High‐risk cytogenetic abnormalities in multiple myeloma: PETHEMA‐GEM experience

Financiación de acceso abierto proporcionada por los Fondos Europeos FEDER y la Junta de Castilla y León en el marco de la Estrategia de Investigación e Innovación para la Especialización Inteligente (RIS3) de Castilla y León 2021-2027

Detalles Bibliográficos
Autores: González de la Calle, Verónica, Rodríguez Otero, Paula, Calasanz, Maria José, Guijarro, Manuela, Martínez López, Joaquín, Rosiñol, Laura, Hernandez, Miguel T., Teruel, Ana Isabel, Gironella, Mercedes, Oriol, Albert, De la Rubia, Javier, Gónzalez Rodríguez, Ana, Bargay, Joan, De Arriba, Felipe, Palomera, Luis, González Pérez, Marta Sonia, Sureda, Anna, Ocio, Enrique M., Lahuerta, Juan José, Bladé, Joan, San Miguel, Jesús F., Mateos Manteca, María Victoria, Gutiérrez Gutiérrez, Norma Carmen
Tipo de recurso: artículo
Estado:Versión publicada
Fecha de publicación:2024
País:España
Institución:Universidad de Salamanca (USAL)
Repositorio:GREDOS. Repositorio Institucional de la Universidad de Salamanca
OAI Identifier:oai:gredos.usal.es:10366/166863
Acceso en línea:http://hdl.handle.net/10366/166863
Access Level:acceso abierto
Palabra clave:Lymphoid Malignancies
Multiple Myeloma
Cytogenetics
3201.01 Oncología
3207.13 Oncología
citogenética
mieloma múltiple
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repository_id_str
spelling High‐risk cytogenetic abnormalities in multiple myeloma: PETHEMA‐GEM experienceGonzález de la Calle, VerónicaRodríguez Otero, PaulaCalasanz, Maria JoséGuijarro, ManuelaMartínez López, JoaquínRosiñol, LauraHernandez, Miguel T.Teruel, Ana IsabelGironella, MercedesOriol, AlbertDe la Rubia, JavierGónzalez Rodríguez, AnaBargay, JoanDe Arriba, FelipePalomera, LuisGonzález Pérez, Marta SoniaSureda, AnnaOcio, Enrique M.Lahuerta, Juan JoséBladé, JoanSan Miguel, Jesús F.Mateos Manteca, María VictoriaGutiérrez Gutiérrez, Norma CarmenLymphoid MalignanciesMultiple MyelomaCytogenetics3201.01 Oncología3207.13 Oncologíacitogenéticamieloma múltipleFinanciación de acceso abierto proporcionada por los Fondos Europeos FEDER y la Junta de Castilla y León en el marco de la Estrategia de Investigación e Innovación para la Especialización Inteligente (RIS3) de Castilla y León 2021-2027[EN] This study examines the impact of cytogenetic abnormalities and their co‐segregation on the prognosis of newly diagnosed multiple myeloma patients. The analysis included 1304 patients from four different GEM‐PETHEMA clinical trials. Genetic alterations, such as t(4;14), t(14;16), del(17p), +1q, and del(1p), were investigated using FISH on CD38 purified plasma cells. The frequency of genetic alterations detected were as follows: del(17p) in 8%, t(4;14) in 12%, t(14;16) in 3%, +1q in 43%, and del(1p) in 8%. The median follow‐up was 61 months, and the median progression‐free survival (PFS) and overall survival (OS) were 44 months and not reached, respectively. Consistent with previous reports, the presence of t(4;14) was associated with shorter PFS and OS. In our series, the presence of t(14;16) did not impact survival, maybe due to limitations in sample size. Del(17p) was linked to poor prognosis using a cut‐off level of ≥20% positive cells, without any impact of higher cut‐off in prognosis, except for patients with clonal fraction ≥80% who had a dismal outcome. Cosegregation of cytogenetic abnormalities patients worsened the prognosis in t(4;14) patients but not in patients with del(17p), which retained its adverse prognosis even as a solitary abnormality. Gain(1q) was associated with significantly shorter PFS and OS, while del(1p) affected PFS but not OS. Nevertheless, when co‐segregation was eliminated, the detrimental effect of +1q or del(1p) was no longer observed. In conclusion, this study confirms the prognostic significance of high‐risk cytogenetic abnormalities in MM and highlights the importance of considering co‐occurrence for accurate prognosis assessment.202520252024info:eu-repo/semantics/articleinfo:eu-repo/semantics/publishedVersionhttp://hdl.handle.net/10366/166863reponame:GREDOS. Repositorio Institucional de la Universidad de Salamancainstname:Universidad de Salamanca (USAL)InglésAttribution-NonCommercial-NoDerivatives 4.0 Internacionalhttp://creativecommons.org/licenses/by-nc-nd/4.0/info:eu-repo/semantics/openAccessoai:gredos.usal.es:10366/1668632026-06-07T06:28:51Z
dc.title.none.fl_str_mv High‐risk cytogenetic abnormalities in multiple myeloma: PETHEMA‐GEM experience
title High‐risk cytogenetic abnormalities in multiple myeloma: PETHEMA‐GEM experience
spellingShingle High‐risk cytogenetic abnormalities in multiple myeloma: PETHEMA‐GEM experience
González de la Calle, Verónica
Lymphoid Malignancies
Multiple Myeloma
Cytogenetics
3201.01 Oncología
3207.13 Oncología
citogenética
mieloma múltiple
title_short High‐risk cytogenetic abnormalities in multiple myeloma: PETHEMA‐GEM experience
title_full High‐risk cytogenetic abnormalities in multiple myeloma: PETHEMA‐GEM experience
title_fullStr High‐risk cytogenetic abnormalities in multiple myeloma: PETHEMA‐GEM experience
title_full_unstemmed High‐risk cytogenetic abnormalities in multiple myeloma: PETHEMA‐GEM experience
title_sort High‐risk cytogenetic abnormalities in multiple myeloma: PETHEMA‐GEM experience
dc.creator.none.fl_str_mv González de la Calle, Verónica
Rodríguez Otero, Paula
Calasanz, Maria José
Guijarro, Manuela
Martínez López, Joaquín
Rosiñol, Laura
Hernandez, Miguel T.
Teruel, Ana Isabel
Gironella, Mercedes
Oriol, Albert
De la Rubia, Javier
Gónzalez Rodríguez, Ana
Bargay, Joan
De Arriba, Felipe
Palomera, Luis
González Pérez, Marta Sonia
Sureda, Anna
Ocio, Enrique M.
Lahuerta, Juan José
Bladé, Joan
San Miguel, Jesús F.
Mateos Manteca, María Victoria
Gutiérrez Gutiérrez, Norma Carmen
author González de la Calle, Verónica
author_facet González de la Calle, Verónica
Rodríguez Otero, Paula
Calasanz, Maria José
Guijarro, Manuela
Martínez López, Joaquín
Rosiñol, Laura
Hernandez, Miguel T.
Teruel, Ana Isabel
Gironella, Mercedes
Oriol, Albert
De la Rubia, Javier
Gónzalez Rodríguez, Ana
Bargay, Joan
De Arriba, Felipe
Palomera, Luis
González Pérez, Marta Sonia
Sureda, Anna
Ocio, Enrique M.
Lahuerta, Juan José
Bladé, Joan
San Miguel, Jesús F.
Mateos Manteca, María Victoria
Gutiérrez Gutiérrez, Norma Carmen
author_role author
author2 Rodríguez Otero, Paula
Calasanz, Maria José
Guijarro, Manuela
Martínez López, Joaquín
Rosiñol, Laura
Hernandez, Miguel T.
Teruel, Ana Isabel
Gironella, Mercedes
Oriol, Albert
De la Rubia, Javier
Gónzalez Rodríguez, Ana
Bargay, Joan
De Arriba, Felipe
Palomera, Luis
González Pérez, Marta Sonia
Sureda, Anna
Ocio, Enrique M.
Lahuerta, Juan José
Bladé, Joan
San Miguel, Jesús F.
Mateos Manteca, María Victoria
Gutiérrez Gutiérrez, Norma Carmen
author2_role author
author
author
author
author
author
author
author
author
author
author
author
author
author
author
author
author
author
author
author
author
author
dc.subject.none.fl_str_mv Lymphoid Malignancies
Multiple Myeloma
Cytogenetics
3201.01 Oncología
3207.13 Oncología
citogenética
mieloma múltiple
topic Lymphoid Malignancies
Multiple Myeloma
Cytogenetics
3201.01 Oncología
3207.13 Oncología
citogenética
mieloma múltiple
description Financiación de acceso abierto proporcionada por los Fondos Europeos FEDER y la Junta de Castilla y León en el marco de la Estrategia de Investigación e Innovación para la Especialización Inteligente (RIS3) de Castilla y León 2021-2027
publishDate 2024
dc.date.none.fl_str_mv 2024
2025
2025
dc.type.none.fl_str_mv info:eu-repo/semantics/article
info:eu-repo/semantics/publishedVersion
format article
status_str publishedVersion
dc.identifier.none.fl_str_mv http://hdl.handle.net/10366/166863
url http://hdl.handle.net/10366/166863
dc.language.none.fl_str_mv Inglés
language_invalid_str_mv Inglés
dc.rights.none.fl_str_mv Attribution-NonCommercial-NoDerivatives 4.0 Internacional
http://creativecommons.org/licenses/by-nc-nd/4.0/
info:eu-repo/semantics/openAccess
rights_invalid_str_mv Attribution-NonCommercial-NoDerivatives 4.0 Internacional
http://creativecommons.org/licenses/by-nc-nd/4.0/
eu_rights_str_mv openAccess
dc.source.none.fl_str_mv reponame:GREDOS. Repositorio Institucional de la Universidad de Salamanca
instname:Universidad de Salamanca (USAL)
instname_str Universidad de Salamanca (USAL)
reponame_str GREDOS. Repositorio Institucional de la Universidad de Salamanca
collection GREDOS. Repositorio Institucional de la Universidad de Salamanca
repository.name.fl_str_mv
repository.mail.fl_str_mv
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score 15,812429

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