Hydroxytyrosol Decreases LPS- and α-Synuclein-Induced Microglial Activation In Vitro

Neuroinflammation is a common feature shared by neurodegenerative disorders, such as Parkinson’s disease (PD), and seems to play a key role in their development and progression. Microglia cells, the principal orchestrators of neuroinflammation, can be polarized in different phenotypes, which means t...

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Autores: Gallardo-Fernández, Marta, Hornedo-Ortega, Ruth, Alonso-Bellido, Isabel María, Rodríguez-Gómez, José A., Troncoso, Ana M., García-Parrilla, M. Carmen, Venero, José L., Espinosa-Oliva, Ana M., Martínez de Pablos, Rocío
Tipo de recurso: artículo
Estado:Versión publicada
Fecha de publicación:2020
País:España
Institución:Consejo Superior de Investigaciones Científicas (CSIC)
Repositorio:DIGITAL.CSIC. Repositorio Institucional del CSIC
OAI Identifier:oai:digital.csic.es:10261/233995
Acceso en línea:http://hdl.handle.net/10261/233995
Access Level:acceso abierto
Palabra clave:Hydroxytyrosol
Microglia
Mediterranean diet
Inflammasome
MAPKs
Lipopolysaccharide
α-synuclein
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spelling Hydroxytyrosol Decreases LPS- and α-Synuclein-Induced Microglial Activation In VitroGallardo-Fernández, MartaHornedo-Ortega, RuthAlonso-Bellido, Isabel MaríaRodríguez-Gómez, José A.Troncoso, Ana M.García-Parrilla, M. CarmenVenero, José L.Espinosa-Oliva, Ana M.Martínez de Pablos, Rocío HydroxytyrosolMicrogliaMediterranean dietInflammasomeMAPKsLipopolysaccharideα-synucleinNeuroinflammation is a common feature shared by neurodegenerative disorders, such as Parkinson’s disease (PD), and seems to play a key role in their development and progression. Microglia cells, the principal orchestrators of neuroinflammation, can be polarized in different phenotypes, which means they are able to have anti-inflammatory, pro-inflammatory, or neurodegenerative effects. Increasing evidence supports that the traditional Mediterranean dietary pattern is related to the reduction of cognitive decline in neurodegenerative diseases. A considerable intake of plant foods, fish, and extra virgin olive oil (EVOO), as well as a moderate consumption of red wine, all characteristic of the Mediterranean diet (MD), are behind these effects. These foods are especially rich in polyphenols, being the most relevant in the MD hydroxytyrosol (HT) and their derivatives present in EVOO, which have demonstrated a wide array of biological activities. Here, we demonstrate that HT is able to reduce the inflammation induced by two different stimuli: lipopolysaccharide and α-synuclein. We also study the possible molecular mechanisms involved in the anti-inflammatory effect of HT, including the study of nuclear factor kappa B (NF-κB), mitogen-activated protein kinases (MAPKs), nicotinamide adenine dinucleotide phosphate (NADPH) oxidase, and inflammasome. Our data support the use of HT to prevent the inflammation associated with PD and shed light into the relationship between MD and this neurological disorder.This research was funded by the Spanish Ministry of Ciencia, Innovación y Universidades/FEDER/UE (RTI2018-098645-B-100); the Spanish Government (MICINN AGL2016-77505-C3-2-R); and the Ministry of Economy, Industry, and Competitiveness (M.G.-F.’ FPI contract). The authors would also like to thank the Fundación Alfonso Martín Escudero for R.H.-O postdoctoral fellowship. The APC was funded by the Spanish Ministerio de Ciencia, Innovación y Universidades/FEDER/UE (RTI2018-098645-B-100).Multidisciplinary Digital Publishing InstituteMinisterio de Ciencia, Innovación y Universidades (España)European CommissionMinisterio de Economía y Competitividad (España)Fundación Alfonso Martín EscuderoConsejo Superior de Investigaciones Científicas [https://ror.org/02gfc7t72]2021202120202021info:eu-repo/semantics/articlehttp://purl.org/coar/resource_type/c_6501Publisher's versioninfo:eu-repo/semantics/publishedVersionhttp://hdl.handle.net/10261/233995reponame:DIGITAL.CSIC. Repositorio Institucional del CSICinstname:Consejo Superior de Investigaciones Científicas (CSIC)Inglés#PLACEHOLDER_PARENT_METADATA_VALUE##PLACEHOLDER_PARENT_METADATA_VALUE#info:eu-repo/grantAgreement/AEI/Plan Estatal de Investigación Científica y Técnica y de Innovación 2017-2020/RTI2018-098645-B-100info:eu-repo/grantAgreement/MINECO/Plan Estatal de Investigación Científica y Técnica y de Innovación 2013-2016/AGL2016-77505-C3-2-Rhttp://doi.org/10.3390/antiox9010036Síinfo:eu-repo/semantics/openAccessoai:digital.csic.es:10261/2339952026-05-22T06:33:51Z
dc.title.none.fl_str_mv Hydroxytyrosol Decreases LPS- and α-Synuclein-Induced Microglial Activation In Vitro
title Hydroxytyrosol Decreases LPS- and α-Synuclein-Induced Microglial Activation In Vitro
spellingShingle Hydroxytyrosol Decreases LPS- and α-Synuclein-Induced Microglial Activation In Vitro
Gallardo-Fernández, Marta
Hydroxytyrosol
Microglia
Mediterranean diet
Inflammasome
MAPKs
Lipopolysaccharide
α-synuclein
title_short Hydroxytyrosol Decreases LPS- and α-Synuclein-Induced Microglial Activation In Vitro
title_full Hydroxytyrosol Decreases LPS- and α-Synuclein-Induced Microglial Activation In Vitro
title_fullStr Hydroxytyrosol Decreases LPS- and α-Synuclein-Induced Microglial Activation In Vitro
title_full_unstemmed Hydroxytyrosol Decreases LPS- and α-Synuclein-Induced Microglial Activation In Vitro
title_sort Hydroxytyrosol Decreases LPS- and α-Synuclein-Induced Microglial Activation In Vitro
dc.creator.none.fl_str_mv Gallardo-Fernández, Marta
Hornedo-Ortega, Ruth
Alonso-Bellido, Isabel María
Rodríguez-Gómez, José A.
Troncoso, Ana M.
García-Parrilla, M. Carmen
Venero, José L.
Espinosa-Oliva, Ana M.
Martínez de Pablos, Rocío
author Gallardo-Fernández, Marta
author_facet Gallardo-Fernández, Marta
Hornedo-Ortega, Ruth
Alonso-Bellido, Isabel María
Rodríguez-Gómez, José A.
Troncoso, Ana M.
García-Parrilla, M. Carmen
Venero, José L.
Espinosa-Oliva, Ana M.
Martínez de Pablos, Rocío
author_role author
author2 Hornedo-Ortega, Ruth
Alonso-Bellido, Isabel María
Rodríguez-Gómez, José A.
Troncoso, Ana M.
García-Parrilla, M. Carmen
Venero, José L.
Espinosa-Oliva, Ana M.
Martínez de Pablos, Rocío
author2_role author
author
author
author
author
author
author
author
dc.contributor.none.fl_str_mv Ministerio de Ciencia, Innovación y Universidades (España)
European Commission
Ministerio de Economía y Competitividad (España)
Fundación Alfonso Martín Escudero
Consejo Superior de Investigaciones Científicas [https://ror.org/02gfc7t72]
dc.subject.none.fl_str_mv Hydroxytyrosol
Microglia
Mediterranean diet
Inflammasome
MAPKs
Lipopolysaccharide
α-synuclein
topic Hydroxytyrosol
Microglia
Mediterranean diet
Inflammasome
MAPKs
Lipopolysaccharide
α-synuclein
description Neuroinflammation is a common feature shared by neurodegenerative disorders, such as Parkinson’s disease (PD), and seems to play a key role in their development and progression. Microglia cells, the principal orchestrators of neuroinflammation, can be polarized in different phenotypes, which means they are able to have anti-inflammatory, pro-inflammatory, or neurodegenerative effects. Increasing evidence supports that the traditional Mediterranean dietary pattern is related to the reduction of cognitive decline in neurodegenerative diseases. A considerable intake of plant foods, fish, and extra virgin olive oil (EVOO), as well as a moderate consumption of red wine, all characteristic of the Mediterranean diet (MD), are behind these effects. These foods are especially rich in polyphenols, being the most relevant in the MD hydroxytyrosol (HT) and their derivatives present in EVOO, which have demonstrated a wide array of biological activities. Here, we demonstrate that HT is able to reduce the inflammation induced by two different stimuli: lipopolysaccharide and α-synuclein. We also study the possible molecular mechanisms involved in the anti-inflammatory effect of HT, including the study of nuclear factor kappa B (NF-κB), mitogen-activated protein kinases (MAPKs), nicotinamide adenine dinucleotide phosphate (NADPH) oxidase, and inflammasome. Our data support the use of HT to prevent the inflammation associated with PD and shed light into the relationship between MD and this neurological disorder.
publishDate 2020
dc.date.none.fl_str_mv 2020
2021
2021
2021
dc.type.none.fl_str_mv info:eu-repo/semantics/article
http://purl.org/coar/resource_type/c_6501
Publisher's version
info:eu-repo/semantics/publishedVersion
format article
status_str publishedVersion
dc.identifier.none.fl_str_mv http://hdl.handle.net/10261/233995
url http://hdl.handle.net/10261/233995
dc.language.none.fl_str_mv Inglés
language_invalid_str_mv Inglés
dc.relation.none.fl_str_mv #PLACEHOLDER_PARENT_METADATA_VALUE#
#PLACEHOLDER_PARENT_METADATA_VALUE#
info:eu-repo/grantAgreement/AEI/Plan Estatal de Investigación Científica y Técnica y de Innovación 2017-2020/RTI2018-098645-B-100
info:eu-repo/grantAgreement/MINECO/Plan Estatal de Investigación Científica y Técnica y de Innovación 2013-2016/AGL2016-77505-C3-2-R
http://doi.org/10.3390/antiox9010036
Sí
dc.rights.none.fl_str_mv info:eu-repo/semantics/openAccess
eu_rights_str_mv openAccess
dc.publisher.none.fl_str_mv Multidisciplinary Digital Publishing Institute
publisher.none.fl_str_mv Multidisciplinary Digital Publishing Institute
dc.source.none.fl_str_mv reponame:DIGITAL.CSIC. Repositorio Institucional del CSIC
instname:Consejo Superior de Investigaciones Científicas (CSIC)
instname_str Consejo Superior de Investigaciones Científicas (CSIC)
reponame_str DIGITAL.CSIC. Repositorio Institucional del CSIC
collection DIGITAL.CSIC. Repositorio Institucional del CSIC
repository.name.fl_str_mv
repository.mail.fl_str_mv
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