Neuroimaging studies of cognitive remediation in schizophrenia: A systematic and critical review

AIM: To examine the effects of cognitive remediation therapies on brain functioning through neuroimaging procedures in patients with schizophrenia. METHODS: A systematic, computerised literature search was conducted in the PubMed/Medline and PsychInfo databases. The search was performed through Febr...

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Autores: Penadés Rubio, Rafael, González Rodríguez, Alexandre, Catalán, Rosa, Segura i Fàbregas, Bàrbara, Bernardo Arroyo, Miquel, Junqué i Plaja, Carme, 1955-
Tipo de recurso: artículo
Estado:Versión publicada
Fecha de publicación:2017
País:España
Institución:Varias* (Consorci de Biblioteques Universitáries de Catalunya, Centre de Serveis Científics i Acadèmics de Catalunya)
Repositorio:Recercat. Dipósit de la Recerca de Catalunya
OAI Identifier:oai:recercat.cat:2445/161360
Acceso en línea:https://hdl.handle.net/2445/161360
Access Level:acceso abierto
Palabra clave:Esquizofrènia
Diagnòstic per la imatge
Neurociències
Schizophrenia
Diagnostic imaging
Neurosciences
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spelling Neuroimaging studies of cognitive remediation in schizophrenia: A systematic and critical reviewPenadés Rubio, RafaelGonzález Rodríguez, AlexandreCatalán, RosaSegura i Fàbregas, BàrbaraBernardo Arroyo, MiquelJunqué i Plaja, Carme, 1955-EsquizofrèniaDiagnòstic per la imatgeNeurociènciesSchizophreniaDiagnostic imagingNeurosciencesAIM: To examine the effects of cognitive remediation therapies on brain functioning through neuroimaging procedures in patients with schizophrenia. METHODS: A systematic, computerised literature search was conducted in the PubMed/Medline and PsychInfo databases. The search was performed through February 2016 without any restrictions on language or publication date. The search was performed using the following search terms: [('cogniti*' and 'remediation' or 'training' or 'enhancement') and ('fMRI' or 'MRI' or 'PET' or 'SPECT') and (schizophrenia or schiz*)]. The search was accompanied by a manual online search and a review of the references from each of the papers selected, and those papers fulfilling our inclusion criteria were also included. RESULTS: A total of 101 studies were found, but only 18 of them fulfilled the inclusion criteria. These studies indicated that cognitive remediation improves brain activation in neuroimaging studies. The most commonly reported changes were those that involved the prefrontal and thalamic regions. Those findings are in agreement with the hypofrontality hypothesis, which proposes that frontal hypoactivation is the underlying mechanism of cognitive impairments in schizophrenia. Nonetheless, great heterogeneity among the studies was found. They presented different hypotheses, different results and different findings. The results of more recent studies interpreted cognitive recovery within broader frameworks, namely, as amelioration of the efficiency of different networks. Furthermore, advances in neuroimaging methodologies, such as the use of whole-brain analysis, tractography, graph analysis, and other sophisticated methodologies of data processing, might be conditioning the interpretation of results and generating new theoretical frameworks. Additionally, structural changes were described in both the grey and white matter, suggesting a neuroprotective effect of cognitive remediation. Cognitive, functional and structural improvements tended to be positively correlated.Baishideng Publishing Group2020202020172020info:eu-repo/semantics/articleinfo:eu-repo/semantics/publishedVersion11 p.application/pdfapplication/pdfhttps://hdl.handle.net/2445/161360Articles publicats en revistes (Medicina)reponame:Recercat. Dipósit de la Recerca de Catalunyainstname:Varias* (Consorci de Biblioteques Universitáries de Catalunya, Centre de Serveis Científics i Acadèmics de Catalunya)InglésReproducció del document publicat a: https://doi.org/10.5498/wjp.v7.i1.34World Journal of Psychiatry, 2017, vol. 7, num. 1, p. 34-43https://doi.org/10.5498/wjp.v7.i1.34cc-by-nc (c) Baishideng Publishing Group, 2017http://creativecommons.org/licenses/by-nc/3.0/esinfo:eu-repo/semantics/openAccessoai:recercat.cat:2445/1613602026-05-29T05:05:01Z
dc.title.none.fl_str_mv Neuroimaging studies of cognitive remediation in schizophrenia: A systematic and critical review
title Neuroimaging studies of cognitive remediation in schizophrenia: A systematic and critical review
spellingShingle Neuroimaging studies of cognitive remediation in schizophrenia: A systematic and critical review
Penadés Rubio, Rafael
Esquizofrènia
Diagnòstic per la imatge
Neurociències
Schizophrenia
Diagnostic imaging
Neurosciences
title_short Neuroimaging studies of cognitive remediation in schizophrenia: A systematic and critical review
title_full Neuroimaging studies of cognitive remediation in schizophrenia: A systematic and critical review
title_fullStr Neuroimaging studies of cognitive remediation in schizophrenia: A systematic and critical review
title_full_unstemmed Neuroimaging studies of cognitive remediation in schizophrenia: A systematic and critical review
title_sort Neuroimaging studies of cognitive remediation in schizophrenia: A systematic and critical review
dc.creator.none.fl_str_mv Penadés Rubio, Rafael
González Rodríguez, Alexandre
Catalán, Rosa
Segura i Fàbregas, Bàrbara
Bernardo Arroyo, Miquel
Junqué i Plaja, Carme, 1955-
author Penadés Rubio, Rafael
author_facet Penadés Rubio, Rafael
González Rodríguez, Alexandre
Catalán, Rosa
Segura i Fàbregas, Bàrbara
Bernardo Arroyo, Miquel
Junqué i Plaja, Carme, 1955-
author_role author
author2 González Rodríguez, Alexandre
Catalán, Rosa
Segura i Fàbregas, Bàrbara
Bernardo Arroyo, Miquel
Junqué i Plaja, Carme, 1955-
author2_role author
author
author
author
author
dc.subject.none.fl_str_mv Esquizofrènia
Diagnòstic per la imatge
Neurociències
Schizophrenia
Diagnostic imaging
Neurosciences
topic Esquizofrènia
Diagnòstic per la imatge
Neurociències
Schizophrenia
Diagnostic imaging
Neurosciences
description AIM: To examine the effects of cognitive remediation therapies on brain functioning through neuroimaging procedures in patients with schizophrenia. METHODS: A systematic, computerised literature search was conducted in the PubMed/Medline and PsychInfo databases. The search was performed through February 2016 without any restrictions on language or publication date. The search was performed using the following search terms: [('cogniti*' and 'remediation' or 'training' or 'enhancement') and ('fMRI' or 'MRI' or 'PET' or 'SPECT') and (schizophrenia or schiz*)]. The search was accompanied by a manual online search and a review of the references from each of the papers selected, and those papers fulfilling our inclusion criteria were also included. RESULTS: A total of 101 studies were found, but only 18 of them fulfilled the inclusion criteria. These studies indicated that cognitive remediation improves brain activation in neuroimaging studies. The most commonly reported changes were those that involved the prefrontal and thalamic regions. Those findings are in agreement with the hypofrontality hypothesis, which proposes that frontal hypoactivation is the underlying mechanism of cognitive impairments in schizophrenia. Nonetheless, great heterogeneity among the studies was found. They presented different hypotheses, different results and different findings. The results of more recent studies interpreted cognitive recovery within broader frameworks, namely, as amelioration of the efficiency of different networks. Furthermore, advances in neuroimaging methodologies, such as the use of whole-brain analysis, tractography, graph analysis, and other sophisticated methodologies of data processing, might be conditioning the interpretation of results and generating new theoretical frameworks. Additionally, structural changes were described in both the grey and white matter, suggesting a neuroprotective effect of cognitive remediation. Cognitive, functional and structural improvements tended to be positively correlated.
publishDate 2017
dc.date.none.fl_str_mv 2017
2020
2020
2020
dc.type.none.fl_str_mv info:eu-repo/semantics/article
info:eu-repo/semantics/publishedVersion
format article
status_str publishedVersion
dc.identifier.none.fl_str_mv https://hdl.handle.net/2445/161360
url https://hdl.handle.net/2445/161360
dc.language.none.fl_str_mv Inglés
language_invalid_str_mv Inglés
dc.relation.none.fl_str_mv Reproducció del document publicat a: https://doi.org/10.5498/wjp.v7.i1.34
World Journal of Psychiatry, 2017, vol. 7, num. 1, p. 34-43
https://doi.org/10.5498/wjp.v7.i1.34
dc.rights.none.fl_str_mv cc-by-nc (c) Baishideng Publishing Group, 2017
http://creativecommons.org/licenses/by-nc/3.0/es
info:eu-repo/semantics/openAccess
rights_invalid_str_mv cc-by-nc (c) Baishideng Publishing Group, 2017
http://creativecommons.org/licenses/by-nc/3.0/es
eu_rights_str_mv openAccess
dc.format.none.fl_str_mv 11 p.
application/pdf
application/pdf
dc.publisher.none.fl_str_mv Baishideng Publishing Group
publisher.none.fl_str_mv Baishideng Publishing Group
dc.source.none.fl_str_mv Articles publicats en revistes (Medicina)
reponame:Recercat. Dipósit de la Recerca de Catalunya
instname:Varias* (Consorci de Biblioteques Universitáries de Catalunya, Centre de Serveis Científics i Acadèmics de Catalunya)
instname_str Varias* (Consorci de Biblioteques Universitáries de Catalunya, Centre de Serveis Científics i Acadèmics de Catalunya)
reponame_str Recercat. Dipósit de la Recerca de Catalunya
collection Recercat. Dipósit de la Recerca de Catalunya
repository.name.fl_str_mv
repository.mail.fl_str_mv
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