Association between Molecular Mechanisms and Tooth Eruption in Children with Obesity

Different works have reported earlier permanent teething in obese/overweight children compared to control ones. In contrast, others have reported a delayed permanent teething in undernutrition/underweight children compared to control one. It has been reported that becoming overweight or suffering fr...

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Authors: Traver, Carla, Miralles Jordá, Lucía, Barcia González, Jorge Miguel
Format: article
Publication Date:2022
Country:España
Institution:Universidad Católica de Valencia San Vicente Mártir
Repository:RIUCV. Repositorio de la Universidad Católica de Valencia San Vicente Mártir
Language:English
OAI Identifier:oai:riucv.ucv.es:20.500.12466/7345
Online Access:https://hdl.handle.net/20.500.12466/7345
Access Level:Open access
Keyword:Pediatric obesity
Tooth eruption
Dentition
Permanent
Leptin
3213.13 Ortodoncia-Estomatología
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spelling Association between Molecular Mechanisms and Tooth Eruption in Children with ObesityTraver, CarlaMiralles Jordá, LucíaBarcia González, Jorge MiguelPediatric obesityTooth eruptionDentitionPermanentLeptin3213.13 Ortodoncia-EstomatologíaDifferent works have reported earlier permanent teething in obese/overweight children compared to control ones. In contrast, others have reported a delayed permanent teething in undernutrition/underweight children compared to control one. It has been reported that becoming overweight or suffering from obesity can increase gingival pro-inflammatory drive and can affect orthodontic treatment (among other complications). In this sense, little is known about the molecular mechanisms affecting dental eruption timing. Leptin and adiponectin are adipocytokines signaling molecules released in overweight and underweight conditions, respectively. These adipocytokines can modulate osteocyte, odontoblast, and cementoblast activity, even regulating dental lamina initiation. The present review focuses on the molecular approach wherein leptin and adiponectin act as modulators of Runt-related transcription factor 2 (Runx 2) gene regulating dental eruption timing.20262026-01-2120222022-08-1120222022-08-11journal articlehttp://purl.org/coar/resource_type/c_6501VoRhttp://purl.org/coar/version/c_970fb48d4fbd8a85info:eu-repo/semantics/articleapplication/pdfhttps://hdl.handle.net/20.500.12466/7345reponame:RIUCV. Repositorio de la Universidad Católica de Valencia San Vicente Mártirinstname:Universidad Católica de Valencia San Vicente MártirInglésengopen accesshttp://purl.org/coar/access_right/c_abf2Attribution 4.0 Internationalhttp://creativecommons.org/licenses/by/4.0/info:eu-repo/semantics/openAccessoai:riucv.ucv.es:20.500.12466/73452026-06-19T08:32:07Z
dc.title.none.fl_str_mv Association between Molecular Mechanisms and Tooth Eruption in Children with Obesity
title Association between Molecular Mechanisms and Tooth Eruption in Children with Obesity
spellingShingle Association between Molecular Mechanisms and Tooth Eruption in Children with Obesity
Traver, Carla
Pediatric obesity
Tooth eruption
Dentition
Permanent
Leptin
3213.13 Ortodoncia-Estomatología
title_short Association between Molecular Mechanisms and Tooth Eruption in Children with Obesity
title_full Association between Molecular Mechanisms and Tooth Eruption in Children with Obesity
title_fullStr Association between Molecular Mechanisms and Tooth Eruption in Children with Obesity
title_full_unstemmed Association between Molecular Mechanisms and Tooth Eruption in Children with Obesity
title_sort Association between Molecular Mechanisms and Tooth Eruption in Children with Obesity
dc.creator.none.fl_str_mv Traver, Carla
Miralles Jordá, Lucía
Barcia González, Jorge Miguel
author Traver, Carla
author_facet Traver, Carla
Miralles Jordá, Lucía
Barcia González, Jorge Miguel
author_role author
author2 Miralles Jordá, Lucía
Barcia González, Jorge Miguel
author2_role author
author
dc.contributor.none.fl_str_mv
dc.subject.none.fl_str_mv Pediatric obesity
Tooth eruption
Dentition
Permanent
Leptin
3213.13 Ortodoncia-Estomatología
topic Pediatric obesity
Tooth eruption
Dentition
Permanent
Leptin
3213.13 Ortodoncia-Estomatología
description Different works have reported earlier permanent teething in obese/overweight children compared to control ones. In contrast, others have reported a delayed permanent teething in undernutrition/underweight children compared to control one. It has been reported that becoming overweight or suffering from obesity can increase gingival pro-inflammatory drive and can affect orthodontic treatment (among other complications). In this sense, little is known about the molecular mechanisms affecting dental eruption timing. Leptin and adiponectin are adipocytokines signaling molecules released in overweight and underweight conditions, respectively. These adipocytokines can modulate osteocyte, odontoblast, and cementoblast activity, even regulating dental lamina initiation. The present review focuses on the molecular approach wherein leptin and adiponectin act as modulators of Runt-related transcription factor 2 (Runx 2) gene regulating dental eruption timing.
publishDate 2022
dc.date.none.fl_str_mv 2022
2022-08-11
2022
2022-08-11
2026
2026-01-21
dc.type.none.fl_str_mv journal article
http://purl.org/coar/resource_type/c_6501
VoR
http://purl.org/coar/version/c_970fb48d4fbd8a85
dc.type.openaire.fl_str_mv info:eu-repo/semantics/article
format article
dc.identifier.none.fl_str_mv https://hdl.handle.net/20.500.12466/7345
url https://hdl.handle.net/20.500.12466/7345
dc.language.none.fl_str_mv Inglés
eng
language_invalid_str_mv Inglés
language eng
dc.rights.none.fl_str_mv open access
http://purl.org/coar/access_right/c_abf2
Attribution 4.0 International
http://creativecommons.org/licenses/by/4.0/
dc.rights.openaire.fl_str_mv info:eu-repo/semantics/openAccess
rights_invalid_str_mv open access
http://purl.org/coar/access_right/c_abf2
Attribution 4.0 International
http://creativecommons.org/licenses/by/4.0/
eu_rights_str_mv openAccess
dc.format.none.fl_str_mv application/pdf
dc.source.none.fl_str_mv reponame:RIUCV. Repositorio de la Universidad Católica de Valencia San Vicente Mártir
instname:Universidad Católica de Valencia San Vicente Mártir
instname_str Universidad Católica de Valencia San Vicente Mártir
reponame_str RIUCV. Repositorio de la Universidad Católica de Valencia San Vicente Mártir
collection RIUCV. Repositorio de la Universidad Católica de Valencia San Vicente Mártir
repository.name.fl_str_mv
repository.mail.fl_str_mv
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score 15,811543

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