Results of ARI-0001 CART19 Cells in Patients With Chronic Lymphocytic Leukemia and Richter's Transformation

Ortiz-Maldonado Gibson, Valentín; Frigola, Gerard; Español Rego, Marta; Balagué, Olga; Martínez Cibrian, Nuria; Magnano, Laura; Giné Soca, Eva; Pascal i Capdevila, Mariona; Correa, Juan G.; Martínez-Roca, Alexandra; Cid Vidal, Joan; Lozano Molero, Miguel; Villamor i Casas, Neus; Benítez-Ribas, Daniel; Esteve Comas, Jordi; López Guillermo, Armando; Campo Güerri, Elias; Urbano Ispizua, Álvaro; Juan, Manel; Delgado, Julio (Delgado González)

Results of ARI-0001 CART19 Cells in Patients With Chronic Lymphocytic Leukemia and Richter's Transformation

CART19 cells are emerging as an alternative therapy for patients with chronic lymphocytic leukemia (CLL). Here we report the outcome of nine consecutive patients with CLL treated with ARI-0001 CART19 cells, six of them with Richter’s transformation (RT). One patient with RT never received therapy. T...

Descripción completa

Detalles Bibliográficos
Autores:	Ortiz-Maldonado Gibson, Valentín, Frigola, Gerard, Español Rego, Marta, Balagué, Olga, Martínez Cibrian, Nuria, Magnano, Laura, Giné Soca, Eva, Pascal i Capdevila, Mariona, Correa, Juan G., Martínez-Roca, Alexandra, Cid Vidal, Joan, Lozano Molero, Miguel, Villamor i Casas, Neus, Benítez-Ribas, Daniel, Esteve Comas, Jordi, López Guillermo, Armando, Campo Güerri, Elias, Urbano Ispizua, Álvaro, Juan, Manel, Delgado, Julio (Delgado González)
Tipo de recurso:	artículo
Estado:	Versión publicada
Fecha de publicación:	2022
País:	España
Institución:	Varias* (Consorci de Biblioteques Universitáries de Catalunya, Centre de Serveis Científics i Acadèmics de Catalunya)
Repositorio:	Recercat. Dipósit de la Recerca de Catalunya
OAI Identifier:	oai:recercat.cat:2445/197660
Acceso en línea:	https://hdl.handle.net/2445/197660
Access Level:	acceso abierto
Palabra clave:	Leucèmia limfocítica crònica Teràpia cel·lular Chronic lymphocytic leukemia Cellular therapy

id	ES_7fc4aa2c75e6f9da060b630da91bedf6
oai_identifier_str	oai:recercat.cat:2445/197660
network_acronym_str	ES
network_name_str	España
repository_id_str
spelling	Results of ARI-0001 CART19 Cells in Patients With Chronic Lymphocytic Leukemia and Richter's TransformationOrtiz-Maldonado Gibson, ValentínFrigola, GerardEspañol Rego, MartaBalagué, OlgaMartínez Cibrian, NuriaMagnano, LauraGiné Soca, EvaPascal i Capdevila, MarionaCorrea, Juan G.Martínez-Roca, AlexandraCid Vidal, JoanLozano Molero, MiguelVillamor i Casas, NeusBenítez-Ribas, DanielEsteve Comas, JordiLópez Guillermo, ArmandoCampo Güerri, EliasUrbano Ispizua, ÁlvaroJuan, ManelDelgado, Julio (Delgado González)Leucèmia limfocítica crònicaTeràpia cel·lularChronic lymphocytic leukemiaCellular therapyCART19 cells are emerging as an alternative therapy for patients with chronic lymphocytic leukemia (CLL). Here we report the outcome of nine consecutive patients with CLL treated with ARI-0001 CART19 cells, six of them with Richter’s transformation (RT). One patient with RT never received therapy. The cytokine release syndrome rate was 87.5% (12.5% grade ≥3). Neurotoxicity was not observed in any patient. All patients experienced absolute B-cell aplasia, and seven (87.5%) responded to therapy. With a median follow-up of 5.6 months, two patients with RT experienced a CD19-negative relapse. In conclusion, ARI-0001 cell therapy was feasible, safe, and effective in patients with high risk CLL or RT2023202320222023info:eu-repo/semantics/articleinfo:eu-repo/semantics/publishedVersion7 p.application/pdfhttps://hdl.handle.net/2445/197660Articles publicats en revistes (Medicina)reponame:Recercat. Dipósit de la Recerca de Catalunyainstname:Varias* (Consorci de Biblioteques Universitáries de Catalunya, Centre de Serveis Científics i Acadèmics de Catalunya)InglésReproducció del document publicat a: https://doi.org/10.3389/fonc.2022.828471Frontiers In Oncology, 2022, vol.12, num. 828471https://doi.org/10.3389/fonc.2022.828471cc by (c) Ortiz Maldonado, Valentín et al., 2022http://creativecommons.org/licenses/by/3.0/es/info:eu-repo/semantics/openAccessoai:recercat.cat:2445/1976602026-05-29T05:05:01Z
dc.title.none.fl_str_mv	Results of ARI-0001 CART19 Cells in Patients With Chronic Lymphocytic Leukemia and Richter's Transformation
title	Results of ARI-0001 CART19 Cells in Patients With Chronic Lymphocytic Leukemia and Richter's Transformation
spellingShingle	Results of ARI-0001 CART19 Cells in Patients With Chronic Lymphocytic Leukemia and Richter's Transformation Ortiz-Maldonado Gibson, Valentín Leucèmia limfocítica crònica Teràpia cel·lular Chronic lymphocytic leukemia Cellular therapy
title_short	Results of ARI-0001 CART19 Cells in Patients With Chronic Lymphocytic Leukemia and Richter's Transformation
title_full	Results of ARI-0001 CART19 Cells in Patients With Chronic Lymphocytic Leukemia and Richter's Transformation
title_fullStr	Results of ARI-0001 CART19 Cells in Patients With Chronic Lymphocytic Leukemia and Richter's Transformation
title_full_unstemmed	Results of ARI-0001 CART19 Cells in Patients With Chronic Lymphocytic Leukemia and Richter's Transformation
title_sort	Results of ARI-0001 CART19 Cells in Patients With Chronic Lymphocytic Leukemia and Richter's Transformation
dc.creator.none.fl_str_mv	Ortiz-Maldonado Gibson, Valentín Frigola, Gerard Español Rego, Marta Balagué, Olga Martínez Cibrian, Nuria Magnano, Laura Giné Soca, Eva Pascal i Capdevila, Mariona Correa, Juan G. Martínez-Roca, Alexandra Cid Vidal, Joan Lozano Molero, Miguel Villamor i Casas, Neus Benítez-Ribas, Daniel Esteve Comas, Jordi López Guillermo, Armando Campo Güerri, Elias Urbano Ispizua, Álvaro Juan, Manel Delgado, Julio (Delgado González)
author	Ortiz-Maldonado Gibson, Valentín
author_facet	Ortiz-Maldonado Gibson, Valentín Frigola, Gerard Español Rego, Marta Balagué, Olga Martínez Cibrian, Nuria Magnano, Laura Giné Soca, Eva Pascal i Capdevila, Mariona Correa, Juan G. Martínez-Roca, Alexandra Cid Vidal, Joan Lozano Molero, Miguel Villamor i Casas, Neus Benítez-Ribas, Daniel Esteve Comas, Jordi López Guillermo, Armando Campo Güerri, Elias Urbano Ispizua, Álvaro Juan, Manel Delgado, Julio (Delgado González)
author_role	author
author2	Frigola, Gerard Español Rego, Marta Balagué, Olga Martínez Cibrian, Nuria Magnano, Laura Giné Soca, Eva Pascal i Capdevila, Mariona Correa, Juan G. Martínez-Roca, Alexandra Cid Vidal, Joan Lozano Molero, Miguel Villamor i Casas, Neus Benítez-Ribas, Daniel Esteve Comas, Jordi López Guillermo, Armando Campo Güerri, Elias Urbano Ispizua, Álvaro Juan, Manel Delgado, Julio (Delgado González)
author2_role	author author author author author author author author author author author author author author author author author author author
dc.subject.none.fl_str_mv	Leucèmia limfocítica crònica Teràpia cel·lular Chronic lymphocytic leukemia Cellular therapy
topic	Leucèmia limfocítica crònica Teràpia cel·lular Chronic lymphocytic leukemia Cellular therapy
description	CART19 cells are emerging as an alternative therapy for patients with chronic lymphocytic leukemia (CLL). Here we report the outcome of nine consecutive patients with CLL treated with ARI-0001 CART19 cells, six of them with Richter’s transformation (RT). One patient with RT never received therapy. The cytokine release syndrome rate was 87.5% (12.5% grade ≥3). Neurotoxicity was not observed in any patient. All patients experienced absolute B-cell aplasia, and seven (87.5%) responded to therapy. With a median follow-up of 5.6 months, two patients with RT experienced a CD19-negative relapse. In conclusion, ARI-0001 cell therapy was feasible, safe, and effective in patients with high risk CLL or RT
publishDate	2022
dc.date.none.fl_str_mv	2022 2023 2023 2023
dc.type.none.fl_str_mv	info:eu-repo/semantics/article info:eu-repo/semantics/publishedVersion
format	article
status_str	publishedVersion
dc.identifier.none.fl_str_mv	https://hdl.handle.net/2445/197660
url	https://hdl.handle.net/2445/197660
dc.language.none.fl_str_mv	Inglés
language_invalid_str_mv	Inglés
dc.relation.none.fl_str_mv	Reproducció del document publicat a: https://doi.org/10.3389/fonc.2022.828471 Frontiers In Oncology, 2022, vol.12, num. 828471 https://doi.org/10.3389/fonc.2022.828471
dc.rights.none.fl_str_mv	cc by (c) Ortiz Maldonado, Valentín et al., 2022 http://creativecommons.org/licenses/by/3.0/es/ info:eu-repo/semantics/openAccess
rights_invalid_str_mv	cc by (c) Ortiz Maldonado, Valentín et al., 2022 http://creativecommons.org/licenses/by/3.0/es/
eu_rights_str_mv	openAccess
dc.format.none.fl_str_mv	7 p. application/pdf
dc.source.none.fl_str_mv	Articles publicats en revistes (Medicina) reponame:Recercat. Dipósit de la Recerca de Catalunya instname:Varias* (Consorci de Biblioteques Universitáries de Catalunya, Centre de Serveis Científics i Acadèmics de Catalunya)
instname_str	Varias* (Consorci de Biblioteques Universitáries de Catalunya, Centre de Serveis Científics i Acadèmics de Catalunya)
reponame_str	Recercat. Dipósit de la Recerca de Catalunya
collection	Recercat. Dipósit de la Recerca de Catalunya
repository.name.fl_str_mv
repository.mail.fl_str_mv
_version_	1869411848868069376
score	15.811543

Results of ARI-0001 CART19 Cells in Patients With Chronic Lymphocytic Leukemia and Richter's Transformation

Similares en LA Referencia