Fetal ischemia monitoring with in vivo implanted electrochemical multiparametric microsensors

Under intrauterine growth restriction (IUGR), abnormal attainment of the nutrients and oxygen by the fetus restricts the normal evolution of the prenatal causing in many cases high morbidity being one of the top-ten causes of neonatal death. The current gold standards in hospitals to detect this rel...

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Autores: Dulay, Samuel, Rivas, Lourdes, Pla, Laura, Berdún Marin, Sergio, Eixarch Roca, Elisenda, Gratacós Solsona, Eduard, Illa Armengol, Míriam, Mir Llorente, Mònica, Samitier i Martí, Josep
Tipo de recurso: artículo
Estado:Versión publicada
Fecha de publicación:2021
País:España
Institución:Varias* (Consorci de Biblioteques Universitáries de Catalunya, Centre de Serveis Científics i Acadèmics de Catalunya)
Repositorio:Recercat. Dipósit de la Recerca de Catalunya
OAI Identifier:oai:recercat.cat:2445/182131
Acceso en línea:https://hdl.handle.net/2445/182131
Access Level:acceso abierto
Palabra clave:Monitoratge fetal
Isquèmia
Fetal monitoring
Ischemia
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spelling Fetal ischemia monitoring with in vivo implanted electrochemical multiparametric microsensorsDulay, SamuelRivas, LourdesPla, LauraBerdún Marin, SergioEixarch Roca, ElisendaGratacós Solsona, EduardIlla Armengol, MíriamMir Llorente, MònicaSamitier i Martí, JosepMonitoratge fetalIsquèmiaFetal monitoringIschemiaUnder intrauterine growth restriction (IUGR), abnormal attainment of the nutrients and oxygen by the fetus restricts the normal evolution of the prenatal causing in many cases high morbidity being one of the top-ten causes of neonatal death. The current gold standards in hospitals to detect this relevant problem is the clinical observation by echography, cardiotocography and Doppler. These qualitative techniques are not conclusive and requires risky invasive fetal scalp blood testing and/or amniocentesis. We developed micro-implantable multiparametric electrochemical sensors for measuring ischemia in real time in fetal tissue and vascular. This implantable technology is designed to continuous monitoring for an early detection of ischemia to avoid potential fetal injury. Two miniaturized electrochemical sensors were developed based on oxygen and pH detection. The sensors were optimized in vitro under controlled concentration, to assess the selectivity and sensitivity required. The sensors were then validated in vivo in the ewe fetus model, by means of their insertion in the muscle leg and inside the iliac artery of the fetus. Ischemia was achieved by gradually obstructing the umbilical cord to regulate the amount of blood reaching the fetus. An important challenge in fetal monitoring is the detection of low levels of oxygen and pH changes under ischemic conditions, requiring high sensitivity sensors. Significant differences were observed in both; pH and pO2 sensors under changes from normoxia to hypoxia states in the fetus tissue and vascular with both sensors. Herein, we demonstrate the feasibility of the developed sensors for future fetal monitoring in medical applications.2022202220212022info:eu-repo/semantics/articleinfo:eu-repo/semantics/publishedVersion11 p.application/pdfhttps://hdl.handle.net/2445/182131Articles publicats en revistes (Enginyeria Electrònica i Biomèdica)reponame:Recercat. Dipósit de la Recerca de Catalunyainstname:Varias* (Consorci de Biblioteques Universitáries de Catalunya, Centre de Serveis Científics i Acadèmics de Catalunya)InglésReproducció del document publicat a: https://doi.org/10.1186/s13036-021-00280-7Journal Of Biological Engineering, 2021, num. 15https://doi.org/10.1186/s13036-021-00280-7info:eu-repo/grantAgreement/EC/H2020/712754cc by (c) Dulay, Samuel et al, 2021http://creativecommons.org/licenses/by/3.0/es/info:eu-repo/semantics/openAccessoai:recercat.cat:2445/1821312026-05-29T05:05:01Z
dc.title.none.fl_str_mv Fetal ischemia monitoring with in vivo implanted electrochemical multiparametric microsensors
title Fetal ischemia monitoring with in vivo implanted electrochemical multiparametric microsensors
spellingShingle Fetal ischemia monitoring with in vivo implanted electrochemical multiparametric microsensors
Dulay, Samuel
Monitoratge fetal
Isquèmia
Fetal monitoring
Ischemia
title_short Fetal ischemia monitoring with in vivo implanted electrochemical multiparametric microsensors
title_full Fetal ischemia monitoring with in vivo implanted electrochemical multiparametric microsensors
title_fullStr Fetal ischemia monitoring with in vivo implanted electrochemical multiparametric microsensors
title_full_unstemmed Fetal ischemia monitoring with in vivo implanted electrochemical multiparametric microsensors
title_sort Fetal ischemia monitoring with in vivo implanted electrochemical multiparametric microsensors
dc.creator.none.fl_str_mv Dulay, Samuel
Rivas, Lourdes
Pla, Laura
Berdún Marin, Sergio
Eixarch Roca, Elisenda
Gratacós Solsona, Eduard
Illa Armengol, Míriam
Mir Llorente, Mònica
Samitier i Martí, Josep
author Dulay, Samuel
author_facet Dulay, Samuel
Rivas, Lourdes
Pla, Laura
Berdún Marin, Sergio
Eixarch Roca, Elisenda
Gratacós Solsona, Eduard
Illa Armengol, Míriam
Mir Llorente, Mònica
Samitier i Martí, Josep
author_role author
author2 Rivas, Lourdes
Pla, Laura
Berdún Marin, Sergio
Eixarch Roca, Elisenda
Gratacós Solsona, Eduard
Illa Armengol, Míriam
Mir Llorente, Mònica
Samitier i Martí, Josep
author2_role author
author
author
author
author
author
author
author
dc.subject.none.fl_str_mv Monitoratge fetal
Isquèmia
Fetal monitoring
Ischemia
topic Monitoratge fetal
Isquèmia
Fetal monitoring
Ischemia
description Under intrauterine growth restriction (IUGR), abnormal attainment of the nutrients and oxygen by the fetus restricts the normal evolution of the prenatal causing in many cases high morbidity being one of the top-ten causes of neonatal death. The current gold standards in hospitals to detect this relevant problem is the clinical observation by echography, cardiotocography and Doppler. These qualitative techniques are not conclusive and requires risky invasive fetal scalp blood testing and/or amniocentesis. We developed micro-implantable multiparametric electrochemical sensors for measuring ischemia in real time in fetal tissue and vascular. This implantable technology is designed to continuous monitoring for an early detection of ischemia to avoid potential fetal injury. Two miniaturized electrochemical sensors were developed based on oxygen and pH detection. The sensors were optimized in vitro under controlled concentration, to assess the selectivity and sensitivity required. The sensors were then validated in vivo in the ewe fetus model, by means of their insertion in the muscle leg and inside the iliac artery of the fetus. Ischemia was achieved by gradually obstructing the umbilical cord to regulate the amount of blood reaching the fetus. An important challenge in fetal monitoring is the detection of low levels of oxygen and pH changes under ischemic conditions, requiring high sensitivity sensors. Significant differences were observed in both; pH and pO2 sensors under changes from normoxia to hypoxia states in the fetus tissue and vascular with both sensors. Herein, we demonstrate the feasibility of the developed sensors for future fetal monitoring in medical applications.
publishDate 2021
dc.date.none.fl_str_mv 2021
2022
2022
2022
dc.type.none.fl_str_mv info:eu-repo/semantics/article
info:eu-repo/semantics/publishedVersion
format article
status_str publishedVersion
dc.identifier.none.fl_str_mv https://hdl.handle.net/2445/182131
url https://hdl.handle.net/2445/182131
dc.language.none.fl_str_mv Inglés
language_invalid_str_mv Inglés
dc.relation.none.fl_str_mv Reproducció del document publicat a: https://doi.org/10.1186/s13036-021-00280-7
Journal Of Biological Engineering, 2021, num. 15
https://doi.org/10.1186/s13036-021-00280-7
info:eu-repo/grantAgreement/EC/H2020/712754
dc.rights.none.fl_str_mv cc by (c) Dulay, Samuel et al, 2021
http://creativecommons.org/licenses/by/3.0/es/
info:eu-repo/semantics/openAccess
rights_invalid_str_mv cc by (c) Dulay, Samuel et al, 2021
http://creativecommons.org/licenses/by/3.0/es/
eu_rights_str_mv openAccess
dc.format.none.fl_str_mv 11 p.
application/pdf
dc.source.none.fl_str_mv Articles publicats en revistes (Enginyeria Electrònica i Biomèdica)
reponame:Recercat. Dipósit de la Recerca de Catalunya
instname:Varias* (Consorci de Biblioteques Universitáries de Catalunya, Centre de Serveis Científics i Acadèmics de Catalunya)
instname_str Varias* (Consorci de Biblioteques Universitáries de Catalunya, Centre de Serveis Científics i Acadèmics de Catalunya)
reponame_str Recercat. Dipósit de la Recerca de Catalunya
collection Recercat. Dipósit de la Recerca de Catalunya
repository.name.fl_str_mv
repository.mail.fl_str_mv
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score 15,812455

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