Glucose sensing by carotid body glomus cells: potential implications in disease

The carotid body (CB) is a key chemoreceptor organ in which glomus cells sense changes in blood O2, CO2, and pH levels. CB glomus cells have also been found to detect hypoglycemia in both non-primate mammals and humans. O2 and low-glucose responses share a common final pathway involving membrane dep...

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Detalhes bibliográficos
Autores: Gao Chen, Lin, Ortega Sáenz, Patricia, García Fernández, María, González Rodríguez, Patricia, Caballero Eraso, Candela, López Barneo, José
Formato: artículo
Estado:Versión publicada
Fecha de publicación:2014
País:España
Recursos:Universidad de Sevilla (US)
Repositorio:idUS. Depósito de Investigación de la Universidad de Sevilla
OAI Identifier:oai:idus.us.es:11441/125141
Acesso em linha:https://hdl.handle.net/11441/125141
https://doi.org/0.3389/fphys.2014.00398
Access Level:acceso abierto
Palavra-chave:Carotid body
Glucose sensing
O2 sensing
Hypoglycemia
Intermittent hypoxia
Sleep apnea
Chronic hypoxia
Diabetes
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spelling Glucose sensing by carotid body glomus cells: potential implications in diseaseGao Chen, LinOrtega Sáenz, PatriciaGarcía Fernández, MaríaGonzález Rodríguez, PatriciaCaballero Eraso, CandelaLópez Barneo, JoséCarotid bodyGlucose sensingO2 sensingHypoglycemiaIntermittent hypoxiaSleep apneaChronic hypoxiaDiabetesThe carotid body (CB) is a key chemoreceptor organ in which glomus cells sense changes in blood O2, CO2, and pH levels. CB glomus cells have also been found to detect hypoglycemia in both non-primate mammals and humans. O2 and low-glucose responses share a common final pathway involving membrane depolarization, extracellular calcium influx, increase in cytosolic calcium concentration, and neurotransmitter secretion, which stimulates afferent sensory fibers to evoke sympathoadrenal activation. On the other hand, hypoxia and low glucose induce separate signal transduction pathways. Unlike O2 sensing, the response of the CB to low glucose is not altered by rotenone, with the low glucose-activated background cationic current unaffected by hypoxia. Responses of the CB to hypoglycemia and hypoxia can be potentiated by each other. The counter-regulatory response to hypoglycemia by the CB is essential for the brain, an organ that is particularly sensitive to low glucose. CB glucose sensing could be altered in diabetic patients, particularly those under insulin treatment, as well as in other medical conditions such as sleep apnea or obstructive pulmonary diseases, where chronic hypoxemia presents with plastic modifications in CB structure and function. The current review will focus on the following main aspects: (1) the CB as a low glucose sensor in both in vitro and in vivo models; (2) molecular and ionic mechanisms of low glucose sensing by glomus cells, (3) the interplay between low glucose and O2 sensing in CB, and (4) the role of CB low glucose sensing in the pathophysiology of cardiorespiratory and metabolic diseases, and how this may serve as a potential therapeutic target.Botín Foundation and the Spanish Ministry of Economy and Innovation (SAF program)Frontiers MediaFisiología Médica y Biofísica2014info:eu-repo/semantics/articleinfo:eu-repo/semantics/publishedVersionapplication/pdfapplication/pdfhttps://hdl.handle.net/11441/125141https://doi.org/0.3389/fphys.2014.00398reponame:idUS. Depósito de Investigación de la Universidad de Sevillainstname:Universidad de Sevilla (US)InglésFrontiers in Physiology, 5, art.n.398.https://www.frontiersin.org/articles/10.3389/fphys.2014.00398/fullinfo:eu-repo/semantics/openAccessoai:idus.us.es:11441/1251412026-06-17T12:51:07Z
dc.title.none.fl_str_mv Glucose sensing by carotid body glomus cells: potential implications in disease
title Glucose sensing by carotid body glomus cells: potential implications in disease
spellingShingle Glucose sensing by carotid body glomus cells: potential implications in disease
Gao Chen, Lin
Carotid body
Glucose sensing
O2 sensing
Hypoglycemia
Intermittent hypoxia
Sleep apnea
Chronic hypoxia
Diabetes
title_short Glucose sensing by carotid body glomus cells: potential implications in disease
title_full Glucose sensing by carotid body glomus cells: potential implications in disease
title_fullStr Glucose sensing by carotid body glomus cells: potential implications in disease
title_full_unstemmed Glucose sensing by carotid body glomus cells: potential implications in disease
title_sort Glucose sensing by carotid body glomus cells: potential implications in disease
dc.creator.none.fl_str_mv Gao Chen, Lin
Ortega Sáenz, Patricia
García Fernández, María
González Rodríguez, Patricia
Caballero Eraso, Candela
López Barneo, José
author Gao Chen, Lin
author_facet Gao Chen, Lin
Ortega Sáenz, Patricia
García Fernández, María
González Rodríguez, Patricia
Caballero Eraso, Candela
López Barneo, José
author_role author
author2 Ortega Sáenz, Patricia
García Fernández, María
González Rodríguez, Patricia
Caballero Eraso, Candela
López Barneo, José
author2_role author
author
author
author
author
dc.contributor.none.fl_str_mv Fisiología Médica y Biofísica
dc.subject.none.fl_str_mv Carotid body
Glucose sensing
O2 sensing
Hypoglycemia
Intermittent hypoxia
Sleep apnea
Chronic hypoxia
Diabetes
topic Carotid body
Glucose sensing
O2 sensing
Hypoglycemia
Intermittent hypoxia
Sleep apnea
Chronic hypoxia
Diabetes
description The carotid body (CB) is a key chemoreceptor organ in which glomus cells sense changes in blood O2, CO2, and pH levels. CB glomus cells have also been found to detect hypoglycemia in both non-primate mammals and humans. O2 and low-glucose responses share a common final pathway involving membrane depolarization, extracellular calcium influx, increase in cytosolic calcium concentration, and neurotransmitter secretion, which stimulates afferent sensory fibers to evoke sympathoadrenal activation. On the other hand, hypoxia and low glucose induce separate signal transduction pathways. Unlike O2 sensing, the response of the CB to low glucose is not altered by rotenone, with the low glucose-activated background cationic current unaffected by hypoxia. Responses of the CB to hypoglycemia and hypoxia can be potentiated by each other. The counter-regulatory response to hypoglycemia by the CB is essential for the brain, an organ that is particularly sensitive to low glucose. CB glucose sensing could be altered in diabetic patients, particularly those under insulin treatment, as well as in other medical conditions such as sleep apnea or obstructive pulmonary diseases, where chronic hypoxemia presents with plastic modifications in CB structure and function. The current review will focus on the following main aspects: (1) the CB as a low glucose sensor in both in vitro and in vivo models; (2) molecular and ionic mechanisms of low glucose sensing by glomus cells, (3) the interplay between low glucose and O2 sensing in CB, and (4) the role of CB low glucose sensing in the pathophysiology of cardiorespiratory and metabolic diseases, and how this may serve as a potential therapeutic target.
publishDate 2014
dc.date.none.fl_str_mv 2014
dc.type.none.fl_str_mv info:eu-repo/semantics/article
info:eu-repo/semantics/publishedVersion
format article
status_str publishedVersion
dc.identifier.none.fl_str_mv https://hdl.handle.net/11441/125141
https://doi.org/0.3389/fphys.2014.00398
url https://hdl.handle.net/11441/125141
https://doi.org/0.3389/fphys.2014.00398
dc.language.none.fl_str_mv Inglés
language_invalid_str_mv Inglés
dc.relation.none.fl_str_mv Frontiers in Physiology, 5, art.n.398.
https://www.frontiersin.org/articles/10.3389/fphys.2014.00398/full
dc.rights.none.fl_str_mv info:eu-repo/semantics/openAccess
eu_rights_str_mv openAccess
dc.format.none.fl_str_mv application/pdf
application/pdf
dc.publisher.none.fl_str_mv Frontiers Media
publisher.none.fl_str_mv Frontiers Media
dc.source.none.fl_str_mv reponame:idUS. Depósito de Investigación de la Universidad de Sevilla
instname:Universidad de Sevilla (US)
instname_str Universidad de Sevilla (US)
reponame_str idUS. Depósito de Investigación de la Universidad de Sevilla
collection idUS. Depósito de Investigación de la Universidad de Sevilla
repository.name.fl_str_mv
repository.mail.fl_str_mv
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