Altered functional connectivity of the subthalamus and the bed nucleus of the stria terminalis in obsessive-compulsive disorder

Background. The assessment of inter-regional functional connectivity (FC) has allowed for the description of the putative mechanism of action of treatments such as deep brain stimulation (DBS) of the nucleus accumbens in patients with obsessive-compulsive disorder (OCD). Nevertheless, the possible F...

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Autores: Cano, M, Alonso, P, Martínez-Zalacaín, I, Subirà, M, Real, E, Segalàs, C, Pujol, J, Cardoner, N, Menchón, JM, Soriano-Mas, C
Formato: artículo
Estado:Versión publicada
Fecha de publicación:2018
País:España
Recursos:Institut d'Investigació i Innovació Parc Taulí (I3PT)
Repositorio:r-I3PT. Repositorio Institucional Producción Científica del Institut d'Investigació i Innovació Parc Taulí
OAI Identifier:oai:i3pt.fundanetsuite.com:p5901
Acesso em linha:https://i3pt.portalinvestigacion.com/publicaciones/5901
Access Level:acceso abierto
Palavra-chave:Functional connectivity
obsessive-compulsive disorder
subthalamic nucleus and bed nucleus of the stria terminalis
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spelling Altered functional connectivity of the subthalamus and the bed nucleus of the stria terminalis in obsessive-compulsive disorderCano, MAlonso, PMartínez-Zalacaín, ISubirà, MReal, ESegalàs, CPujol, JCardoner, NMenchón, JMSoriano-Mas, CFunctional connectivityobsessive-compulsive disordersubthalamic nucleus and bed nucleus of the stria terminalisBackground. The assessment of inter-regional functional connectivity (FC) has allowed for the description of the putative mechanism of action of treatments such as deep brain stimulation (DBS) of the nucleus accumbens in patients with obsessive-compulsive disorder (OCD). Nevertheless, the possible FC alterations of other clinically-effective DBS targets have not been explored. Here we evaluated the FC patterns of the subthalamic nucleus (STN) and the bed nucleus of the stria terminalis (BNST) in patients with OCD, as well as their association with symptom severity. Methods. Eighty-six patients with OCD and 104 healthy participants were recruited. A resting-state image was acquired for each participant and a seed-based analysis focused on our two regions of interest was performed using statistical parametric mapping software (SPM8). Between-group differences in FC patterns were assessed with two-sample t test models, while the association between symptom severity and FC patterns was assessed with multiple regression analyses. Results. In comparison with controls, patients with OCD showed: (1) increased FC between the left STN and the right pre-motor cortex, (2) decreased FC between the right STN and the lenticular nuclei, and (3) increased FC between the left BNST and the right frontopolar cortex. Multiple regression analyses revealed a negative association between clinical severity and FC between the right STN and lenticular nucleus. Conclusions. This study provides a neurobiological framework to understand the mechanism of action of DBS on the STN and the BNST, which seems to involve brain circuits related with motor response inhibition and anxiety control, respectively.CAMBRIDGE UNIV PRESS2018info:eu-repo/semantics/articleinfo:eu-repo/semantics/publishedVersionhttps://i3pt.portalinvestigacion.com/publicaciones/5901PSYCHOLOGICAL MEDICINEISSN: 00332917ISSNe: 14698978reponame:r-I3PT. Repositorio Institucional Producción Científica del Institut d'Investigació i Innovació Parc Taulíinstname:Institut d'Investigació i Innovació Parc Taulí (I3PT)Inglésinfo:eu-repo/semantics/openAccessoai:i3pt.fundanetsuite.com:p59012026-06-21T15:30:37Z
dc.title.none.fl_str_mv Altered functional connectivity of the subthalamus and the bed nucleus of the stria terminalis in obsessive-compulsive disorder
title Altered functional connectivity of the subthalamus and the bed nucleus of the stria terminalis in obsessive-compulsive disorder
spellingShingle Altered functional connectivity of the subthalamus and the bed nucleus of the stria terminalis in obsessive-compulsive disorder
Cano, M
Functional connectivity
obsessive-compulsive disorder
subthalamic nucleus and bed nucleus of the stria terminalis
title_short Altered functional connectivity of the subthalamus and the bed nucleus of the stria terminalis in obsessive-compulsive disorder
title_full Altered functional connectivity of the subthalamus and the bed nucleus of the stria terminalis in obsessive-compulsive disorder
title_fullStr Altered functional connectivity of the subthalamus and the bed nucleus of the stria terminalis in obsessive-compulsive disorder
title_full_unstemmed Altered functional connectivity of the subthalamus and the bed nucleus of the stria terminalis in obsessive-compulsive disorder
title_sort Altered functional connectivity of the subthalamus and the bed nucleus of the stria terminalis in obsessive-compulsive disorder
dc.creator.none.fl_str_mv Cano, M
Alonso, P
Martínez-Zalacaín, I
Subirà, M
Real, E
Segalàs, C
Pujol, J
Cardoner, N
Menchón, JM
Soriano-Mas, C
author Cano, M
author_facet Cano, M
Alonso, P
Martínez-Zalacaín, I
Subirà, M
Real, E
Segalàs, C
Pujol, J
Cardoner, N
Menchón, JM
Soriano-Mas, C
author_role author
author2 Alonso, P
Martínez-Zalacaín, I
Subirà, M
Real, E
Segalàs, C
Pujol, J
Cardoner, N
Menchón, JM
Soriano-Mas, C
author2_role author
author
author
author
author
author
author
author
author
dc.subject.none.fl_str_mv Functional connectivity
obsessive-compulsive disorder
subthalamic nucleus and bed nucleus of the stria terminalis
topic Functional connectivity
obsessive-compulsive disorder
subthalamic nucleus and bed nucleus of the stria terminalis
description Background. The assessment of inter-regional functional connectivity (FC) has allowed for the description of the putative mechanism of action of treatments such as deep brain stimulation (DBS) of the nucleus accumbens in patients with obsessive-compulsive disorder (OCD). Nevertheless, the possible FC alterations of other clinically-effective DBS targets have not been explored. Here we evaluated the FC patterns of the subthalamic nucleus (STN) and the bed nucleus of the stria terminalis (BNST) in patients with OCD, as well as their association with symptom severity. Methods. Eighty-six patients with OCD and 104 healthy participants were recruited. A resting-state image was acquired for each participant and a seed-based analysis focused on our two regions of interest was performed using statistical parametric mapping software (SPM8). Between-group differences in FC patterns were assessed with two-sample t test models, while the association between symptom severity and FC patterns was assessed with multiple regression analyses. Results. In comparison with controls, patients with OCD showed: (1) increased FC between the left STN and the right pre-motor cortex, (2) decreased FC between the right STN and the lenticular nuclei, and (3) increased FC between the left BNST and the right frontopolar cortex. Multiple regression analyses revealed a negative association between clinical severity and FC between the right STN and lenticular nucleus. Conclusions. This study provides a neurobiological framework to understand the mechanism of action of DBS on the STN and the BNST, which seems to involve brain circuits related with motor response inhibition and anxiety control, respectively.
publishDate 2018
dc.date.none.fl_str_mv 2018
dc.type.none.fl_str_mv info:eu-repo/semantics/article
info:eu-repo/semantics/publishedVersion
format article
status_str publishedVersion
dc.identifier.none.fl_str_mv https://i3pt.portalinvestigacion.com/publicaciones/5901
url https://i3pt.portalinvestigacion.com/publicaciones/5901
dc.language.none.fl_str_mv Inglés
language_invalid_str_mv Inglés
dc.rights.none.fl_str_mv info:eu-repo/semantics/openAccess
eu_rights_str_mv openAccess
dc.publisher.none.fl_str_mv CAMBRIDGE UNIV PRESS
publisher.none.fl_str_mv CAMBRIDGE UNIV PRESS
dc.source.none.fl_str_mv PSYCHOLOGICAL MEDICINE
ISSN: 00332917
ISSNe: 14698978
reponame:r-I3PT. Repositorio Institucional Producción Científica del Institut d'Investigació i Innovació Parc Taulí
instname:Institut d'Investigació i Innovació Parc Taulí (I3PT)
instname_str Institut d'Investigació i Innovació Parc Taulí (I3PT)
reponame_str r-I3PT. Repositorio Institucional Producción Científica del Institut d'Investigació i Innovació Parc Taulí
collection r-I3PT. Repositorio Institucional Producción Científica del Institut d'Investigació i Innovació Parc Taulí
repository.name.fl_str_mv
repository.mail.fl_str_mv
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score 15.812429

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