Autoantibodies and damage in patients with idiopathic inflammatory myopathies: A longitudinal multicenter study from the MYONET international network

Autoantibodies; Inflammatory myopathies; Organ damage

Detalles Bibliográficos
Autores: Espinosa-Ortega, Fabricio, Lodin, Karin, Dastmalchi, Maryam, Vencovsky, Jiri, Diederichsen, Louise, Shinjo, Samuel, Selva-O'Callaghan, Albert
Tipo de recurso: artículo
Estado:Versión publicada
Fecha de publicación:2024
País:España
Institución:Varias* (Consorci de Biblioteques Universitáries de Catalunya, Centre de Serveis Científics i Acadèmics de Catalunya)
Repositorio:Recercat. Dipósit de la Recerca de Catalunya
OAI Identifier:oai:recercat.cat:11351/12616
Acceso en línea:https://hdl.handle.net/11351/12616
http://hdl.handle.net/11351/12616
Access Level:acceso abierto
Palabra clave:Autoanticossos
Dermatomiositis
Músculs - Malalties
CHEMICALS AND DRUGS::Amino Acids, Peptides, and Proteins::Proteins::Blood Proteins::Immunoproteins::Immunoglobulins::Antibodies::Autoantibodies
DISEASES::Musculoskeletal Diseases::Muscular Diseases::Myositis::Polymyositis::Dermatomyositis
DISEASES::Musculoskeletal Diseases::Muscular Diseases::Myositis
COMPUESTOS QUÍMICOS Y DROGAS::aminoácidos, péptidos y proteínas::proteínas::proteínas sanguíneas::inmunoproteínas::inmunoglobulinas::anticuerpos::autoanticuerpos
ENFERMEDADES::enfermedades musculoesqueléticas::enfermedades musculares::miositis::polimiositis::dermatomiositis
ENFERMEDADES::enfermedades musculoesqueléticas::enfermedades musculares::miositis
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oai_identifier_str oai:recercat.cat:11351/12616
network_acronym_str ES
network_name_str España
repository_id_str
dc.title.none.fl_str_mv Autoantibodies and damage in patients with idiopathic inflammatory myopathies: A longitudinal multicenter study from the MYONET international network
title Autoantibodies and damage in patients with idiopathic inflammatory myopathies: A longitudinal multicenter study from the MYONET international network
spellingShingle Autoantibodies and damage in patients with idiopathic inflammatory myopathies: A longitudinal multicenter study from the MYONET international network
Espinosa-Ortega, Fabricio
Autoanticossos
Dermatomiositis
Músculs - Malalties
CHEMICALS AND DRUGS::Amino Acids, Peptides, and Proteins::Proteins::Blood Proteins::Immunoproteins::Immunoglobulins::Antibodies::Autoantibodies
DISEASES::Musculoskeletal Diseases::Muscular Diseases::Myositis::Polymyositis::Dermatomyositis
DISEASES::Musculoskeletal Diseases::Muscular Diseases::Myositis
COMPUESTOS QUÍMICOS Y DROGAS::aminoácidos, péptidos y proteínas::proteínas::proteínas sanguíneas::inmunoproteínas::inmunoglobulinas::anticuerpos::autoanticuerpos
ENFERMEDADES::enfermedades musculoesqueléticas::enfermedades musculares::miositis::polimiositis::dermatomiositis
ENFERMEDADES::enfermedades musculoesqueléticas::enfermedades musculares::miositis
title_short Autoantibodies and damage in patients with idiopathic inflammatory myopathies: A longitudinal multicenter study from the MYONET international network
title_full Autoantibodies and damage in patients with idiopathic inflammatory myopathies: A longitudinal multicenter study from the MYONET international network
title_fullStr Autoantibodies and damage in patients with idiopathic inflammatory myopathies: A longitudinal multicenter study from the MYONET international network
title_full_unstemmed Autoantibodies and damage in patients with idiopathic inflammatory myopathies: A longitudinal multicenter study from the MYONET international network
title_sort Autoantibodies and damage in patients with idiopathic inflammatory myopathies: A longitudinal multicenter study from the MYONET international network
dc.creator.none.fl_str_mv Espinosa-Ortega, Fabricio
Lodin, Karin
Dastmalchi, Maryam
Vencovsky, Jiri
Diederichsen, Louise
Shinjo, Samuel
Selva-O'Callaghan, Albert
author Espinosa-Ortega, Fabricio
author_facet Espinosa-Ortega, Fabricio
Lodin, Karin
Dastmalchi, Maryam
Vencovsky, Jiri
Diederichsen, Louise
Shinjo, Samuel
Selva-O'Callaghan, Albert
author_role author
author2 Lodin, Karin
Dastmalchi, Maryam
Vencovsky, Jiri
Diederichsen, Louise
Shinjo, Samuel
Selva-O'Callaghan, Albert
author2_role author
author
author
author
author
author
dc.contributor.none.fl_str_mv Institut Català de la Salut
[Espinosa-Ortega F, Lodin K, Dastmalchi M] Division of Rheumatology, Department of Medicine, Solna, Karolinska Institutet, Stockholm, Sweden. Department of Gastro, Dermatology and Rheumatology, Karolinska University Hospital, Stockholm, Sweden. [Vencovsky J] Institute of Rheumatology and Department of Rheumatology, 1st Medical Faculty, Charles University, Prague, Czech Republic. [Diederichsen LP] Center for Rheumatology and Spine Diseases, Copenhagen University Hospital, Rigshospitalet, Copenhagen, Denmark. Department of Rheumatology, Odense University Hospital, Odense, Denmark. [Shinjo SK] Division of Rheumatology, Faculdade de Medicina FMUSP, Universidade de Sao Paulo, Sao Paulo, SP, Brazil. [Selva-O'Callaghan A] Àrea de Malalties Autoimmunes Sistèmiques, Vall d’Hebron Hospital Universitari, Barcelona, Spain. Universitat Autònoma de Barcelona, Bellaterra, Spain
Vall d'Hebron Barcelona Hospital Campus
dc.subject.none.fl_str_mv Autoanticossos
Dermatomiositis
Músculs - Malalties
CHEMICALS AND DRUGS::Amino Acids, Peptides, and Proteins::Proteins::Blood Proteins::Immunoproteins::Immunoglobulins::Antibodies::Autoantibodies
DISEASES::Musculoskeletal Diseases::Muscular Diseases::Myositis::Polymyositis::Dermatomyositis
DISEASES::Musculoskeletal Diseases::Muscular Diseases::Myositis
COMPUESTOS QUÍMICOS Y DROGAS::aminoácidos, péptidos y proteínas::proteínas::proteínas sanguíneas::inmunoproteínas::inmunoglobulinas::anticuerpos::autoanticuerpos
ENFERMEDADES::enfermedades musculoesqueléticas::enfermedades musculares::miositis::polimiositis::dermatomiositis
ENFERMEDADES::enfermedades musculoesqueléticas::enfermedades musculares::miositis
topic Autoanticossos
Dermatomiositis
Músculs - Malalties
CHEMICALS AND DRUGS::Amino Acids, Peptides, and Proteins::Proteins::Blood Proteins::Immunoproteins::Immunoglobulins::Antibodies::Autoantibodies
DISEASES::Musculoskeletal Diseases::Muscular Diseases::Myositis::Polymyositis::Dermatomyositis
DISEASES::Musculoskeletal Diseases::Muscular Diseases::Myositis
COMPUESTOS QUÍMICOS Y DROGAS::aminoácidos, péptidos y proteínas::proteínas::proteínas sanguíneas::inmunoproteínas::inmunoglobulinas::anticuerpos::autoanticuerpos
ENFERMEDADES::enfermedades musculoesqueléticas::enfermedades musculares::miositis::polimiositis::dermatomiositis
ENFERMEDADES::enfermedades musculoesqueléticas::enfermedades musculares::miositis
description Autoantibodies; Inflammatory myopathies; Organ damage
publishDate 2024
dc.date.none.fl_str_mv 2024
2025
2025
dc.type.none.fl_str_mv info:eu-repo/semantics/article
info:eu-repo/semantics/publishedVersion
format article
status_str publishedVersion
dc.identifier.none.fl_str_mv https://hdl.handle.net/11351/12616
http://hdl.handle.net/11351/12616
url https://hdl.handle.net/11351/12616
http://hdl.handle.net/11351/12616
dc.language.none.fl_str_mv Inglés
language_invalid_str_mv Inglés
dc.relation.none.fl_str_mv Seminars in Arthritis and Rheumatism;68
https://doi.org/10.1016/j.semarthrit.2024.152529
dc.rights.none.fl_str_mv Attribution 4.0 International
http://creativecommons.org/licenses/by/4.0/
info:eu-repo/semantics/openAccess
rights_invalid_str_mv Attribution 4.0 International
http://creativecommons.org/licenses/by/4.0/
eu_rights_str_mv openAccess
dc.format.none.fl_str_mv application/pdf
dc.publisher.none.fl_str_mv Elsevier
publisher.none.fl_str_mv Elsevier
dc.source.none.fl_str_mv Scientia
reponame:Recercat. Dipósit de la Recerca de Catalunya
instname:Varias* (Consorci de Biblioteques Universitáries de Catalunya, Centre de Serveis Científics i Acadèmics de Catalunya)
instname_str Varias* (Consorci de Biblioteques Universitáries de Catalunya, Centre de Serveis Científics i Acadèmics de Catalunya)
reponame_str Recercat. Dipósit de la Recerca de Catalunya
collection Recercat. Dipósit de la Recerca de Catalunya
repository.name.fl_str_mv
repository.mail.fl_str_mv
_version_ 1869411775080824832
spelling Autoantibodies and damage in patients with idiopathic inflammatory myopathies: A longitudinal multicenter study from the MYONET international networkEspinosa-Ortega, FabricioLodin, KarinDastmalchi, MaryamVencovsky, JiriDiederichsen, LouiseShinjo, SamuelSelva-O'Callaghan, AlbertAutoanticossosDermatomiositisMúsculs - MalaltiesCHEMICALS AND DRUGS::Amino Acids, Peptides, and Proteins::Proteins::Blood Proteins::Immunoproteins::Immunoglobulins::Antibodies::AutoantibodiesDISEASES::Musculoskeletal Diseases::Muscular Diseases::Myositis::Polymyositis::DermatomyositisDISEASES::Musculoskeletal Diseases::Muscular Diseases::MyositisCOMPUESTOS QUÍMICOS Y DROGAS::aminoácidos, péptidos y proteínas::proteínas::proteínas sanguíneas::inmunoproteínas::inmunoglobulinas::anticuerpos::autoanticuerposENFERMEDADES::enfermedades musculoesqueléticas::enfermedades musculares::miositis::polimiositis::dermatomiositisENFERMEDADES::enfermedades musculoesqueléticas::enfermedades musculares::miositisAutoantibodies; Inflammatory myopathies; Organ damageAutoanticossos; Miopaties inflamatòries; Dany als òrgansAutoanticuerpos; Miopatías inflamatorias; Daño a los órganosObjective: To study the trajectories of changes in damage over time and explore associations with autoantibody defined subgroups using a large international cohort of patients with idiopathic inflammatory myopathies (IIM). Methods: Data from the MYONET registry, including patients who were tested for autoantibodies and had at least one assessment of damage using the Myositis Damage Index (MDI), were analyzed. Patients were sub-grouped according to their autoantibody profiles (myositis-specific, myositis-associated, or seronegative). The index date was defined as the time point for the first registered MDI assessment. The longitudinal trajectories of damage with autoantibody status as the main predictor were analyzed using linear mixed models. Results: A total of 757 adult patients were included in this study. Each year of disease duration since diagnosis had an estimated MDI score increase of 0.16 units for the seronegative group (reference). Compared with the seronegative group as reference, patients with dermatomyositis-specific autoantibodies developed less damage per year of follow-up since diagnosis (average 0.08 less score, P = 0.04), whereas patients with anti-PM/Scl autoantibodies developed more damage per year of follow-up since diagnosis (average 0.28 higher score, P = 0.03) independent of sex and age at diagnosis. The seronegative subgroup and the immune-mediated necrotizing myopathy autoantibody subgroup had the strongest correlation between severity of muscle damage and HAQ-DI scores at five years of follow-up, rho=0.84, P < 0.001 and rho=0.72, P < 0.001, respectively. Conclusion: Our study is the first to describe patterns and trajectories of change in damage over time in relation to autoantibody defined subgroups in a large international multicenter cohort of patients with IIM. Patients with anti-PM/Scl scored a greater extent of damage, whereas patients with dermatomyositis-specific antibodies had less damage than seronegative patients. Severity in muscle damage had moderate to strong correlation with functional disability among the IMNM and seronegative subgroups with lower correlations for the other subgroups. These findings suggest that autoantibodies may be useful predictors of long-term damage.ElsevierInstitut Català de la Salut[Espinosa-Ortega F, Lodin K, Dastmalchi M] Division of Rheumatology, Department of Medicine, Solna, Karolinska Institutet, Stockholm, Sweden. Department of Gastro, Dermatology and Rheumatology, Karolinska University Hospital, Stockholm, Sweden. [Vencovsky J] Institute of Rheumatology and Department of Rheumatology, 1st Medical Faculty, Charles University, Prague, Czech Republic. [Diederichsen LP] Center for Rheumatology and Spine Diseases, Copenhagen University Hospital, Rigshospitalet, Copenhagen, Denmark. Department of Rheumatology, Odense University Hospital, Odense, Denmark. [Shinjo SK] Division of Rheumatology, Faculdade de Medicina FMUSP, Universidade de Sao Paulo, Sao Paulo, SP, Brazil. [Selva-O'Callaghan A] Àrea de Malalties Autoimmunes Sistèmiques, Vall d’Hebron Hospital Universitari, Barcelona, Spain. Universitat Autònoma de Barcelona, Bellaterra, SpainVall d'Hebron Barcelona Hospital Campus202520252024info:eu-repo/semantics/articleinfo:eu-repo/semantics/publishedVersionapplication/pdfhttps://hdl.handle.net/11351/12616http://hdl.handle.net/11351/12616Scientiareponame:Recercat. Dipósit de la Recerca de Catalunyainstname:Varias* (Consorci de Biblioteques Universitáries de Catalunya, Centre de Serveis Científics i Acadèmics de Catalunya)InglésSeminars in Arthritis and Rheumatism;68https://doi.org/10.1016/j.semarthrit.2024.152529Attribution 4.0 Internationalhttp://creativecommons.org/licenses/by/4.0/info:eu-repo/semantics/openAccessoai:recercat.cat:11351/126162026-05-29T05:05:01Z
score 15.811543

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