Photobacterium damselae subsp. damselae: analysis of the genetic diversity and characterization of a conserved two-component system regulating virulence

Photobacterium damselae subsp. damselae is an emerging pathogen of marine aquaculture. By combining phenotypic and genotypic data, and comparative genomics analyses, we here show that this pathogen exhibits a high genetic diversity and that outbreaks in fish are caused by multiclonal populations. We...

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Detalles Bibliográficos
Autor: Terceti, Mateus de Souza
Tipo de recurso: tesis doctoral
Fecha de publicación:2018
País:España
Institución:Universidad de Santiago de Compostela (USC)
Repositorio:Minerva. Repositorio Institucional de la Universidad de Santiago de Compostela
Idioma:inglés
OAI Identifier:oai:minerva.usc.gal:10347/18131
Acceso en línea:http://hdl.handle.net/10347/18131
Access Level:acceso abierto
Palabra clave:Materias::Investigación::24 Ciencias de la vida::2414 Microbiología::241404 Bacteriología
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spelling Photobacterium damselae subsp. damselae: analysis of the genetic diversity and characterization of a conserved two-component system regulating virulenceTerceti, Mateus de SouzaMaterias::Investigación::24 Ciencias de la vida::2414 Microbiología::241404 BacteriologíaPhotobacterium damselae subsp. damselae is an emerging pathogen of marine aquaculture. By combining phenotypic and genotypic data, and comparative genomics analyses, we here show that this pathogen exhibits a high genetic diversity and that outbreaks in fish are caused by multiclonal populations. We identified and characterized the RstAB two-component signal transduction system, a major positive regulator of virulence and of many aspects of cell physiology in this bacterium. The RstAB regulon comprises the major cytotoxins Dly, PhlyP and PhlyC, as well as hitherto unreported proteins secreted by the type two secretion system (T2SS), that may constitute novel virulence factors in this pathogen.Rodríguez Osorio, CarlosUniversidade de Santiago de Compostela. Centro Internacional de Estudos de Doutoramento e Avanzados (CIEDUS)Universidade de Santiago de Compostela. Escola de Doutoramento Internacional en Ciencias da Saúde20182018-01-0120182018-01-01doctoral thesishttp://purl.org/coar/resource_type/c_db06info:eu-repo/semantics/doctoralThesisapplication/pdfhttp://hdl.handle.net/10347/18131reponame:Minerva. Repositorio Institucional de la Universidad de Santiago de Compostelainstname:Universidad de Santiago de Compostela (USC)Inglésengopen accesshttp://purl.org/coar/access_right/c_abf2Attribution-NonCommercial-NoDerivatives 4.0 Internacionalhttp://creativecommons.org/licenses/by-nc-nd/4.0/info:eu-repo/semantics/openAccessoai:minerva.usc.gal:10347/181312026-06-15T12:47:27Z
dc.title.none.fl_str_mv Photobacterium damselae subsp. damselae: analysis of the genetic diversity and characterization of a conserved two-component system regulating virulence
title Photobacterium damselae subsp. damselae: analysis of the genetic diversity and characterization of a conserved two-component system regulating virulence
spellingShingle Photobacterium damselae subsp. damselae: analysis of the genetic diversity and characterization of a conserved two-component system regulating virulence
Terceti, Mateus de Souza
Materias::Investigación::24 Ciencias de la vida::2414 Microbiología::241404 Bacteriología
title_short Photobacterium damselae subsp. damselae: analysis of the genetic diversity and characterization of a conserved two-component system regulating virulence
title_full Photobacterium damselae subsp. damselae: analysis of the genetic diversity and characterization of a conserved two-component system regulating virulence
title_fullStr Photobacterium damselae subsp. damselae: analysis of the genetic diversity and characterization of a conserved two-component system regulating virulence
title_full_unstemmed Photobacterium damselae subsp. damselae: analysis of the genetic diversity and characterization of a conserved two-component system regulating virulence
title_sort Photobacterium damselae subsp. damselae: analysis of the genetic diversity and characterization of a conserved two-component system regulating virulence
dc.creator.none.fl_str_mv Terceti, Mateus de Souza
author Terceti, Mateus de Souza
author_facet Terceti, Mateus de Souza
author_role author
dc.contributor.none.fl_str_mv Rodríguez Osorio, Carlos
Universidade de Santiago de Compostela. Centro Internacional de Estudos de Doutoramento e Avanzados (CIEDUS)
Universidade de Santiago de Compostela. Escola de Doutoramento Internacional en Ciencias da Saúde
dc.subject.none.fl_str_mv Materias::Investigación::24 Ciencias de la vida::2414 Microbiología::241404 Bacteriología
topic Materias::Investigación::24 Ciencias de la vida::2414 Microbiología::241404 Bacteriología
description Photobacterium damselae subsp. damselae is an emerging pathogen of marine aquaculture. By combining phenotypic and genotypic data, and comparative genomics analyses, we here show that this pathogen exhibits a high genetic diversity and that outbreaks in fish are caused by multiclonal populations. We identified and characterized the RstAB two-component signal transduction system, a major positive regulator of virulence and of many aspects of cell physiology in this bacterium. The RstAB regulon comprises the major cytotoxins Dly, PhlyP and PhlyC, as well as hitherto unreported proteins secreted by the type two secretion system (T2SS), that may constitute novel virulence factors in this pathogen.
publishDate 2018
dc.date.none.fl_str_mv 2018
2018-01-01
2018
2018-01-01
dc.type.none.fl_str_mv doctoral thesis
http://purl.org/coar/resource_type/c_db06
dc.type.openaire.fl_str_mv info:eu-repo/semantics/doctoralThesis
format doctoralThesis
dc.identifier.none.fl_str_mv http://hdl.handle.net/10347/18131
url http://hdl.handle.net/10347/18131
dc.language.none.fl_str_mv Inglés
eng
language_invalid_str_mv Inglés
language eng
dc.rights.none.fl_str_mv open access
http://purl.org/coar/access_right/c_abf2
Attribution-NonCommercial-NoDerivatives 4.0 Internacional
http://creativecommons.org/licenses/by-nc-nd/4.0/
dc.rights.openaire.fl_str_mv info:eu-repo/semantics/openAccess
rights_invalid_str_mv open access
http://purl.org/coar/access_right/c_abf2
Attribution-NonCommercial-NoDerivatives 4.0 Internacional
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eu_rights_str_mv openAccess
dc.format.none.fl_str_mv application/pdf
dc.source.none.fl_str_mv reponame:Minerva. Repositorio Institucional de la Universidad de Santiago de Compostela
instname:Universidad de Santiago de Compostela (USC)
instname_str Universidad de Santiago de Compostela (USC)
reponame_str Minerva. Repositorio Institucional de la Universidad de Santiago de Compostela
collection Minerva. Repositorio Institucional de la Universidad de Santiago de Compostela
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