In search of an evidence-based strategy for quality assessment of human tissue samples: report of the tissue Biospecimen Research Working Group of the Spanish Biobank Network
The purpose of the present work is to underline the importance of obtaining a standardized procedure to ensure and evaluate both clinical and research usability of human tissue samples. The study, which was carried out by the Biospecimen Science Working Group of the Spanish Biobank Network, is based...
| Autores: | , , , , , , , , , , , , , , , , , |
|---|---|
| Tipo de recurso: | artículo |
| Fecha de publicación: | 2019 |
| País: | España |
| Institución: | Instituto de Salud Carlos III (ISCIII) |
| Repositorio: | Repisalud |
| Idioma: | inglés |
| OAI Identifier: | oai:repisalud.isciii.es:20.500.12105/9351 |
| Acceso en línea: | http://hdl.handle.net/20.500.12105/9351 |
| Access Level: | acceso abierto |
| Palabra clave: | Adhesión en Parafina Investigación Biomédica Humanos Bancos de Muestras Biológicas Medicina Basada en la Evidencia Garantía de la Calidad de Atención de Salud Fijación del Tejido España Quality Assurance, Health Care Tissue Fixation Spain Evidence-Based Medicine Humans Paraffin Embedding Biological Specimen Banks Biomedical Research |
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In search of an evidence-based strategy for quality assessment of human tissue samples: report of the tissue Biospecimen Research Working Group of the Spanish Biobank NetworkEsteva-Socias, MargalidaArtiga, Maria JesusBahamonde, OlgaBelar, OihanaBermudo, RaquelCastro, ErikaEscámez, TeresaFraga, MáximoJauregui-Mosquera, LauraNovoa, IsabelPeiró-Chova LRejón, Juan-DavidRuiz-Miró, MaríaVieiro-Balo, PaulaVillar-Campo, VirginiaZazo, SandraRábano, AlbertoVillena, CristinaAdhesión en ParafinaInvestigación BiomédicaHumanosBancos de Muestras BiológicasMedicina Basada en la EvidenciaGarantía de la Calidad de Atención de SaludFijación del TejidoEspañaQuality Assurance, Health CareTissue FixationSpainEvidence-Based MedicineHumansParaffin EmbeddingBiological Specimen BanksBiomedical ResearchThe purpose of the present work is to underline the importance of obtaining a standardized procedure to ensure and evaluate both clinical and research usability of human tissue samples. The study, which was carried out by the Biospecimen Science Working Group of the Spanish Biobank Network, is based on a general overview of the current situation about quality assurance in human tissue biospecimens. It was conducted an exhaustive review of the analytical techniques used to evaluate the quality of human tissue samples over the past 30 years, as well as their reference values if they were published, and classified them according to the biomolecules evaluated: (i) DNA, (ii) RNA, and (iii) soluble or/and fixed proteins for immunochemistry. More than 130 publications released between 1989 and 2019 were analysed, most of them reporting results focused on the analysis of tumour and biopsy samples. A quality assessment proposal with an algorithm has been developed for both frozen tissue samples and formalin-fixed paraffin-embedded (FFPE) samples, according to the expected quality of sample based on the available pre-analytical information and the experience of the participants in the Working Group. The high heterogeneity of human tissue samples and the wide number of pre-analytic factors associated to quality of samples makes it very difficult to harmonize the quality criteria. However, the proposed method to assess human tissue sample integrity and antigenicity will not only help to evaluate whether stored human tissue samples fit for the purpose of biomarker development, but will also allow to perform further studies, such as assessing the impact of different pre-analytical factors on very well characterized samples or evaluating the readjustment of tissue sample collection, processing and storing procedures. By ensuring the quality of the samples used on research, the reproducibility of scientific results will be guaranteed.BioMed Central (BMC)Ministerio de Ciencia, Innovación y Universidades (España)Instituto de Salud Carlos IIIRed Nacional de Biobancos (España)Unión Europea. Fondo Europeo de Desarrollo Regional (FEDER/ERDF)Govern de les Illes Balears (España)20202020-03-2720192019-11-1220192019-11-12review articlehttp://purl.org/coar/resource_type/c_dcae04bcVoRhttp://purl.org/coar/version/c_970fb48d4fbd8a85info:eu-repo/semantics/articleapplication/pdfhttp://hdl.handle.net/20.500.12105/9351reponame:Repisaludinstname:Instituto de Salud Carlos III (ISCIII)Inglésengopen accesshttp://purl.org/coar/access_right/c_abf2Atribución-NoComercial-CompartirIgual 4.0 Internacionalhttp://creativecommons.org/licenses/by-nc-sa/4.0/info:eu-repo/semantics/openAccessoai:repisalud.isciii.es:20.500.12105/93512026-06-12T12:43:37Z |
| dc.title.none.fl_str_mv |
In search of an evidence-based strategy for quality assessment of human tissue samples: report of the tissue Biospecimen Research Working Group of the Spanish Biobank Network |
| title |
In search of an evidence-based strategy for quality assessment of human tissue samples: report of the tissue Biospecimen Research Working Group of the Spanish Biobank Network |
| spellingShingle |
In search of an evidence-based strategy for quality assessment of human tissue samples: report of the tissue Biospecimen Research Working Group of the Spanish Biobank Network Esteva-Socias, Margalida Adhesión en Parafina Investigación Biomédica Humanos Bancos de Muestras Biológicas Medicina Basada en la Evidencia Garantía de la Calidad de Atención de Salud Fijación del Tejido España Quality Assurance, Health Care Tissue Fixation Spain Evidence-Based Medicine Humans Paraffin Embedding Biological Specimen Banks Biomedical Research |
| title_short |
In search of an evidence-based strategy for quality assessment of human tissue samples: report of the tissue Biospecimen Research Working Group of the Spanish Biobank Network |
| title_full |
In search of an evidence-based strategy for quality assessment of human tissue samples: report of the tissue Biospecimen Research Working Group of the Spanish Biobank Network |
| title_fullStr |
In search of an evidence-based strategy for quality assessment of human tissue samples: report of the tissue Biospecimen Research Working Group of the Spanish Biobank Network |
| title_full_unstemmed |
In search of an evidence-based strategy for quality assessment of human tissue samples: report of the tissue Biospecimen Research Working Group of the Spanish Biobank Network |
| title_sort |
In search of an evidence-based strategy for quality assessment of human tissue samples: report of the tissue Biospecimen Research Working Group of the Spanish Biobank Network |
| dc.creator.none.fl_str_mv |
Esteva-Socias, Margalida Artiga, Maria Jesus Bahamonde, Olga Belar, Oihana Bermudo, Raquel Castro, Erika Escámez, Teresa Fraga, Máximo Jauregui-Mosquera, Laura Novoa, Isabel Peiró-Chova L Rejón, Juan-David Ruiz-Miró, María Vieiro-Balo, Paula Villar-Campo, Virginia Zazo, Sandra Rábano, Alberto Villena, Cristina |
| author |
Esteva-Socias, Margalida |
| author_facet |
Esteva-Socias, Margalida Artiga, Maria Jesus Bahamonde, Olga Belar, Oihana Bermudo, Raquel Castro, Erika Escámez, Teresa Fraga, Máximo Jauregui-Mosquera, Laura Novoa, Isabel Peiró-Chova L Rejón, Juan-David Ruiz-Miró, María Vieiro-Balo, Paula Villar-Campo, Virginia Zazo, Sandra Rábano, Alberto Villena, Cristina |
| author_role |
author |
| author2 |
Artiga, Maria Jesus Bahamonde, Olga Belar, Oihana Bermudo, Raquel Castro, Erika Escámez, Teresa Fraga, Máximo Jauregui-Mosquera, Laura Novoa, Isabel Peiró-Chova L Rejón, Juan-David Ruiz-Miró, María Vieiro-Balo, Paula Villar-Campo, Virginia Zazo, Sandra Rábano, Alberto Villena, Cristina |
| author2_role |
author author author author author author author author author author author author author author author author author |
| dc.contributor.none.fl_str_mv |
Ministerio de Ciencia, Innovación y Universidades (España) Instituto de Salud Carlos III Red Nacional de Biobancos (España) Unión Europea. Fondo Europeo de Desarrollo Regional (FEDER/ERDF) Govern de les Illes Balears (España) |
| dc.subject.none.fl_str_mv |
Adhesión en Parafina Investigación Biomédica Humanos Bancos de Muestras Biológicas Medicina Basada en la Evidencia Garantía de la Calidad de Atención de Salud Fijación del Tejido España Quality Assurance, Health Care Tissue Fixation Spain Evidence-Based Medicine Humans Paraffin Embedding Biological Specimen Banks Biomedical Research |
| topic |
Adhesión en Parafina Investigación Biomédica Humanos Bancos de Muestras Biológicas Medicina Basada en la Evidencia Garantía de la Calidad de Atención de Salud Fijación del Tejido España Quality Assurance, Health Care Tissue Fixation Spain Evidence-Based Medicine Humans Paraffin Embedding Biological Specimen Banks Biomedical Research |
| description |
The purpose of the present work is to underline the importance of obtaining a standardized procedure to ensure and evaluate both clinical and research usability of human tissue samples. The study, which was carried out by the Biospecimen Science Working Group of the Spanish Biobank Network, is based on a general overview of the current situation about quality assurance in human tissue biospecimens. It was conducted an exhaustive review of the analytical techniques used to evaluate the quality of human tissue samples over the past 30 years, as well as their reference values if they were published, and classified them according to the biomolecules evaluated: (i) DNA, (ii) RNA, and (iii) soluble or/and fixed proteins for immunochemistry. More than 130 publications released between 1989 and 2019 were analysed, most of them reporting results focused on the analysis of tumour and biopsy samples. A quality assessment proposal with an algorithm has been developed for both frozen tissue samples and formalin-fixed paraffin-embedded (FFPE) samples, according to the expected quality of sample based on the available pre-analytical information and the experience of the participants in the Working Group. The high heterogeneity of human tissue samples and the wide number of pre-analytic factors associated to quality of samples makes it very difficult to harmonize the quality criteria. However, the proposed method to assess human tissue sample integrity and antigenicity will not only help to evaluate whether stored human tissue samples fit for the purpose of biomarker development, but will also allow to perform further studies, such as assessing the impact of different pre-analytical factors on very well characterized samples or evaluating the readjustment of tissue sample collection, processing and storing procedures. By ensuring the quality of the samples used on research, the reproducibility of scientific results will be guaranteed. |
| publishDate |
2019 |
| dc.date.none.fl_str_mv |
2019 2019-11-12 2019 2019-11-12 2020 2020-03-27 |
| dc.type.none.fl_str_mv |
review article http://purl.org/coar/resource_type/c_dcae04bc VoR http://purl.org/coar/version/c_970fb48d4fbd8a85 |
| dc.type.openaire.fl_str_mv |
info:eu-repo/semantics/article |
| format |
article |
| dc.identifier.none.fl_str_mv |
http://hdl.handle.net/20.500.12105/9351 |
| url |
http://hdl.handle.net/20.500.12105/9351 |
| dc.language.none.fl_str_mv |
Inglés eng |
| language_invalid_str_mv |
Inglés |
| language |
eng |
| dc.rights.none.fl_str_mv |
open access http://purl.org/coar/access_right/c_abf2 Atribución-NoComercial-CompartirIgual 4.0 Internacional http://creativecommons.org/licenses/by-nc-sa/4.0/ |
| dc.rights.openaire.fl_str_mv |
info:eu-repo/semantics/openAccess |
| rights_invalid_str_mv |
open access http://purl.org/coar/access_right/c_abf2 Atribución-NoComercial-CompartirIgual 4.0 Internacional http://creativecommons.org/licenses/by-nc-sa/4.0/ |
| eu_rights_str_mv |
openAccess |
| dc.format.none.fl_str_mv |
application/pdf |
| dc.publisher.none.fl_str_mv |
BioMed Central (BMC) |
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BioMed Central (BMC) |
| dc.source.none.fl_str_mv |
reponame:Repisalud instname:Instituto de Salud Carlos III (ISCIII) |
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Instituto de Salud Carlos III (ISCIII) |
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Repisalud |
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Repisalud |
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1869411843143892992 |
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15,812455 |