An immunohistochemical study of cyclooxygenase-2 expression in canine multicentric lymphoma
Cyclooxygenase-2 (COX-2) expression has been associated with development and progression in spontaneous human and dogs tumors. Studies demonstrated that non-steroidal anti-inflammatory drugs, which inhibit COX enzyme, may be used in the treatment of some tumors. Lymphoma is a systemic disease and th...
| Autores: | , , , , |
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| Tipo de recurso: | artículo |
| Fecha de publicación: | 2011 |
| País: | España |
| Institución: | Universidad de Murcia |
| Repositorio: | DIGITUM. Depósito Digital Institucional de la Universidad de Murcia |
| OAI Identifier: | oai:digitum.um.es:10201/28842 |
| Acceso en línea: | http://hdl.handle.net/10201/28842 |
| Access Level: | acceso abierto |
| Palabra clave: | Cancer Dog 636 - Veterinaria. Explotación y cría de animales. Cría del ganado y de animales domésticos |
| Sumario: | Cyclooxygenase-2 (COX-2) expression has been associated with development and progression in spontaneous human and dogs tumors. Studies demonstrated that non-steroidal anti-inflammatory drugs, which inhibit COX enzyme, may be used in the treatment of some tumors. Lymphoma is a systemic disease and the most common hematological malignancy in dogs. There are few studies about COX-2 expression in human and canine lymphoma. In this study, immunohistochemical evaluation for COX-2 expression was performed in 12 dogs with multicentric lymphoma. The diagnosis was confirmed by histopathological examination. Six samples of normal lymph nodes were either used in the study. No COX-2 immunoreactivity was detected in all samples from canine lymphoma and normal lymph nodes, as well previous studies in canine lymphoma. |
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