Purpose in life promotes resilience to age-related brain burden in middle-aged adults
Disease-modifying agents to counteract cognitive impairment in older age remain elusive. Hence, identifying modifiable factors promoting resilience, as the capacity of the brain to maintain cognition and function with aging and disease, is paramount. In Alzheimer's disease (AD), education and o...
| Autores: | , , , , , , , , , , , |
|---|---|
| Tipo de recurso: | artículo |
| Fecha de publicación: | 2023 |
| País: | España |
| Institución: | Universitat Autònoma de Barcelona |
| Repositorio: | Dipòsit Digital de Documents de la UAB |
| Idioma: | inglés |
| OAI Identifier: | oai:ddd.uab.cat:302784 |
| Acceso en línea: | https://ddd.uab.cat/record/302784 https://dx.doi.org/urn:doi:10.1186/s13195-023-01198-6 |
| Access Level: | acceso abierto |
| Palabra clave: | Brain reserve Cognition Cognitive reserve Neuroimaging Psychological well-being Purpose in life Resilience |
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Purpose in life promotes resilience to age-related brain burden in middle-aged adultsAbellaneda Pérez, Kilian|||0000-0001-6447-1248Cattaneo, Gabriele|||0000-0002-7411-6829Cabello-Toscano, María|||0000-0001-5066-3476Solana-Sánchez, Javier|||0000-0003-0880-7856Mulet-Pons, L.Vaqué-Alcázar, Lídia|||0000-0002-6776-6559Perellón-Alfonso, R.Solé-Padullés, C.Bargalló, Núria|||0000-0001-6284-5402Tormos, Jose M.|||0000-0002-8764-2289Pascual Leone, Álvaro|||0000-0001-8975-0382Bartrés-Faz, David|||0000-0001-6020-4118Brain reserveCognitionCognitive reserveNeuroimagingPsychological well-beingPurpose in lifeResilienceDisease-modifying agents to counteract cognitive impairment in older age remain elusive. Hence, identifying modifiable factors promoting resilience, as the capacity of the brain to maintain cognition and function with aging and disease, is paramount. In Alzheimer's disease (AD), education and occupation are typical cognitive reserve proxies. However, the importance of psychological factors is being increasingly recognized, as their operating biological mechanisms are elucidated. Purpose in life (PiL), one of the pillars of psychological well-being, has previously been found to reduce the deleterious effects of AD-related pathological changes on cognition. However, whether PiL operates as a resilience factor in middle-aged individuals and what are the underlying neural mechanisms remain unknown. Data was obtained from 624 middle-aged adults (mean age 53.71 ± 6.9; 303 women) from the Barcelona Brain Health Initiative cohort. Individuals with lower (LP; N = 146) and higher (HP; N = 100) PiL rates, according to the division of this variable into quintiles, were compared in terms of cognitive status, a measure reflecting brain burden (white matter lesions; WMLs), and resting-state functional connectivity, examining system segregation (SyS) parameters using 14 common brain circuits. Neuropsychological status and WMLs burden did not differ between the PiL groups. However, in the LP group, greater WMLs entailed a negative impact on executive functions. Subjects in the HP group showed lower SyS of the dorsal default-mode network (dDMN), indicating lesser segregation of this network from other brain circuits. Specifically, HP individuals had greater inter-network connectivity between specific dDMN nodes, including the frontal cortex, the hippocampal formation, the midcingulate region, and the rest of the brain. Greater functional connectivity in some of these nodes positively correlated with cognitive performance. Expanding previous findings on AD pathology and advanced age, the present results suggest that higher rates of PiL may promote resilience against brain changes already observable in middle age. Furthermore, having a purposeful life implies larger functional integration of the dDMN, which may potentially reflect greater brain reserve associated to better cognitive function.Universitat Autònoma de Barcelona 22023-01-0120232023-01-01Articlehttp://purl.org/coar/resource_type/c_6501VoRhttp://purl.org/coar/version/c_970fb48d4fbd8a85info:eu-repo/semantics/articleapplication/pdfhttps://ddd.uab.cat/record/302784https://dx.doi.org/urn:doi:10.1186/s13195-023-01198-6reponame:Dipòsit Digital de Documents de la UABinstname:Universitat Autònoma de BarcelonaInglésengopen accesshttp://purl.org/coar/access_right/c_abf2Aquest document està subjecte a una llicència d'ús Creative Commons. Es permet la reproducció total o parcial, la distribució, la comunicació pública de l'obra i la creació d'obres derivades, fins i tot amb finalitats comercials, sempre i quan es reconegui l'autoria de l'obra original.https://creativecommons.org/licenses/by/4.0/info:eu-repo/semantics/openAccessoai:ddd.uab.cat:3027842026-06-06T12:50:31Z |
| dc.title.none.fl_str_mv |
Purpose in life promotes resilience to age-related brain burden in middle-aged adults |
| title |
Purpose in life promotes resilience to age-related brain burden in middle-aged adults |
| spellingShingle |
Purpose in life promotes resilience to age-related brain burden in middle-aged adults Abellaneda Pérez, Kilian|||0000-0001-6447-1248 Brain reserve Cognition Cognitive reserve Neuroimaging Psychological well-being Purpose in life Resilience |
| title_short |
Purpose in life promotes resilience to age-related brain burden in middle-aged adults |
| title_full |
Purpose in life promotes resilience to age-related brain burden in middle-aged adults |
| title_fullStr |
Purpose in life promotes resilience to age-related brain burden in middle-aged adults |
| title_full_unstemmed |
Purpose in life promotes resilience to age-related brain burden in middle-aged adults |
| title_sort |
Purpose in life promotes resilience to age-related brain burden in middle-aged adults |
| dc.creator.none.fl_str_mv |
Abellaneda Pérez, Kilian|||0000-0001-6447-1248 Cattaneo, Gabriele|||0000-0002-7411-6829 Cabello-Toscano, María|||0000-0001-5066-3476 Solana-Sánchez, Javier|||0000-0003-0880-7856 Mulet-Pons, L. Vaqué-Alcázar, Lídia|||0000-0002-6776-6559 Perellón-Alfonso, R. Solé-Padullés, C. Bargalló, Núria|||0000-0001-6284-5402 Tormos, Jose M.|||0000-0002-8764-2289 Pascual Leone, Álvaro|||0000-0001-8975-0382 Bartrés-Faz, David|||0000-0001-6020-4118 |
| author |
Abellaneda Pérez, Kilian|||0000-0001-6447-1248 |
| author_facet |
Abellaneda Pérez, Kilian|||0000-0001-6447-1248 Cattaneo, Gabriele|||0000-0002-7411-6829 Cabello-Toscano, María|||0000-0001-5066-3476 Solana-Sánchez, Javier|||0000-0003-0880-7856 Mulet-Pons, L. Vaqué-Alcázar, Lídia|||0000-0002-6776-6559 Perellón-Alfonso, R. Solé-Padullés, C. Bargalló, Núria|||0000-0001-6284-5402 Tormos, Jose M.|||0000-0002-8764-2289 Pascual Leone, Álvaro|||0000-0001-8975-0382 Bartrés-Faz, David|||0000-0001-6020-4118 |
| author_role |
author |
| author2 |
Cattaneo, Gabriele|||0000-0002-7411-6829 Cabello-Toscano, María|||0000-0001-5066-3476 Solana-Sánchez, Javier|||0000-0003-0880-7856 Mulet-Pons, L. Vaqué-Alcázar, Lídia|||0000-0002-6776-6559 Perellón-Alfonso, R. Solé-Padullés, C. Bargalló, Núria|||0000-0001-6284-5402 Tormos, Jose M.|||0000-0002-8764-2289 Pascual Leone, Álvaro|||0000-0001-8975-0382 Bartrés-Faz, David|||0000-0001-6020-4118 |
| author2_role |
author author author author author author author author author author author |
| dc.contributor.none.fl_str_mv |
Universitat Autònoma de Barcelona |
| dc.subject.none.fl_str_mv |
Brain reserve Cognition Cognitive reserve Neuroimaging Psychological well-being Purpose in life Resilience |
| topic |
Brain reserve Cognition Cognitive reserve Neuroimaging Psychological well-being Purpose in life Resilience |
| description |
Disease-modifying agents to counteract cognitive impairment in older age remain elusive. Hence, identifying modifiable factors promoting resilience, as the capacity of the brain to maintain cognition and function with aging and disease, is paramount. In Alzheimer's disease (AD), education and occupation are typical cognitive reserve proxies. However, the importance of psychological factors is being increasingly recognized, as their operating biological mechanisms are elucidated. Purpose in life (PiL), one of the pillars of psychological well-being, has previously been found to reduce the deleterious effects of AD-related pathological changes on cognition. However, whether PiL operates as a resilience factor in middle-aged individuals and what are the underlying neural mechanisms remain unknown. Data was obtained from 624 middle-aged adults (mean age 53.71 ± 6.9; 303 women) from the Barcelona Brain Health Initiative cohort. Individuals with lower (LP; N = 146) and higher (HP; N = 100) PiL rates, according to the division of this variable into quintiles, were compared in terms of cognitive status, a measure reflecting brain burden (white matter lesions; WMLs), and resting-state functional connectivity, examining system segregation (SyS) parameters using 14 common brain circuits. Neuropsychological status and WMLs burden did not differ between the PiL groups. However, in the LP group, greater WMLs entailed a negative impact on executive functions. Subjects in the HP group showed lower SyS of the dorsal default-mode network (dDMN), indicating lesser segregation of this network from other brain circuits. Specifically, HP individuals had greater inter-network connectivity between specific dDMN nodes, including the frontal cortex, the hippocampal formation, the midcingulate region, and the rest of the brain. Greater functional connectivity in some of these nodes positively correlated with cognitive performance. Expanding previous findings on AD pathology and advanced age, the present results suggest that higher rates of PiL may promote resilience against brain changes already observable in middle age. Furthermore, having a purposeful life implies larger functional integration of the dDMN, which may potentially reflect greater brain reserve associated to better cognitive function. |
| publishDate |
2023 |
| dc.date.none.fl_str_mv |
2 2023-01-01 2023 2023-01-01 |
| dc.type.none.fl_str_mv |
Article http://purl.org/coar/resource_type/c_6501 VoR http://purl.org/coar/version/c_970fb48d4fbd8a85 |
| dc.type.openaire.fl_str_mv |
info:eu-repo/semantics/article |
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article |
| dc.identifier.none.fl_str_mv |
https://ddd.uab.cat/record/302784 https://dx.doi.org/urn:doi:10.1186/s13195-023-01198-6 |
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https://ddd.uab.cat/record/302784 https://dx.doi.org/urn:doi:10.1186/s13195-023-01198-6 |
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Inglés eng |
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Inglés |
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eng |
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open access http://purl.org/coar/access_right/c_abf2 https://creativecommons.org/licenses/by/4.0/ |
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info:eu-repo/semantics/openAccess |
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open access http://purl.org/coar/access_right/c_abf2 https://creativecommons.org/licenses/by/4.0/ |
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openAccess |
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