Cannabis Use Induces Distinctive Proteomic Alterations in Olfactory Neuroepithelial Cells of Schizophrenia Patients

A close epidemiological link has been reported between cannabis use and schizophrenia (SCZ). However, biochemical markers in living humans related to the impact of cannabis in this disease are still missing. Olfactory neuroepithelium (ON) cells express neural features and offer a unique advantage to...

Descripción completa

Detalles Bibliográficos
Autores: Barrera-Conde, Marta|||0000-0002-0106-0000, Ausin, Karina|||0000-0003-4914-9466, Lachén-Montes, Mercedes, Fernández-Irigoyen, Joaquín|||0000-0001-5072-4099, Galindo, Liliana|||0000-0002-2396-4772, Cuenca-Royo, Aida|||0000-0001-8551-5457, Fernández-Avilés, Cristina|||0000-0002-1029-9216, Pérez Solà, Víctor|||0000-0002-5825-2337, Torre, Rafael de la|||0000-0002-6765-1866, Santamaría, Enrique, Robledo, Patricia
Tipo de recurso: artículo
Fecha de publicación:2021
País:España
Institución:Universitat Autònoma de Barcelona
Repositorio:Dipòsit Digital de Documents de la UAB
Idioma:inglés
OAI Identifier:oai:ddd.uab.cat:238775
Acceso en línea:https://ddd.uab.cat/record/238775
https://dx.doi.org/urn:doi:10.3390/jpm11030160
Access Level:acceso abierto
Palabra clave:Cannabis
Schizophrenia
Proteomics
Olfactory neuroepithelium
Metabolism
RNA
ZNF326
MTREX
Descripción
Sumario:A close epidemiological link has been reported between cannabis use and schizophrenia (SCZ). However, biochemical markers in living humans related to the impact of cannabis in this disease are still missing. Olfactory neuroepithelium (ON) cells express neural features and offer a unique advantage to study biomarkers of psychiatric diseases. The aim of our study was to find exclusively deregulated proteins in ON cells of SCZ patients with and without a history of cannabis use. Thus, we compared the proteomic profiles of SCZ non-cannabis users (SCZ/nc) and SCZ cannabis users (SCZ/c) with control subjects non-cannabis users (C/nc) and control cannabis users (C/c). The results revealed that the main cascades affected in SCZ/nc were cell cycle, DNA replication, signal transduction and protein localization. Conversely, cannabis use in SCZ patients induced specific alterations in metabolism of RNA and metabolism of proteins. The levels of targeted proteins in each population were then correlated with cognitive performance and clinical scores. In SCZ/c, the expression levels of 2 proteins involved in the metabolism of RNA (MTREX and ZNF326) correlated with several cognitive markers and clinical signs. Moreover, use duration of cannabis negatively correlated with ZNF326 expression. These findings indicate that RNA-related proteins might be relevant to understand the influence of cannabis use on SCZ.

Similares en LA Referencia