HIV-1/HAART-Related Lipodystrophy Syndrome (HALS) Is Associated with Decreased Circulating sTWEAK Levels

Background and Objectives Obesity and HIV-1/HAART-associated lipodystrophy syndrome (HALS) share clinical, pathological and mechanistic features. Tumor necrosis factor-like weak inducer of apoptosis (TWEAK) is a multifunctional cytokine that plays an important role in obesity and related diseases. W...

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Autores: López Dupla, Miguel, Maymó Masip, Elsa, Martínez Chamorro, Esteban José, Domingo, Pere (Domingo Pedrol), Leal, Manuel, Peraire, Joaquim, Viladés, Consuelo, Veloso, Sergi, Arnedo, Mireia, Ferrando-Martínez, Sara, Beltrán-Debón, Raúl, Alba, Verónica, Gatell, José M., Vendrell, Joan, Vidal Marsal, Francisco, Chacón, Matilde R.
Tipo de recurso: artículo
Estado:Versión publicada
Fecha de publicación:2015
País:España
Institución:Universidad de Barcelona
Repositorio:Dipòsit Digital de la UB
OAI Identifier:oai:diposit.ub.edu:2445/100401
Acceso en línea:https://hdl.handle.net/2445/100401
Access Level:acceso abierto
Palabra clave:Síndrome de lipodistròfia associada a VIH
VIH (Virus)
Antiretrovirals
Obesitat
Estudi de casos
HIV-associated lipodystrophy syndrome
HIV (Viruses)
Antiretroviral agents
Obesity
Case studies
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repository_id_str
spelling HIV-1/HAART-Related Lipodystrophy Syndrome (HALS) Is Associated with Decreased Circulating sTWEAK LevelsLópez Dupla, MiguelMaymó Masip, ElsaMartínez Chamorro, Esteban JoséDomingo, Pere (Domingo Pedrol)Leal, ManuelPeraire, JoaquimViladés, ConsueloVeloso, SergiArnedo, MireiaFerrando-Martínez, SaraBeltrán-Debón, RaúlAlba, VerónicaGatell, José M.Vendrell, JoanVidal Marsal, FranciscoChacón, Matilde R.Síndrome de lipodistròfia associada a VIHVIH (Virus)AntiretroviralsObesitatEstudi de casosHIV-associated lipodystrophy syndromeHIV (Viruses)Antiretroviral agentsObesityCase studiesBackground and Objectives Obesity and HIV-1/HAART-associated lipodystrophy syndrome (HALS) share clinical, pathological and mechanistic features. Tumor necrosis factor-like weak inducer of apoptosis (TWEAK) is a multifunctional cytokine that plays an important role in obesity and related diseases. We sought to explore the relationship between HALS and circulating levels of soluble (s) TWEAK and its scavenger receptor sCD163. Methods This was a cross-sectional multicenter study of 120 HIV-1-infected patients treated with a stable HAART regimen; 56 with overt HALS and 64 without HALS. Epidemiological and clinical variables were determined. Serum levels of sTWEAK and sCD163 levels were measured by ELISA. Results were analyzed with Student's t-test, Mann-Whitney U and χ2 test. Pearson and Spearman correlation were used to estimate the strength of association between variables. Results Circulating sTWEAK was significantly decreased in HALS patients compared with non-HALS patients (2.81±0.2 vs. 2.94±0.28 pg/mL, p = 0.018). No changes were observed in sCD163 levels in the studied cohorts. On multivariate analysis, a lower log sTWEAK concentration was independently associated with the presence of HALS (OR 0.027, 95% CI 0.001-0.521, p = 0.027). Conclusions HALS is associated with decreased sTWEAK levels.Public Library of Science (PLoS)2015info:eu-repo/semantics/articleinfo:eu-repo/semantics/publishedVersionapplication/pdfhttps://hdl.handle.net/2445/100401Articles publicats en revistes (Medicina)reponame:Dipòsit Digital de la UBinstname:Universidad de BarcelonaInglésReproducció del document publicat a: http://dx.doi.org/10.1371/journal.pone.0144789PLoS One, 2015, vol. 10, num. 12http://dx.doi.org/10.1371/journal.pone.0144789cc-by (c) López-Dupla, M. et al., 2015http://creativecommons.org/licenses/by/3.0/esinfo:eu-repo/semantics/openAccessoai:diposit.ub.edu:2445/1004012026-05-27T06:46:51Z
dc.title.none.fl_str_mv HIV-1/HAART-Related Lipodystrophy Syndrome (HALS) Is Associated with Decreased Circulating sTWEAK Levels
title HIV-1/HAART-Related Lipodystrophy Syndrome (HALS) Is Associated with Decreased Circulating sTWEAK Levels
spellingShingle HIV-1/HAART-Related Lipodystrophy Syndrome (HALS) Is Associated with Decreased Circulating sTWEAK Levels
López Dupla, Miguel
Síndrome de lipodistròfia associada a VIH
VIH (Virus)
Antiretrovirals
Obesitat
Estudi de casos
HIV-associated lipodystrophy syndrome
HIV (Viruses)
Antiretroviral agents
Obesity
Case studies
title_short HIV-1/HAART-Related Lipodystrophy Syndrome (HALS) Is Associated with Decreased Circulating sTWEAK Levels
title_full HIV-1/HAART-Related Lipodystrophy Syndrome (HALS) Is Associated with Decreased Circulating sTWEAK Levels
title_fullStr HIV-1/HAART-Related Lipodystrophy Syndrome (HALS) Is Associated with Decreased Circulating sTWEAK Levels
title_full_unstemmed HIV-1/HAART-Related Lipodystrophy Syndrome (HALS) Is Associated with Decreased Circulating sTWEAK Levels
title_sort HIV-1/HAART-Related Lipodystrophy Syndrome (HALS) Is Associated with Decreased Circulating sTWEAK Levels
dc.creator.none.fl_str_mv López Dupla, Miguel
Maymó Masip, Elsa
Martínez Chamorro, Esteban José
Domingo, Pere (Domingo Pedrol)
Leal, Manuel
Peraire, Joaquim
Viladés, Consuelo
Veloso, Sergi
Arnedo, Mireia
Ferrando-Martínez, Sara
Beltrán-Debón, Raúl
Alba, Verónica
Gatell, José M.
Vendrell, Joan
Vidal Marsal, Francisco
Chacón, Matilde R.
author López Dupla, Miguel
author_facet López Dupla, Miguel
Maymó Masip, Elsa
Martínez Chamorro, Esteban José
Domingo, Pere (Domingo Pedrol)
Leal, Manuel
Peraire, Joaquim
Viladés, Consuelo
Veloso, Sergi
Arnedo, Mireia
Ferrando-Martínez, Sara
Beltrán-Debón, Raúl
Alba, Verónica
Gatell, José M.
Vendrell, Joan
Vidal Marsal, Francisco
Chacón, Matilde R.
author_role author
author2 Maymó Masip, Elsa
Martínez Chamorro, Esteban José
Domingo, Pere (Domingo Pedrol)
Leal, Manuel
Peraire, Joaquim
Viladés, Consuelo
Veloso, Sergi
Arnedo, Mireia
Ferrando-Martínez, Sara
Beltrán-Debón, Raúl
Alba, Verónica
Gatell, José M.
Vendrell, Joan
Vidal Marsal, Francisco
Chacón, Matilde R.
author2_role author
author
author
author
author
author
author
author
author
author
author
author
author
author
author
dc.subject.none.fl_str_mv Síndrome de lipodistròfia associada a VIH
VIH (Virus)
Antiretrovirals
Obesitat
Estudi de casos
HIV-associated lipodystrophy syndrome
HIV (Viruses)
Antiretroviral agents
Obesity
Case studies
topic Síndrome de lipodistròfia associada a VIH
VIH (Virus)
Antiretrovirals
Obesitat
Estudi de casos
HIV-associated lipodystrophy syndrome
HIV (Viruses)
Antiretroviral agents
Obesity
Case studies
description Background and Objectives Obesity and HIV-1/HAART-associated lipodystrophy syndrome (HALS) share clinical, pathological and mechanistic features. Tumor necrosis factor-like weak inducer of apoptosis (TWEAK) is a multifunctional cytokine that plays an important role in obesity and related diseases. We sought to explore the relationship between HALS and circulating levels of soluble (s) TWEAK and its scavenger receptor sCD163. Methods This was a cross-sectional multicenter study of 120 HIV-1-infected patients treated with a stable HAART regimen; 56 with overt HALS and 64 without HALS. Epidemiological and clinical variables were determined. Serum levels of sTWEAK and sCD163 levels were measured by ELISA. Results were analyzed with Student's t-test, Mann-Whitney U and χ2 test. Pearson and Spearman correlation were used to estimate the strength of association between variables. Results Circulating sTWEAK was significantly decreased in HALS patients compared with non-HALS patients (2.81±0.2 vs. 2.94±0.28 pg/mL, p = 0.018). No changes were observed in sCD163 levels in the studied cohorts. On multivariate analysis, a lower log sTWEAK concentration was independently associated with the presence of HALS (OR 0.027, 95% CI 0.001-0.521, p = 0.027). Conclusions HALS is associated with decreased sTWEAK levels.
publishDate 2015
dc.date.none.fl_str_mv 2015
dc.type.none.fl_str_mv info:eu-repo/semantics/article
info:eu-repo/semantics/publishedVersion
format article
status_str publishedVersion
dc.identifier.none.fl_str_mv https://hdl.handle.net/2445/100401
url https://hdl.handle.net/2445/100401
dc.language.none.fl_str_mv Inglés
language_invalid_str_mv Inglés
dc.relation.none.fl_str_mv Reproducció del document publicat a: http://dx.doi.org/10.1371/journal.pone.0144789
PLoS One, 2015, vol. 10, num. 12
http://dx.doi.org/10.1371/journal.pone.0144789
dc.rights.none.fl_str_mv cc-by (c) López-Dupla, M. et al., 2015
http://creativecommons.org/licenses/by/3.0/es
info:eu-repo/semantics/openAccess
rights_invalid_str_mv cc-by (c) López-Dupla, M. et al., 2015
http://creativecommons.org/licenses/by/3.0/es
eu_rights_str_mv openAccess
dc.format.none.fl_str_mv application/pdf
dc.publisher.none.fl_str_mv Public Library of Science (PLoS)
publisher.none.fl_str_mv Public Library of Science (PLoS)
dc.source.none.fl_str_mv Articles publicats en revistes (Medicina)
reponame:Dipòsit Digital de la UB
instname:Universidad de Barcelona
instname_str Universidad de Barcelona
reponame_str Dipòsit Digital de la UB
collection Dipòsit Digital de la UB
repository.name.fl_str_mv
repository.mail.fl_str_mv
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score 15,300724

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