Metformin as an archetype immuno-metabolic adjuvant for cancer immunotherapy

The development of a single immuno-metabolic adjuvant capable of modulating, in the appropriate direction and intensity, the complex antagonistic and symbiotic interplays between tumor cells, immune cells, and the gut microbiota may appear pharmacologically implausible. Metformin might help solve th...

Descripción completa

Detalles Bibliográficos
Autores: Verdura, Sara, Cuyàs, Elisabet, Martin Castillo, Begoña, Menéndez Menéndez, Javier Abel
Tipo de recurso: artículo
Estado:Versión publicada
Fecha de publicación:2019
País:España
Institución:Varias* (Consorci de Biblioteques Universitáries de Catalunya, Centre de Serveis Científics i Acadèmics de Catalunya)
Repositorio:Recercat. Dipósit de la Recerca de Catalunya
OAI Identifier:oai:recercat.cat:10256/18299
Acceso en línea:http://hdl.handle.net/10256/18299
Access Level:acceso abierto
Palabra clave:Metformina
Metformin
Adjuvants immunològics
Immunological adjuvants
Càncer -- Immunoteràpia
Cancer -- Immunotherapy
Càncer -- Tractament
Cancer -- Treatment
Descripción
Sumario:The development of a single immuno-metabolic adjuvant capable of modulating, in the appropriate direction and intensity, the complex antagonistic and symbiotic interplays between tumor cells, immune cells, and the gut microbiota may appear pharmacologically implausible. Metformin might help solve this conundrum and beneficially impact the state of cancer-immune system interactions