openaire.fl_str_mv info:eu-repo/semantics/article
format article
dc.identifier.none.fl_str_mv https://hdl.handle.net/20.500.14352/24049
url https://hdl.handle.net/20.500.14352/24049
dc.language.none.fl_str_mv Inglés
eng
language_invalid_str_mv Inglés
language eng
dc.rights.none.fl_str_mv open access
http://purl.org/coar/access_right/c_abf2
dc.rights.openaire.fl_str_mv info:eu-repo/semantics/openAccess
rights_invalid_str_mv open access
http://purl.org/coar/access_right/c_abf2
eu_rights_str_mv openAccess
dc.format.none.fl_str_mv application/pdf
dc.publisher.none.fl_str_mv Elsevier
publisher.none.fl_str_mv Elsevier
dc.source.none.fl_str_mv reponame:Docta Complutense
instname:Universidad Complutense de Madrid (UCM)
instname_str Universidad Complutense de Madrid (UCM)
reponame_str Docta Complutense
collection Docta Complutense
repository.name.fl_str_mv
repository.mail.fl_str_mv
_version_ 1869411853130530816
score 15,301603

Similares en LA Referencia