Premetazoan Origin of the Hippo Signaling Pathway

Nonaggregative multicellularity requires strict control of cell number. The Hippo signaling pathway coordinates cell proliferation and apoptosis and is a central regulator of organ size in animals. Recent studies have shown the presence of key members of the Hippo pathway in nonbilaterian animals, b...

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Autores: Sebé Pedrós, Arnau, Zheng, Yonggang, Ruiz Trillo, Iñaki, Pan, Duojia
Tipo de recurso: artículo
Estado:Versión publicada
Fecha de publicación:2012
País:España
Institución:Universidad de Barcelona
Repositorio:Dipòsit Digital de la UB
OAI Identifier:oai:diposit.ub.edu:2445/149447
Acceso en línea:https://hdl.handle.net/2445/149447
Access Level:acceso abierto
Palabra clave:Metazous
Genètica molecular
Metazoa
Molecular genetics
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spelling Premetazoan Origin of the Hippo Signaling PathwaySebé Pedrós, ArnauZheng, YonggangRuiz Trillo, IñakiPan, DuojiaMetazousGenètica molecularMetazoaMolecular geneticsNonaggregative multicellularity requires strict control of cell number. The Hippo signaling pathway coordinates cell proliferation and apoptosis and is a central regulator of organ size in animals. Recent studies have shown the presence of key members of the Hippo pathway in nonbilaterian animals, but failed to identify this pathway outside Metazoa. Through comparative analyses of recently sequenced holozoan genomes, we show that Hippo pathway components, such as the kinases Hippo and Warts, the coactivator Yorkie, and the transcription factor Scalloped, were already present in the unicellular ancestors of animals. Remarkably, functional analysis of Hippo components of the amoeboid holozoan Capsaspora owczarzaki, performed in Drosophila melanogaster, demonstrate that the growth-regulatory activity of the Hippo pathway is conserved in this unicellular lineage. Our findings show that the Hippo pathway evolved well before the origin of Metazoa and highlight the importance of Hippo signaling as a key developmental mechanism predating the origin of Metazoa.Elsevier2012info:eu-repo/semantics/articleinfo:eu-repo/semantics/publishedVersionapplication/pdfhttps://hdl.handle.net/2445/149447Articles publicats en revistes (Genètica, Microbiologia i Estadística)reponame:Dipòsit Digital de la UBinstname:Universidad de BarcelonaInglésReproducció del document publicat a: https://doi.org/10.1016/j.celrep.2011.11.004Cell Reports, 2012, vol. 1, num. 1, p. 13-20https://doi.org/10.1016/j.celrep.2011.11.004info:eu-repo/grantAgreement/EC/FP7/206883cc-by (c) Sebé Pedrós, Arnau et al., 2012http://creativecommons.org/licenses/by/3.0/esinfo:eu-repo/semantics/openAccessoai:diposit.ub.edu:2445/1494472026-05-27T06:46:51Z
dc.title.none.fl_str_mv Premetazoan Origin of the Hippo Signaling Pathway
title Premetazoan Origin of the Hippo Signaling Pathway
spellingShingle Premetazoan Origin of the Hippo Signaling Pathway
Sebé Pedrós, Arnau
Metazous
Genètica molecular
Metazoa
Molecular genetics
title_short Premetazoan Origin of the Hippo Signaling Pathway
title_full Premetazoan Origin of the Hippo Signaling Pathway
title_fullStr Premetazoan Origin of the Hippo Signaling Pathway
title_full_unstemmed Premetazoan Origin of the Hippo Signaling Pathway
title_sort Premetazoan Origin of the Hippo Signaling Pathway
dc.creator.none.fl_str_mv Sebé Pedrós, Arnau
Zheng, Yonggang
Ruiz Trillo, Iñaki
Pan, Duojia
author Sebé Pedrós, Arnau
author_facet Sebé Pedrós, Arnau
Zheng, Yonggang
Ruiz Trillo, Iñaki
Pan, Duojia
author_role author
author2 Zheng, Yonggang
Ruiz Trillo, Iñaki
Pan, Duojia
author2_role author
author
author
dc.subject.none.fl_str_mv Metazous
Genètica molecular
Metazoa
Molecular genetics
topic Metazous
Genètica molecular
Metazoa
Molecular genetics
description Nonaggregative multicellularity requires strict control of cell number. The Hippo signaling pathway coordinates cell proliferation and apoptosis and is a central regulator of organ size in animals. Recent studies have shown the presence of key members of the Hippo pathway in nonbilaterian animals, but failed to identify this pathway outside Metazoa. Through comparative analyses of recently sequenced holozoan genomes, we show that Hippo pathway components, such as the kinases Hippo and Warts, the coactivator Yorkie, and the transcription factor Scalloped, were already present in the unicellular ancestors of animals. Remarkably, functional analysis of Hippo components of the amoeboid holozoan Capsaspora owczarzaki, performed in Drosophila melanogaster, demonstrate that the growth-regulatory activity of the Hippo pathway is conserved in this unicellular lineage. Our findings show that the Hippo pathway evolved well before the origin of Metazoa and highlight the importance of Hippo signaling as a key developmental mechanism predating the origin of Metazoa.
publishDate 2012
dc.date.none.fl_str_mv 2012
dc.type.none.fl_str_mv info:eu-repo/semantics/article
info:eu-repo/semantics/publishedVersion
format article
status_str publishedVersion
dc.identifier.none.fl_str_mv https://hdl.handle.net/2445/149447
url https://hdl.handle.net/2445/149447
dc.language.none.fl_str_mv Inglés
language_invalid_str_mv Inglés
dc.relation.none.fl_str_mv Reproducció del document publicat a: https://doi.org/10.1016/j.celrep.2011.11.004
Cell Reports, 2012, vol. 1, num. 1, p. 13-20
https://doi.org/10.1016/j.celrep.2011.11.004
info:eu-repo/grantAgreement/EC/FP7/206883
dc.rights.none.fl_str_mv cc-by (c) Sebé Pedrós, Arnau et al., 2012
http://creativecommons.org/licenses/by/3.0/es
info:eu-repo/semantics/openAccess
rights_invalid_str_mv cc-by (c) Sebé Pedrós, Arnau et al., 2012
http://creativecommons.org/licenses/by/3.0/es
eu_rights_str_mv openAccess
dc.format.none.fl_str_mv application/pdf
dc.publisher.none.fl_str_mv Elsevier
publisher.none.fl_str_mv Elsevier
dc.source.none.fl_str_mv Articles publicats en revistes (Genètica, Microbiologia i Estadística)
reponame:Dipòsit Digital de la UB
instname:Universidad de Barcelona
instname_str Universidad de Barcelona
reponame_str Dipòsit Digital de la UB
collection Dipòsit Digital de la UB
repository.name.fl_str_mv
repository.mail.fl_str_mv
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score 15.300719

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