Medical treatment of cystic echinococcosis: systematic review and meta-analysis

Background: Cystic echinococcosis (CE) is a well-known neglected parasitic disease. However, evidence supporting the four current treatment modalities is inadequate, and treatment options remain controversial. The aim of this work is to analyse the available data to answer clinical questions regardi...

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Autores: Velasco-Tirado, Virginia, Alonso-Sardón, Montserrat, López-Bernús, Amparo, Romero-Alegría, Ángela, Burguillo, Francisco Javier, Muro, Antonio, Carpio-Pérez, Adela, Muñoz Bellido, Juan Luis, Pardo Lledías, Javier, Cordero, Miguel, Belhassen García, Moncef
Tipo de recurso: artículo
Fecha de publicación:2018
País:España
Institución:Universidad de Cantabria (UC)
Repositorio:UCrea Repositorio Abierto de la Universidad de Cantabria
Idioma:inglés
OAI Identifier:oai:repositorio.unican.es:10902/29041
Acceso en línea:https://hdl.handle.net/10902/29041
Access Level:acceso abierto
Palabra clave:Echinococcus granulosus
Cystic echinococcosis
Albendazole
Mebendazole
Praziquantel
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spelling Medical treatment of cystic echinococcosis: systematic review and meta-analysisVelasco-Tirado, VirginiaAlonso-Sardón, MontserratLópez-Bernús, AmparoRomero-Alegría, ÁngelaBurguillo, Francisco JavierMuro, AntonioCarpio-Pérez, AdelaMuñoz Bellido, Juan LuisPardo Lledías, JavierCordero, MiguelBelhassen García, MoncefEchinococcus granulosusCystic echinococcosisAlbendazoleMebendazolePraziquantelBackground: Cystic echinococcosis (CE) is a well-known neglected parasitic disease. However, evidence supporting the four current treatment modalities is inadequate, and treatment options remain controversial. The aim of this work is to analyse the available data to answer clinical questions regarding medical treatment of CE. Methods A thorough electronic search of the relevant literature without language restrictions was carried out using PubMed (Medline), Cochrane Central Register of Controlled Trials, BioMed, Database of Abstracts of Reviews of Effects, and Cochrane Plus databases up to February 1, 2017. All descriptive studies reporting an assessment of CE treatment and published in a peer-reviewed journal with available full-text were considered for a qualitative analysis. Randomized controlled trials were included in a quantitative meta-analysis. We used the standard methodological procedures established by the Preferred Reporting Items for Systematic Reviews and Meta-Analyses statement. Results We included 33 studies related to the pharmacological treatment of CE in humans. Of these, 22 studies with levels of evidence 2 to 4 were qualitatively analysed, and 11 randomized controlled trials were quantitatively analysed by meta-analysis. Conclusions Treatment outcomes are better when surgery or PAIR (Puncture, Aspiration, Injection of protoscolicidal agent and Reaspiration) is combined with benzimidazole drugs given pre- and/or post-operation. Albendazole chemotherapy was found to be the primary pharmacological treatment to consider in the medical management of CE. Nevertheless, combined treatment with albendazole plus praziquantel resulted in higher scolicidal and anti-cyst activity and was more likely to result in cure or improvement relative to albendazole alone.Funding: This work was supported by the Health Research Projects: Technological Development Project in Health [Grant number DTS16/00207] and Health Research Project [Grant number PI16/ 01784] of funding institution Instituto de Salud Carlos III and the Network Biomedical Research on Tropical Diseases (RICET in Spanish) RD12/0018/0001, supported by the European Regional Development Fund (FEDER) from the European Commission. Moreover, financial regional/local support came from Proyectos Integrados IBSAL [IBY15/00003; Salamanca, Spain] and CIETUS-University of Salamanca Acknowledgements: To Luis Perez del Villar, who started this work with us and could not see it finished.BioMed CentralUniversidad de Cantabria20182018-01-01journal articlehttp://purl.org/coar/resource_type/c_6501NAhttp://purl.org/coar/version/c_be7fb7dd8ff6fe43info:eu-repo/semantics/articlehttps://hdl.handle.net/10902/29041BMC infectious diseases (2018) 18:306reponame:UCrea Repositorio Abierto de la Universidad de Cantabriainstname:Universidad de Cantabria (UC)Inglésengopen accesshttp://purl.org/coar/access_right/c_abf2Attribution 4.0 Internationalhttp://creativecommons.org/licenses/by/4.0/info:eu-repo/semantics/openAccessoai:repositorio.unican.es:10902/290412026-06-02T12:39:31Z
dc.title.none.fl_str_mv Medical treatment of cystic echinococcosis: systematic review and meta-analysis
title Medical treatment of cystic echinococcosis: systematic review and meta-analysis
spellingShingle Medical treatment of cystic echinococcosis: systematic review and meta-analysis
Velasco-Tirado, Virginia
Echinococcus granulosus
Cystic echinococcosis
Albendazole
Mebendazole
Praziquantel
title_short Medical treatment of cystic echinococcosis: systematic review and meta-analysis
title_full Medical treatment of cystic echinococcosis: systematic review and meta-analysis
title_fullStr Medical treatment of cystic echinococcosis: systematic review and meta-analysis
title_full_unstemmed Medical treatment of cystic echinococcosis: systematic review and meta-analysis
title_sort Medical treatment of cystic echinococcosis: systematic review and meta-analysis
dc.creator.none.fl_str_mv Velasco-Tirado, Virginia
Alonso-Sardón, Montserrat
López-Bernús, Amparo
Romero-Alegría, Ángela
Burguillo, Francisco Javier
Muro, Antonio
Carpio-Pérez, Adela
Muñoz Bellido, Juan Luis
Pardo Lledías, Javier
Cordero, Miguel
Belhassen García, Moncef
author Velasco-Tirado, Virginia
author_facet Velasco-Tirado, Virginia
Alonso-Sardón, Montserrat
López-Bernús, Amparo
Romero-Alegría, Ángela
Burguillo, Francisco Javier
Muro, Antonio
Carpio-Pérez, Adela
Muñoz Bellido, Juan Luis
Pardo Lledías, Javier
Cordero, Miguel
Belhassen García, Moncef
author_role author
author2 Alonso-Sardón, Montserrat
López-Bernús, Amparo
Romero-Alegría, Ángela
Burguillo, Francisco Javier
Muro, Antonio
Carpio-Pérez, Adela
Muñoz Bellido, Juan Luis
Pardo Lledías, Javier
Cordero, Miguel
Belhassen García, Moncef
author2_role author
author
author
author
author
author
author
author
author
author
dc.contributor.none.fl_str_mv Universidad de Cantabria
dc.subject.none.fl_str_mv Echinococcus granulosus
Cystic echinococcosis
Albendazole
Mebendazole
Praziquantel
topic Echinococcus granulosus
Cystic echinococcosis
Albendazole
Mebendazole
Praziquantel
description Background: Cystic echinococcosis (CE) is a well-known neglected parasitic disease. However, evidence supporting the four current treatment modalities is inadequate, and treatment options remain controversial. The aim of this work is to analyse the available data to answer clinical questions regarding medical treatment of CE. Methods A thorough electronic search of the relevant literature without language restrictions was carried out using PubMed (Medline), Cochrane Central Register of Controlled Trials, BioMed, Database of Abstracts of Reviews of Effects, and Cochrane Plus databases up to February 1, 2017. All descriptive studies reporting an assessment of CE treatment and published in a peer-reviewed journal with available full-text were considered for a qualitative analysis. Randomized controlled trials were included in a quantitative meta-analysis. We used the standard methodological procedures established by the Preferred Reporting Items for Systematic Reviews and Meta-Analyses statement. Results We included 33 studies related to the pharmacological treatment of CE in humans. Of these, 22 studies with levels of evidence 2 to 4 were qualitatively analysed, and 11 randomized controlled trials were quantitatively analysed by meta-analysis. Conclusions Treatment outcomes are better when surgery or PAIR (Puncture, Aspiration, Injection of protoscolicidal agent and Reaspiration) is combined with benzimidazole drugs given pre- and/or post-operation. Albendazole chemotherapy was found to be the primary pharmacological treatment to consider in the medical management of CE. Nevertheless, combined treatment with albendazole plus praziquantel resulted in higher scolicidal and anti-cyst activity and was more likely to result in cure or improvement relative to albendazole alone.
publishDate 2018
dc.date.none.fl_str_mv 2018
2018-01-01
dc.type.none.fl_str_mv journal article
http://purl.org/coar/resource_type/c_6501
NA
http://purl.org/coar/version/c_be7fb7dd8ff6fe43
dc.type.openaire.fl_str_mv info:eu-repo/semantics/article
format article
dc.identifier.none.fl_str_mv https://hdl.handle.net/10902/29041
url https://hdl.handle.net/10902/29041
dc.language.none.fl_str_mv Inglés
eng
language_invalid_str_mv Inglés
language eng
dc.rights.none.fl_str_mv open access
http://purl.org/coar/access_right/c_abf2
Attribution 4.0 International
http://creativecommons.org/licenses/by/4.0/
dc.rights.openaire.fl_str_mv info:eu-repo/semantics/openAccess
rights_invalid_str_mv open access
http://purl.org/coar/access_right/c_abf2
Attribution 4.0 International
http://creativecommons.org/licenses/by/4.0/
eu_rights_str_mv openAccess
dc.publisher.none.fl_str_mv BioMed Central
publisher.none.fl_str_mv BioMed Central
dc.source.none.fl_str_mv BMC infectious diseases (2018) 18:306
reponame:UCrea Repositorio Abierto de la Universidad de Cantabria
instname:Universidad de Cantabria (UC)
instname_str Universidad de Cantabria (UC)
reponame_str UCrea Repositorio Abierto de la Universidad de Cantabria
collection UCrea Repositorio Abierto de la Universidad de Cantabria
repository.name.fl_str_mv
repository.mail.fl_str_mv
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