Physical comorbidities of older age bipolar disorder (OABD) patients: A global replication analysis of prevalence and sex differences

Objectives: To compare the prevalence of physical morbidities between older aged patients with bipolar disorder (OABD) and non-psychiatric comparisons (NC), and to analyze sex differences in prevalence. Methods: OABD was defined as bipolar disorder among adults aged >= 50 years. Outcomes analyzed...

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Detalles Bibliográficos
Autores: Teixeira, AL, Almeida, OP, Lavin, P, Barbosa, IG, Alda, M, Altinbas, K, Balanza-Martinez, V, Briggs, FBS, Calkin, C, Chen, PJ, Dols, A, Eyler, LT, Forester, BP, Forlenza, OV, Gildengers, AG, Hajek, T, Haarman, B, Korten, N, Jimenez, E, Lafer, B, Levin, JB, Montejo, L, Nunes, PV, Olagunju, AT, Oluwaniyi, S, Oudega, ML, Patrick, RE, Radua, J, Rej, S, Schouws, S, Soares, JC, Sutherland, AN, Vieta, E, Yala, J, Sajatovic, M
Tipo de recurso: artículo
Estado:Versión publicada
Fecha de publicación:2024
País:España
Institución:INCLIVA
Repositorio:r-INCLIVA. Repositorio Institucional de Producción Científica de INCLIVA
OAI Identifier:oai:incliva.fundanetsuite.com:p19195
Acceso en línea:https://incliva.portalinvestigacion.com/publicaciones/19195
Access Level:acceso abierto
Palabra clave:Bipolar disorder
Elderly
Geriatrics
Older age bipolar disorder
Psychiatry
Physical illness
Sex differences
Descripción
Sumario:Objectives: To compare the prevalence of physical morbidities between older aged patients with bipolar disorder (OABD) and non-psychiatric comparisons (NC), and to analyze sex differences in prevalence. Methods: OABD was defined as bipolar disorder among adults aged >= 50 years. Outcomes analyzed were the prevalence of diseases affecting the cardiovascular, respiratory, gastrointestinal, genitourinary, renal, musculoskeletal, and endocrine systems. The analysis used cross-sectional data of OABD participants ( n = 878; mean age 60.9 +/- 8.0 years, n = 496 (56%) women) from the collaborative Global Aging & Geriatric Experiments in Bipolar Disorder (GAGE -BD) dataset and NC participants recruited at the same sites ( n = 355; mean age 64.4 +/- 9.7 years, n = 215 (61%) women). Results: After controlling for sex, age, education, and smoking history, the OABD group had more cardiovascular (odds ratio [95% confidence interval]: 2.12 [1.38-3.30]), renal (5.97 [1.31-43.16]), musculoskeletal (2.09 [1.30-3.43]) and endocrine (1.90 [1.20-3.05]) diseases than NC. Women with OABD had more gastrointestinal (1.56 [0.99-2.49]), genitourinary (1.72 [1.02-2.92]), musculoskeletal (2.64 [1.66-4.37]) and endocrine (1.71 [1.08-2.73]) comorbidities than men with OABD, when age, education, smoking history, and study site were controlled. Conclusions: This replication GAGE -BD study confirms previous findings indicating that OABD present more physical morbidities than matched comparison participants, and that this health burden is significantly greater among women.

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