Biomarkers for diagnosis and prediction of therapy responses in allergic diseases and asthma.

Modern health care requires a proactive and individualized response to diseases, combining precision diagnosis and personalized treatment. Accordingly, the approach to patients with allergic diseases encompasses novel developments in the area of personalized medicine, disease phenotyping and endotyp...

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Autores: Breiteneder, Heimo, Peng, Ya-Qi, Agache, Ioana, Diamant, Zuzana, Eiwegger, Thomas, Fokkens, Wytske J, Traidl-Hoffmann, Claudia, Nadeau, Kari, O'Hehir, Robyn E, O'Mahony, Liam, Pfaar, Oliver, Torres, Maria J, Wang, De-Yun, Zhang, Luo, Akdis, Cezmi A
Formato: artículo
Fecha de publicación:2020
País:España
Recursos:Instituto de Salud Carlos III (ISCIII)
Repositorio:Repisalud
Idioma:inglés
OAI Identifier:oai:repisalud.isciii.es:20.500.12105/18129
Acesso em linha:http://hdl.handle.net/20.500.12105/18129
Access Level:acceso abierto
Palavra-chave:Allergen immunotherapy
Allergic rhinitis
Asthma phenotypes and endotypes
Biomarkers
Food allergy
Asthma
Dermatitis, Atopic
Food Hypersensitivity
Humans
Hypersensitivity
Rhinitis, Allergic
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repository_id_str
spelling Biomarkers for diagnosis and prediction of therapy responses in allergic diseases and asthma.Breiteneder, HeimoPeng, Ya-QiAgache, IoanaDiamant, ZuzanaEiwegger, ThomasFokkens, Wytske JTraidl-Hoffmann, ClaudiaNadeau, KariO'Hehir, Robyn EO'Mahony, LiamPfaar, OliverTorres, Maria JWang, De-YunZhang, LuoAkdis, Cezmi AAllergen immunotherapyAllergic rhinitisAsthma phenotypes and endotypesBiomarkersFood allergyAsthmaBiomarkersDermatitis, AtopicFood HypersensitivityHumansHypersensitivityRhinitis, AllergicModern health care requires a proactive and individualized response to diseases, combining precision diagnosis and personalized treatment. Accordingly, the approach to patients with allergic diseases encompasses novel developments in the area of personalized medicine, disease phenotyping and endotyping, and the development and application of reliable biomarkers. A detailed clinical history and physical examination followed by the detection of IgE immunoreactivity against specific allergens still represents the state of the art. However, nowadays, further emphasis focuses on the optimization of diagnostic and therapeutic standards and a large number of studies have been investigating the biomarkers of allergic diseases, including asthma, atopic dermatitis, allergic rhinitis, food allergy, urticaria and anaphylaxis. Various biomarkers have been developed by omics technologies, some of which lead to a better classification of distinct phenotypes or endotypes. The introduction of biologicals to clinical practice increases the need for biomarkers for patient selection, prediction of outcomes and monitoring, to allow for an adequate choice of the duration of these costly and long-lasting therapies. Escalating healthcare costs together with questions about the efficacy of the current management of allergic diseases require further development of a biomarker-driven approach. Here, we review biomarkers in diagnosis and treatment of asthma, atopic dermatitis, allergic rhinitis, viral infections, chronic rhinosinusitis, food allergy, drug hypersensitivity and allergen immunotherapy with a special emphasis on specific IgE, the microbiome and the epithelial barrier. In addition, EAACI guidelines on biologicals are discussed within the perspective of biomarkers.20242024-02-1220202020-09-3020202020-09-30research articlehttp://purl.org/coar/resource_type/c_2df8fbb1VoRhttp://purl.org/coar/version/c_970fb48d4fbd8a85info:eu-repo/semantics/articlehttp://hdl.handle.net/20.500.12105/18129reponame:Repisaludinstname:Instituto de Salud Carlos III (ISCIII)Inglésengopen accesshttp://purl.org/coar/access_right/c_abf2Attribution-NonCommercial 4.0 Internationalhttp://creativecommons.org/licenses/by-nc/4.0/info:eu-repo/semantics/openAccessoai:repisalud.isciii.es:20.500.12105/181292026-06-12T12:43:37Z
dc.title.none.fl_str_mv Biomarkers for diagnosis and prediction of therapy responses in allergic diseases and asthma.
title Biomarkers for diagnosis and prediction of therapy responses in allergic diseases and asthma.
spellingShingle Biomarkers for diagnosis and prediction of therapy responses in allergic diseases and asthma.
Breiteneder, Heimo
Allergen immunotherapy
Allergic rhinitis
Asthma phenotypes and endotypes
Biomarkers
Food allergy
Asthma
Biomarkers
Dermatitis, Atopic
Food Hypersensitivity
Humans
Hypersensitivity
Rhinitis, Allergic
title_short Biomarkers for diagnosis and prediction of therapy responses in allergic diseases and asthma.
title_full Biomarkers for diagnosis and prediction of therapy responses in allergic diseases and asthma.
title_fullStr Biomarkers for diagnosis and prediction of therapy responses in allergic diseases and asthma.
title_full_unstemmed Biomarkers for diagnosis and prediction of therapy responses in allergic diseases and asthma.
title_sort Biomarkers for diagnosis and prediction of therapy responses in allergic diseases and asthma.
dc.creator.none.fl_str_mv Breiteneder, Heimo
Peng, Ya-Qi
Agache, Ioana
Diamant, Zuzana
Eiwegger, Thomas
Fokkens, Wytske J
Traidl-Hoffmann, Claudia
Nadeau, Kari
O'Hehir, Robyn E
O'Mahony, Liam
Pfaar, Oliver
Torres, Maria J
Wang, De-Yun
Zhang, Luo
Akdis, Cezmi A
author Breiteneder, Heimo
author_facet Breiteneder, Heimo
Peng, Ya-Qi
Agache, Ioana
Diamant, Zuzana
Eiwegger, Thomas
Fokkens, Wytske J
Traidl-Hoffmann, Claudia
Nadeau, Kari
O'Hehir, Robyn E
O'Mahony, Liam
Pfaar, Oliver
Torres, Maria J
Wang, De-Yun
Zhang, Luo
Akdis, Cezmi A
author_role author
author2 Peng, Ya-Qi
Agache, Ioana
Diamant, Zuzana
Eiwegger, Thomas
Fokkens, Wytske J
Traidl-Hoffmann, Claudia
Nadeau, Kari
O'Hehir, Robyn E
O'Mahony, Liam
Pfaar, Oliver
Torres, Maria J
Wang, De-Yun
Zhang, Luo
Akdis, Cezmi A
author2_role author
author
author
author
author
author
author
author
author
author
author
author
author
author
dc.contributor.none.fl_str_mv
dc.subject.none.fl_str_mv Allergen immunotherapy
Allergic rhinitis
Asthma phenotypes and endotypes
Biomarkers
Food allergy
Asthma
Biomarkers
Dermatitis, Atopic
Food Hypersensitivity
Humans
Hypersensitivity
Rhinitis, Allergic
topic Allergen immunotherapy
Allergic rhinitis
Asthma phenotypes and endotypes
Biomarkers
Food allergy
Asthma
Biomarkers
Dermatitis, Atopic
Food Hypersensitivity
Humans
Hypersensitivity
Rhinitis, Allergic
description Modern health care requires a proactive and individualized response to diseases, combining precision diagnosis and personalized treatment. Accordingly, the approach to patients with allergic diseases encompasses novel developments in the area of personalized medicine, disease phenotyping and endotyping, and the development and application of reliable biomarkers. A detailed clinical history and physical examination followed by the detection of IgE immunoreactivity against specific allergens still represents the state of the art. However, nowadays, further emphasis focuses on the optimization of diagnostic and therapeutic standards and a large number of studies have been investigating the biomarkers of allergic diseases, including asthma, atopic dermatitis, allergic rhinitis, food allergy, urticaria and anaphylaxis. Various biomarkers have been developed by omics technologies, some of which lead to a better classification of distinct phenotypes or endotypes. The introduction of biologicals to clinical practice increases the need for biomarkers for patient selection, prediction of outcomes and monitoring, to allow for an adequate choice of the duration of these costly and long-lasting therapies. Escalating healthcare costs together with questions about the efficacy of the current management of allergic diseases require further development of a biomarker-driven approach. Here, we review biomarkers in diagnosis and treatment of asthma, atopic dermatitis, allergic rhinitis, viral infections, chronic rhinosinusitis, food allergy, drug hypersensitivity and allergen immunotherapy with a special emphasis on specific IgE, the microbiome and the epithelial barrier. In addition, EAACI guidelines on biologicals are discussed within the perspective of biomarkers.
publishDate 2020
dc.date.none.fl_str_mv 2020
2020-09-30
2020
2020-09-30
2024
2024-02-12
dc.type.none.fl_str_mv research article
http://purl.org/coar/resource_type/c_2df8fbb1
VoR
http://purl.org/coar/version/c_970fb48d4fbd8a85
dc.type.openaire.fl_str_mv info:eu-repo/semantics/article
format article
dc.identifier.none.fl_str_mv http://hdl.handle.net/20.500.12105/18129
url http://hdl.handle.net/20.500.12105/18129
dc.language.none.fl_str_mv Inglés
eng
language_invalid_str_mv Inglés
language eng
dc.rights.none.fl_str_mv open access
http://purl.org/coar/access_right/c_abf2
Attribution-NonCommercial 4.0 International
http://creativecommons.org/licenses/by-nc/4.0/
dc.rights.openaire.fl_str_mv info:eu-repo/semantics/openAccess
rights_invalid_str_mv open access
http://purl.org/coar/access_right/c_abf2
Attribution-NonCommercial 4.0 International
http://creativecommons.org/licenses/by-nc/4.0/
eu_rights_str_mv openAccess
dc.source.none.fl_str_mv reponame:Repisalud
instname:Instituto de Salud Carlos III (ISCIII)
instname_str Instituto de Salud Carlos III (ISCIII)
reponame_str Repisalud
collection Repisalud
repository.name.fl_str_mv
repository.mail.fl_str_mv
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score 15,81155

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