Functional ibuprofen-loaded cationic nanoemulsion: Development and optimization for dry eye disease treatment

Producción Científica

Detalles Bibliográficos
Autores: Jurišić Dukovski, Bisera, Juretić, Marina, Bračko, Danka, Randjelović, Danijela, Savić, Snežana, Crespo Moral, Mario, Diebold Luque, María Yolanda, Filipović Grčić, Jelena, Pepić, Ivan, Lovrić, Jasmina
Tipo de recurso: artículo
Estado:Versión publicada
Fecha de publicación:2020
País:España
Institución:Universidad de Valladolid
Repositorio:UVaDOC. Repositorio Documental de la Universidad de Valladolid
OAI Identifier:oai:uvadoc.uva.es:10324/64984
Acceso en línea:https://doi.org/10.1016/j.ijpharm.2019.118979
https://uvadoc.uva.es/handle/10324/64984
Access Level:acceso abierto
Palabra clave:Oftalmología
Dry eye disease
Nanoemulsion
NSAID
Enfermedad del ojo seco
Nanoemulsión
AINE
3201.09 Oftalmología
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spelling Functional ibuprofen-loaded cationic nanoemulsion: Development and optimization for dry eye disease treatmentJurišić Dukovski, BiseraJuretić, MarinaBračko, DankaRandjelović, DanijelaSavić, SnežanaCrespo Moral, MarioDiebold Luque, María YolandaFilipović Grčić, JelenaPepić, IvanLovrić, JasminaOftalmologíaDry eye diseaseNanoemulsionNSAIDEnfermedad del ojo secoNanoemulsiónAINE3201.09 OftalmologíaProducción CientíficaInflammation plays a key role in dry eye disease (DED) affecting millions of people worldwide. Non-steroidal anti-inflammatory drugs (NSAIDs) can be used topically to act on the inflammatory component of DED, but their limited aqueous solubility raises formulation issues. The aim of this study was development and optimization of functional cationic nanoemulsions (NEs) for DED treatment, as a formulation approach to circumvent solubility problems, prolong drug residence at the ocular surface and stabilize the tear film. Ibuprofen was employed as the model NSAID, chitosan as the cationic agent, and lecithin as the anionic surfactant enabling chitosan incorporation. Moreover, lecithin is a mixture of phospholipids including phosphatidylcholine and phosphatidylethanolamine, two constituents of the natural tear film important for its stability. NEs were characterized in terms of droplet size, polydispersity index, zeta-potential, pH, viscosity, osmolarity, surface tension, entrapment efficiency, stability, sterilizability and in vitro release. NEs mucoadhesive properties were tested rheologically after mixing with mucin dispersion. Biocompatibility was assessed employing 3D HCE-T cell-based model and ex vivo model using porcine corneas. The results of our study pointed out the NE formulation with 0.05% (w/w) chitosan as the lead formulation with physicochemical properties adequate for ophthalmic application, mucoadhesive character and excellent biocompatibility.Ministerio de Ciencia e Innovación y Ministerio de Universidades - AEI/FEDER (RTI2018-094071-B-C21)Beca Regional JCyL/Programa Fondo Social Europeo ORDEN EDU/128/2015Elsevier2020info:eu-repo/semantics/articleinfo:eu-repo/semantics/publishedVersionapplication/pdfhttps://doi.org/10.1016/j.ijpharm.2019.118979https://uvadoc.uva.es/handle/10324/64984reponame:UVaDOC. Repositorio Documental de la Universidad de Valladolidinstname:Universidad de ValladolidIngléshttps://www.sciencedirect.com/science/article/pii/S0378517319310397?via%3Dihubinfo:eu-repo/semantics/openAccesshttp://creativecommons.org/licenses/by-nc-nd/4.0/oai:uvadoc.uva.es:10324/649842026-06-13T12:44:47Z
dc.title.none.fl_str_mv Functional ibuprofen-loaded cationic nanoemulsion: Development and optimization for dry eye disease treatment
title Functional ibuprofen-loaded cationic nanoemulsion: Development and optimization for dry eye disease treatment
spellingShingle Functional ibuprofen-loaded cationic nanoemulsion: Development and optimization for dry eye disease treatment
Jurišić Dukovski, Bisera
Oftalmología
Dry eye disease
Nanoemulsion
NSAID
Enfermedad del ojo seco
Nanoemulsión
AINE
3201.09 Oftalmología
title_short Functional ibuprofen-loaded cationic nanoemulsion: Development and optimization for dry eye disease treatment
title_full Functional ibuprofen-loaded cationic nanoemulsion: Development and optimization for dry eye disease treatment
title_fullStr Functional ibuprofen-loaded cationic nanoemulsion: Development and optimization for dry eye disease treatment
title_full_unstemmed Functional ibuprofen-loaded cationic nanoemulsion: Development and optimization for dry eye disease treatment
title_sort Functional ibuprofen-loaded cationic nanoemulsion: Development and optimization for dry eye disease treatment
dc.creator.none.fl_str_mv Jurišić Dukovski, Bisera
Juretić, Marina
Bračko, Danka
Randjelović, Danijela
Savić, Snežana
Crespo Moral, Mario
Diebold Luque, María Yolanda
Filipović Grčić, Jelena
Pepić, Ivan
Lovrić, Jasmina
author Jurišić Dukovski, Bisera
author_facet Jurišić Dukovski, Bisera
Juretić, Marina
Bračko, Danka
Randjelović, Danijela
Savić, Snežana
Crespo Moral, Mario
Diebold Luque, María Yolanda
Filipović Grčić, Jelena
Pepić, Ivan
Lovrić, Jasmina
author_role author
author2 Juretić, Marina
Bračko, Danka
Randjelović, Danijela
Savić, Snežana
Crespo Moral, Mario
Diebold Luque, María Yolanda
Filipović Grčić, Jelena
Pepić, Ivan
Lovrić, Jasmina
author2_role author
author
author
author
author
author
author
author
author
dc.subject.none.fl_str_mv Oftalmología
Dry eye disease
Nanoemulsion
NSAID
Enfermedad del ojo seco
Nanoemulsión
AINE
3201.09 Oftalmología
topic Oftalmología
Dry eye disease
Nanoemulsion
NSAID
Enfermedad del ojo seco
Nanoemulsión
AINE
3201.09 Oftalmología
description Producción Científica
publishDate 2020
dc.date.none.fl_str_mv 2020
dc.type.none.fl_str_mv info:eu-repo/semantics/article
info:eu-repo/semantics/publishedVersion
format article
status_str publishedVersion
dc.identifier.none.fl_str_mv https://doi.org/10.1016/j.ijpharm.2019.118979
https://uvadoc.uva.es/handle/10324/64984
url https://doi.org/10.1016/j.ijpharm.2019.118979
https://uvadoc.uva.es/handle/10324/64984
dc.language.none.fl_str_mv Inglés
language_invalid_str_mv Inglés
dc.relation.none.fl_str_mv https://www.sciencedirect.com/science/article/pii/S0378517319310397?via%3Dihub
dc.rights.none.fl_str_mv info:eu-repo/semantics/openAccess
http://creativecommons.org/licenses/by-nc-nd/4.0/
eu_rights_str_mv openAccess
rights_invalid_str_mv http://creativecommons.org/licenses/by-nc-nd/4.0/
dc.format.none.fl_str_mv application/pdf
dc.publisher.none.fl_str_mv Elsevier
publisher.none.fl_str_mv Elsevier
dc.source.none.fl_str_mv reponame:UVaDOC. Repositorio Documental de la Universidad de Valladolid
instname:Universidad de Valladolid
instname_str Universidad de Valladolid
reponame_str UVaDOC. Repositorio Documental de la Universidad de Valladolid
collection UVaDOC. Repositorio Documental de la Universidad de Valladolid
repository.name.fl_str_mv
repository.mail.fl_str_mv
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