Oleic acid chlorohydrin, a new early biomarker for the prediction of acute pancreatitis severity in humans

The early prediction of the severity of acute pancreatitis still represents a challenge for clinicians. Experimental studies have revealed the generation of specific halogenated lipids, in particular oleic acid chlorohydrin, in the early stages of acute pancreatitis. We hypothesized that the levels...

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Autores: de-Madaria, Enrique|||0000-0002-2412-9541, Molero, Xavier|||0000-0003-2473-7405, Bonjoch, Laia|||0000-0002-3351-0037, Casas, Josefina|||0000-0002-7926-5209, Cárdenas Jaén, Karina, Montenegro, Andrea, Closa Autet, Daniel|||0000-0003-3797-3095
Tipo de recurso: artículo
Fecha de publicación:2018
País:España
Institución:Universitat Autònoma de Barcelona
Repositorio:Dipòsit Digital de Documents de la UAB
Idioma:inglés
OAI Identifier:oai:ddd.uab.cat:187857
Acceso en línea:https://ddd.uab.cat/record/187857
https://dx.doi.org/urn:doi:10.1186/s13613-017-0346-6
Access Level:acceso abierto
Palabra clave:Acute pancreatitis
Chlorohydrins
Inflammation
Fatty acids
SIRS
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spelling Oleic acid chlorohydrin, a new early biomarker for the prediction of acute pancreatitis severity in humansde-Madaria, Enrique|||0000-0002-2412-9541Molero, Xavier|||0000-0003-2473-7405Bonjoch, Laia|||0000-0002-3351-0037Casas, Josefina|||0000-0002-7926-5209Cárdenas Jaén, KarinaMontenegro, AndreaClosa Autet, Daniel|||0000-0003-3797-3095Acute pancreatitisChlorohydrinsInflammationFatty acidsSIRSThe early prediction of the severity of acute pancreatitis still represents a challenge for clinicians. Experimental studies have revealed the generation of specific halogenated lipids, in particular oleic acid chlorohydrin, in the early stages of acute pancreatitis. We hypothesized that the levels of circulating oleic acid chlorohydrin might be a useful early prognostic biomarker in acute pancreatitis in humans. In a prospective, multicenter cohort study, plasma samples collected within 24 h after presentation in the emergency room from 59 patients with acute pancreatitis and from 9 healthy subjects were assessed for oleic acid chlorohydrin levels. Pancreatitis was mild in 30 patients, moderately severe in 16 and severe in 13. Oleic acid chlorohydrin levels within 24 h after presentation were significantly higher in patients that later progressed to moderate and severe acute pancreatitis. Using 7.49 nM as the cutoff point, oleic acid chlorohydrin distinguished mild from moderately severe-to-severe pancreatitis with high sensitivity/specificity (96.6/90.0%) and positive/negative predictive values (90.3/96.4%). Using 32.40 nM as the cutoff value sensitivity, specificity, positive and negative predictive values were all 100% for severe acute pancreatitis. It was found to be a better prognostic marker than BISAP score, hematocrit at 48 h, SIRS at admission, persistent SIRS or C-reactive protein at 48 h. Oleic acid chlorohydrin concentration in plasma is elevated in patients with acute pancreatitis on admission and correlates with a high degree with the final severity of the disease, indicating that it has potential to serve as an early prognostic marker for acute pancreatitis severity.Universitat Autònoma de Barcelona 22018-01-0120182018-01-01Articlehttp://purl.org/coar/resource_type/c_6501VoRhttp://purl.org/coar/version/c_970fb48d4fbd8a85info:eu-repo/semantics/articleapplication/pdfhttps://ddd.uab.cat/record/187857https://dx.doi.org/urn:doi:10.1186/s13613-017-0346-6reponame:Dipòsit Digital de Documents de la UABinstname:Universitat Autònoma de BarcelonaInglésengInstituto de Salud Carlos III https://doi.org/10.13039/501100004587 PI13-00019Agència de Gestió d'Ajuts Universitaris i de Recerca https://doi.org/10.13039/501100003030 FI-DGR-2013open accesshttp://purl.org/coar/access_right/c_abf2Aquest document està subjecte a una llicència d'ús Creative Commons. Es permet la reproducció total o parcial, la distribució, la comunicació pública de l'obra i la creació d'obres derivades, fins i tot amb finalitats comercials, sempre i quan es reconegui l'autoria de l'obra original.https://creativecommons.org/licenses/by/4.0/info:eu-repo/semantics/openAccessoai:ddd.uab.cat:1878572026-06-06T12:50:31Z
dc.title.none.fl_str_mv Oleic acid chlorohydrin, a new early biomarker for the prediction of acute pancreatitis severity in humans
title Oleic acid chlorohydrin, a new early biomarker for the prediction of acute pancreatitis severity in humans
spellingShingle Oleic acid chlorohydrin, a new early biomarker for the prediction of acute pancreatitis severity in humans
de-Madaria, Enrique|||0000-0002-2412-9541
Acute pancreatitis
Chlorohydrins
Inflammation
Fatty acids
SIRS
title_short Oleic acid chlorohydrin, a new early biomarker for the prediction of acute pancreatitis severity in humans
title_full Oleic acid chlorohydrin, a new early biomarker for the prediction of acute pancreatitis severity in humans
title_fullStr Oleic acid chlorohydrin, a new early biomarker for the prediction of acute pancreatitis severity in humans
title_full_unstemmed Oleic acid chlorohydrin, a new early biomarker for the prediction of acute pancreatitis severity in humans
title_sort Oleic acid chlorohydrin, a new early biomarker for the prediction of acute pancreatitis severity in humans
dc.creator.none.fl_str_mv de-Madaria, Enrique|||0000-0002-2412-9541
Molero, Xavier|||0000-0003-2473-7405
Bonjoch, Laia|||0000-0002-3351-0037
Casas, Josefina|||0000-0002-7926-5209
Cárdenas Jaén, Karina
Montenegro, Andrea
Closa Autet, Daniel|||0000-0003-3797-3095
author de-Madaria, Enrique|||0000-0002-2412-9541
author_facet de-Madaria, Enrique|||0000-0002-2412-9541
Molero, Xavier|||0000-0003-2473-7405
Bonjoch, Laia|||0000-0002-3351-0037
Casas, Josefina|||0000-0002-7926-5209
Cárdenas Jaén, Karina
Montenegro, Andrea
Closa Autet, Daniel|||0000-0003-3797-3095
author_role author
author2 Molero, Xavier|||0000-0003-2473-7405
Bonjoch, Laia|||0000-0002-3351-0037
Casas, Josefina|||0000-0002-7926-5209
Cárdenas Jaén, Karina
Montenegro, Andrea
Closa Autet, Daniel|||0000-0003-3797-3095
author2_role author
author
author
author
author
author
dc.contributor.none.fl_str_mv Universitat Autònoma de Barcelona
dc.subject.none.fl_str_mv Acute pancreatitis
Chlorohydrins
Inflammation
Fatty acids
SIRS
topic Acute pancreatitis
Chlorohydrins
Inflammation
Fatty acids
SIRS
description The early prediction of the severity of acute pancreatitis still represents a challenge for clinicians. Experimental studies have revealed the generation of specific halogenated lipids, in particular oleic acid chlorohydrin, in the early stages of acute pancreatitis. We hypothesized that the levels of circulating oleic acid chlorohydrin might be a useful early prognostic biomarker in acute pancreatitis in humans. In a prospective, multicenter cohort study, plasma samples collected within 24 h after presentation in the emergency room from 59 patients with acute pancreatitis and from 9 healthy subjects were assessed for oleic acid chlorohydrin levels. Pancreatitis was mild in 30 patients, moderately severe in 16 and severe in 13. Oleic acid chlorohydrin levels within 24 h after presentation were significantly higher in patients that later progressed to moderate and severe acute pancreatitis. Using 7.49 nM as the cutoff point, oleic acid chlorohydrin distinguished mild from moderately severe-to-severe pancreatitis with high sensitivity/specificity (96.6/90.0%) and positive/negative predictive values (90.3/96.4%). Using 32.40 nM as the cutoff value sensitivity, specificity, positive and negative predictive values were all 100% for severe acute pancreatitis. It was found to be a better prognostic marker than BISAP score, hematocrit at 48 h, SIRS at admission, persistent SIRS or C-reactive protein at 48 h. Oleic acid chlorohydrin concentration in plasma is elevated in patients with acute pancreatitis on admission and correlates with a high degree with the final severity of the disease, indicating that it has potential to serve as an early prognostic marker for acute pancreatitis severity.
publishDate 2018
dc.date.none.fl_str_mv 2
2018-01-01
2018
2018-01-01
dc.type.none.fl_str_mv Article
http://purl.org/coar/resource_type/c_6501
VoR
http://purl.org/coar/version/c_970fb48d4fbd8a85
dc.type.openaire.fl_str_mv info:eu-repo/semantics/article
format article
dc.identifier.none.fl_str_mv https://ddd.uab.cat/record/187857
https://dx.doi.org/urn:doi:10.1186/s13613-017-0346-6
url https://ddd.uab.cat/record/187857
https://dx.doi.org/urn:doi:10.1186/s13613-017-0346-6
dc.language.none.fl_str_mv Inglés
eng
language_invalid_str_mv Inglés
language eng
dc.relation.none.fl_str_mv Instituto de Salud Carlos III https://doi.org/10.13039/501100004587 PI13-00019
Agència de Gestió d'Ajuts Universitaris i de Recerca https://doi.org/10.13039/501100003030 FI-DGR-2013
dc.rights.none.fl_str_mv open access
http://purl.org/coar/access_right/c_abf2
https://creativecommons.org/licenses/by/4.0/
dc.rights.openaire.fl_str_mv info:eu-repo/semantics/openAccess
rights_invalid_str_mv open access
http://purl.org/coar/access_right/c_abf2
https://creativecommons.org/licenses/by/4.0/
eu_rights_str_mv openAccess
dc.format.none.fl_str_mv application/pdf
dc.source.none.fl_str_mv reponame:Dipòsit Digital de Documents de la UAB
instname:Universitat Autònoma de Barcelona
instname_str Universitat Autònoma de Barcelona
reponame_str Dipòsit Digital de Documents de la UAB
collection Dipòsit Digital de Documents de la UAB
repository.name.fl_str_mv
repository.mail.fl_str_mv
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