New theranostic approaches in inflammatory diseases using [89ZR]ZR-ANTI-TNF-α PET imaging

Immune-mediated inflammatory diseases are chronic disorders involving abnormal activation of the immune system, leading to persistent inflammation and tissue damage. They share mechanisms such as overexpression of pro-inflammatory cytokines. Anti-TNF-a agents like adalimumab are effective, but up to...

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Detalles Bibliográficos
Autor: Fraga Codesido, Jessica
Tipo de recurso: tesis doctoral
Fecha de publicación:2026
País:España
Institución:Universidad de Santiago de Compostela (USC)
Repositorio:Minerva. Repositorio Institucional de la Universidad de Santiago de Compostela
Idioma:inglés
OAI Identifier:oai:dnet:minerva_____::a2337e35e1cfa5e6fd885f8ed55f6126
Acceso en línea:https://hdl.handle.net/10347/46700
Access Level:acceso abierto
Palabra clave:PET
antiTNF
adalimumab
320910 Radiofármacos
241202 Anticuerpos
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spelling New theranostic approaches in inflammatory diseases using [89ZR]ZR-ANTI-TNF-α PET imagingFraga Codesido, JessicaPETantiTNFadalimumab320910 Radiofármacos241202 AnticuerposImmune-mediated inflammatory diseases are chronic disorders involving abnormal activation of the immune system, leading to persistent inflammation and tissue damage. They share mechanisms such as overexpression of pro-inflammatory cytokines. Anti-TNF-a agents like adalimumab are effective, but up to 40% of patients do not respond. This thesis developed a PET-based methodology using [89Zr]Zr-DFOadalimumab to analyze biodistribution and pharmacokinetics in murine models of inflammatory bowel disease, uveitis, and rheumatoid arthritis, administered intravenously, subcutaneously, and intravitreally. This work opens new possibilities for both diagnosis and individualized therapeutic monitoring in inflammatory diseases (theragnosis).Aguiar Fernández, PabloOtero Espinar, Francisco JavierFernández Ferreiro, AnxoUniversidade de Santiago de Compostela. Escola de Doutoramento Internacional (EDIUS)20262026-01-0120262026-01-01doctoral thesishttp://purl.org/coar/resource_type/c_db06info:eu-repo/semantics/doctoralThesisapplication/pdfhttps://hdl.handle.net/10347/46700reponame:Minerva. Repositorio Institucional de la Universidad de Santiago de Compostelainstname:Universidad de Santiago de Compostela (USC)Inglésengopen accesshttp://purl.org/coar/access_right/c_abf2Attribution-NonCommercial-NoDerivatives 4.0 Internationalhttp://creativecommons.org/licenses/by-nc-nd/4.0/info:eu-repo/semantics/openAccessoai:dnet:minerva_____::a2337e35e1cfa5e6fd885f8ed55f61262026-06-15T12:47:27Z
dc.title.none.fl_str_mv New theranostic approaches in inflammatory diseases using [89ZR]ZR-ANTI-TNF-α PET imaging
title New theranostic approaches in inflammatory diseases using [89ZR]ZR-ANTI-TNF-α PET imaging
spellingShingle New theranostic approaches in inflammatory diseases using [89ZR]ZR-ANTI-TNF-α PET imaging
Fraga Codesido, Jessica
PET
antiTNF
adalimumab
320910 Radiofármacos
241202 Anticuerpos
title_short New theranostic approaches in inflammatory diseases using [89ZR]ZR-ANTI-TNF-α PET imaging
title_full New theranostic approaches in inflammatory diseases using [89ZR]ZR-ANTI-TNF-α PET imaging
title_fullStr New theranostic approaches in inflammatory diseases using [89ZR]ZR-ANTI-TNF-α PET imaging
title_full_unstemmed New theranostic approaches in inflammatory diseases using [89ZR]ZR-ANTI-TNF-α PET imaging
title_sort New theranostic approaches in inflammatory diseases using [89ZR]ZR-ANTI-TNF-α PET imaging
dc.creator.none.fl_str_mv Fraga Codesido, Jessica
author Fraga Codesido, Jessica
author_facet Fraga Codesido, Jessica
author_role author
dc.contributor.none.fl_str_mv Aguiar Fernández, Pablo
Otero Espinar, Francisco Javier
Fernández Ferreiro, Anxo
Universidade de Santiago de Compostela. Escola de Doutoramento Internacional (EDIUS)
dc.subject.none.fl_str_mv PET
antiTNF
adalimumab
320910 Radiofármacos
241202 Anticuerpos
topic PET
antiTNF
adalimumab
320910 Radiofármacos
241202 Anticuerpos
description Immune-mediated inflammatory diseases are chronic disorders involving abnormal activation of the immune system, leading to persistent inflammation and tissue damage. They share mechanisms such as overexpression of pro-inflammatory cytokines. Anti-TNF-a agents like adalimumab are effective, but up to 40% of patients do not respond. This thesis developed a PET-based methodology using [89Zr]Zr-DFOadalimumab to analyze biodistribution and pharmacokinetics in murine models of inflammatory bowel disease, uveitis, and rheumatoid arthritis, administered intravenously, subcutaneously, and intravitreally. This work opens new possibilities for both diagnosis and individualized therapeutic monitoring in inflammatory diseases (theragnosis).
publishDate 2026
dc.date.none.fl_str_mv 2026
2026-01-01
2026
2026-01-01
dc.type.none.fl_str_mv doctoral thesis
http://purl.org/coar/resource_type/c_db06
dc.type.openaire.fl_str_mv info:eu-repo/semantics/doctoralThesis
format doctoralThesis
dc.identifier.none.fl_str_mv https://hdl.handle.net/10347/46700
url https://hdl.handle.net/10347/46700
dc.language.none.fl_str_mv Inglés
eng
language_invalid_str_mv Inglés
language eng
dc.rights.none.fl_str_mv open access
http://purl.org/coar/access_right/c_abf2
Attribution-NonCommercial-NoDerivatives 4.0 International
http://creativecommons.org/licenses/by-nc-nd/4.0/
dc.rights.openaire.fl_str_mv info:eu-repo/semantics/openAccess
rights_invalid_str_mv open access
http://purl.org/coar/access_right/c_abf2
Attribution-NonCommercial-NoDerivatives 4.0 International
http://creativecommons.org/licenses/by-nc-nd/4.0/
eu_rights_str_mv openAccess
dc.format.none.fl_str_mv application/pdf
dc.source.none.fl_str_mv reponame:Minerva. Repositorio Institucional de la Universidad de Santiago de Compostela
instname:Universidad de Santiago de Compostela (USC)
instname_str Universidad de Santiago de Compostela (USC)
reponame_str Minerva. Repositorio Institucional de la Universidad de Santiago de Compostela
collection Minerva. Repositorio Institucional de la Universidad de Santiago de Compostela
repository.name.fl_str_mv
repository.mail.fl_str_mv
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score 15,811543

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