Stroke genetics informs drug discovery and risk prediction across ancestries

Mishra, A; Malik, R; Hachiya, T; Jurgenson, T; Namba, S; Posner, DC; Kamanu, FK; Koido, M; Shi, MY; He, YY; Georgakis, MK; Caro, I; Krebs, K; Liaw, YC; Vaura, FC; Lin, K; Winsvold, BS; Srinivasasainagendra, V; Parodi, L; Bae, HJ; Chauhan, G; Chong, MCR; Tomppo, L; Akinyemi, R; Roshchupkin, GV; Habib, N; Jee, YH; Thomassen, JQ; Abedi, V; Carcel-Marquez, J; Nygaard, M; Leonard, HL; Yang, CJ; Yonova-Doing, E; Knol, MJ; Lewis, AJ; Judy, RL; Ago, T; Amouyel, P; Armstrong, ND; Bakker, MK; Bartz, TM; Bennett, DA; Bordes, C; Borte, S; Cain, A; Ridker, PM; Cho, K; Chen, ZM; Cruchaga, C; Cole, JW; Endres, M; Hata, J; He, J; Ho, YL; Havulinna, AS; Hopewell, JC; Hyacinth, HI; Inouye, M; Jacob, MA; Jeon, CE; Jern, C; Kamouchi, M; Keene, KL; Kitazono, T; Kittner, SJ; Konuma, T; Kumar, A; Lacaze, P; Launer, LJ; Lee, KJ; Lepik, K; Li, J; Li, LM; Manichaikul, A; Markus, HS; Marston, NA; Meitinger, T; Mitchell, BD; Montellano, FA; Morisaki, T; Mosley, TH; Nalls, MA; O'Donnell, MJ; Okada, Y; Ovbiagele, B; Peters, A; Psaty, BM; Rich, SS; Rosand, J; Sabatine, MS; Sacco, RL; Saleheen, D; Sandset, EC; Salomaa, V; Sasaki, M; Satizabal, CL; Schmidt, CO; Shimizu, A; Smith, NL; Sloane, KL; Sutoh, Y; Sun, YV; Tanno, K; Tiedt, S; Tatlisumak, T; Torres-Aguila, NP; Tiwari, HK; Tregouet, DA; Trompet, S; Tuladhar, AM; Tybjaerg-Hansen, A; Vibo, R; Wiggins, KL; Wennberg, P; Woo, D; Wilson, PWF; Xu, HC; Yang, Q; Yoon, K; Bis, JC; Lee, JM; Cheng, YC; Meschia, JF; Chen, WM; Sale, MM; Zonderman, AB; Evans, MK; Wilson, JG; Correa, A; Traylor, M; Lewis, CM; Carty, CL; Reiner, A; Langefeld, CD; Yaffe, K; Liu, YM; Lange, LA; Furie, KL; Arnett, DK; Benavente, OR; Grewal, RP; Peddareddygari, LR; Kooperberg, C; Lindstrom, S; Wang, L; Smith, EN; Gordon, W; Vlieg, AV; de Andrade, M; Brody, JA; Pattee, JW; Haessler, J; Suchon, P; Chen, MH; Frazer, KA; Turman, C; Germain, M; MacDonald, J; Braekkan, SK; Armasu, SM; Pankratz, N; Giulianini, F; Puurunen, MK; Ibrahim, M; Heckbert, SR; Bammler, TK; McCauley, BM; Pankow, JS; Reiner, AP; Deleuze, JF; O'Donnell, CJ; Kim, J; McKnight, B; Kraft, P; Hansen, JB; Rosendaal, FR; Heit, JA; Tang, WH; Morange, PE; Johnson, AD; Kabrhel, C; van Dijk, EJ; Koudstaal, PJ; Luijckx, GJ; van Oostenbrugge, RJ; Visser, MC; Wermer, MJH; Kappelle, LJ; Esko, T; Metspalu, A; Magi, R; Nelis, M; Levi, CR; Maguire, J; Jimenez-Conde, J; Sharma, P; Sudlow, CLM; Rannikmae, K; Schmidt, R; Slowik, A; Pera, J; Thijs, VNS; Lindgren, AG; Ilinca, A; Melander, O; Engstrom, G; Rexrode, KM; Rothwell, PM; Stanne, TM; Johnson, JA; Danesh, J; Butterworth, AS; Heitsch, L; Boncoraglio, GB; Kubo, M; Pezzini, A; Rolfs, A; Weir, D; Jackson, RD; Ross, OA; Lemmons, R; Soderholm, M; Cushman, M; Jood, K; McDonough, CW; Bell, S; Linkohr, B; Lee, TH; Putaala, J; Lopez, OL; Jian, XQ; Schminke, U; Cullell, N; Ibanez, L; Krupinski, J; Lioutas, V; Matsuda, K; Montaner, J; Muino, E; Roquer, J; Sarnowski, C; Sattar, N; Sibolt, G; Teumer, A; Rutten-Jacobs, L; Kanai, M; Giese, AK; Gretarsdottir, S; Rost, NS; Yusuf, S; Almgren, P; Ay, H; Bevan, S; Brown, RD; Carrera, C; Buring, JE; Cotlarciuc, I; de Bakker, PIW; DeStefano, AL; den Hoed, M; Duan, Q; Engelter, ST; Falcone, GJ; Gustafsson, S; Hassan, A; Holliday, EG; Howard, G; Hsu, FC; Ingelsson, E; Harris, TB; Kissela, BM; Kleindorfer, DO; Langenberg, C; Lemmens, R; Leys, D; Lin, WY; Lorentzen, E; Magnusson, PK; McArdle, PF; Pulit, SL; Rice, K; Sakaue, S; Sapkota, BR; Tanislav, C; Thorleifsson, G; Thorsteinsdottir, U; Tzourio, C; van Duijn, CM; Walters, M; Wareham, NJ; Amin, N; Aparicio, HJ; Attia, J; Berr, C; Bustamante, M; Caso, V; Choi, SH; Chowhan, A; Dartigues, JF; Delavaran, H; Dorr, M; Ford, I; Gurpreet, WS; Hamsten, A; Hozawa, A; Ingelsson, M; Iwasaki, M; Kaffashian, S; Kalra, L; Kjartansson, O; Kloss, M; Labovitz, DL; Laurie, CC; Li, LN; Lind, L; Lindgren, CM; Makoto, H; Minegishi, N; Morris, AP; Muller-Nurasyid, M; Norrving, B; Ogishima, S; Parati, EA; Pedersen, NL; Perola, M; Jousilahti, P; Pileggi, S; Rabionet, R; Riba-Llena, I; Ribases, M; Romero, JR; Rudd, AG; Sarin, AP; Sarju, R; Satoh, M; Sawada, N; Sigurdsson, A; Smith, A; Stine, OC; Stott, DJ; Strauch, K; Takai, T; Tanaka, H; Touze, E; Tsugane, S; Uitterlinden, AG; Valdimarsson, EM; van der Lee, SJ; Wakai, K; Williams, SR; Wolfe, CDA; Wong, QN; Yamaji, T; Sanghera, DK; Stefansson, K; Taylor, KD; Martinez-Majander, N; Sobue, K; Soriano-Tarraga, C; Volzke, H; Akpa, O; Sarfo, FS; Akpalu, A; Obiako, R; Wahab, K; Osaigbovo, G; Owolabi, L; Komolafe, M; Jenkins, C; Arulogun, O; Ogbole, G; Adeoye, AM; Akinyemi, J; Agunloye, A; Fakunle, AG; Uvere, E; Olalere, A; Adebajo, OJ; Chen, JS; Clarke, R; Collins, R; Guo, Y; Wang, C; Lv, J; Peto, R; Chen, YP; Fairhurst-Hunter, Z; Hill, M; Pozarickij, A; Schmidt, D; Stevens, B; Turnbull, I; Yu, CQ; Le Grand, Q; Ferreira, LE; Nagai, A; Murakami, Y; Geerlings, MI; Gasca, NC; Gudnason, V; van Vugt, M; Gottesman, RF; Shiroma, EJ; Sigurdsson, S; Ghanbari, M; Boerwinkle, E; Beiser, AS; Fongang, B; Wang, RQ; Ikram, MK; Volker, U; de Jager, PL; de Cid, R; Nordestgaard, BG; Sargurupremraj, M; Verma, SS; de Laat, KF; van Norden, AGW; de Kort, PL; Vermeer, SE; Brouwers, PJAM; Gons, RAR; Nederkoorn, PJ; den Heijer, T; van Dijk, GW; van Rooij, FGW; Aamodt, AH; Skogholt, AH; Brumpton, BM; Willer, CJ; Heuch, I; Hagen, K; Fritsche, LG; Pedersen, LM; Gabrielsen, ME; Ellekjaer, H; Zhou, W; Martinsen, AE; Kristoffersen, ES; Nielsen, JB; Hveem, K; Thomas, LF; Kleinschnitz, C; Frantz, S; Ungethum, K; Gallego-Fabrega, C; Lledos, M; Llucia-Carol, L; Sobrino, T; Campos, F; Castillo, J; Freijo, M; Arenillas, JF; Obach, V; Alvarez-Sabin, J; Molina, CA; Ribo, M; Munoz-Narbona, L; Lopez-Cancio, E; Millan, M; Diaz-Navarro, R; Vives-Bauza, C; Serrano-Heras, G; Segura, T; Delgado, P; Dhar, R; Delgado-Mederos, R; Prats-Sanchez, L; Camps-Renom, P; Blay, N; Sumoy, L; Marti-Fabregas, J; Schnohr, P; Jensen, GB; Benn, M; Afzal, S; Kamstrup, PR; van Setten, J; van der Laan, SW; Vonk, JMJ; Kim, BJ; Curtze, S; Tiainen, M; Kinnunen, J; Menon, V; Sung, YJ; Yang, CR; Saillour-Glenisson, F; Gravel, S; Onland-Moret, NC; Heath, AK; Millwood, IY; Gieger, C; Ninomiya, T; Grabe, HJ; Jukema, JW; Rissanen, IL; Strbian, D; Kim, YJ; Chen, PH; Mayerhofer, E; Howson, JMM; Irvin, MR; Adams, H; Wassertheil-Smoller, S; Christensen, K; Ikram, MA; Rundek, T; Worrall, BB; Lathrop, GM; Riaz, M; Simonsick, EM; Korv, J; Franca, PHC; Zand, R; Prasad, K; Frikke-Schmidt, R; de Leeuw, FE; Liman, T; Haeusler, KG; Ruigrok, YM; Heuschmann, PU; Longstreth, WT; Jung, KJ; Bastarache, L; Pare, G; Damrauer, SM; Chasman, DI; Rotter, JI; Anderson, CD; Zwart, JA; Niiranen, TJ; Fornage, M; Liaw, YP; Seshadri, S; Fernandez-Cadenas, I; Walters, RG; Ruff, CT; Owolabi, MO; Huffman, JE; Milani, L; Kamatani, Y; Dichgans, M; Debette, S

Stroke genetics informs drug discovery and risk prediction across ancestries

Previous genome-wide association studies (GWASs) of stroke - the second leading cause of death worldwide - were conducted predominantly in populations of European ancestry(1,2). Here, in cross-ancestry GWAS meta-analyses of 110,182 patients who have had a stroke (five ancestries, 33% non-European) a...

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Detalles Bibliográficos
Autores:	Mishra, A, Malik, R, Hachiya, T, Jurgenson, T, Namba, S, Posner, DC, Kamanu, FK, Koido, M, Shi, MY, He, YY, Georgakis, MK, Caro, I, Krebs, K, Liaw, YC, Vaura, FC, Lin, K, Winsvold, BS, Srinivasasainagendra, V, Parodi, L, Bae, HJ, Chauhan, G, Chong, MCR, Tomppo, L, Akinyemi, R, Roshchupkin, GV, Habib, N, Jee, YH, Thomassen, JQ, Abedi, V, Carcel-Marquez, J, Nygaard, M, Leonard, HL, Yang, CJ, Yonova-Doing, E, Knol, MJ, Lewis, AJ, Judy, RL, Ago, T, Amouyel, P, Armstrong, ND, Bakker, MK, Bartz, TM, Bennett, DA, Bordes, C, Borte, S, Cain, A, Ridker, PM, Cho, K, Chen, ZM, Cruchaga, C, Cole, JW, Endres, M, Hata, J, He, J, Ho, YL, Havulinna, AS, Hopewell, JC, Hyacinth, HI, Inouye, M, Jacob, MA, Jeon, CE, Jern, C, Kamouchi, M, Keene, KL, Kitazono, T, Kittner, SJ, Konuma, T, Kumar, A, Lacaze, P, Launer, LJ, Lee, KJ, Lepik, K, Li, J, Li, LM, Manichaikul, A, Markus, HS, Marston, NA, Meitinger, T, Mitchell, BD, Montellano, FA, Morisaki, T, Mosley, TH, Nalls, MA, O'Donnell, MJ, Okada, Y, Ovbiagele, B, Peters, A, Psaty, BM, Rich, SS, Rosand, J, Sabatine, MS, Sacco, RL, Saleheen, D, Sandset, EC, Salomaa, V, Sasaki, M, Satizabal, CL, Schmidt, CO, Shimizu, A, Smith, NL, Sloane, KL, Sutoh, Y, Sun, YV, Tanno, K, Tiedt, S, Tatlisumak, T, Torres-Aguila, NP, Tiwari, HK, Tregouet, DA, Trompet, S, Tuladhar, AM, Tybjaerg-Hansen, A, Vibo, R, Wiggins, KL, Wennberg, P, Woo, D, Wilson, PWF, Xu, HC, Yang, Q, Yoon, K, Bis, JC, Lee, JM, Cheng, YC, Meschia, JF, Chen, WM, Sale, MM, Zonderman, AB, Evans, MK, Wilson, JG, Correa, A, Traylor, M, Lewis, CM, Carty, CL, Reiner, A, Langefeld, CD, Yaffe, K, Liu, YM, Lange, LA, Furie, KL, Arnett, DK, Benavente, OR, Grewal, RP, Peddareddygari, LR, Kooperberg, C, Lindstrom, S, Wang, L, Smith, EN, Gordon, W, Vlieg, AV, de Andrade, M, Brody, JA, Pattee, JW, Haessler, J, Suchon, P, Chen, MH, Frazer, KA, Turman, C, Germain, M, MacDonald, J, Braekkan, SK, Armasu, SM, Pankratz, N, Giulianini, F, Puurunen, MK, Ibrahim, M, Heckbert, SR, Bammler, TK, McCauley, BM, Pankow, JS, Reiner, AP, Deleuze, JF, O'Donnell, CJ, Kim, J, McKnight, B, Kraft, P, Hansen, JB, Rosendaal, FR, Heit, JA, Tang, WH, Morange, PE, Johnson, AD, Kabrhel, C, van Dijk, EJ, Koudstaal, PJ, Luijckx, GJ, van Oostenbrugge, RJ, Visser, MC, Wermer, MJH, Kappelle, LJ, Esko, T, Metspalu, A, Magi, R, Nelis, M, Levi, CR, Maguire, J, Jimenez-Conde, J, Sharma, P, Sudlow, CLM, Rannikmae, K, Schmidt, R, Slowik, A, Pera, J, Thijs, VNS, Lindgren, AG, Ilinca, A, Melander, O, Engstrom, G, Rexrode, KM, Rothwell, PM, Stanne, TM, Johnson, JA, Danesh, J, Butterworth, AS, Heitsch, L, Boncoraglio, GB, Kubo, M, Pezzini, A, Rolfs, A, Weir, D, Jackson, RD, Ross, OA, Lemmons, R, Soderholm, M, Cushman, M, Jood, K, McDonough, CW, Bell, S, Linkohr, B, Lee, TH, Putaala, J, Lopez, OL, Jian, XQ, Schminke, U, Cullell, N, Ibanez, L, Krupinski, J, Lioutas, V, Matsuda, K, Montaner, J, Muino, E, Roquer, J, Sarnowski, C, Sattar, N, Sibolt, G, Teumer, A, Rutten-Jacobs, L, Kanai, M, Giese, AK, Gretarsdottir, S, Rost, NS, Yusuf, S, Almgren, P, Ay, H, Bevan, S, Brown, RD, Carrera, C, Buring, JE, Cotlarciuc, I, de Bakker, PIW, DeStefano, AL, den Hoed, M, Duan, Q, Engelter, ST, Falcone, GJ, Gustafsson, S, Hassan, A, Holliday, EG, Howard, G, Hsu, FC, Ingelsson, E, Harris, TB, Kissela, BM, Kleindorfer, DO, Langenberg, C, Lemmens, R, Leys, D, Lin, WY, Lorentzen, E, Magnusson, PK, McArdle, PF, Pulit, SL, Rice, K, Sakaue, S, Sapkota, BR, Tanislav, C, Thorleifsson, G, Thorsteinsdottir, U, Tzourio, C, van Duijn, CM, Walters, M, Wareham, NJ, Amin, N, Aparicio, HJ, Attia, J, Berr, C, Bustamante, M, Caso, V, Choi, SH, Chowhan, A, Dartigues, JF, Delavaran, H, Dorr, M, Ford, I, Gurpreet, WS, Hamsten, A, Hozawa, A, Ingelsson, M, Iwasaki, M, Kaffashian, S, Kalra, L, Kjartansson, O, Kloss, M, Labovitz, DL, Laurie, CC, Li, LN, Lind, L, Lindgren, CM, Makoto, H, Minegishi, N, Morris, AP, Muller-Nurasyid, M, Norrving, B, Ogishima, S, Parati, EA, Pedersen, NL, Perola, M, Jousilahti, P, Pileggi, S, Rabionet, R, Riba-Llena, I, Ribases, M, Romero, JR, Rudd, AG, Sarin, AP, Sarju, R, Satoh, M, Sawada, N, Sigurdsson, A, Smith, A, Stine, OC, Stott, DJ, Strauch, K, Takai, T, Tanaka, H, Touze, E, Tsugane, S, Uitterlinden, AG, Valdimarsson, EM, van der Lee, SJ, Wakai, K, Williams, SR, Wolfe, CDA, Wong, QN, Yamaji, T, Sanghera, DK, Stefansson, K, Taylor, KD, Martinez-Majander, N, Sobue, K, Soriano-Tarraga, C, Volzke, H, Akpa, O, Sarfo, FS, Akpalu, A, Obiako, R, Wahab, K, Osaigbovo, G, Owolabi, L, Komolafe, M, Jenkins, C, Arulogun, O, Ogbole, G, Adeoye, AM, Akinyemi, J, Agunloye, A, Fakunle, AG, Uvere, E, Olalere, A, Adebajo, OJ, Chen, JS, Clarke, R, Collins, R, Guo, Y, Wang, C, Lv, J, Peto, R, Chen, YP, Fairhurst-Hunter, Z, Hill, M, Pozarickij, A, Schmidt, D, Stevens, B, Turnbull, I, Yu, CQ, Le Grand, Q, Ferreira, LE, Nagai, A, Murakami, Y, Geerlings, MI, Gasca, NC, Gudnason, V, van Vugt, M, Gottesman, RF, Shiroma, EJ, Sigurdsson, S, Ghanbari, M, Boerwinkle, E, Beiser, AS, Fongang, B, Wang, RQ, Ikram, MK, Volker, U, de Jager, PL, de Cid, R, Nordestgaard, BG, Sargurupremraj, M, Verma, SS, de Laat, KF, van Norden, AGW, de Kort, PL, Vermeer, SE, Brouwers, PJAM, Gons, RAR, Nederkoorn, PJ, den Heijer, T, van Dijk, GW, van Rooij, FGW, Aamodt, AH, Skogholt, AH, Brumpton, BM, Willer, CJ, Heuch, I, Hagen, K, Fritsche, LG, Pedersen, LM, Gabrielsen, ME, Ellekjaer, H, Zhou, W, Martinsen, AE, Kristoffersen, ES, Nielsen, JB, Hveem, K, Thomas, LF, Kleinschnitz, C, Frantz, S, Ungethum, K, Gallego-Fabrega, C, Lledos, M, Llucia-Carol, L, Sobrino, T, Campos, F, Castillo, J, Freijo, M, Arenillas, JF, Obach, V, Alvarez-Sabin, J, Molina, CA, Ribo, M, Munoz-Narbona, L, Lopez-Cancio, E, Millan, M, Diaz-Navarro, R, Vives-Bauza, C, Serrano-Heras, G, Segura, T, Delgado, P, Dhar, R, Delgado-Mederos, R, Prats-Sanchez, L, Camps-Renom, P, Blay, N, Sumoy, L, Marti-Fabregas, J, Schnohr, P, Jensen, GB, Benn, M, Afzal, S, Kamstrup, PR, van Setten, J, van der Laan, SW, Vonk, JMJ, Kim, BJ, Curtze, S, Tiainen, M, Kinnunen, J, Menon, V, Sung, YJ, Yang, CR, Saillour-Glenisson, F, Gravel, S, Onland-Moret, NC, Heath, AK, Millwood, IY, Gieger, C, Ninomiya, T, Grabe, HJ, Jukema, JW, Rissanen, IL, Strbian, D, Kim, YJ, Chen, PH, Mayerhofer, E, Howson, JMM, Irvin, MR, Adams, H, Wassertheil-Smoller, S, Christensen, K, Ikram, MA, Rundek, T, Worrall, BB, Lathrop, GM, Riaz, M, Simonsick, EM, Korv, J, Franca, PHC, Zand, R, Prasad, K, Frikke-Schmidt, R, de Leeuw, FE, Liman, T, Haeusler, KG, Ruigrok, YM, Heuschmann, PU, Longstreth, WT, Jung, KJ, Bastarache, L, Pare, G, Damrauer, SM, Chasman, DI, Rotter, JI, Anderson, CD, Zwart, JA, Niiranen, TJ, Fornage, M, Liaw, YP, Seshadri, S, Fernandez-Cadenas, I, Walters, RG, Ruff, CT, Owolabi, MO, Huffman, JE, Milani, L, Kamatani, Y, Dichgans, M, Debette, S
Tipo de recurso:	artículo
Estado:	Versión publicada
Fecha de publicación:	2022
País:	España
Institución:	Institut d’Investigació Biomèdica Sant Pau (IIB Sant Pau)
Repositorio:	r-IIB SANT PAU. Repositorio Institucional de Producción Científica del Instituto de Investigación Biomédica Sant Pau
OAI Identifier:	oai:iibsantpau.fundanetsuite.com:p13904
Acceso en línea:	https://iibsantpau.fundanetsuite.com/Publicaciones/ProdCientif/PublicacionFrw.aspx?id=13904
Access Level:	acceso abierto
Palabra clave:	brain ischemia cerebrovascular accident drug development genetic predisposition genetics genome-wide association study human single nucleotide polymorphism Brain Ischemia Drug Discovery Genetic Predisposition to Disease Genome-Wide Association Study Humans Ischemic Stroke Polymorphism, Single Nucleotide Stroke

id	ES_7ed798dc209b4c60cb264dff230f7e44
oai_identifier_str	oai:iibsantpau.fundanetsuite.com:p13904
network_acronym_str	ES
network_name_str	España
repository_id_str
dc.title.none.fl_str_mv	Stroke genetics informs drug discovery and risk prediction across ancestries
title	Stroke genetics informs drug discovery and risk prediction across ancestries
spellingShingle	Stroke genetics informs drug discovery and risk prediction across ancestries Mishra, A brain ischemia cerebrovascular accident drug development genetic predisposition genetics genome-wide association study human single nucleotide polymorphism Brain Ischemia Drug Discovery Genetic Predisposition to Disease Genome-Wide Association Study Humans Ischemic Stroke Polymorphism, Single Nucleotide Stroke
title_short	Stroke genetics informs drug discovery and risk prediction across ancestries
title_full	Stroke genetics informs drug discovery and risk prediction across ancestries
title_fullStr	Stroke genetics informs drug discovery and risk prediction across ancestries
title_full_unstemmed	Stroke genetics informs drug discovery and risk prediction across ancestries
title_sort	Stroke genetics informs drug discovery and risk prediction across ancestries
dc.creator.none.fl_str_mv	Mishra, A Malik, R Hachiya, T Jurgenson, T Namba, S Posner, DC Kamanu, FK Koido, M Shi, MY He, YY Georgakis, MK Caro, I Krebs, K Liaw, YC Vaura, FC Lin, K Winsvold, BS Srinivasasainagendra, V Parodi, L Bae, HJ Chauhan, G Chong, MCR Tomppo, L Akinyemi, R Roshchupkin, GV Habib, N Jee, YH Thomassen, JQ Abedi, V Carcel-Marquez, J Nygaard, M Leonard, HL Yang, CJ Yonova-Doing, E Knol, MJ Lewis, AJ Judy, RL Ago, T Amouyel, P Armstrong, ND Bakker, MK Bartz, TM Bennett, DA Bordes, C Borte, S Cain, A Ridker, PM Cho, K Chen, ZM Cruchaga, C Cole, JW Endres, M Hata, J He, J Ho, YL Havulinna, AS Hopewell, JC Hyacinth, HI Inouye, M Jacob, MA Jeon, CE Jern, C Kamouchi, M Keene, KL Kitazono, T Kittner, SJ Konuma, T Kumar, A Lacaze, P Launer, LJ Lee, KJ Lepik, K Li, J Li, LM Manichaikul, A Markus, HS Marston, NA Meitinger, T Mitchell, BD Montellano, FA Morisaki, T Mosley, TH Nalls, MA O'Donnell, MJ Okada, Y Ovbiagele, B Peters, A Psaty, BM Rich, SS Rosand, J Sabatine, MS Sacco, RL Saleheen, D Sandset, EC Salomaa, V Sasaki, M Satizabal, CL Schmidt, CO Shimizu, A Smith, NL Sloane, KL Sutoh, Y Sun, YV Tanno, K Tiedt, S Tatlisumak, T Torres-Aguila, NP Tiwari, HK Tregouet, DA Trompet, S Tuladhar, AM Tybjaerg-Hansen, A Vibo, R Wiggins, KL Wennberg, P Woo, D Wilson, PWF Xu, HC Yang, Q Yoon, K Bis, JC Lee, JM Cheng, YC Meschia, JF Chen, WM Sale, MM Zonderman, AB Evans, MK Wilson, JG Correa, A Traylor, M Lewis, CM Carty, CL Reiner, A Langefeld, CD Yaffe, K Liu, YM Lange, LA Furie, KL Arnett, DK Benavente, OR Grewal, RP Peddareddygari, LR Kooperberg, C Lindstrom, S Wang, L Smith, EN Gordon, W Vlieg, AV de Andrade, M Brody, JA Pattee, JW Haessler, J Suchon, P Chen, MH Frazer, KA Turman, C Germain, M MacDonald, J Braekkan, SK Armasu, SM Pankratz, N Giulianini, F Puurunen, MK Ibrahim, M Heckbert, SR Bammler, TK McCauley, BM Pankow, JS Reiner, AP Deleuze, JF O'Donnell, CJ Kim, J McKnight, B Kraft, P Hansen, JB Rosendaal, FR Heit, JA Tang, WH Morange, PE Johnson, AD Kabrhel, C van Dijk, EJ Koudstaal, PJ Luijckx, GJ van Oostenbrugge, RJ Visser, MC Wermer, MJH Kappelle, LJ Esko, T Metspalu, A Magi, R Nelis, M Levi, CR Maguire, J Jimenez-Conde, J Sharma, P Sudlow, CLM Rannikmae, K Schmidt, R Slowik, A Pera, J Thijs, VNS Lindgren, AG Ilinca, A Melander, O Engstrom, G Rexrode, KM Rothwell, PM Stanne, TM Johnson, JA Danesh, J Butterworth, AS Heitsch, L Boncoraglio, GB Kubo, M Pezzini, A Rolfs, A Weir, D Jackson, RD Ross, OA Lemmons, R Soderholm, M Cushman, M Jood, K McDonough, CW Bell, S Linkohr, B Lee, TH Putaala, J Lopez, OL Jian, XQ Schminke, U Cullell, N Ibanez, L Krupinski, J Lioutas, V Matsuda, K Montaner, J Muino, E Roquer, J Sarnowski, C Sattar, N Sibolt, G Teumer, A Rutten-Jacobs, L Kanai, M Giese, AK Gretarsdottir, S Rost, NS Yusuf, S Almgren, P Ay, H Bevan, S Brown, RD Carrera, C Buring, JE Chen, WM Cotlarciuc, I de Bakker, PIW DeStefano, AL den Hoed, M Duan, Q Engelter, ST Falcone, GJ Gustafsson, S Hassan, A Holliday, EG Howard, G Hsu, FC Ingelsson, E Harris, TB Kissela, BM Kleindorfer, DO Langenberg, C Lemmens, R Leys, D Lin, WY Lorentzen, E Magnusson, PK McArdle, PF Pulit, SL Rice, K Sakaue, S Sapkota, BR Tanislav, C Thorleifsson, G Thorsteinsdottir, U Tzourio, C van Duijn, CM Walters, M Wareham, NJ Amin, N Aparicio, HJ Attia, J Berr, C Bustamante, M Caso, V Choi, SH Chowhan, A Dartigues, JF Delavaran, H Dorr, M Ford, I Gurpreet, WS Hamsten, A Hozawa, A Ingelsson, M Iwasaki, M Kaffashian, S Kalra, L Kjartansson, O Kloss, M Labovitz, DL Laurie, CC Li, LN Lind, L Lindgren, CM Makoto, H Minegishi, N Morris, AP Muller-Nurasyid, M Norrving, B Ogishima, S Parati, EA Pedersen, NL Perola, M Jousilahti, P Pileggi, S Rabionet, R Riba-Llena, I Ribases, M Romero, JR Rudd, AG Sarin, AP Sarju, R Satoh, M Sawada, N Sigurdsson, A Smith, A Stine, OC Stott, DJ Strauch, K Takai, T Tanaka, H Touze, E Tsugane, S Uitterlinden, AG Valdimarsson, EM van der Lee, SJ Wakai, K Williams, SR Wolfe, CDA Wong, QN Yamaji, T Sanghera, DK Stefansson, K Taylor, KD Martinez-Majander, N Sobue, K Soriano-Tarraga, C Volzke, H Akpa, O Sarfo, FS Akpalu, A Obiako, R Wahab, K Osaigbovo, G Owolabi, L Komolafe, M Jenkins, C Arulogun, O Ogbole, G Adeoye, AM Akinyemi, J Agunloye, A Fakunle, AG Uvere, E Olalere, A Adebajo, OJ Chen, JS Clarke, R Collins, R Guo, Y Wang, C Lv, J Peto, R Chen, YP Fairhurst-Hunter, Z Hill, M Pozarickij, A Schmidt, D Stevens, B Turnbull, I Yu, CQ Le Grand, Q Ferreira, LE Nagai, A Murakami, Y Geerlings, MI Gasca, NC Gudnason, V van Vugt, M Gottesman, RF Shiroma, EJ Sigurdsson, S Ghanbari, M Boerwinkle, E Beiser, AS Fongang, B Wang, RQ Ikram, MK Volker, U de Jager, PL de Cid, R Nordestgaard, BG Sargurupremraj, M Verma, SS de Laat, KF van Norden, AGW de Kort, PL Vermeer, SE Brouwers, PJAM Gons, RAR Nederkoorn, PJ den Heijer, T van Dijk, GW van Rooij, FGW Aamodt, AH Skogholt, AH Brumpton, BM Willer, CJ Heuch, I Hagen, K Fritsche, LG Pedersen, LM Gabrielsen, ME Ellekjaer, H Zhou, W Martinsen, AE Kristoffersen, ES Nielsen, JB Hveem, K Thomas, LF Kleinschnitz, C Frantz, S Ungethum, K Gallego-Fabrega, C Lledos, M Llucia-Carol, L Sobrino, T Campos, F Castillo, J Freijo, M Arenillas, JF Obach, V Alvarez-Sabin, J Molina, CA Ribo, M Munoz-Narbona, L Lopez-Cancio, E Millan, M Diaz-Navarro, R Vives-Bauza, C Serrano-Heras, G Segura, T Delgado, P Dhar, R Delgado-Mederos, R Prats-Sanchez, L Camps-Renom, P Blay, N Sumoy, L Marti-Fabregas, J Schnohr, P Jensen, GB Benn, M Afzal, S Kamstrup, PR van Setten, J van der Laan, SW Vonk, JMJ Kim, BJ Curtze, S Tiainen, M Kinnunen, J Menon, V Sung, YJ Yang, CR Saillour-Glenisson, F Gravel, S Onland-Moret, NC Heath, AK Millwood, IY Gieger, C Ninomiya, T Grabe, HJ Jukema, JW Rissanen, IL Strbian, D Kim, YJ Chen, PH Mayerhofer, E Howson, JMM Irvin, MR Adams, H Wassertheil-Smoller, S Christensen, K Ikram, MA Rundek, T Worrall, BB Lathrop, GM Riaz, M Simonsick, EM Korv, J Franca, PHC Zand, R Prasad, K Frikke-Schmidt, R de Leeuw, FE Liman, T Haeusler, KG Ruigrok, YM Heuschmann, PU Longstreth, WT Jung, KJ Bastarache, L Pare, G Damrauer, SM Chasman, DI Rotter, JI Anderson, CD Zwart, JA Niiranen, TJ Fornage, M Liaw, YP Seshadri, S Fernandez-Cadenas, I Walters, RG Ruff, CT Owolabi, MO Huffman, JE Milani, L Kamatani, Y Dichgans, M Debette, S
author	Mishra, A
author_facet	Mishra, A Malik, R Hachiya, T Jurgenson, T Namba, S Posner, DC Kamanu, FK Koido, M Shi, MY He, YY Georgakis, MK Caro, I Krebs, K Liaw, YC Vaura, FC Lin, K Winsvold, BS Srinivasasainagendra, V Parodi, L Bae, HJ Chauhan, G Chong, MCR Tomppo, L Akinyemi, R Roshchupkin, GV Habib, N Jee, YH Thomassen, JQ Abedi, V Carcel-Marquez, J Nygaard, M Leonard, HL Yang, CJ Yonova-Doing, E Knol, MJ Lewis, AJ Judy, RL Ago, T Amouyel, P Armstrong, ND Bakker, MK Bartz, TM Bennett, DA Bordes, C Borte, S Cain, A Ridker, PM Cho, K Chen, ZM Cruchaga, C Cole, JW Endres, M Hata, J He, J Ho, YL Havulinna, AS Hopewell, JC Hyacinth, HI Inouye, M Jacob, MA Jeon, CE Jern, C Kamouchi, M Keene, KL Kitazono, T Kittner, SJ Konuma, T Kumar, A Lacaze, P Launer, LJ Lee, KJ Lepik, K Li, J Li, LM Manichaikul, A Markus, HS Marston, NA Meitinger, T Mitchell, BD Montellano, FA Morisaki, T Mosley, TH Nalls, MA O'Donnell, MJ Okada, Y Ovbiagele, B Peters, A Psaty, BM Rich, SS Rosand, J Sabatine, MS Sacco, RL Saleheen, D Sandset, EC Salomaa, V Sasaki, M Satizabal, CL Schmidt, CO Shimizu, A Smith, NL Sloane, KL Sutoh, Y Sun, YV Tanno, K Tiedt, S Tatlisumak, T Torres-Aguila, NP Tiwari, HK Tregouet, DA Trompet, S Tuladhar, AM Tybjaerg-Hansen, A Vibo, R Wiggins, KL Wennberg, P Woo, D Wilson, PWF Xu, HC Yang, Q Yoon, K Bis, JC Lee, JM Cheng, YC Meschia, JF Chen, WM Sale, MM Zonderman, AB Evans, MK Wilson, JG Correa, A Traylor, M Lewis, CM Carty, CL Reiner, A Langefeld, CD Yaffe, K Liu, YM Lange, LA Furie, KL Arnett, DK Benavente, OR Grewal, RP Peddareddygari, LR Kooperberg, C Lindstrom, S Wang, L Smith, EN Gordon, W Vlieg, AV de Andrade, M Brody, JA Pattee, JW Haessler, J Suchon, P Chen, MH Frazer, KA Turman, C Germain, M MacDonald, J Braekkan, SK Armasu, SM Pankratz, N Giulianini, F Puurunen, MK Ibrahim, M Heckbert, SR Bammler, TK McCauley, BM Pankow, JS Reiner, AP Deleuze, JF O'Donnell, CJ Kim, J McKnight, B Kraft, P Hansen, JB Rosendaal, FR Heit, JA Tang, WH Morange, PE Johnson, AD Kabrhel, C van Dijk, EJ Koudstaal, PJ Luijckx, GJ van Oostenbrugge, RJ Visser, MC Wermer, MJH Kappelle, LJ Esko, T Metspalu, A Magi, R Nelis, M Levi, CR Maguire, J Jimenez-Conde, J Sharma, P Sudlow, CLM Rannikmae, K Schmidt, R Slowik, A Pera, J Thijs, VNS Lindgren, AG Ilinca, A Melander, O Engstrom, G Rexrode, KM Rothwell, PM Stanne, TM Johnson, JA Danesh, J Butterworth, AS Heitsch, L Boncoraglio, GB Kubo, M Pezzini, A Rolfs, A Weir, D Jackson, RD Ross, OA Lemmons, R Soderholm, M Cushman, M Jood, K McDonough, CW Bell, S Linkohr, B Lee, TH Putaala, J Lopez, OL Jian, XQ Schminke, U Cullell, N Ibanez, L Krupinski, J Lioutas, V Matsuda, K Montaner, J Muino, E Roquer, J Sarnowski, C Sattar, N Sibolt, G Teumer, A Rutten-Jacobs, L Kanai, M Giese, AK Gretarsdottir, S Rost, NS Yusuf, S Almgren, P Ay, H Bevan, S Brown, RD Carrera, C Buring, JE Cotlarciuc, I de Bakker, PIW DeStefano, AL den Hoed, M Duan, Q Engelter, ST Falcone, GJ Gustafsson, S Hassan, A Holliday, EG Howard, G Hsu, FC Ingelsson, E Harris, TB Kissela, BM Kleindorfer, DO Langenberg, C Lemmens, R Leys, D Lin, WY Lorentzen, E Magnusson, PK McArdle, PF Pulit, SL Rice, K Sakaue, S Sapkota, BR Tanislav, C Thorleifsson, G Thorsteinsdottir, U Tzourio, C van Duijn, CM Walters, M Wareham, NJ Amin, N Aparicio, HJ Attia, J Berr, C Bustamante, M Caso, V Choi, SH Chowhan, A Dartigues, JF Delavaran, H Dorr, M Ford, I Gurpreet, WS Hamsten, A Hozawa, A Ingelsson, M Iwasaki, M Kaffashian, S Kalra, L Kjartansson, O Kloss, M Labovitz, DL Laurie, CC Li, LN Lind, L Lindgren, CM Makoto, H Minegishi, N Morris, AP Muller-Nurasyid, M Norrving, B Ogishima, S Parati, EA Pedersen, NL Perola, M Jousilahti, P Pileggi, S Rabionet, R Riba-Llena, I Ribases, M Romero, JR Rudd, AG Sarin, AP Sarju, R Satoh, M Sawada, N Sigurdsson, A Smith, A Stine, OC Stott, DJ Strauch, K Takai, T Tanaka, H Touze, E Tsugane, S Uitterlinden, AG Valdimarsson, EM van der Lee, SJ Wakai, K Williams, SR Wolfe, CDA Wong, QN Yamaji, T Sanghera, DK Stefansson, K Taylor, KD Martinez-Majander, N Sobue, K Soriano-Tarraga, C Volzke, H Akpa, O Sarfo, FS Akpalu, A Obiako, R Wahab, K Osaigbovo, G Owolabi, L Komolafe, M Jenkins, C Arulogun, O Ogbole, G Adeoye, AM Akinyemi, J Agunloye, A Fakunle, AG Uvere, E Olalere, A Adebajo, OJ Chen, JS Clarke, R Collins, R Guo, Y Wang, C Lv, J Peto, R Chen, YP Fairhurst-Hunter, Z Hill, M Pozarickij, A Schmidt, D Stevens, B Turnbull, I Yu, CQ Le Grand, Q Ferreira, LE Nagai, A Murakami, Y Geerlings, MI Gasca, NC Gudnason, V van Vugt, M Gottesman, RF Shiroma, EJ Sigurdsson, S Ghanbari, M Boerwinkle, E Beiser, AS Fongang, B Wang, RQ Ikram, MK Volker, U de Jager, PL de Cid, R Nordestgaard, BG Sargurupremraj, M Verma, SS de Laat, KF van Norden, AGW de Kort, PL Vermeer, SE Brouwers, PJAM Gons, RAR Nederkoorn, PJ den Heijer, T van Dijk, GW van Rooij, FGW Aamodt, AH Skogholt, AH Brumpton, BM Willer, CJ Heuch, I Hagen, K Fritsche, LG Pedersen, LM Gabrielsen, ME Ellekjaer, H Zhou, W Martinsen, AE Kristoffersen, ES Nielsen, JB Hveem, K Thomas, LF Kleinschnitz, C Frantz, S Ungethum, K Gallego-Fabrega, C Lledos, M Llucia-Carol, L Sobrino, T Campos, F Castillo, J Freijo, M Arenillas, JF Obach, V Alvarez-Sabin, J Molina, CA Ribo, M Munoz-Narbona, L Lopez-Cancio, E Millan, M Diaz-Navarro, R Vives-Bauza, C Serrano-Heras, G Segura, T Delgado, P Dhar, R Delgado-Mederos, R Prats-Sanchez, L Camps-Renom, P Blay, N Sumoy, L Marti-Fabregas, J Schnohr, P Jensen, GB Benn, M Afzal, S Kamstrup, PR van Setten, J van der Laan, SW Vonk, JMJ Kim, BJ Curtze, S Tiainen, M Kinnunen, J Menon, V Sung, YJ Yang, CR Saillour-Glenisson, F Gravel, S Onland-Moret, NC Heath, AK Millwood, IY Gieger, C Ninomiya, T Grabe, HJ Jukema, JW Rissanen, IL Strbian, D Kim, YJ Chen, PH Mayerhofer, E Howson, JMM Irvin, MR Adams, H Wassertheil-Smoller, S Christensen, K Ikram, MA Rundek, T Worrall, BB Lathrop, GM Riaz, M Simonsick, EM Korv, J Franca, PHC Zand, R Prasad, K Frikke-Schmidt, R de Leeuw, FE Liman, T Haeusler, KG Ruigrok, YM Heuschmann, PU Longstreth, WT Jung, KJ Bastarache, L Pare, G Damrauer, SM Chasman, DI Rotter, JI Anderson, CD Zwart, JA Niiranen, TJ Fornage, M Liaw, YP Seshadri, S Fernandez-Cadenas, I Walters, RG Ruff, CT Owolabi, MO Huffman, JE Milani, L Kamatani, Y Dichgans, M Debette, S
author_role	author
author2	Malik, R Hachiya, T Jurgenson, T Namba, S Posner, DC Kamanu, FK Koido, M Shi, MY He, YY Georgakis, MK Caro, I Krebs, K Liaw, YC Vaura, FC Lin, K Winsvold, BS Srinivasasainagendra, V Parodi, L Bae, HJ Chauhan, G Chong, MCR Tomppo, L Akinyemi, R Roshchupkin, GV Habib, N Jee, YH Thomassen, JQ Abedi, V Carcel-Marquez, J Nygaard, M Leonard, HL Yang, CJ Yonova-Doing, E Knol, MJ Lewis, AJ Judy, RL Ago, T Amouyel, P Armstrong, ND Bakker, MK Bartz, TM Bennett, DA Bordes, C Borte, S Cain, A Ridker, PM Cho, K Chen, ZM Cruchaga, C Cole, JW Endres, M Hata, J He, J Ho, YL Havulinna, AS Hopewell, JC Hyacinth, HI Inouye, M Jacob, MA Jeon, CE Jern, C Kamouchi, M Keene, KL Kitazono, T Kittner, SJ Konuma, T Kumar, A Lacaze, P Launer, LJ Lee, KJ Lepik, K Li, J Li, LM Manichaikul, A Markus, HS Marston, NA Meitinger, T Mitchell, BD Montellano, FA Morisaki, T Mosley, TH Nalls, MA O'Donnell, MJ Okada, Y Ovbiagele, B Peters, A Psaty, BM Rich, SS Rosand, J Sabatine, MS Sacco, RL Saleheen, D Sandset, EC Salomaa, V Sasaki, M Satizabal, CL Schmidt, CO Shimizu, A Smith, NL Sloane, KL Sutoh, Y Sun, YV Tanno, K Tiedt, S Tatlisumak, T Torres-Aguila, NP Tiwari, HK Tregouet, DA Trompet, S Tuladhar, AM Tybjaerg-Hansen, A Vibo, R Wiggins, KL Wennberg, P Woo, D Wilson, PWF Xu, HC Yang, Q Yoon, K Bis, JC Lee, JM Cheng, YC Meschia, JF Chen, WM Sale, MM Zonderman, AB Evans, MK Wilson, JG Correa, A Traylor, M Lewis, CM Carty, CL Reiner, A Langefeld, CD Yaffe, K Liu, YM Lange, LA Furie, KL Arnett, DK Benavente, OR Grewal, RP Peddareddygari, LR Kooperberg, C Lindstrom, S Wang, L Smith, EN Gordon, W Vlieg, AV de Andrade, M Brody, JA Pattee, JW Haessler, J Suchon, P Chen, MH Frazer, KA Turman, C Germain, M MacDonald, J Braekkan, SK Armasu, SM Pankratz, N Giulianini, F Puurunen, MK Ibrahim, M Heckbert, SR Bammler, TK McCauley, BM Pankow, JS Reiner, AP Deleuze, JF O'Donnell, CJ Kim, J McKnight, B Kraft, P Hansen, JB Rosendaal, FR Heit, JA Tang, WH Morange, PE Johnson, AD Kabrhel, C van Dijk, EJ Koudstaal, PJ Luijckx, GJ van Oostenbrugge, RJ Visser, MC Wermer, MJH Kappelle, LJ Esko, T Metspalu, A Magi, R Nelis, M Levi, CR Maguire, J Jimenez-Conde, J Sharma, P Sudlow, CLM Rannikmae, K Schmidt, R Slowik, A Pera, J Thijs, VNS Lindgren, AG Ilinca, A Melander, O Engstrom, G Rexrode, KM Rothwell, PM Stanne, TM Johnson, JA Danesh, J Butterworth, AS Heitsch, L Boncoraglio, GB Kubo, M Pezzini, A Rolfs, A Weir, D Jackson, RD Ross, OA Lemmons, R Soderholm, M Cushman, M Jood, K McDonough, CW Bell, S Linkohr, B Lee, TH Putaala, J Lopez, OL Jian, XQ Schminke, U Cullell, N Ibanez, L Krupinski, J Lioutas, V Matsuda, K Montaner, J Muino, E Roquer, J Sarnowski, C Sattar, N Sibolt, G Teumer, A Rutten-Jacobs, L Kanai, M Giese, AK Gretarsdottir, S Rost, NS Yusuf, S Almgren, P Ay, H Bevan, S Brown, RD Carrera, C Buring, JE Cotlarciuc, I de Bakker, PIW DeStefano, AL den Hoed, M Duan, Q Engelter, ST Falcone, GJ Gustafsson, S Hassan, A Holliday, EG Howard, G Hsu, FC Ingelsson, E Harris, TB Kissela, BM Kleindorfer, DO Langenberg, C Lemmens, R Leys, D Lin, WY Lorentzen, E Magnusson, PK McArdle, PF Pulit, SL Rice, K Sakaue, S Sapkota, BR Tanislav, C Thorleifsson, G Thorsteinsdottir, U Tzourio, C van Duijn, CM Walters, M Wareham, NJ Amin, N Aparicio, HJ Attia, J Berr, C Bustamante, M Caso, V Choi, SH Chowhan, A Dartigues, JF Delavaran, H Dorr, M Ford, I Gurpreet, WS Hamsten, A Hozawa, A Ingelsson, M Iwasaki, M Kaffashian, S Kalra, L Kjartansson, O Kloss, M Labovitz, DL Laurie, CC Li, LN Lind, L Lindgren, CM Makoto, H Minegishi, N Morris, AP Muller-Nurasyid, M Norrving, B Ogishima, S Parati, EA Pedersen, NL Perola, M Jousilahti, P Pileggi, S Rabionet, R Riba-Llena, I Ribases, M Romero, JR Rudd, AG Sarin, AP Sarju, R Satoh, M Sawada, N Sigurdsson, A Smith, A Stine, OC Stott, DJ Strauch, K Takai, T Tanaka, H Touze, E Tsugane, S Uitterlinden, AG Valdimarsson, EM van der Lee, SJ Wakai, K Williams, SR Wolfe, CDA Wong, QN Yamaji, T Sanghera, DK Stefansson, K Taylor, KD Martinez-Majander, N Sobue, K Soriano-Tarraga, C Volzke, H Akpa, O Sarfo, FS Akpalu, A Obiako, R Wahab, K Osaigbovo, G Owolabi, L Komolafe, M Jenkins, C Arulogun, O Ogbole, G Adeoye, AM Akinyemi, J Agunloye, A Fakunle, AG Uvere, E Olalere, A Adebajo, OJ Chen, JS Clarke, R Collins, R Guo, Y Wang, C Lv, J Peto, R Chen, YP Fairhurst-Hunter, Z Hill, M Pozarickij, A Schmidt, D Stevens, B Turnbull, I Yu, CQ Le Grand, Q Ferreira, LE Nagai, A Murakami, Y Geerlings, MI Gasca, NC Gudnason, V van Vugt, M Gottesman, RF Shiroma, EJ Sigurdsson, S Ghanbari, M Boerwinkle, E Beiser, AS Fongang, B Wang, RQ Ikram, MK Volker, U de Jager, PL de Cid, R Nordestgaard, BG Sargurupremraj, M Verma, SS de Laat, KF van Norden, AGW de Kort, PL Vermeer, SE Brouwers, PJAM Gons, RAR Nederkoorn, PJ den Heijer, T van Dijk, GW van Rooij, FGW Aamodt, AH Skogholt, AH Brumpton, BM Willer, CJ Heuch, I Hagen, K Fritsche, LG Pedersen, LM Gabrielsen, ME Ellekjaer, H Zhou, W Martinsen, AE Kristoffersen, ES Nielsen, JB Hveem, K Thomas, LF Kleinschnitz, C Frantz, S Ungethum, K Gallego-Fabrega, C Lledos, M Llucia-Carol, L Sobrino, T Campos, F Castillo, J Freijo, M Arenillas, JF Obach, V Alvarez-Sabin, J Molina, CA Ribo, M Munoz-Narbona, L Lopez-Cancio, E Millan, M Diaz-Navarro, R Vives-Bauza, C Serrano-Heras, G Segura, T Delgado, P Dhar, R Delgado-Mederos, R Prats-Sanchez, L Camps-Renom, P Blay, N Sumoy, L Marti-Fabregas, J Schnohr, P Jensen, GB Benn, M Afzal, S Kamstrup, PR van Setten, J van der Laan, SW Vonk, JMJ Kim, BJ Curtze, S Tiainen, M Kinnunen, J Menon, V Sung, YJ Yang, CR Saillour-Glenisson, F Gravel, S Onland-Moret, NC Heath, AK Millwood, IY Gieger, C Ninomiya, T Grabe, HJ Jukema, JW Rissanen, IL Strbian, D Kim, YJ Chen, PH Mayerhofer, E Howson, JMM Irvin, MR Adams, H Wassertheil-Smoller, S Christensen, K Ikram, MA Rundek, T Worrall, BB Lathrop, GM Riaz, M Simonsick, EM Korv, J Franca, PHC Zand, R Prasad, K Frikke-Schmidt, R de Leeuw, FE Liman, T Haeusler, KG Ruigrok, YM Heuschmann, PU Longstreth, WT Jung, KJ Bastarache, L Pare, G Damrauer, SM Chasman, DI Rotter, JI Anderson, CD Zwart, JA Niiranen, TJ Fornage, M Liaw, YP Seshadri, S Fernandez-Cadenas, I Walters, RG Ruff, CT Owolabi, MO Huffman, JE Milani, L Kamatani, Y Dichgans, M Debette, S
author2_role	author author author author author author author author author author author author author author author author author author author author author author author author author author author author author author author author author author author author author author author author author author author author author author author author author author author author author author author author author author author author author author author author author author author author author author author author author author author author author author author author author author author author author author author author author author author author author author author author author author author author author author author author author author author author author author author author author author author author author author author author author author author author author author author author author author author author author author author author author author author author author author author author author author author author author author author author author author author author author author author author author author author author author author author author author author author author author author author author author author author author author author author author author author author author author author author author author author author author author author author author author author author author author author author author author author author author author author author author author author author author author author author author author author author author author author author author author author author author author author author author author author author author author author author author author author author author author author author author author author author author author author author author author author author author author author author author author author author author author author author author author author author author author author author author author author author author author author author author author author author author author author author author author author author author author author author author author author author author author author author author author author author author author author author author author author author author author author author author author author author author author author author author author author author author author author author author author author author author author author author author author author author author author author author author author author author author author author author author author author author author author author author author author author author author author author author author author author author author author author author author author author author author author author author author author author author author author author author author author author author author author author author author author author author author author author author author author author author author author author author author author author author author author author author author author author author author author author author author author author author author author author author author author author author author author author author author author author author author author author author author author author author author author author author author author author author author author author author author author author author author author author author author author author author author author author author author author author author author author author author author author author author author author author author author author author author author author author author author author author author author author author author author
dc.subject.none.fl_str_mv	brain ischemia cerebrovascular accident drug development genetic predisposition genetics genome-wide association study human single nucleotide polymorphism Brain Ischemia Drug Discovery Genetic Predisposition to Disease Genome-Wide Association Study Humans Ischemic Stroke Polymorphism, Single Nucleotide Stroke
topic	brain ischemia cerebrovascular accident drug development genetic predisposition genetics genome-wide association study human single nucleotide polymorphism Brain Ischemia Drug Discovery Genetic Predisposition to Disease Genome-Wide Association Study Humans Ischemic Stroke Polymorphism, Single Nucleotide Stroke
description	Previous genome-wide association studies (GWASs) of stroke - the second leading cause of death worldwide - were conducted predominantly in populations of European ancestry(1,2). Here, in cross-ancestry GWAS meta-analyses of 110,182 patients who have had a stroke (five ancestries, 33% non-European) and 1,503,898 control individuals, we identify association signals for stroke and its subtypes at 89 (61 new) independent loci: 60 in primary inverse-variance-weighted analyses and 29 in secondary meta-regression and multitrait analyses. On the basis of internal cross-ancestry validation and an independent follow-up in 89,084 additional cases of stroke (30% non-European) and 1,013,843 control individuals, 87% of the primary stroke risk loci and 60% of the secondary stroke risk loci were replicated (P < 0.05). Effect sizes were highly correlated across ancestries. Cross-ancestry fine-mapping, in silico mutagenesis analysis(3), and transcriptome-wide and proteome-wide association analyses revealed putative causal genes (such as SH3PXD2A and FURIN) and variants (such as at GRK5 and NOS3). Using a three-pronged approach(4), we provide genetic evidence for putative drug effects, highlighting F11, KLKB1, PROC, GP1BA, LAMC2 and VCAM1 as possible targets, with drugs already under investigation for stroke for F11 and PROC. A polygenic score integrating cross-ancestry and ancestry-specific stroke GWASs with vascular-risk factor GWASs (integrative polygenic scores) strongly predicted ischaemic stroke in populations of European, East Asian and African ancestry(5). Stroke genetic risk scores were predictive of ischaemic stroke independent of clinical risk factors in 52,600 clinical-trial participants with cardiometabolic disease. Our results provide insights to inform biology, reveal potential drug targets and derive genetic risk prediction tools across ancestries.
publishDate	2022
dc.date.none.fl_str_mv	2022
dc.type.none.fl_str_mv	info:eu-repo/semantics/article info:eu-repo/semantics/publishedVersion
format	article
status_str	publishedVersion
dc.identifier.none.fl_str_mv	https://iibsantpau.fundanetsuite.com/Publicaciones/ProdCientif/PublicacionFrw.aspx?id=13904
url	https://iibsantpau.fundanetsuite.com/Publicaciones/ProdCientif/PublicacionFrw.aspx?id=13904
dc.language.none.fl_str_mv	Inglés
language_invalid_str_mv	Inglés
dc.rights.none.fl_str_mv	info:eu-repo/semantics/openAccess
eu_rights_str_mv	openAccess
dc.publisher.none.fl_str_mv	NATURE PORTFOLIO
publisher.none.fl_str_mv	NATURE PORTFOLIO
dc.source.none.fl_str_mv	NATURE ISSN: 00280836 ISSNe: 14764687 reponame:r-IIB SANT PAU. Repositorio Institucional de Producción Científica del Instituto de Investigación Biomédica Sant Pau instname:Institut d’Investigació Biomèdica Sant Pau (IIB Sant Pau)
instname_str	Institut d’Investigació Biomèdica Sant Pau (IIB Sant Pau)
reponame_str	r-IIB SANT PAU. Repositorio Institucional de Producción Científica del Instituto de Investigación Biomédica Sant Pau
collection	r-IIB SANT PAU. Repositorio Institucional de Producción Científica del Instituto de Investigación Biomédica Sant Pau
repository.name.fl_str_mv
repository.mail.fl_str_mv
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spelling	Stroke genetics informs drug discovery and risk prediction across ancestriesMishra, AMalik, RHachiya, TJurgenson, TNamba, SPosner, DCKamanu, FKKoido, MShi, MYHe, YYGeorgakis, MKCaro, IKrebs, KLiaw, YCVaura, FCLin, KWinsvold, BSSrinivasasainagendra, VParodi, LBae, HJChauhan, GChong, MCRTomppo, LAkinyemi, RRoshchupkin, GVHabib, NJee, YHThomassen, JQAbedi, VCarcel-Marquez, JNygaard, MLeonard, HLYang, CJYonova-Doing, EKnol, MJLewis, AJJudy, RLAgo, TAmouyel, PArmstrong, NDBakker, MKBartz, TMBennett, DABordes, CBorte, SCain, ARidker, PMCho, KChen, ZMCruchaga, CCole, JWEndres, MHata, JHe, JHo, YLHavulinna, ASHopewell, JCHyacinth, HIInouye, MJacob, MAJeon, CEJern, CKamouchi, MKeene, KLKitazono, TKittner, SJKonuma, TKumar, ALacaze, PLauner, LJLee, KJLepik, KLi, JLi, LMManichaikul, AMarkus, HSMarston, NAMeitinger, TMitchell, BDMontellano, FAMorisaki, TMosley, THNalls, MAO'Donnell, MJOkada, YOvbiagele, BPeters, APsaty, BMRich, SSRosand, JSabatine, MSSacco, RLSaleheen, DSandset, ECSalomaa, VSasaki, MSatizabal, CLSchmidt, COShimizu, ASmith, NLSloane, KLSutoh, YSun, YVTanno, KTiedt, STatlisumak, TTorres-Aguila, NPTiwari, HKTregouet, DATrompet, STuladhar, AMTybjaerg-Hansen, AVibo, RWiggins, KLWennberg, PWoo, DWilson, PWFXu, HCYang, QYoon, KBis, JCLee, JMCheng, YCMeschia, JFChen, WMSale, MMZonderman, ABEvans, MKWilson, JGCorrea, ATraylor, MLewis, CMCarty, CLReiner, ALangefeld, CDYaffe, KLiu, YMLange, LAFurie, KLArnett, DKBenavente, ORGrewal, RPPeddareddygari, LRKooperberg, CLindstrom, SWang, LSmith, ENGordon, WVlieg, AVde Andrade, MBrody, JAPattee, JWHaessler, JSuchon, PChen, MHFrazer, KATurman, CGermain, MMacDonald, JBraekkan, SKArmasu, SMPankratz, NGiulianini, FPuurunen, MKIbrahim, MHeckbert, SRBammler, TKMcCauley, BMPankow, JSReiner, APDeleuze, JFO'Donnell, CJKim, JMcKnight, BKraft, PHansen, JBRosendaal, FRHeit, JATang, WHMorange, PEJohnson, ADKabrhel, Cvan Dijk, EJKoudstaal, PJLuijckx, GJvan Oostenbrugge, RJVisser, MCWermer, MJHKappelle, LJEsko, TMetspalu, AMagi, RNelis, MLevi, CRMaguire, JJimenez-Conde, JSharma, PSudlow, CLMRannikmae, KSchmidt, RSlowik, APera, JThijs, VNSLindgren, AGIlinca, AMelander, OEngstrom, GRexrode, KMRothwell, PMStanne, TMJohnson, JADanesh, JButterworth, ASHeitsch, LBoncoraglio, GBKubo, MPezzini, ARolfs, AWeir, DJackson, RDRoss, OALemmons, RSoderholm, MCushman, MJood, KMcDonough, CWBell, SLinkohr, BLee, THPutaala, JLopez, OLJian, XQSchminke, UCullell, NIbanez, LKrupinski, JLioutas, VMatsuda, KMontaner, JMuino, ERoquer, JSarnowski, CSattar, NSibolt, GTeumer, ARutten-Jacobs, LKanai, MGiese, AKGretarsdottir, SRost, NSYusuf, SAlmgren, PAy, HBevan, SBrown, RDCarrera, CBuring, JEChen, WMCotlarciuc, Ide Bakker, PIWDeStefano, ALden Hoed, MDuan, QEngelter, STFalcone, GJGustafsson, SHassan, AHolliday, EGHoward, GHsu, FCIngelsson, EHarris, TBKissela, BMKleindorfer, DOLangenberg, CLemmens, RLeys, DLin, WYLorentzen, EMagnusson, PKMcArdle, PFPulit, SLRice, KSakaue, SSapkota, BRTanislav, CThorleifsson, GThorsteinsdottir, UTzourio, Cvan Duijn, CMWalters, MWareham, NJAmin, NAparicio, HJAttia, JBerr, CBustamante, MCaso, VChoi, SHChowhan, ADartigues, JFDelavaran, HDorr, MFord, IGurpreet, WSHamsten, AHozawa, AIngelsson, MIwasaki, MKaffashian, SKalra, LKjartansson, OKloss, MLabovitz, DLLaurie, CCLi, LNLind, LLindgren, CMMakoto, HMinegishi, NMorris, APMuller-Nurasyid, MNorrving, BOgishima, SParati, EAPedersen, NLPerola, MJousilahti, PPileggi, SRabionet, RRiba-Llena, IRibases, MRomero, JRRudd, AGSarin, APSarju, RSatoh, MSawada, NSigurdsson, ASmith, AStine, OCStott, DJStrauch, KTakai, TTanaka, HTouze, ETsugane, SUitterlinden, AGValdimarsson, EMvan der Lee, SJWakai, KWilliams, SRWolfe, CDAWong, QNYamaji, TSanghera, DKStefansson, KTaylor, KDMartinez-Majander, NSobue, KSoriano-Tarraga, CVolzke, HAkpa, OSarfo, FSAkpalu, AObiako, RWahab, KOsaigbovo, GOwolabi, LKomolafe, MJenkins, CArulogun, OOgbole, GAdeoye, AMAkinyemi, JAgunloye, AFakunle, AGUvere, EOlalere, AAdebajo, OJChen, JSClarke, RCollins, RGuo, YWang, CLv, JPeto, RChen, YPFairhurst-Hunter, ZHill, MPozarickij, ASchmidt, DStevens, BTurnbull, IYu, CQLe Grand, QFerreira, LENagai, AMurakami, YGeerlings, MIGasca, NCGudnason, Vvan Vugt, MGottesman, RFShiroma, EJSigurdsson, SGhanbari, MBoerwinkle, EBeiser, ASFongang, BWang, RQIkram, MKVolker, Ude Jager, PLde Cid, RNordestgaard, BGSargurupremraj, MVerma, SSde Laat, KFvan Norden, AGWde Kort, PLVermeer, SEBrouwers, PJAMGons, RARNederkoorn, PJden Heijer, Tvan Dijk, GWvan Rooij, FGWAamodt, AHSkogholt, AHBrumpton, BMWiller, CJHeuch, IHagen, KFritsche, LGPedersen, LMGabrielsen, MEEllekjaer, HZhou, WMartinsen, AEKristoffersen, ESNielsen, JBHveem, KThomas, LFKleinschnitz, CFrantz, SUngethum, KGallego-Fabrega, CLledos, MLlucia-Carol, LSobrino, TCampos, FCastillo, JFreijo, MArenillas, JFObach, VAlvarez-Sabin, JMolina, CARibo, MMunoz-Narbona, LLopez-Cancio, EMillan, MDiaz-Navarro, RVives-Bauza, CSerrano-Heras, GSegura, TDelgado, PDhar, RDelgado-Mederos, RPrats-Sanchez, LCamps-Renom, PBlay, NSumoy, LMarti-Fabregas, JSchnohr, PJensen, GBBenn, MAfzal, SKamstrup, PRvan Setten, Jvan der Laan, SWVonk, JMJKim, BJCurtze, STiainen, MKinnunen, JMenon, VSung, YJYang, CRSaillour-Glenisson, FGravel, SOnland-Moret, NCHeath, AKMillwood, IYGieger, CNinomiya, TGrabe, HJJukema, JWRissanen, ILStrbian, DKim, YJChen, PHMayerhofer, EHowson, JMMIrvin, MRAdams, HWassertheil-Smoller, SChristensen, KIkram, MARundek, TWorrall, BBLathrop, GMRiaz, MSimonsick, EMKorv, JFranca, PHCZand, RPrasad, KFrikke-Schmidt, Rde Leeuw, FELiman, THaeusler, KGRuigrok, YMHeuschmann, PULongstreth, WTJung, KJBastarache, LPare, GDamrauer, SMChasman, DIRotter, JIAnderson, CDZwart, JANiiranen, TJFornage, MLiaw, YPSeshadri, SFernandez-Cadenas, IWalters, RGRuff, CTOwolabi, MOHuffman, JEMilani, LKamatani, YDichgans, MDebette, Sbrain ischemiacerebrovascular accidentdrug developmentgenetic predispositiongeneticsgenome-wide association studyhumansingle nucleotide polymorphismBrain IschemiaDrug DiscoveryGenetic Predisposition to DiseaseGenome-Wide Association StudyHumansIschemic StrokePolymorphism, Single NucleotideStrokePrevious genome-wide association studies (GWASs) of stroke - the second leading cause of death worldwide - were conducted predominantly in populations of European ancestry(1,2). Here, in cross-ancestry GWAS meta-analyses of 110,182 patients who have had a stroke (five ancestries, 33% non-European) and 1,503,898 control individuals, we identify association signals for stroke and its subtypes at 89 (61 new) independent loci: 60 in primary inverse-variance-weighted analyses and 29 in secondary meta-regression and multitrait analyses. On the basis of internal cross-ancestry validation and an independent follow-up in 89,084 additional cases of stroke (30% non-European) and 1,013,843 control individuals, 87% of the primary stroke risk loci and 60% of the secondary stroke risk loci were replicated (P < 0.05). Effect sizes were highly correlated across ancestries. Cross-ancestry fine-mapping, in silico mutagenesis analysis(3), and transcriptome-wide and proteome-wide association analyses revealed putative causal genes (such as SH3PXD2A and FURIN) and variants (such as at GRK5 and NOS3). Using a three-pronged approach(4), we provide genetic evidence for putative drug effects, highlighting F11, KLKB1, PROC, GP1BA, LAMC2 and VCAM1 as possible targets, with drugs already under investigation for stroke for F11 and PROC. A polygenic score integrating cross-ancestry and ancestry-specific stroke GWASs with vascular-risk factor GWASs (integrative polygenic scores) strongly predicted ischaemic stroke in populations of European, East Asian and African ancestry(5). Stroke genetic risk scores were predictive of ischaemic stroke independent of clinical risk factors in 52,600 clinical-trial participants with cardiometabolic disease. Our results provide insights to inform biology, reveal potential drug targets and derive genetic risk prediction tools across ancestries.NATURE PORTFOLIO2022info:eu-repo/semantics/articleinfo:eu-repo/semantics/publishedVersionhttps://iibsantpau.fundanetsuite.com/Publicaciones/ProdCientif/PublicacionFrw.aspx?id=13904NATUREISSN: 00280836ISSNe: 14764687reponame:r-IIB SANT PAU. Repositorio Institucional de Producción Científica del Instituto de Investigación Biomédica Sant Pauinstname:Institut d’Investigació Biomèdica Sant Pau (IIB Sant Pau)Inglésinfo:eu-repo/semantics/openAccessoai:iibsantpau.fundanetsuite.com:p139042026-06-14T12:41:47Z
score	15.811543

Stroke genetics informs drug discovery and risk prediction across ancestries

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