Structural brain imaging studies offer clues about the effects of the shared genetic etiology among neuropsychiatric disorders

Malalties; Genètica

Detalles Bibliográficos
Autores: Radonjić, Nevena V., Hess, Jonathan L., Rovira Lorente, Paula, Andreassen, Ole, Buitelaar, Jan K., Ching, Christopher R. K.
Tipo de recurso: artículo
Estado:Versión publicada
Fecha de publicación:2021
País:España
Institución:Varias* (Consorci de Biblioteques Universitáries de Catalunya, Centre de Serveis Científics i Acadèmics de Catalunya)
Repositorio:Recercat. Dipósit de la Recerca de Catalunya
OAI Identifier:oai:recercat.cat:11351/6875
Acceso en línea:https://hdl.handle.net/11351/6875
http://hdl.handle.net/11351/6875
Access Level:acceso abierto
Palabra clave:Cervell - Imatgeria
Malalties mentals - Aspectes genètics
ANATOMY::Nervous System::Central Nervous System::Brain
Other subheadings::Other subheadings::Other subheadings::/diagnostic imaging
PSYCHIATRY AND PSYCHOLOGY::Mental Disorders
Other subheadings::Other subheadings::Other subheadings::/genetics
ANATOMÍA::sistema nervioso::sistema nervioso central::encéfalo
Otros calificadores::Otros calificadores::Otros calificadores::/diagnóstico por imagen
PSIQUIATRÍA Y PSICOLOGÍA::trastornos mentales
Otros calificadores::Otros calificadores::Otros calificadores::/genética
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oai_identifier_str oai:recercat.cat:11351/6875
network_acronym_str ES
network_name_str España
repository_id_str
spelling Structural brain imaging studies offer clues about the effects of the shared genetic etiology among neuropsychiatric disordersRadonjić, Nevena V.Hess, Jonathan L.Rovira Lorente, PaulaAndreassen, OleBuitelaar, Jan K.Ching, Christopher R. K.Cervell - ImatgeriaMalalties mentals - Aspectes genèticsANATOMY::Nervous System::Central Nervous System::BrainOther subheadings::Other subheadings::Other subheadings::/diagnostic imagingPSYCHIATRY AND PSYCHOLOGY::Mental DisordersOther subheadings::Other subheadings::Other subheadings::/geneticsANATOMÍA::sistema nervioso::sistema nervioso central::encéfaloOtros calificadores::Otros calificadores::Otros calificadores::/diagnóstico por imagenPSIQUIATRÍA Y PSICOLOGÍA::trastornos mentalesOtros calificadores::Otros calificadores::Otros calificadores::/genéticaMalalties; GenèticaEnfermedades; GenéticaDiseases; GeneticsGenomewide association studies have found significant genetic correlations among many neuropsychiatric disorders. In contrast, we know much less about the degree to which structural brain alterations are similar among disorders and, if so, the degree to which such similarities have a genetic etiology. From the Enhancing Neuroimaging Genetics through Meta-Analysis (ENIGMA) consortium, we acquired standardized mean differences (SMDs) in regional brain volume and cortical thickness between cases and controls. We had data on 41 brain regions for: attention-deficit/hyperactivity disorder (ADHD), autism spectrum disorder (ASD), bipolar disorder (BD), epilepsy, major depressive disorder (MDD), obsessive compulsive disorder (OCD), and schizophrenia (SCZ). These data had been derived from 24,360 patients and 37,425 controls. The SMDs were significantly correlated between SCZ and BD, OCD, MDD, and ASD. MDD was positively correlated with BD and OCD. BD was positively correlated with OCD and negatively correlated with ADHD. These pairwise correlations among disorders were correlated with the corresponding pairwise correlations among disorders derived from genomewide association studies (r = 0.494). Our results show substantial similarities in sMRI phenotypes among neuropsychiatric disorders and suggest that these similarities are accounted for, in part, by corresponding similarities in common genetic variant architectures.Springer NatureInstitut Català de la Salut[Radonjić NV] Department of Psychiatry, SUNY Upstate Medical University, Syracuse, NY, USA. [Hess JL] Departments of Psychiatry and of Neuroscience and Physiology, SUNY Upstate Medical University, Syracuse, NY, USA. [Rovira P] Unitat de Genètica Psiquiàtrica, Grup de Psiquiatria, Salut Mental i Addiccions, Vall d’Hebron Institut de Recerca (VHIR), Barcelona, Spain. Universitat Autònoma de Barcelona, Bellaterra, Spain. Servei de Psiquiatria, Vall d’Hebron Hospital Universitari, Barcelona, Spain. [Andreassen O] NORMENT—Institute of Clinical Medicine, Division of Mental Health and Addiction, Oslo University Hospital, University of Oslo, Oslo, Norway. [Buitelaar JK] Radboudumc, Radboud University Medical Center, Nijmegen, The Netherlands. Donders Institute for Brain, Cognition and Behaviour, Radboud University Medical Center, Nijmegen, The Netherlands. Department of Cognitive Neuroscience, Radboud. [Ching CRK] Imaging Genetics Center, USC Mark and Mary Stevens Neuroimaging and Informatics Institute, Keck School of Medicine of the University of Southern California, Marina Del Rey, CA, USAVall d'Hebron Barcelona Hospital Campus202220222021info:eu-repo/semantics/articleinfo:eu-repo/semantics/publishedVersionapplication/pdfapplication/pdfhttps://hdl.handle.net/11351/6875http://hdl.handle.net/11351/6875Scientiareponame:Recercat. Dipósit de la Recerca de Catalunyainstname:Varias* (Consorci de Biblioteques Universitáries de Catalunya, Centre de Serveis Científics i Acadèmics de Catalunya)InglésMolecular Psychiatry;26https://doi.org/10.1038/s41380-020-01002-zAttribution 4.0 Internationalhttp://creativecommons.org/licenses/by/4.0/info:eu-repo/semantics/openAccessoai:recercat.cat:11351/68752026-05-29T05:05:01Z
dc.title.none.fl_str_mv Structural brain imaging studies offer clues about the effects of the shared genetic etiology among neuropsychiatric disorders
title Structural brain imaging studies offer clues about the effects of the shared genetic etiology among neuropsychiatric disorders
spellingShingle Structural brain imaging studies offer clues about the effects of the shared genetic etiology among neuropsychiatric disorders
Radonjić, Nevena V.
Cervell - Imatgeria
Malalties mentals - Aspectes genètics
ANATOMY::Nervous System::Central Nervous System::Brain
Other subheadings::Other subheadings::Other subheadings::/diagnostic imaging
PSYCHIATRY AND PSYCHOLOGY::Mental Disorders
Other subheadings::Other subheadings::Other subheadings::/genetics
ANATOMÍA::sistema nervioso::sistema nervioso central::encéfalo
Otros calificadores::Otros calificadores::Otros calificadores::/diagnóstico por imagen
PSIQUIATRÍA Y PSICOLOGÍA::trastornos mentales
Otros calificadores::Otros calificadores::Otros calificadores::/genética
title_short Structural brain imaging studies offer clues about the effects of the shared genetic etiology among neuropsychiatric disorders
title_full Structural brain imaging studies offer clues about the effects of the shared genetic etiology among neuropsychiatric disorders
title_fullStr Structural brain imaging studies offer clues about the effects of the shared genetic etiology among neuropsychiatric disorders
title_full_unstemmed Structural brain imaging studies offer clues about the effects of the shared genetic etiology among neuropsychiatric disorders
title_sort Structural brain imaging studies offer clues about the effects of the shared genetic etiology among neuropsychiatric disorders
dc.creator.none.fl_str_mv Radonjić, Nevena V.
Hess, Jonathan L.
Rovira Lorente, Paula
Andreassen, Ole
Buitelaar, Jan K.
Ching, Christopher R. K.
author Radonjić, Nevena V.
author_facet Radonjić, Nevena V.
Hess, Jonathan L.
Rovira Lorente, Paula
Andreassen, Ole
Buitelaar, Jan K.
Ching, Christopher R. K.
author_role author
author2 Hess, Jonathan L.
Rovira Lorente, Paula
Andreassen, Ole
Buitelaar, Jan K.
Ching, Christopher R. K.
author2_role author
author
author
author
author
dc.contributor.none.fl_str_mv Institut Català de la Salut
[Radonjić NV] Department of Psychiatry, SUNY Upstate Medical University, Syracuse, NY, USA. [Hess JL] Departments of Psychiatry and of Neuroscience and Physiology, SUNY Upstate Medical University, Syracuse, NY, USA. [Rovira P] Unitat de Genètica Psiquiàtrica, Grup de Psiquiatria, Salut Mental i Addiccions, Vall d’Hebron Institut de Recerca (VHIR), Barcelona, Spain. Universitat Autònoma de Barcelona, Bellaterra, Spain. Servei de Psiquiatria, Vall d’Hebron Hospital Universitari, Barcelona, Spain. [Andreassen O] NORMENT—Institute of Clinical Medicine, Division of Mental Health and Addiction, Oslo University Hospital, University of Oslo, Oslo, Norway. [Buitelaar JK] Radboudumc, Radboud University Medical Center, Nijmegen, The Netherlands. Donders Institute for Brain, Cognition and Behaviour, Radboud University Medical Center, Nijmegen, The Netherlands. Department of Cognitive Neuroscience, Radboud. [Ching CRK] Imaging Genetics Center, USC Mark and Mary Stevens Neuroimaging and Informatics Institute, Keck School of Medicine of the University of Southern California, Marina Del Rey, CA, USA
Vall d'Hebron Barcelona Hospital Campus
dc.subject.none.fl_str_mv Cervell - Imatgeria
Malalties mentals - Aspectes genètics
ANATOMY::Nervous System::Central Nervous System::Brain
Other subheadings::Other subheadings::Other subheadings::/diagnostic imaging
PSYCHIATRY AND PSYCHOLOGY::Mental Disorders
Other subheadings::Other subheadings::Other subheadings::/genetics
ANATOMÍA::sistema nervioso::sistema nervioso central::encéfalo
Otros calificadores::Otros calificadores::Otros calificadores::/diagnóstico por imagen
PSIQUIATRÍA Y PSICOLOGÍA::trastornos mentales
Otros calificadores::Otros calificadores::Otros calificadores::/genética
topic Cervell - Imatgeria
Malalties mentals - Aspectes genètics
ANATOMY::Nervous System::Central Nervous System::Brain
Other subheadings::Other subheadings::Other subheadings::/diagnostic imaging
PSYCHIATRY AND PSYCHOLOGY::Mental Disorders
Other subheadings::Other subheadings::Other subheadings::/genetics
ANATOMÍA::sistema nervioso::sistema nervioso central::encéfalo
Otros calificadores::Otros calificadores::Otros calificadores::/diagnóstico por imagen
PSIQUIATRÍA Y PSICOLOGÍA::trastornos mentales
Otros calificadores::Otros calificadores::Otros calificadores::/genética
description Malalties; Genètica
publishDate 2021
dc.date.none.fl_str_mv 2021
2022
2022
dc.type.none.fl_str_mv info:eu-repo/semantics/article
info:eu-repo/semantics/publishedVersion
format article
status_str publishedVersion
dc.identifier.none.fl_str_mv https://hdl.handle.net/11351/6875
http://hdl.handle.net/11351/6875
url https://hdl.handle.net/11351/6875
http://hdl.handle.net/11351/6875
dc.language.none.fl_str_mv Inglés
language_invalid_str_mv Inglés
dc.relation.none.fl_str_mv Molecular Psychiatry;26
https://doi.org/10.1038/s41380-020-01002-z
dc.rights.none.fl_str_mv Attribution 4.0 International
http://creativecommons.org/licenses/by/4.0/
info:eu-repo/semantics/openAccess
rights_invalid_str_mv Attribution 4.0 International
http://creativecommons.org/licenses/by/4.0/
eu_rights_str_mv openAccess
dc.format.none.fl_str_mv application/pdf
application/pdf
dc.publisher.none.fl_str_mv Springer Nature
publisher.none.fl_str_mv Springer Nature
dc.source.none.fl_str_mv Scientia
reponame:Recercat. Dipósit de la Recerca de Catalunya
instname:Varias* (Consorci de Biblioteques Universitáries de Catalunya, Centre de Serveis Científics i Acadèmics de Catalunya)
instname_str Varias* (Consorci de Biblioteques Universitáries de Catalunya, Centre de Serveis Científics i Acadèmics de Catalunya)
reponame_str Recercat. Dipósit de la Recerca de Catalunya
collection Recercat. Dipósit de la Recerca de Catalunya
repository.name.fl_str_mv
repository.mail.fl_str_mv
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score 15.81155

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